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21. 发明申请

WO2016061202A1 SYSTEM FOR AMBULATORY OPTIMIZATION OF MULTI-SITE PACING USING HEART SOUNDS 审中-公开
标题翻译：使用心脏声音进行多场景优化的系统
公开(公告)号：WO2016061202A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055497
申请日：2015-10-14
申请人： CARDIAC PACEMAKERS, INC.
发明人： AN, Qi , THAKUR, Pramodsingh Hirasingh , YU, Yinghong
IPC分类号： A61N1/05 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3686 , A61N1/0563 , A61N1/3622 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/37247
摘要： An example of a system for pacing through multiple electrodes in a ventricle includes a sensing circuit to sense cardiac signal(s), a pacing output circuit to deliver pacing pulses, a heart sound sensor to sense a heart sound signal, and a control circuit to control the delivery of the pacing pulses. The control circuit includes a heart sound detector to detect heart sounds using the heart sound signal, an electrical event detector to detect cardiac electrical events using the cardiac signal(s), a measurement module to measure an optimization parameter using the detected heart sounds, an optimization module to perform an optimization procedure using the optimization parameter in response to an optimization command, and an optimization initiator to generate the optimization command. The optimization procedure includes selection of a single electrode or a plurality of electrodes from the multiple electrodes in the ventricle for pacing that ventricle.
摘要翻译：用于起搏通过心室中的多个电极的系统的示例包括用于感测心脏信号的感测电路，用于输送起搏脉冲的起搏输出电路，用于感测心脏声音信号的心脏声音传感器以及控制电路控制起搏脉冲的输送。控制电路包括使用心音信号检测心脏声音的心脏声音检测器，使用心脏信号检测心脏电气事件的电子事件检测器，使用检测到的心脏声音来测量优化参数的测量模块，优化模块，根据优化指令执行使用优化参数的优化过程，以及优化启动器生成优化命令。优化过程包括从心室中的多个电极中选择单个电极或多个电极，用于起搏该心室。

22. 发明申请

WO2015191893A3 SYSTEMS AND METHODS FOR RATE RESPONSIVEPACING WITH A LEADLESS CARDIAC PACEMAKER 审中-公开
标题翻译：用无铅CARDIAC PACEMAKER进行速率响应的系统和方法
公开(公告)号：WO2015191893A3
公开(公告)日：2016-04-14
申请号：PCT/US2015035389
申请日：2015-06-11
申请人： CARDIAC PACEMAKERS INC
发明人： KANE MICHAEL J , STAHMANN JEFFREY E , MAILE KEITH R
IPC分类号： A61N1/365 , A61N1/05 , A61N1/368 , A61N1/372 , G06F17/30
CPC分类号： A61N1/36585 , A61N1/0563 , A61N1/36521 , A61N1/36542 , A61N1/3684 , A61N1/37288 , A61N1/3756
摘要： Systems and methods for providing rate responsive pacing therapy to a heart of a patient. One example method for providing rate responsive pacing therapy includes sensing cardiac electrical data with a leadless cardiac pacemaker (LCP) that is implanted within or proximate the heart. From this location, the LCP may provide pacing therapy to the heart based at least in part on the sensed cardiac electrical data. An implantable medical device located remotely from the heart may sense patient activity, and may wirelessly communicate patient activity data from the implantable medical device to the LCP, sometimes using conducted communication. The LCP may be then determine an adjustment to the provided pacing therapy (e.g. adjust the pacing rate) based at least in part on the received patient activity data signal.
摘要翻译：用于向患者的心脏提供速率响应起搏治疗的系统和方法。用于提供速率响应起搏治疗的一个示例性方法包括用植入心脏内或心脏附近的无引线心脏起搏器（LCP）来感测心脏电数据。从该位置，LCP可以至少部分地基于所感测的心脏电数据来向心脏提供起搏治疗。位于远离心脏的可植入医疗装置可以感测患者活动，并且可以有时使用进行的通信将患者活动数据从可植入医疗装置无线地传送到LCP。然后，LCP可以至少部分地基于所接收的患者活动数据信号来确定对所提供的起搏治疗的调整（例如调整起搏速率）。

