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1. 发明申请

WO1995012421A1 APPARATUS AND METHOD FOR ASPIRATING INTRAVASCULAR, PULMONARY AND CARDIAC OBSTRUCTIONS 审中-公开
标题翻译：吸入血管内，肺动脉和心脏梗阻的装置和方法
公开(公告)号：WO1995012421A1
公开(公告)日：1995-05-11
申请号：PCT/US1994012804
申请日：1994-11-04
申请人： RUGGIO, Joseph, M.
IPC分类号： A61M01/00
CPC分类号： A61B17/22 , A61B2017/22038 , A61B2017/22084 , A61M1/0084
摘要： Disclosed is an apparatus and technique for aspirating substances partially or completely occluding blood vessels or chambers of the heart. The aspirator assembly comprises a catheter assembly and a suction member for aspirating substances through the catheter. The catheter assembly comprises a catheter which travels over a guidewire. Exemplary suction members used for aspirating include a syringe or a vacuum reservoir. The method of treating the intravascular site comprises the steps of advancing a catheter assembly through a patient's vasculature until a distal end of the catheter assembly reaches an area close to the site, and aspirating occluding substances in the vicinity of the site through the distal end of the catheter assembly. The method may also include the additional steps of introducing medication through the catheter, and pulverizing the occlusion or any of its residue, prior to aspirating the occluding substances.
摘要翻译：公开了一种用于吸入物质部分或完全闭塞心脏血管或腔室的装置和技术。抽吸器组件包括导管组件和用于通过导管抽吸物质的抽吸构件。导管组件包括在导丝上行进的导管。用于抽吸的示例性抽吸构件包括注射器或真空容器。治疗血管内部位的方法包括以下步骤：使导管组件穿过病人的脉管系统，直到导管组件的远端到达接近该部位的区域，并且通过远端的远端抽吸位于该部位附近的闭塞物质导管组件。该方法还可以包括在吸入封闭物质之前通过导管引入药物以及粉碎闭塞或其任何残留物的附加步骤。

2. 发明申请

WO2004066817A2 METHODS AND SYSTEMS FOR MEASURING CARDIAC PARAMETERS 审中-公开
标题翻译：测量心脏参数的方法和系统
公开(公告)号：WO2004066817A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001834
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC. , ZDEBLICK, Mark , RUGGIO, Joseph, M.
发明人： ZDEBLICK, Mark , RUGGIO, Joseph, M.
IPC分类号： A61B
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61B5/1107 , A61B5/1473 , A61B5/6882
摘要： Methods and systems of the present invention provide for measurement of various cardiac parameters. Methods generally involve causing a change in volume and/or pressure in a heart chamber, measuring the change, and calculating at least one cardiac parameter based on the change. Systems typically include at least one actuator, at least one sensor, and a catheter or other device for positioning at least partially in a heart chamber. In some embodiments, the system may also include a controller, such as a computer or other processor, an external actuator, an external sensor, and/or an ECG device. Methods and systems of the invention may be used to more accurately diagnose cardiac conditions in order to make more informed treatment decisions.
摘要翻译：本发明的方法和系统提供各种心脏参数的测量。方法通常包括引起心室中体积和/或压力的变化，测量变化，以及基于变化计算至少一个心脏参数。系统通常包括至少一个致动器，至少一个传感器，以及用于至少部分地定位在心室中的导管或其它装置。在一些实施例中，系统还可以包括诸如计算机或其他处理器的控制器，外部致动器，外部传感器和/或ECG设备。可以使用本发明的方法和系统来更准确地诊断心脏病状，以便做出更明智的治疗决定。

3. 发明申请

WO2004067081A3 METHODS AND APPARATUS FOR ENHANCING CARDIAC PACING 审中-公开
公开(公告)号：WO2004067081A3
公开(公告)日：2004-08-12
申请号：PCT/US2004/001806
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC. , ZDEBLICK, Mark , RUGGIO, Joseph, M.
发明人： ZDEBLICK, Mark , RUGGIO, Joseph, M.
IPC分类号： A61N1/18
摘要： Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device (20). Devices may include at least one catheter (14) (such as a multiplexed catheter with one or more sensors (16, 18) and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.

4. 发明申请

WO2004067081A2 METHODS AND APPARATUS FOR ENHANCING CARDIAC PACING 审中-公开
标题翻译：用于增强心脏肥大的方法和装置
公开(公告)号：WO2004067081A2
公开(公告)日：2004-08-12
申请号：PCT/US2004001806
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , RUGGIO JOSEPH M
发明人： ZDEBLICK MARK , RUGGIO JOSEPH M
IPC分类号： A61N20060101 , A61N1/18 , A61N1/362 , A61N1/365 , A61N1/368 , A61N
CPC分类号： A61N1/365 , A61B5/02028 , A61B5/02055 , A61B5/0215 , A61B5/02158 , A61B5/026 , A61B5/14535 , A61B5/14539 , A61B5/1459 , A61B5/6883 , A61N1/3627 , A61N1/36528 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device. Devices may include at least one catheter (such as a multiplexed catheter with one or more sensors and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.
摘要翻译：用于增强心脏起搏的方法，装置和系统通常提供测量至少一个心脏特征，基于所测量的特征来计算至少一个心脏性能参数，以及调整心脏起搏装置的至少一个功能参数。装置可以包括至少一个导管（例如具有一个或多个传感器和/或致动器的多路导管），至少一个植入物（例如可植入心脏壁的传感器）或两者的组合。可以对各种心脏性能参数和/或起搏装置性能参数进行加权，并且可以使用参数及其各自的权重来确定对起搏装置进行的一项或多项调整。在某些情况下，会自动进行调整。

