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31. 发明申请

WO2012016135A1 BALLOON WITH SURFACE ELECTRODES AND INTEGRAL COOLING FOR RENAL NERVE ABLATION 审中-公开
标题翻译：具有表面电极的气泡和用于肾神经退化的整体冷却
公开(公告)号：WO2012016135A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045879
申请日：2011-07-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WILLARD, Martin, R. , KOBLISH, Joe , HASTINGS, Roger
发明人： WILLARD, Martin, R. , KOBLISH, Joe , HASTINGS, Roger
IPC分类号： A61B18/14 , A61B17/00
CPC分类号： A61B18/1492 , A61B2017/00026 , A61B2017/00092 , A61B2018/00011 , A61B2018/00023 , A61B2018/00047 , A61B2018/00095 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00744 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/0212
摘要： A catheter arrangement includes a flexible shaft and a balloon disposed at a distal end of the shaft and configurable for deployment within a target vessel of the body, such as a renal artery. Ablation electrodes, supported by a balloon wall, are arranged in a predefined pattern. The electrodes deliver electrical energy sufficient to ablate target tissue, such as perivascular renal nerves, proximate the target vessel wall when the balloon is in a deployed configuration. A cooling arrangement is encompassed at least in part by the balloon and provides cooling to at least the electrodes during ablation such that a location at which steady-state ablative heating begins is translated from an electrode-tissue interface at the target vessel wall to a location a predetermined distance away from the electrode-tissue interface.
摘要翻译：导管装置包括柔性轴和设置在轴的远端处的球囊，并且可配置用于展开在诸如肾动脉的身体的靶容器内。由气球壁支撑的消融电极以预定图案排列。当气囊处于展开构型时，电极传递足以消融目标组织（例如血管周围肾神经）的电能，靠近目标血管壁。冷却装置至少部分地由气球包围，并且在消融期间至少提供电极的冷却，使得开始稳态烧蚀加热的位置从目标血管壁的电极 - 组织界面平移到位置距离电极组织界面预定的距离。

32. 发明申请

WO2005032388A1 TISSUE PROBE ASSEMBLY WITH VACUUM-BASED STABILIZER 审中-公开
标题翻译：组织探头组件与基于真空的稳定器
公开(公告)号：WO2005032388A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/028733
申请日：2004-09-03
申请人： SCIMED LIFE SYSTEMS, INC. , PHAN, Huy, D.
发明人： PHAN, Huy, D.
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/16 , A61B2018/00065 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00238 , A61B2018/00291 , A61B2018/00351
摘要： An operative tissue probe includes an elongate member, an electrode element carried on a distal end of the elongate member, the electrode element having an expandable-collapsible body, and a stabilizer element carried on the distal end of the elongate member, the stabilizer element at least partially surrounding the electrode element and configured for applying a vacuum force to secure the electrode element to a tissue surface.
摘要翻译：手术组织探针包括细长构件，承载在细长构件的远端上的电极元件，电极元件具有可膨胀的可折叠主体，以及承载在细长构件的远端上的稳定器元件，稳定器元件至少部分地围绕所述电极元件并且被配置为施加真空力以将所述电极元件固定到组织表面。