23. 发明申请

WO2016039877A1 SYSTEM AND METHOD FOR DUAL-CHAMBER PACING 审中-公开
标题翻译：双室加热系统及方法
公开(公告)号：WO2016039877A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/042334
申请日：2015-07-28
申请人： MEDTRONIC, INC.
发明人： DEMMER, Wade M. , GREENHUT, Saul E. , SHELDON, Todd J. , ANDERSON, David A. , KLECKNER, Karen J. , CARNEY, James K.
IPC分类号： A61N1/05 , A61N1/375 , A61N1/372 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/365 , A61N1/0573 , A61N1/3627 , A61N1/36507 , A61N1/36514 , A61N1/36528 , A61N1/36542 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/368 , A61N1/3684 , A61N1/3688 , A61N1/37205 , A61N1/3756
摘要： A medical device system including a pacemaker implantable in an atrial chamber of a patient's heart is configured to sense near field atrial events from a cardiac signal received by a sensing module of the pacemaker and to sense far field ventricular events. The pacemaker is configured to establish an atrial lower rate interval to control a rate of delivery of atrial pacing pulses, determine a rate of the far field ventricular events sensed by the sensing module, determine an atrial event rate, compare the rate of the sensed far field ventricular events to the atrial event rate, and adjust the atrial lower rate interval in response to the comparison.
摘要翻译：包括可植入在患者心脏的房室中的起搏器的医疗装置系统被配置为从由起搏器的感测模块接收的心脏信号感测近场心房事件并感测远场心室事件。心脏起搏器被配置为建立心房较低速率间隔以控制心房起搏脉冲的传递速率，确定由感测模块感测的远场心室事件的速率，确定心房事件发生率，比较感测到的远程速率场心室事件与心房事件发生率相关，并根据比较调整心房较低速率区间。

24. 发明申请

WO2016007657A1 POWER SAVING COMMUNICATION FOR MEDICAL DEVICES 审中-公开
标题翻译：省电通信医疗器械
公开(公告)号：WO2016007657A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/039590
申请日：2015-07-08
申请人： CARDIAC PACEMAKERS, INC.
发明人： HUELSKAMP, Paul , MAILE, Keith R.
IPC分类号： A61N1/372 , A61N1/368 , A61N1/39 , A61N1/362 , A61N1/37 , A61N1/375 , A61B5/046 , A61B5/0464 , A61B5/0472
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/021 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/11 , A61B5/14542 , A61B5/686 , A61B5/7275 , A61B5/7282 , A61B7/023 , A61B2560/0209 , A61B2560/0214 , A61N1/3622 , A61N1/3625 , A61N1/3684 , A61N1/3708 , A61N1/37205 , A61N1/37276 , A61N1/37288 , A61N1/3756 , A61N1/3956
摘要： Power saving communication techniques for communicating in a medical device system. One example medical device system may be for delivering electrical stimulation therapy to a heart of a patient, and may include a first implantable medical device implanted in a first chamber of the heart and configured to determine one or more parameters, a medical device physically spaced from and communicatively coupled to the first implantable medical device, the medical device configured to deliver electrical stimulation therapy to the heart of the patient, wherein the first implantable medical device is further configured to: compare a value of a first determined parameter to a first threshold; if the value of the first determined parameter passed the first threshold, communicate a first indication to the medical device; and if the value of the first determined parameter has not passed the first threshold, not communicating the first indication to the medical device.
摘要翻译：用于在医疗设备系统中进行通信的节电通信技术。一个示例性的医疗设备系统可以用于将电刺激治疗递送到患者的心脏，并且可以包括植入心脏的第一腔室中并被配置为确定一个或多个参数的第一可植入医疗设备，医疗设备物理上与并且通信地耦合到所述第一可植入医疗装置，所述医疗装置被配置为向患者的心脏递送电刺激治疗，其中所述第一可植入医疗装置还被配置为：将第一确定参数的值与第一阈值进行比较; 如果第一确定参数的值通过第一阈值，则将第一指示传达到医疗设备; 并且如果第一确定参数的值没有超过第一阈值，则不将第一指示传达到医疗设备。

25. 发明申请

WO2015095581A9 SYSTEMS AND METHODS FOR FACILITATING SELECTING OF ONE OR MORE VECTORS IN A MEDICAL DEVICE 审中-公开
标题翻译：用于促进在医疗设备中选择一个或多个向量的系统和方法
公开(公告)号：WO2015095581A9
公开(公告)日：2015-10-08
申请号：PCT/US2014071253
申请日：2014-12-18
申请人： CARDIAC PACEMAKERS INC
发明人： ROCKWEILER HOLLY E , SAHA SUNIPA , HERRMANN KEITH L , YU YINGHONG , KRUEGER JOEL A
IPC分类号： A61N1/372 , A61N1/36 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3686 , A61N1/36185 , A61N1/36521 , A61N1/371 , A61N1/37247
摘要： Some systems and methods may facilitate selection of a vector for delivering electrical stimulation to a patient's heart. One method may include displaying a plurality of vectors on a display screen wherein each vector represents a different combination of three or more electro-stimulation electrodes, determining an electrical impedance for each of the plurality of vectors, displaying on the display screen the electrical impedance for each of the plurality of vectors, receiving a selection of a set of the plurality of vectors, determining, for each of the vectors in the set of vectors, a capture threshold, displaying on the display screen the capture threshold for each of the vectors in the set of vectors, receiving a selection of a vector from the set of vectors for delivery of electrical stimulation to the patient's heart, and programming the electro-stimulation device electrical stimulation to the patient's heart via the selected vector.
摘要翻译：一些系统和方法可以有助于选择用于向患者的心脏递送电刺激的载体。一种方法可以包括在显示屏上显示多个矢量，其中每个矢量表示三个或更多个电刺激电极的不同组合，确定多个矢量中的每一个的电阻抗，在显示屏上显示用于所述多个矢量中的每一个接收对所述多个矢量的集合的选择，针对所述矢量集合中的每个矢量确定捕获阈值，在显示屏幕上显示每个矢量的捕获阈值，该组矢量从用于向患者的心脏递送电刺激的矢量集合中接收矢量的选择，并且经由选择的矢量将电刺激设备电刺激编程到患者的心脏。

