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31. 发明申请

WO2007068935A2 METHODS, MEANS AND COMPOSITIONS FOR ENHANCING AGROBACTERIUM-MEDIATED PLANT CELL TRANSFORMATION EFFICIENCY 审中-公开
标题翻译：用于增强农杆菌介导的植物细胞转化效率的方法，手段和组合物
公开(公告)号：WO2007068935A2
公开(公告)日：2007-06-21
申请号：PCT/GB2006004688
申请日：2006-12-15
申请人： PLANT BIOSCIENCE LTD , ZIPFEL CYRIL , JONES JONATHAN DALLAS GEORGE , HANN DAGMAR RENATE , RATHJEN JOHN PAUL
发明人： ZIPFEL CYRIL , JONES JONATHAN DALLAS GEORGE , HANN DAGMAR RENATE , RATHJEN JOHN PAUL
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8205 , C07K14/415
摘要： Higher eukaryotes sense microbes through perception of pathogen-associated molecular patterns (PAMPs). The flagellin receptor FLS2 represents so far the only known pattern recognition receptor (PRR) in Arabidopsis. Arabidopsis plants detect a variety of PAMPs including specific epitopes of the bacterial proteins flagellin and EF-Tu. Here, we show that flagellin and EF-Tu activate a common set of signalling events and defence responses, but without clear additive or synergistic effects. Treatment with either PAMP results in increased receptor sites for both PAMPs, a finding employed in a reverse-genetic approach to identify the receptor kinase EFR as the EF-Tu receptor. Transient expression of EFR in Nicotiana benthamian
摘要翻译：高等真核生物通过感染病原体相关分子模式（PAMPs）感知微生物。鞭毛蛋白受体FLS2代表迄今为止在拟南芥中唯一已知的模式识别受体（PRR）。拟南芥植物检测各种PAMP，包括细菌蛋白鞭毛蛋白和EF-Tu的特异性表位。在这里，我们显示鞭毛蛋白和EF-Tu激活了一组共同的信号事件和防御反应，但没有明显的添加剂或协同效应。用PAMP治疗导致两种PAMP的受体位点增加，这是用于鉴定作为EF-Tu受体的受体激酶EFR的反向遗传方法的发现。烟草在烟草中的瞬时表达

32. 发明申请

WO2006111743A2 IDENTIFYING LANTIBIOTIC GENE CLUSTERS AND NOVEL LANTIBIOTIC GENES 审中-公开
标题翻译：鉴定生物基因群和新生土生物基因
公开(公告)号：WO2006111743A2
公开(公告)日：2006-10-26
申请号：PCT/GB2006001429
申请日：2006-04-20
申请人： PLANT BIOSCIENCE LTD , DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
发明人： DODD HELEN , GASSON MICHAEL JOHN , MAYER MELINDA , NARBAD ARJAN
IPC分类号： C12Q1/68 , C07K14/355 , C07K14/36 , C12P1/06
CPC分类号： C07K14/36 , C12Q1/689
摘要： This invention provides a method for discovery of new lantibiotic pathways by mining available sequence information and by exploiting conserved regions in lantibiotic biosynthetic enzymes to design probes and PCR primers for analysis of un-studied organisms. We have found that lantibiotic biosynthetic enzymes are broadly distributed in Gram-positive. New pathways are being cloned and sequenced and their lantibiotic products are being defined and disclosed.
摘要翻译：本发明提供了一种通过挖掘可获得的序列信息和通过利用羊毛硫抗生素生物合成酶中的保守区域来设计探针和PCR引物来分析未研究的生物体的方法来发现新的羊毛硫抗生素途径。我们发现羊毛硫素生物合成酶广泛分布在革兰氏阳性菌中。正在克隆和测序新的途径，并且定义和披露其羊毛硫抗生素产品。