33. 发明申请

WO2004055229A2 COATING REINFORCING UNDERLAYMENT AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：涂层增强底层及其制造方法
公开(公告)号：WO2004055229A2
公开(公告)日：2004-07-01
申请号：PCT/US2003/036604
申请日：2003-11-14
申请人： ORION INDUSTRIES, LTD.
发明人： NESBITT, Bruce
IPC分类号： C23C
CPC分类号： A47J36/025 , A61B18/14 , A61B18/1402 , A61B2018/0013 , A61B2018/00148 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2420/08 , B05D3/0281 , B05D3/20 , B05D5/00 , B05D5/02 , B05D5/06 , B05D5/08 , B05D5/083 , B05D7/52 , B05D7/54 , B05D2601/20 , B65G49/064 , B65G2249/02 , C03B35/14 , F16C33/201 , Y10T428/24372 , Y10T428/2438 , Y10T428/24413 , Y10T428/254 , Y10T428/31725 , Y10T428/32
摘要： A reinforcing underlayment including dry uniform particles evenly applied to a wet bonding material layer on a surface of a substrate. The substrate, including the layers, is then cured to harden the one or more of the layers. A final coating or topcoat is applied to the cured surface of the substrate. The dry particles are evenly distributed onto the bonding material layer creating a uniform surface for subsequent coatings. The dry particles increase the strength of the liquid coatings increasing solid particle density within the coating system and thereby imparting properties not available for the liquid coatings. The present invention enables a user to easily introduce very heavy, dense, strong particles into a liquid coating and allows the user to apply very dense, heavy particles into and onto a wet bonding material layer followed by a subsequent wet topcoat layer which is cured as one contiguous material with reinforcement and underlayment strengthening coming from the added, dry particles.
摘要翻译：加强垫层，其包括均匀地施加到基底表面上的湿粘结材料层上的干均匀颗粒。然后将包括这些层的基底固化以使一个或多个层硬化。将最终的涂层或面涂层施加到基材的固化表面。干颗粒均匀地分布在粘合材料层上，为后续涂层产生均匀的表面。干颗粒增加液体涂层的强度，增加涂料体系内的固体颗粒密度，从而赋予液体涂料不可用的性质。本发明使用户能够容易地将非常重，致密，强的颗粒引入到液体涂层中，并且允许使用者将非常致密的重颗粒施加到湿粘结材料层中和之上，随后是随后的湿顶涂层，其被固化为一个连续的材料，具有加强和底层加固来自添加的干燥颗粒。

34. 发明申请

WO03061456A2 ELECTROSURGICAL INSTRUMENT AND METHOD OF USE 审中-公开
标题翻译：静电仪器及其使用方法
公开(公告)号：WO03061456A2
公开(公告)日：2003-07-31
申请号：PCT/US0302131
申请日：2003-01-22
申请人： SCIOGEN LLC
发明人： TRUCKAI CSABA , SHADDUCK JOHN H , BAKER JAMES A
IPC分类号： A61B18/12 , A61B20060101 , A61B1/00 , A61B18/04 , A61B18/14 , A61B18/18 , A61B
CPC分类号： A61B18/1442 , A61B2018/00077 , A61B2018/00083 , A61B2018/00125 , A61B2018/00148 , A61B2018/0063
摘要： An electrosurgical medical device and method for creating thermal welds in engaged tissue. In one embodiment, at least one jaw of the instrument defines a tissue engagement plane carrying a conductive-resistive matrix of a conductively-doped non-conductive elastomer. The engagement surface portions thus can be described as a positive temperature coefficient material that has a unique selected decreased electrical conductance at each selected increased temperature thereof over a targeted treatment range. The conductive-resistive matrix can be engineered to bracket a targeted thermal treatment range, for example about 60 oC. to 80 oC., at which tissue welding can be accomplished. In one mode of operation, the engagement plane will automatically modulate and spatially localize ohmic heating within the engaged tissue from Rf energy application-across micron-scale portions of the engagement surface. In another mode of operation, a conductive-resistive matrix can induce a "wave" of Rf energy density to sweep across the tissue to thereby weld tissue.
摘要翻译：一种用于在接合组织中产生热焊缝的电外科医疗装置和方法。在一个实施例中，仪器的至少一个钳口限定了携带导电掺杂非导电弹性体的导电电阻矩阵的组织接合平面。因此，接合表面部分可以描述为正温度系数材料，其在目标处理范围内在其每个选定的升高温度下具有唯一选择的降低的电导率。导电电阻矩阵可以被设计成支架于目标热处理范围，例如约60℃。至80℃，可以进行组织焊接。在一种操作模式中，接合平面将自动地调节并且在接合表面的微米级部分上从Rf能量施加 - 自动地调节所接合组织内的欧姆加热。在另一种操作模式中，导电电阻矩阵可以引起Rf能量密度的“波”，从而扫过组织从而焊接组织。