26. 发明申请

WO2015143327A1 MULTI-ELECTRODE EPICARDIAL PACING 审中-公开
标题翻译：多电极环氧树脂
公开(公告)号：WO2015143327A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/021758
申请日：2015-03-20
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , ST. ANNE'S UNIVERSITY HOSPITAL BRNO
发明人： SYED, Faisal F. , BRUCE, Charles J. , DESIMONE, Christopher V. , FRIEDMAN, Paul A. , ASIRVATHAM, Samuel J. , KARA, Tomas , LEINVEBER, Pavel , NOVAK, Miroslav , STAREK, Zdenek , WOLF, Jiri
IPC分类号： A61N1/05 , A61N1/36 , A61N1/368
CPC分类号： A61N1/0587 , A61B18/14 , A61B18/1492 , A61B2018/00279 , A61B2018/00363 , A61B2018/00577 , A61B2018/1467 , A61N1/059 , A61N1/0597 , A61N1/3627 , A61N1/37211 , A61N1/3962
摘要： Systems and methods for epicardial pacing are provided. For example, this document provides epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods provided can be used for ablation, defibrillation, and/or defibrillation in combination with pacing.
摘要翻译：提供心外膜起搏的系统和方法。例如，本文件提供使用经皮输送的分叉起搏导联的心外膜起搏，其具有定向绝缘的多个电极，以防止心外刺激，包括预防膈刺激。此外，提供的装置，系统和方法可以与起搏组合用于消融，除颤和/或除颤。

27. 发明申请

WO2015120466A1 MULTI-CHAMBER LEADLESS PACEMAKER SYSTEM WITH INTER-DEVICE COMMUNICATION 审中-公开
标题翻译：具有设备间通信功能的多层无铅门禁系统
公开(公告)号：WO2015120466A1
公开(公告)日：2015-08-13
申请号：PCT/US2015/015247
申请日：2015-02-10
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E.
IPC分类号： A61N1/372 , A61N1/375 , A61N1/368 , A61N1/362
CPC分类号： A61N1/3684 , A61N1/3622 , A61N1/3624 , A61N1/36592 , A61N1/3682 , A61N1/37205 , A61N1/37288 , A61N1/3756
摘要： Systems and methods for switching modes in a multi-device medical system. In one example, a first leadless cardiac pacemaker (LCP) may be implantable at a ventricular site, and a second leadless cardiac pacemaker (LCP) may be implantable at an atrial site and configured to sensing atrial contractions. The first LCP and the second LCP may be configured to be communicatively coupled such that the first LCP and the second LCP can deliver pacing therapy to the ventricular site in a tracking mode. The first LCP and/or the second LCP may additionally be configured to deliver pacing therapy to the ventricular site in a non-tracking mode if an interval between atrial contractions sensed by the second LCP becomes shorter than a threshold duration.
摘要翻译：用于在多设备医疗系统中切换模式的系统和方法。在一个示例中，第一无引线心脏起搏器（LCP）可以植入在心室部位，并且第二无引线心脏起搏器（LCP）可以植入在心房部位并被配置成感测心房收缩。第一LCP和第二LCP可以被配置为通信地耦合，使得第一LCP和第二LCP可以在跟踪模式中向心室部位提供起搏治疗。如果由第二LCP感测到的心房收缩之间的间隔变得短于阈值持续时间，则第一LCP和/或第二LCP可另外被配置为以非跟踪模式将起搏治疗递送到心室部位。

