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1. 发明申请

WO2010001096A3 TREATMENT 审中-公开
标题翻译：治疗
公开(公告)号：WO2010001096A3
公开(公告)日：2010-04-08
申请号：PCT/GB2009001593
申请日：2009-06-25
申请人： PROVEXIS NATURAL PRODUCTS LTD , PLANT BIOSCIENCE LTD , O'KENNEDY NIAMH , MITHEN RICHARD
发明人： O'KENNEDY NIAMH , MITHEN RICHARD
IPC分类号： A61K31/26 , A61K36/31 , A61K45/06 , A61P1/00 , A61P19/02 , A61P29/00
CPC分类号： A61K31/26 , A23L2/02 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K9/0095 , A61K36/31 , A61K36/87 , A61K45/06 , A23V2250/21 , A23V2250/21166 , A23V2200/324
摘要： The present invention concerns compositions that may be used in the prevention or treatment of medical conditions characterised by having an inflammatory component. The compositions comprise a therapeutically effective amount of an isothiocyanate (ITC). The composition may comprise further anti-inflammatory agents (e.g. plant- derived polyphenols).
摘要翻译：本发明涉及可用于预防或治疗特征在于具有炎性成分的医学病症的组合物。该组合物包含治疗有效量的异硫氰酸酯（ITC）。该组合物可以包含其他抗炎剂（例如植物衍生的多酚）。

2. 发明申请

WO2010049709A3 THERAPEUTIC COMPOSITIONS COMPRISING PHENOLIC ACIDS FOR TREATING CONDITIONS RELATED TO INAP PRORIATE PLATELET AGGREGATION 审中-公开
标题翻译：包含酚醛酸的治疗组合物用于治疗与INAP先天性细胞聚集相关的病症
公开(公告)号：WO2010049709A3
公开(公告)日：2010-06-24
申请号：PCT/GB2009002595
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LTD , O'KENNEDY NIAMH
发明人： O'KENNEDY NIAMH
IPC分类号： A61K31/192 , A61K31/216 , A61K31/235 , A61K31/7034 , A61K45/06 , A61P7/02 , A61P9/00
CPC分类号： A61K31/192 , A61K31/216 , A61K31/235 , A61K31/353 , A61K31/7034 , A61K31/7048 , A61K45/06 , A61K47/48092 , A61K47/549
摘要： The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C1 or C2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH; for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The compositions of the invention may be used to maintain heart health by reducing platelet aggregation; benefit the circulation; and/or normalize or otherwise benefit blood flow
摘要翻译：本发明提供包含治疗有效量的通式（I）的化合物的组合物：其中R 1，R 2和R 3可以独立地选自H，OH和OMe; 其中X是C1或C2，其中对于C2，每个碳通过单键或多键（优选双键）连接并被一个或多个H或OH取代; 用作治疗或预防以不适当血小板聚集为特征的医学病症的发展的药物。本发明的组合物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血液流通正常化或以其他方式受益

3. 发明申请

WO2010049705A2 THERAPEUTIC COMPOSITIONS 审中-公开
标题翻译：治疗组合物
公开(公告)号：WO2010049705A2
公开(公告)日：2010-05-06
申请号：PCT/GB2009/002591
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LIMITED , O'KENNEDY, Niamh
发明人： O'KENNEDY, Niamh
IPC分类号： A61K31/352 , A61K31/353 , A61K45/06 , A61P7/02 , A61P9/10
CPC分类号： A61K31/352 , A61K31/353 , A61K45/06
摘要： The invention provides compositions comprising a therapeutic or prophylactic effective amount of plant flavonoid or derivative thereof for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The flavonoid may be conjugated with a sugar. The flavonoid may be conjugated with another molecule by an ester bond. The compositions may also incorporate phenolic acids or nucleosides. Compositions of the invention are useful for maintaining heart health by reducing platelet aggregation; benefiting the circulation; and normalizing or otherwise benefiting blood flow.
摘要翻译：本发明提供了包含治疗或预防有效量的植物类黄酮或其衍生物的组合物，其用作治疗或预防以不合适的血小板聚集为特征的医学病症的发展的药物。类黄酮可与糖结合。类黄酮可以通过酯键与另一个分子共轭。组合物还可以掺入酚酸或核苷。本发明的组合物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 并使血流正常化或以其他方式受益。

