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31. 发明申请

WO2006116718A2 PHARMA-INFORMATICS SYSTEM 审中-公开
标题翻译：药物信息系统
公开(公告)号：WO2006116718A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/016370
申请日：2006-04-28
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , THOMPSON, Andrew , PIKELNY, Aleksandr , ROBERTSON, Timothy
发明人： ZDEBLICK, Mark , THOMPSON, Andrew , PIKELNY, Aleksandr , ROBERTSON, Timothy
IPC分类号： G06F19/00
CPC分类号： A61B5/6861 , A61B5/0028 , A61B5/0031 , A61B5/07 , A61B5/073 , A61B5/1473 , A61B5/4833 , A61B5/4839 , A61B5/681 , A61B5/7282 , A61B2560/0214 , A61B2560/0462 , A61B2562/08 , A61B2562/162 , A61J3/007 , G06F19/00 , G06K7/10168 , H01Q1/273 , Y10T29/49117
摘要： Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
摘要翻译：提供了允许检测药物到身体的实际物理输送的组合物，系统和方法。组合物的实施方案包括标识符和活性剂。本发明可用于各种不同的应用，包括但不限于监测治疗方案依从性，跟踪药剂的历史等。

32. 发明申请

WO2004066814A2 METHOD AND SYSTEM FOR REMOTE HEMODYNAMIC MONITORING 审中-公开
标题翻译：远程血液动力监测方法与系统
公开(公告)号：WO2004066814A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001814
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC. , ZDEBLICK, Mark , RUGGIO, Joseph, M.
发明人： ZDEBLICK, Mark , RUGGIO, Joseph, M.
IPC分类号： A61B
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61B5/1107 , A61B5/1473 , A61B5/6882 , A61N1/3627 , A61N1/36514 , A61N1/36585 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A cardiac sensor system includes implanted cardiac sensor assemblies and an external controller which receives information from the implanted sensors. The sensors permit direct measurement of a number of physiologic parameters. The external controller permits calculation of a variety of performance values based on the measured physiological parameters. Optionally, patient oxygen consumption can be measured externally and combined with the internally measured physiologic parameters in order to calculate a variety of unique performance values.
摘要翻译：心脏传感器系统包括植入的心脏传感器组件和从植入的传感器接收信息的外部控制器。传感器允许直接测量多个生理参数。外部控制器允许基于测量的生理参数计算各种性能值。任选地，可以外部测量患者的氧气消耗量并结合内部测量的生理参数，以便计算各种独特的性能值。

33. 发明申请

WO2011014464A2 LEAD FOR USE IN RF FIELD 审中-公开
标题翻译：用于射频场的引线
公开(公告)号：WO2011014464A2
公开(公告)日：2011-02-03
申请号：PCT/US2010/043286
申请日：2010-07-27
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , THOMPSON, Todd
发明人： ZDEBLICK, Mark , THOMPSON, Todd
CPC分类号： A61N1/05 , A61N1/086
摘要： A lead such as used for pacemaking or neural stimulation has a current block IC which blocks current when RF is detected. In this way problems of tissue heating are reduced or eliminated when the patient carrying such a lead is given an MRI. The lead may also detect localized temperature, to be reported to equipment external to the lead. This may permit more judicious use of the RF energy, for example during an MRI session. Localized and spurious tissue heating nearby to an electrode of a lead, due to RF energy from an MRI, is reduced or eliminated by detecting the RF field, deriving energy from the field, and actively driving a node that is coupled to such an electrode so as to minimize voltage excursions at the electrode. A state is maintained or set within electronics nearby to an electrode of a lead, so that a can which connects with the lead is able to learn whether an MRI event has occurred since the last time that the can had sent commands to the electronics to set particular internal states. For a lead that delivers pacing pulses, a pacing detector is provided in addition to an MRI detector, and the blocking action is carried out most of the time but is disabled briefly for each pacing pulse. During a time of presence of RF energy, a bucking circuit attempts, to the extent possible, to drive a node toward blood potential, the node capacitively coupled with electrodes of the lead.
摘要翻译：诸如用于起搏或神经刺激的引线具有当检测到RF时阻止电流的电流块IC。以这种方式，当携带这种铅的患者被给予MRI时，组织加热的问题被减少或消除。铅也可能检测局部温度，报告给铅外部的设备。这可以允许更准确地使用RF能量，例如在MRI期间。通过检测RF场，从场导出能量，并主动驱动耦合到这样一个电极的节点，减少或消除了来自MRI的RF能量附近的引线附近的局部和杂散组织加热以最小化电极处的电压偏移。在铅电极附近的电子设备内维持或设置状态，使得与引线连接的罐能够从上次发送命令到电子设备以后是否发生了MRI事件特定的内部状态。对于提供起搏脉冲的引线，除了MRI检测器之外还提供起搏检测器，并且阻塞动作在大部分时间内被执行，但是对于每个起搏脉冲被短暂地禁止。在存在RF能量的时间期间，降压电路尽可能尝试将节点驱动到血液电位，该节点与电极的电极电容耦合。