28. 发明申请

WO2014143923A1 MODULATE PACING RATE TO INCREASE THE PERCENTAGE OF EFFECTIVE VENTRICULAR CAPTURE DURING ATRIAL FIBRILLATION 审中-公开
标题翻译：调节速度在ATRIAL FIBRILLATION期间增加有效的心室收缩的百分比
公开(公告)号：WO2014143923A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028108
申请日：2014-03-14
申请人： MEDTRONIC, INC.
发明人： LU, Richard M.T. , GHOSH, Subham , STADLER, Robert W.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37 , A61B5/046
CPC分类号： A61N1/371 , A61B5/046 , A61N1/3622 , A61N1/3624 , A61N1/3684 , A61N1/3716
摘要： The present disclosure pertains to cardiac pacing methods and systems, and, more particularly, to cardiac resynchronization therapy (CRT). In particular, the present disclosure pertains to determining whether a patient is experiencing atrial fibrillation (AF). If the patient is experiencing AF, the efficacy of CRT is determined. A signal is sensed in response to a ventricular pacing stimulus. Through signal processing, a number of features are parsed from the signal and a determination is made as to whether the ventricular pacing stimulus evoked a response from the ventricle. In response to the determination of effective capture, the ventricular pacing rate during atrial fibrillation is modified, hence increasing a percentage of effective ventricular capture during atrial fibrillation responsive to modifying the pacing rate during atrial fibrillation.
摘要翻译：本公开涉及心脏起搏方法和系统，更具体地，涉及心脏再同步治疗（CRT）。特别地，本公开涉及确定患者是否正在经历心房颤动（AF）。如果患者正在经历房颤，则CRT的功效得以确定。响应于心室起搏刺激感测信号。通过信号处理，从信号中解析出许多特征，并且确定心室起搏刺激是否引起了心室的反应。响应于有效捕获的确定，心房颤动期间的心室起搏速率被修改，因此响应于改变心房颤动期间的起搏速率而增加心房颤动期间有效心室捕获的百分比。

29. 发明申请

WO2014105306A1 SYSTEMS AND METHODS TO OPTIMIZE PACING FUSION WITH NATIVE ACTIVATION 审中-公开
标题翻译：用优化活化激光的系统和方法
公开(公告)号：WO2014105306A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/071247
申请日：2013-11-21
申请人： CARDIAC PACEMAKERS, INC.
发明人： MASKARA, Barun , SHUROS, Allan C.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36564 , A61N1/3684
摘要： In an example, a pacing therapy can be optimized using information indicative of an offset duration between an intrinsic first atrioventricular delay of a subject at rest and a second atrioventricular delay specified to enhance a cardiac output of the subject heart when the subject is at rest. Optimizing the therapy can include receiving information about a heart rate of the subject and receiving information about an intrinsic, heart rate dependent atrioventricular delay. In an example, a therapy parameter, such as a therapy atrioventricular delay, can be adjusted using information about the received heart rate of the subject, the heart-rate-dependent third AV delay, or the offset duration.
摘要翻译：在一个示例中，可以使用指示休息的受试者的固有的第一房室延迟与被指定的第二房室延迟之间的偏移持续时间的信息来优化起搏治疗，以在受试者静止时增强主体心脏的心输出量。优化治疗可以包括接收关于受试者的心率的信息并且接收关于固有的心率依赖性房室延迟的信息。在一个示例中，可以使用关于受试者的接收心率，心率依赖的第三AV延迟或偏移持续时间的信息来调整诸如治疗房室延迟的治疗参数。

30. 发明申请

WO2014058611A1 CARDIAC PACING DURING MEDICAL PROCEDURES 审中-公开
标题翻译：医疗过程中的心脏病
公开(公告)号：WO2014058611A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/061364
申请日：2013-09-24
申请人： MEDTRONIC, INC.
发明人： ELLINGSON, Michael, L.
IPC分类号： A61N1/368
CPC分类号： A61N1/3688
摘要： An implantable medical device may comprise a therapy module configured to generate pacing therapy for a heart of a patient and a control module configured to control the therapy module. The control module may also be configured to detect a condition indicative of the presence of a magnetic resonance imaging (MRI) device and switch operation from a first pacing therapy program to a second pacing therapy program in response to detecting the condition indicative of the presence of the MRI device. While operating in the second pacing therapy program, control module may control the therapy module to generate a pacing pulse to an atrium of the heart of the patient during a time period between the end of an atrial refractory period of a previous atrial depolarization and the end of a ventricular refractory period of a previous ventricular depolarization corresponding to the previous atrial depolarization
摘要翻译：可植入医疗装置可以包括治疗模块，该治疗模块被配置为产生用于患者心脏的起搏治疗和被配置为控制治疗模块的控制模块。控制模块还可以被配置为响应于检测到指示存在的条件，检测指示磁共振成像（MRI）设备的存在和从第一起搏治疗程序到第二起搏治疗程序的切换操作的状况 MRI装置。当在第二起搏治疗程序中操作时，控制模块可以控制治疗模块，以在先前的心房去极化的心房不应期的结束与末端之间的时间段期间，向患者心脏的心房产生起搏脉冲的先前心室去极化的心室不应期与先前的心房去极化相对应

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