4. 发明申请

WO2007141495A1 THERAPEUTIC USES OF TOMATO EXTRACTS 审中-公开
标题翻译： TOMATO提取物的治疗用途
公开(公告)号：WO2007141495A1
公开(公告)日：2007-12-13
申请号：PCT/GB2007/002034
申请日：2007-06-01
申请人： PROVEXIS NATURAL PRODUCTS LIMITED , O'KENNEDY, Niamh , SONG, Hyun-Ju
发明人： O'KENNEDY, Niamh , SONG, Hyun-Ju
IPC分类号： A61K36/81 , A61P7/02
CPC分类号： A61K36/81
摘要： The present invention relates to tomato extracts or an active fraction thereof for use in preventing or inhibiting the initiation of venous thrombosis and fibrin clot formation in a vein.
摘要翻译：本发明涉及用于预防或抑制静脉中静脉血栓形成和纤维蛋白凝块形成的番茄提取物或其活性成分。

5. 发明申请

WO2010049707A9 FRUIT EXTRACTS 审中-公开
标题翻译：水果提取物
公开(公告)号：WO2010049707A9
公开(公告)日：2011-11-03
申请号：PCT/GB2009002593
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LTD , O'KENNEDY NIAMH
发明人： O'KENNEDY NIAMH
IPC分类号： A61K36/81
CPC分类号： A61K36/81 , A61K31/7048 , A61K31/7064
摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.
摘要翻译：提供制备茄果科水果提取物的方法，其中加工水果以优化提取物的血小板聚集抑制活性。这些方法涉及制备匀化水果的初始混合物; 从水果固体中分离水溶性部分; 过滤水溶性部分; 活性剂在过滤渗透液中的浓度本发明还提供了通过这种方法制备的水果提取物，以及含有糖基化酚酸或酚酯或其衍生物的水果提取物; 糖基化类黄酮; 和一个核苷。本发明的提取物可用作治疗或预防以不适当的血小板聚集为特征的医学症状的药物。特别地，药物可用于通过减少血小板聚集维持心脏健康; 有利于流通; 和/或正常化或以其他方式有益于血流。

6. 发明申请

WO2010049707A3 FRUIT EXTRACTS 审中-公开
标题翻译：水果提取物
公开(公告)号：WO2010049707A3
公开(公告)日：2011-09-29
申请号：PCT/GB2009002593
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LTD , O'KENNEDY NIAMH
发明人： O'KENNEDY NIAMH
IPC分类号： A61K36/81
CPC分类号： A61K36/81 , A61K31/7048 , A61K31/7064
摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.
摘要翻译：提供制造茄科的果实提取物的方法，其中加工水果以优化提取物的血小板聚集抑制活性。该方法包括制备均质水果的起始混合物; 从水果固体中分离出水溶性部分; 过滤水溶性部分; 和过滤渗透物中活性剂的浓度本发明还提供了通过这些方法制造的水果提取物，还提供了含有糖基化的酚酸或酚酯或其衍生物的果实提取物; 糖基化黄酮; 和核苷。本发明的提取物可用作治疗或预防以血小板聚集不当为特征的医学病症的药物。特别地，药物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血液流动正常化或以其他方式受益。

7. 发明申请

WO2010049705A3 THERAPEUTIC COMPOSITIONS COMPRISING FLAVONOIDS 审中-公开
标题翻译：包含FLAVONOIDS的治疗组合物
公开(公告)号：WO2010049705A3
公开(公告)日：2010-06-24
申请号：PCT/GB2009002591
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LTD , O'KENNEDY NIAMH
发明人： O'KENNEDY NIAMH
IPC分类号： A61K31/352 , A61K31/353 , A61K45/06 , A61P7/02 , A61P9/10
CPC分类号： A61K31/352 , A61K31/353 , A61K45/06
摘要： The invention provides compositions comprising a therapeutic or prophylactic effective amount of plant flavonoid or derivative thereof for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The flavonoid may be conjugated with a sugar. The flavonoid may be conjugated with another molecule by an ester bond. The compositions may also incorporate phenolic acids or nucleosides. Compositions of the invention are useful for maintaining heart health by reducing platelet aggregation; benefiting the circulation; and normalizing or otherwise benefiting blood flow.
摘要翻译：本发明提供了包含治疗或预防有效量的植物类黄酮或其衍生物的组合物，其用作治疗或预防以不合适的血小板聚集为特征的医学病症的发展的药物。类黄酮可与糖结合。类黄酮可以通过酯键与另一个分子共轭。组合物还可以掺入酚酸或核苷。本发明的组合物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 并使血流正常化或以其他方式受益。