33. 发明申请

WO0234784A3 AN ACYL COENZYME A CARBOXYLASE FROM STREPTOMYCES 审中-公开
标题翻译： ACYL COENZYME来自结构式的羧酸酶
公开(公告)号：WO0234784A3
公开(公告)日：2003-01-16
申请号：PCT/GB0104709
申请日：2001-10-23
申请人： PLANT BIOSCIENCE LTD
发明人： GRAMAJO HUGO CESAR , RODRIGUEZ EDUARDO JOSE
IPC分类号： C12N9/00 , C12P17/06 , C12P17/10 , C07K14/745 , C12N9/74
CPC分类号： C12N9/93 , C12P17/06 , C12P17/10
摘要： The nucleic acid and amino acid sequences of alpha 1, alpha 2, beta and epsilon subunits of acetyl-CoA carboxylase (ACCase) from Streptomyces coelicolor are provided. This subunit structure differs from that of known acyl carboxylases. Materials and methods are provided of increasing ACCase activity and production of secondary metabolites (such as polyketides and especially antibiotics) by causing expression in Streptomyces of such nucleic acid. Also provided are methods of increasing ACCase activity and production of secondary metabolites (such as polyketides and especially antibiotics) by culturing Streptomyces in the presence of exogenous malonate.
摘要翻译：提供了来自Streptomyces coelicolor的乙酰辅酶A羧化酶（ACCase）的α1，α2，β和ε亚基的核酸和氨基酸序列。该亚基结构与已知的酰基羧化酶的不同。提供的材料和方法是通过在这种核酸的链霉菌中表达而提高ACCase活性和次生代谢产物（如聚酮化合物，特别是抗生素）的产生。还提供了通过在外源性丙二酸酯存在下培养链霉菌来增加ACCase活性和次生代谢产物（例如聚酮化合物，特别是抗生素）的生产的方法。

34. 发明申请

WO0046358A3 ARABIDOPSIS THALIANA DERIVED FRIGIDA GENE CONFERRING LATE FLOWERING 审中-公开
公开(公告)号：WO0046358A3
公开(公告)日：2000-11-30
申请号：PCT/GB0000197
申请日：2000-01-25
申请人： PLANT BIOSCIENCE LTD , JOHANSON URBAN , WEST JOANNE , DEAN CAROLINE
发明人： JOHANSON URBAN , WEST JOANNE , DEAN CAROLINE
IPC分类号： C07K14/415 , C12N15/82 , C12N15/29 , A01H1/00 , C07K16/16 , C12N15/63
CPC分类号： C07K14/415 , A01K2217/05 , C12N15/827
摘要： Disclosed are isolated nucleic acids obtainable from the FRI locus of plants which encode polypeptides capable of specifically altering, particularly delaying, the flowering time of a plant into which the nucleic acid is introduced. One preferred embodiment is the FRI nucleotide sequence which encodes the polypeptide of Fig 6 (see the sequence of Fig 5, particularly bases 362-2188 thereof) or sequences degeneratively equivalent to these. Also provided are variant sequences (e.g. alleles, orthologues, derivatives) and complementary sequences, plus vectors, host cells, plants and associated processes of production and methods of use e.g. for influencing or affecting flowering time in a plant by expression or suppression of FRI or variant sequences.
摘要翻译：公开了可从植物的FRI基因座获得的分离的核酸，其编码能够特异性改变，特别是延迟引入核酸的植物的开花时间的多肽。一个优选的实施方案是编码图6的多肽的FRI核苷酸序列（参见图5的序列，特别是其362-2188碱基）或者与这些变性相等的序列。还提供了变体序列（例如等位基因，直向同源物，衍生物）和互补序列，加上载体，宿主细胞，植物和相关生产过程以及使用方法，例如。通过表达或抑制FRI或变体序列影响或影响植物中的开花时间。

35. 发明申请

WO2011045113A9 COMPETITIVE EXCLUSION COMPOSITION AND METHODS 审中-公开
标题翻译：竞争排除组合和方法
公开(公告)号：WO2011045113A9
公开(公告)日：2011-06-16
申请号：PCT/EP2010062423
申请日：2010-08-25
申请人： PLANT BIOSCIENCE LTD , HORN NICOLA , LEE ANDREW , NARBAD ARJAN , SHEARMAN CLAIRE , WEGMANN UDO
发明人： HORN NICOLA , LEE ANDREW , NARBAD ARJAN , SHEARMAN CLAIRE , WEGMANN UDO
IPC分类号： C07K14/435
CPC分类号： C12N15/52 , A23K10/16 , A23K10/18 , A23K50/75 , A23L33/135 , A23V2002/00 , A23Y2220/00 , C12R1/225 , A23V2200/3204
摘要： The present invention relates to compositions, including live organisms, nucleic acid and amino acid sequences, constructs and cells comprising these, which are used to competitively exclude pathogenic organisms from the alimentary canals of vertebrates to achieve prophylaxis or therapeutic effects.
摘要翻译：本发明涉及组合物，包括活生物体，核酸和氨基酸序列，包含它们的构建体和细胞，其用于从脊椎动物的消化道竞争性排除病原生物体以实现预防或治疗效果。