34. 发明申请

WO2010135463A3 METHOD AND APPARATUS FOR NEURAL SIGNAL DETERMINATION AND THERAPY ENHANCEMENT 审中-公开
公开(公告)号：WO2010135463A3
公开(公告)日：2010-11-25
申请号：PCT/US2010/035466
申请日：2010-05-19
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , WHITE, Robert
发明人： ZDEBLICK, Mark , WHITE, Robert
IPC分类号： A61B5/16 , A61B5/04
摘要： A method and device are provided that detect and identify a neural signal by type and optionally or automatically provide a signal that affects a nerve carrying the neural signal. A plurality of electrodes is positioned along a nerve and monitors the electrical activity of the nerve. The invented system analyzes the monitored data to determine when the monitored activity can be identified as a known type of bioelectric signal, e.g., a pain nerve signal. The system may optionally attempt to affect, disrupt, diminish, nullify or block transmission of bioelectric signals along the nerve, e.g., by directing electrical energy through an electrode to nullify a bioelectric signal along a pain nerve.

35. 发明申请

WO2010091435A2 MULTIPLEXED MULTI-ELECTRODE NEUROSTIMULATION DEVICES WITH INTEGRATED CIRCUIT HAVING INTEGRATED ELECTRODES 审中-公开
标题翻译：具有集成电路的集成电路的多电极多电极神经元装置
公开(公告)号：WO2010091435A2
公开(公告)日：2010-08-12
申请号：PCT/US2010/023687
申请日：2010-02-09
申请人： PROTEUS BIOMEDICAL, INC. , THOMPSON, Todd , ZDEBLICK, Mark , STRAND, Angela , JENSEN, Marc
发明人： THOMPSON, Todd , ZDEBLICK, Mark , STRAND, Angela , JENSEN, Marc
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0551 , A61N1/025 , A61N1/0556 , A61N1/36185 , A61N1/372 , A61N1/3756
摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated control circuit operatively coupled to one or more electrodes. Also provided are methods of manufacturing wherein the application of laser welding is avoided in forming the satellite electrode structures and an integrated control circuit thereof is thereby shielded from mechanical stress during satellite manufacture. Additionally provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.
摘要翻译：提供可植入的刺激装置。器件的方面包括配置用于神经刺激的复用多电极部件。多路复用多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。卫星结构包括可操作地耦合到一个或多个电极的密封的集成控制电路。还提供了制造方法，其中在形成卫星电极结构时避免了激光焊接的应用，并且其整体控制电路因此在卫星制造期间被屏蔽而不受机械应力。另外提供了包括本发明的装置的系统，以及在各种不同应用中使用系统和装置的方法。

36. 发明申请

WO2010080843A2 INGESTION-RELATED BIOFEEDBACK AND PERSONALIZED MEDICAL THERAPY METHOD AND SYSTEM 审中-公开
标题翻译：注射相关的生物安全和个性化医疗治疗方法和系统
公开(公告)号：WO2010080843A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020269
申请日：2010-01-06
申请人： PROTEUS BIOMEDICAL, INC. , JENSEN, Marc , LEICHNER, Robert , BEAULIEU, Patrick , AU-YEUNG, Kit Yee , ARNE, Lawrence , ZDEBLICK, Mark , THOMPSON, Andrew , SAVAGE, George , ROBERTSON, Timothy , BEHZADI, Yashar
发明人： JENSEN, Marc , LEICHNER, Robert , BEAULIEU, Patrick , AU-YEUNG, Kit Yee , ARNE, Lawrence , ZDEBLICK, Mark , THOMPSON, Andrew , SAVAGE, George , ROBERTSON, Timothy , BEHZADI, Yashar
IPC分类号： A61B1/00 , A61B5/02 , A61B5/0482 , H04B13/00
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/1112 , A61B5/486 , A61B5/6833 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H10/60 , G16H20/00 , G16H20/10 , H04B13/005
摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.
摘要翻译：提供了用于获取有助于支持患者实施和遵守医学上规定的治疗方案的信息的方法，装置和系统。该疗法可以包括生物反馈方法和/或个性化治疗方面。一种方法包括以下步骤：由接收装置接收与可摄取事件标记相关联的生物特征信息; 通过具有微处理器的计算设备分析生物特征信息; 以及至少部分地基于分析和/或将生物反馈技术集成到患者治疗或活动中来确定治疗推荐。一种系统包括用于接收与可摄取事件标记相关联的生物特征信息的生物特征信息模块; 分析生物特征信息的分析模块; 以及确定模块，用于至少部分地基于分析来可选地确定和传达治疗推荐。