8. 发明申请

WO2010049709A2 THERAPEUTIC COMPOSITIONS 审中-公开
标题翻译：治疗组合物
公开(公告)号：WO2010049709A2
公开(公告)日：2010-05-06
申请号：PCT/GB2009/002595
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LIMITED , O'KENNEDY, Niamh
发明人： O'KENNEDY, Niamh
IPC分类号： A61K31/192 , A61K31/216 , A61K31/235 , A61K31/7034 , A61K45/06 , A61P7/02 , A61P9/00
CPC分类号： A61K31/192 , A61K31/216 , A61K31/235 , A61K31/353 , A61K31/7034 , A61K31/7048 , A61K45/06 , A61K47/48092 , A61K47/549
摘要： The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C 1 or C 2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH; for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The compositions of the invention may be used to maintain heart health by reducing platelet aggregation; benefit the circulation; and/or normalize or otherwise benefit blood flow
摘要翻译：本发明提供包含治疗有效量的通式（I）的化合物的组合物：其中R 1，R 2和R 3可以独立地选自H，OH和OMe; 其中X是C1或C2，其中对于C2，每个碳通过单键或多键（优选双键）连接并被一个或多个H或OH取代; 用作治疗或预防以不适当血小板聚集为特征的医学病症的发展的药物。本发明的组合物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血液流通正常化或以其他方式受益

9. 发明申请

WO2010049709A8 THERAPEUTIC COMPOSITIONS COMPRISING PHENOLIC ACIDS FOR TREATING CONDITIONS RELATED TO INAPPROPRIATE PLATELET AGGREGATION 审中-公开
标题翻译：包含酚醛类化合物的治疗组合物用于处理与不合适的细胞聚集相关的条件
公开(公告)号：WO2010049709A8
公开(公告)日：2011-07-14
申请号：PCT/GB2009002595
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LTD , O'KENNEDY NIAMH
发明人： O'KENNEDY NIAMH
IPC分类号： A61K31/192 , A61K31/216 , A61K31/235 , A61K31/7034 , A61K45/06 , A61P7/02 , A61P9/00
CPC分类号： A61K31/192 , A61K31/216 , A61K31/235 , A61K31/353 , A61K31/7034 , A61K31/7048 , A61K45/06 , A61K47/48092 , A61K47/549
摘要： The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C1 or C2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH; for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The compositions of the invention may be used to maintain heart health by reducing platelet aggregation; benefit the circulation; and/or normalize or otherwise benefit blood flow
摘要翻译：本发明提供包含治疗有效量的通式（I）化合物的组合物：其中R 1，R 2和R 3可以独立地选自H，OH和OMe; 其中X是C1或C2，其中对于C2，每个碳通过单键或多键（优选双键）连接并被一个或多个H或OH取代; 用作治疗或预防以不适当血小板聚集为特征的医学病症的发展的药物。本发明的组合物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血液流通正常化或以其他方式受益

10. 发明申请

WO2010049707A2 FRUIT EXTRACTS 审中-公开
标题翻译：水果提取物
公开(公告)号：WO2010049707A2
公开(公告)日：2010-05-06
申请号：PCT/GB2009/002593
申请日：2009-11-02
申请人： PROVEXIS NATURAL PRODUCTS LIMITED , O'KENNEDY, Niamh
发明人： O'KENNEDY, Niamh
IPC分类号： A61K36/81 , A61K31/00
CPC分类号： A61K36/81 , A61K31/7048 , A61K31/7064
摘要： Provided are methods of making an extract of fruit of the Solanaceae family wherein fruit is processed to optimise the platelet aggregation inhibiting activity of the extract. The methods involve preparing a start mix of homogenised fruit; separating a water soluble fraction from fruit solids; filtration of the water soluble fraction; and concentration of active agents in the filtration permeate The invention also provides fruit extracts manufactured by such methods, and also fruit extracts containing glycosylated phenolic acid or a phenolic ester, or derivatives thereof; a glycosylated flavonoid; and a nucleoside. The extracts of the invention are useful as medicaments for the treatment or prevention of a medical condition characterised by inappropriate platelet aggregation. In particular, the medicaments may be of use in maintaining heart health by reducing platelet aggregation; benefiting the circulation; and/or normalizing or otherwise benefiting blood flow.
摘要翻译：提供了制作茄科的果实提取物的方法，其中加工水果以优化提取物的血小板聚集抑制活性。该方法包括制备均质水果的起始混合物; 从水果固体中分离水溶性部分; 过滤水溶性部分; 和过滤渗透物中活性剂的浓度本发明还提供了通过这些方法制备的水果提取物，还提供了含有糖基化的酚酸或酚酯或其衍生物的果实提取物; 糖基化黄酮; 和核苷。本发明的提取物可用作治疗或预防以血小板聚集不良为特征的医学病症的药物。特别地，药物可用于通过减少血小板聚集来维持心脏健康; 有利于流通; 和/或使血流正常化或以其他方式受益。

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