36. 发明申请

WO2010023491A3 PLANT PATHOGEN RESISTANCE 审中-公开
标题翻译：植物耐药性
公开(公告)号：WO2010023491A3
公开(公告)日：2010-04-29
申请号：PCT/GB2009051098
申请日：2009-09-01
申请人： PLANT BIOSCIENCE LTD , NICHOLSON PAUL
发明人： NICHOLSON PAUL
IPC分类号： C12N15/82
CPC分类号： C12N15/8282 , C12N15/8297
摘要： The present invention relates to a method for protecting a plant from infection by a pathogen by decreasing the presence of a plant hormone or reducing the responsiveness of a plant to a plant hormone. In particular, the invention relates to infection by a necrotrophic pathogen, such as Fusarium Head Blight (FHB) and the plant hormone is selected from ethylene or gibberellin.
摘要翻译：本发明涉及通过减少植物激素的存在或降低植物对植物激素的反应性来保护植物免受病原体感染的方法。特别地，本发明涉及坏死性病原体如Fusarium Head Blight（FHB）的感染，并且植物激素选自乙烯或赤霉素。

37. 发明申请

WO2010001096A3 TREATMENT 审中-公开
标题翻译：治疗
公开(公告)号：WO2010001096A3
公开(公告)日：2010-04-08
申请号：PCT/GB2009001593
申请日：2009-06-25
申请人： PROVEXIS NATURAL PRODUCTS LTD , PLANT BIOSCIENCE LTD , O'KENNEDY NIAMH , MITHEN RICHARD
发明人： O'KENNEDY NIAMH , MITHEN RICHARD
IPC分类号： A61K31/26 , A61K36/31 , A61K45/06 , A61P1/00 , A61P19/02 , A61P29/00
CPC分类号： A61K31/26 , A23L2/02 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K9/0095 , A61K36/31 , A61K36/87 , A61K45/06 , A23V2250/21 , A23V2250/21166 , A23V2200/324
摘要： The present invention concerns compositions that may be used in the prevention or treatment of medical conditions characterised by having an inflammatory component. The compositions comprise a therapeutically effective amount of an isothiocyanate (ITC). The composition may comprise further anti-inflammatory agents (e.g. plant- derived polyphenols).
摘要翻译：本发明涉及可用于预防或治疗特征在于具有炎性成分的医学病症的组合物。该组合物包含治疗有效量的异硫氰酸酯（ITC）。该组合物可以包含其他抗炎剂（例如植物衍生的多酚）。

38. 发明申请

WO2009060165A3 COMPOSITIONS AND METHODS FOR SYNERGISTIC MANIPULATION OF PLANT AND INSECT DEFENCES 审中-公开
标题翻译：植物和昆虫防御的协同操作组合物和方法
公开(公告)号：WO2009060165A3
公开(公告)日：2009-07-09
申请号：PCT/GB2008001419
申请日：2008-04-24
申请人： PLANT BIOSCIENCE LTD , MOORES GRAHAM , BINGHAM GEORGINA
发明人： MOORES GRAHAM , BINGHAM GEORGINA
IPC分类号： A01N61/00 , A01N25/26 , A01N25/28 , A01N25/30 , A01N35/06 , A01N37/40 , A01N37/44 , A01N43/30 , A01N49/00 , A01P3/00 , A01P7/02 , A01P15/00
CPC分类号： A01N37/40 , A01N43/30 , A01N61/00 , A01N25/26 , A01N25/28 , A01N25/30 , A01N35/06 , A01N37/42 , A01N37/44 , A01N49/00 , A01N2300/00
摘要： This invention relates to the control of plant pests, such as aphid and whitefly by treating plants with a compound which inhibits the plant pest's ability to overcome plant defence responses, such as piperonyl butoxide or propyl gallate, in combination with a compound which activates plant defence responses, such as cis-Jasmone or beta-amino butyric acid.
摘要翻译：本发明涉及通过用抑制植物害虫克服植物防御反应的能力的化合物如胡椒基丁醚或没食子酸丙酯与能激活植物防御的化合物一起处理植物来防治植物有害生物如蚜虫和粉虱反应，如顺式茉莉酮或β-氨基丁酸。