35. 发明申请

WO2003047043A1 INVASIVE THERAPEUTIC PROBE 审中-公开
标题翻译：入侵治疗方案
公开(公告)号：WO2003047043A1
公开(公告)日：2003-06-05
申请号：PCT/US2002/037534
申请日：2002-11-22
申请人： MEDLENNIUM TECHNOLOGIES, INC.
发明人： MAHON, John , RHEINISH, Scott , SHISHEGAR, Ahmad , CHIU, John
IPC分类号： H01R12/20
CPC分类号： A61B18/18 , A61B18/1815 , A61B2018/00083 , A61B2018/00148 , A61B2018/00577 , A61B2018/00702 , A61B2018/00791 , A61B2018/183
摘要： An invasive therapeutic probe assembly and related methods for application of RF energy to a volume of body tissue are provided. The probe assembly includes an RF source configured to provide an RF energy having selected characteristics, a probe having a probe shaft and an antenna (18) positioned therein, and a feed line (20) for providing conductivity from the RF source to the antenna (18) probe. The probe assembly is adapted to generate a zone of therapeutic effectiveness having a selected geometry and volume. The related method includes positioning the probe in a selected location with reference to a target tissue, initiating an electromagnetic field from the antenna (18) having a selected geometry, and producing a zone of therapeutic effectiveness having a selected geometry and volume. The producing step preferably includes, taking periodic temperature measurements from sensors positioned at a selected location, and manipulating the selected characteristics of the RF energy to include duration and/or power level.
摘要翻译：提供侵入式治疗探针组件以及将RF能量应用于体积组织的相关方法。探针组件包括被配置为提供具有所选特征的RF能量的RF源，具有探针轴和位于其中的天线（18）的探针和用于提供从RF源到天线的导电性的馈电线（20） 18）探针。探针组件适于产生具有所选几何和体积的治疗有效性区域。相关方法包括将探针定位在参考目标组织的选定位置，从具有所选几何形状的天线（18）启动电磁场，并产生具有所选几何和体积的治疗有效性区域。生产步骤优选地包括从定位在所选位置的传感器进行周期性温度测量，以及操纵所选择的RF能量特征以包括持续时间和/或功率水平。

36. 发明申请

WO02038052A2 STEERABLE LOOP STRUCTURES FOR SUPPORTING DIAGNOSTIC AND THERAPEUTIC ELEMENTS IN CONTACT WITH BODY TISSUE 审中-公开
标题翻译：用于支持与身体组织接触的诊断和治疗元素的可转向环结构
公开(公告)号：WO02038052A2
公开(公告)日：2002-05-16
申请号：PCT/EP2001/012243
申请日：2001-10-23
IPC分类号： A61B5/0408 , A61B5/0478 , A61B5/0492 , A61B18/04 , A61B18/14 , A61N1/05 , A61N1/39 , A61B17/00
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/00797 , A61B2018/00898 , A61B2018/1253 , A61B2018/126 , A61B2018/141
摘要： A probe that includes a elongate body (12) and a steerable loop structure (30, 74) that supports electrodes (20) or other operative elements against the body tissue.
摘要翻译：探针，其包括细长体（12）和支撑电极（20）或抵抗身体组织的其它操作元件的可操纵环结构（30,74）。

37. 发明申请

WO0137723A3 LOOP STRUCTURES FOR SUPPORTING DIAGNOSTIC AND THERAPEUTIC ELEMENTS IN CONTACT WITH BODY TISSUE 审中-公开
标题翻译：支持与身体组织接触的诊断和治疗元素的环结构
公开(公告)号：WO0137723A3
公开(公告)日：2002-05-02
申请号：PCT/EP0011639
申请日：2000-11-22
申请人： BOSTON SCIENT LTD
发明人： KOBLISH JOSEF V , THOMPSON RUSSELL B , JENKINS THOMAS R , HEGDE ANANT V , SWANSON DAVID K
IPC分类号： A61B5/01 , A61B5/0408 , A61B5/0478 , A61B5/0492 , A61B18/12 , A61B18/14 , A61N1/04 , A61N1/39
CPC分类号： A61B18/1492 , A61B2018/00065 , A61B2018/00077 , A61B2018/00113 , A61B2018/00148 , A61B2018/00214 , A61B2018/00375 , A61B2018/00797 , A61B2018/00821 , A61B2018/1435 , A61B2018/1467
摘要： A probe that facilitates the creation of circumferential lesions in body tissue. The probe includes a elongate body and a loop structure, in the form of a helical structure or other loop structure, that supports electrodes or other operative elements against the body tissue.
摘要翻译：有助于在身体组织中产生周缘损伤的探针。探针包括细长主体和呈螺旋结构或其它环形结构形式的环形结构，其支撑电极或其它操作元件抵抗身体组织。