5. 发明申请

WO2004066814A3 METHOD AND SYSTEM FOR REMOTE HEMODYNAMIC MONITORING 审中-公开
标题翻译：远程血液动力监测方法与系统
公开(公告)号：WO2004066814A3
公开(公告)日：2005-05-19
申请号：PCT/US2004001814
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , RUGGIO JOSEPH M
发明人： ZDEBLICK MARK , RUGGIO JOSEPH M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/02 , A61B5/0205 , A61B5/0215 , A61B5/029 , A61B5/04 , A61B5/11 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61B5/1107 , A61B5/1473 , A61B5/6882 , A61N1/3627 , A61N1/36514 , A61N1/36585 , A61N1/3684 , A61N1/3702
摘要： A cardiac sensor system includes implanted cardiac sensor assemblies and an external controller which receives information from the implanted sensors. The sensors permit direct measurement of a number of physiologic parameters. The external controller permits calculation of a variety of performance values based on the measured physiological parameters. Optionally, patient oxygen consumption can be measured externally and combined with the internally measured physiologic parameters in order to calculate a variety of unique performance values.
摘要翻译：心脏传感器系统包括植入的心脏传感器组件和从植入的传感器接收信息的外部控制器。传感器允许直接测量多个生理参数。外部控制器允许基于测量的生理参数计算各种性能值。任选地，可以外部测量患者的氧气消耗量并结合内部测量的生理参数，以便计算各种独特的性能值。

6. 发明申请

WO2004066817A3 METHODS AND SYSTEMS FOR MEASURING CARDIAC PARAMETERS 审中-公开
标题翻译：测量心脏参数的方法和系统
公开(公告)号：WO2004066817A3
公开(公告)日：2005-03-17
申请号：PCT/US2004001834
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , RUGGIO JOSEPH M
发明人： ZDEBLICK MARK , RUGGIO JOSEPH M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/02 , A61B5/0205 , A61B5/0215 , A61B5/029 , A61B5/11
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61B5/1107 , A61B5/1473 , A61B5/6882
摘要： Methods and systems of the present invention provide for measurement of various cardiac parameters. Methods generally involve causing a change in volume and/or pressure in a heart chamber, measuring the change, and calculating at least one cardiac parameter based on the change. Systems typically include at least one actuator, at least one sensor, and a catheter or other device for positioning at least partially in a heart chamber. In some embodiments, the system may also include a controller, such as a computer or other processor, an external actuator, an external sensor, and/or an ECG device. Methods and systems of the invention may be used to more accurately diagnose cardiac conditions in order to make more informed treatment decisions.
摘要翻译：本发明的方法和系统提供各种心脏参数的测量。方法通常包括引起心室中体积和/或压力的变化，测量变化，以及基于变化计算至少一个心脏参数。系统通常包括至少一个致动器，至少一个传感器，以及用于至少部分地定位在心室中的导管或其它装置。在一些实施例中，系统还可以包括诸如计算机或其他处理器的控制器，外部致动器，外部传感器和/或ECG设备。可以使用本发明的方法和系统来更准确地诊断心脏病状，以便做出更明智的治疗决定。

7. 发明申请

WO2004066814A2 METHOD AND SYSTEM FOR REMOTE HEMODYNAMIC MONITORING 审中-公开
标题翻译：远程血液动力监测方法与系统
公开(公告)号：WO2004066814A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001814
申请日：2004-01-23
申请人： PROTEUS BIOMEDICAL INC. , ZDEBLICK, Mark , RUGGIO, Joseph, M.
发明人： ZDEBLICK, Mark , RUGGIO, Joseph, M.
IPC分类号： A61B
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02158 , A61B5/029 , A61B5/1107 , A61B5/1473 , A61B5/6882 , A61N1/3627 , A61N1/36514 , A61N1/36585 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A cardiac sensor system includes implanted cardiac sensor assemblies and an external controller which receives information from the implanted sensors. The sensors permit direct measurement of a number of physiologic parameters. The external controller permits calculation of a variety of performance values based on the measured physiological parameters. Optionally, patient oxygen consumption can be measured externally and combined with the internally measured physiologic parameters in order to calculate a variety of unique performance values.
摘要翻译：心脏传感器系统包括植入的心脏传感器组件和从植入的传感器接收信息的外部控制器。传感器允许直接测量多个生理参数。外部控制器允许基于测量的生理参数计算各种性能值。任选地，可以外部测量患者的氧气消耗量并结合内部测量的生理参数，以便计算各种独特的性能值。

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