39. 发明申请

WO2008087562A2 METHODS AND COMPOSITIONS FOR MODULATING THE MIRNA PATHWAY 审中-公开
标题翻译：调整米拉斯路径的方法和组合
公开(公告)号：WO2008087562A2
公开(公告)日：2008-07-24
申请号：PCT/IB2008000987
申请日：2008-01-18
申请人： PLANT BIOSCIENCE LTD PBL , NAVARRO LIONEL , VOINNET OLIVER
发明人： NAVARRO LIONEL , VOINNET OLIVER
CPC分类号： C12N15/8279 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/12
摘要： A specific spectrum of plant and animal miRNAs confer enhanced resistance to virulent pathogens. Plants deficient in miRNA accumulation are hyper-susceptible to non-virulent bacterial pathogens, and virulent bacteria suppress miRNA pathways by means of injected type-Ill secreted (TTS) proteins. Methods and compositions for modulating the miRNA pathway in plants and animals are disclosed whereby adverse effects on plant and animal development are avoided or minimized.
摘要翻译：植物和动物miRNA的特定谱带来对强毒性病原体的增强抗性。缺乏miRNA积累的植物对非毒性细菌病原体是高度敏感的，并且有毒细菌通过注射型III型分泌型（TTS）蛋白抑制miRNA途径。公开了调节植物和动物中的miRNA途径的方法和组合物，其中避免或最小化对植物和动物发育的不利影响。

40. 发明申请

WO2005001118A3 DETECTION SYSTEM 审中-公开
标题翻译：检测系统
公开(公告)号：WO2005001118A3
公开(公告)日：2005-04-21
申请号：PCT/GB2004002685
申请日：2004-06-23
申请人： PLANT BIOSCIENCE LTD , HUTCHINGS MATTHEW IAN , HONG HEE-JEON , BUTTNER MARK JEREMY
发明人： HUTCHINGS MATTHEW IAN , HONG HEE-JEON , BUTTNER MARK JEREMY
IPC分类号： C12N9/10 , C12Q1/18 , C12Q1/48 , C12N1/00 , C12Q1/37
CPC分类号： C12N9/104 , C12Q1/18 , C12Q1/48
摘要： The invention provides a methods and materials for detecting an activity of a glycopeptide antibiotic (such as a vancomycin-type antibiotic), in a sample, the method comprising the steps of: (a) providing a microorganism in which a first endogenous gene encoding peptidyltransferase activity is inactivated, which activity is necessary for growth of the microorganism, and which activity can be complemented by a second, different, peptidyltransferase, which second peptidyltransferase is inducible in the microorganism by the presence of the antibiotic, (b) contacting the sample with the microorganism, (c) observing the microorganism for growth, wherein growth of the microorganism is correlated with the presence of the antibiotic. Unlike systems of the prior art, the system does not rely on the expression of a heterologous reporter gene in order to detect antibiotic activity, but instead utilises a "drug dependent" microorganism that can only grow in the presence of antibiotics that act as inducers of the relevant genes.
摘要翻译：本发明提供了用于检测样品中糖肽类抗生素（例如万古霉素类抗生素）活性的方法和材料，所述方法包括以下步骤：（a）提供微生物，其中编码肽基转移酶的第一内源基因活性是失活的，该活性对于微生物的生长是必需的，并且该活性可以通过第二种不同的肽基转移酶补充，该第二肽基转移酶在微生物中通过抗生素的存在是可诱导的，（b）使样品与（c）观察微生物生长，其中微生物的生长与抗生素的存在相关。与现有技术的系统不同，该系统不依赖于异源报道基因的表达来检测抗生素活性，而是使用仅在抗生素存在下生长的“药物依赖性”微生物，所述抗生素作为相关的基因。

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