38. 发明申请

WO00066052A1 INTEGRATED TISSUE HEATING AND COOLING APPARATUS 审中-公开
标题翻译：一体化组织加热和冷却装置
公开(公告)号：WO00066052A1
公开(公告)日：2000-11-09
申请号：PCT/US2000/012204
申请日：2000-05-02
IPC分类号： A61M25/00 , A61B18/00 , A61B18/04 , A61B18/12 , A61B18/14 , A61F7/00 , A61F7/12
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00041 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00494 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/143 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems, and methods integrate the control of an energy generator (38), to supply energy to an electrode structure to heat a tissue region, and the control of a pumping mechanism (44), to supply cooling fluid to control tissue temperature in the region.
摘要翻译：系统和方法集成了能量发生器（38）的控制，以向电极结构供应能量以加热组织区域，并且控制泵送机构（44），以供应冷却流体以控制该区域中的组织温度。

39. 发明申请

WO00066020A1 ASSEMBLIES TO VISUALIZE AND TREAT SPHINCTERS AND ADJOINING TISSUE REGIONS 审中-公开
标题翻译：组织可视化和治疗结核病和组织组织
公开(公告)号：WO00066020A1
公开(公告)日：2000-11-09
申请号：PCT/US2000/012071
申请日：2000-05-02
IPC分类号： A61B18/00 , A61B18/04 , A61B18/12 , A61B18/14 , A61B18/18
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Assemblies for treating a tissue region at or near a sphincter have a support structure (26) with a distal end, and an electrode (66) carried by the support structure for contact with the tissue region. A lumen in the support structure accommodates passage of a body (84) through the support structure, and beyond the distal end of the support structure. The body can comprise a guide wire or an endoscope (84).
摘要翻译：用于治疗括约肌处或附近的组织区域的组件具有具有远端的支撑结构（26）和由所述支撑结构承载的用于与组织区域接触的电极（66）。支撑结构中的内腔容纳主体（84）通过支撑结构并超出支撑结构的远端的通道。主体可以包括导丝或内窥镜（84）。

40. 发明申请

WO99053853A1 UTERINE TREATMENT APPARATUS 审中-公开
标题翻译：子宫治疗装置
公开(公告)号：WO99053853A1
公开(公告)日：1999-10-28
申请号：PCT/US1999/008811
申请日：1999-04-21
IPC分类号： A61B17/00 , A61B17/22 , A61B17/42 , A61B18/00 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/14 , A61B18/18 , A61F2/958 , A61F7/12 , A61M3/02 , A61M16/04 , A61N1/05 , A61N1/06 , A61N1/08 , A61N1/40 , A61B17/36 , A61N5/04
CPC分类号： A61B18/1206 , A61B18/00 , A61B18/1477 , A61B18/148 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00867 , A61B2017/22062 , A61B2017/22072 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00738 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2218/002 , A61F7/12 , A61M3/0279 , A61M16/0429 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40 , C08L2201/12
摘要： An apparatus to treat a uterus includes a deployable member (22) configured to be positioned in a uterine cavity in at least a partially deployed state to define a microwave chamber (20) in an interior of the deployable member (22), and removed from the uterine cavity in a non-deployed state. The deployable member (22) is at least partially microwave energy absorbable and formed of a fluid permeable material to house and controllably release a fluidic medium (34) from the microwave chamber (20) when the deployable member (22) is positioned in the uterine cavity in the at least partially deployed state. A microwave emitter (24) is positioned in the microwave chamber (20), the microwave emitter (24) is configured to be coupled to a microwave energy source and deliver microwave energy to the fluidic medium (34), wherein the fluidic medium (34) transfers thermal energy from the microwave emitter (24) to a uterine structure.
摘要翻译：治疗子宫的装置包括可展开构件（22），其构造成至少部分展开状态定位在子宫腔中，以在可展开构件（22）的内部限定微波室（20），并从子宫腔处于非部署状态。可部署构件（22）至少部分地是微波能量可吸收的，并且当可展开构件（22）位于子宫中时，由流体可渗透材料形成以容纳和可控制地从微波室（20）释放流体介质（34）在至少部分展开状态下的空腔。微波发射器（24）定位在微波室（20）中，微波发射器（24）被配置为耦合到微波能量源并将微波能量递送到流体介质（34），其中流体介质（34））将热能从微波发射器（24）传递到子宫结构。

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