37. 发明申请

WO2010068818A2 EVALUATION OF GASTROINTESTINAL FUNCTION USING PORTABLE ELECTROVISCEROGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：使用便携式电子显微镜系统评估胃肠功能及使用相同方法
公开(公告)号：WO2010068818A2
公开(公告)日：2010-06-17
申请号：PCT/US2009/067584
申请日：2009-12-10
申请人： PROTEUS BIOMEDICAL, INC. , SAVAGE, George , HAFEZI, Hooman , COLLIOU, Olivier , ZDEBLICK, Mark , STRAND, Angela
发明人： SAVAGE, George , HAFEZI, Hooman , COLLIOU, Olivier , ZDEBLICK, Mark , STRAND, Angela
IPC分类号： A61B5/05 , A61B1/273
CPC分类号： A61B5/053 , A61B5/04884 , A61B5/073 , A61B5/1107 , A61B5/14539 , A61B5/42 , A61B5/6861 , A61B2560/0214 , A61B2560/0242 , G06F19/00
摘要： Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data processor configured to receive data from the body-associated receiver and generate and electroviscerogram from the received data. Also provided are methods of producing electroviscerograms using systems of the present invention.
摘要翻译：
提供便携式电子视觉检查系统。系统的各方面包括身体关联的接收器和可摄取的识别器单元，两者均被配置为检测内脏电信号。该系统与体外数据处理器通信，该体外数据处理器被配置为从身体关联的接收器接收数据并且从接收到的数据生成和电化学图。还提供了使用本发明的系统产生电描记图的方法。

38. 发明申请

WO2010056438A3 SHIELDED STIMULATION AND SENSING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2010056438A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/059704
申请日：2009-10-06
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61N1/36 , A61N1/04
摘要： Spatial arrays of electrodes are provided, each array in a region of tissue. The electrodes of an array are connected so that some of the electrodes serve as shield electrodes relative to a pair of electrodes used for pulse stimulation or sensing of electrical activity, or both. The shield electrodes are connected together, defining an electrical node, the node defining a stable potential in predetermined relationship with power supply levels or with reference voltages for sensing circuitry. Multiplexing techniques may be employed so that sensed activity at each of several electrode locations can be communicated to electronics external to the electrode locations.

39. 发明申请

WO2008008281A2 SMART PARENTERAL ADMINISTRATION SYSTEM 审中-公开
标题翻译：智能外部管理系统
公开(公告)号：WO2008008281A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015547
申请日：2007-07-06
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61B5/03
CPC分类号： A61M15/0068 , A61B5/117 , A61B5/411 , A61M1/16 , A61M1/1656 , A61M1/1668 , A61M1/167 , A61M1/28 , A61M5/14 , A61M5/1782 , A61M15/00 , A61M15/008 , A61M2016/0021 , A61M2016/0027 , A61M2205/13 , A61M2205/3523 , A61M2205/3538 , A61M2205/3553 , A61M2205/3561 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/6018 , A61M2205/6081 , A61M2230/06 , A61M2230/30 , A61M2230/42 , A61M2230/50 , A61M2230/63 , H04B13/005
摘要： The invention provides methods and systems for evaluating a fluid transfer event between a parenteral fluid delivery and a patient. The evaluation of the fluid transfer event can be prospective, real-time and/or historic, as desired, and take a variety of different formats.
摘要翻译：本发明提供了用于评估肠胃外流体递送和患者之间的流体转移事件的方法和系统。根据需要，流体转移事件的评估可以是预期的，实时的和/或历史性的，并且采取各种不同的格式。

40. 发明申请

WO2007130491A3 PATIENT CUSTOMIZED THERAPEUTIC REGIMENS 审中-公开
公开(公告)号：WO2007130491A3
公开(公告)日：2007-11-15
申请号：PCT/US2007/010688
申请日：2007-05-02
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , THOMPSON, Andrew , SAVAGE, George
发明人： ZDEBLICK, Mark , THOMPSON, Andrew , SAVAGE, George
IPC分类号： G06Q10/00
摘要： Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.

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