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21. 发明申请

WO1997008301A1 NOVEL FACTORS WHICH MODIFY GENE TRANSCRIPTION AND METHODS OF USE THEREFOR 审中-公开
标题翻译：修饰基因转录因子的方法及其使用方法
公开(公告)号：WO1997008301A1
公开(公告)日：1997-03-06
申请号：PCT/US1996014192
申请日：1996-08-28
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , YOUNG, Richard, A. , KOLESKE, Anthony, J. , THOMPSON, Craig, M. , CHAO, David, M.
IPC分类号： C12N09/12
CPC分类号： C12N9/1247 , C07K14/395 , C07K14/4702 , C07K16/14 , G01N33/573
摘要： Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory proteins are described. These holoenzymes selectively initiate transcription in vitro when supplemented with general transcription factors. The regulatory proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
摘要翻译：描述了含有RNA聚合酶II和一种或多种调节蛋白的真核RNA聚合酶II全酶。当补充一般转录因子时，这些全酶在体外选择性启动转录。调节蛋白质通过与RNA聚合酶II的功能相互作用，至少部分地起到调节转录起始的作用。

22. 发明申请

WO1997008300A1 CRYSTALLINE ZAP FAMILY PROTEINS 审中-公开
标题翻译：结晶ZAP家族蛋白
公开(公告)号：WO1997008300A1
公开(公告)日：1997-03-06
申请号：PCT/US1996013918
申请日：1996-08-30
申请人： ARIAD PHARMACEUTICALS, INC.
发明人： ARIAD PHARMACEUTICALS, INC. , HATADA, Marcos, H. , LU, Xiaode , LAIRD, Ellen, R. , KARAS, Jennifer, L. , ZOLLER, Mark, J. , HOLT, Dennis, A.
IPC分类号： C12N09/12
CPC分类号： C12N9/1205
摘要： The invention relates to human ZAP-70, and in particular, to the region of ZAP-70 containing the tandem Src homology-2 ("SH2") domains, to crystalline forms thereof, liganded or unliganded, which are particularly useful for the determination of the three-dimensional structure of the protein. The three-dimensional structure of the tandem SH2 region of ZAP provides information useful for the design of pharmaceutical compositions which inhibit the biological function of ZAP and other members of the ZAP family of SH2 domain-containing proteins, particularly those biological functions mediated by molecular interactions involving one or both SH2 domains.
摘要翻译：本发明涉及人ZAP-70，特别涉及含有串联Src同源性-2（“SH2”）结构域的ZAP-70区域，其结构形式为配体或非配体，其特别可用于测定的蛋白质的三维结构。 ZAP的串联SH2区域的三维结构提供了有用的药物组合物设计的信息，该药物组合物抑制ZAP和含SH2结构域的蛋白质的ZAP家族的其他成员的生物学功能，特别是那些通过分子相互作用介导的生物功能涉及一个或两个SH2结构域。

23. 发明申请

WO1996015233A1 MUTANT DNA ENCODING INSULIN-STIMULATED PROTEIN KINASE 审中-公开
标题翻译： MUTANT DNA编码胰岛素刺激的蛋白激酶
公开(公告)号：WO1996015233A1
公开(公告)日：1996-05-23
申请号：PCT/DK1995000448
申请日：1995-11-10
申请人： NOVO NORDISK A/S , PEDERSEN, Oluf , ECHWALD, Soren, Morgenthaler , BJORBÆK, Christian
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/12
CPC分类号： C12N9/1205 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a DNA isolate comprising a DNA sequence encoding insulin-stimulated protein kinase (ISPK-1), the DNA sequence containing a mutation of at least one nucleotide, or comprising a fragment of the DNA sequence including said mutation.
摘要翻译：本发明涉及包含编码胰岛素刺激蛋白激酶（ISPK-1）的DNA序列，含有至少一个核苷酸突变的DNA序列或包含包含所述突变的DNA序列的片段的DNA分离物。

24. 发明申请

WO1993005148A1 MUTATED GROWTH FACTOR RECEPTOR AS MEDICAMENT AND ITS USE FOR TREATING CANCER 审中-公开
标题翻译：作为药物的突变型生长因子受体及其用于治疗癌症的用途
公开(公告)号：WO1993005148A1
公开(公告)日：1993-03-18
申请号：PCT/EP1992002058
申请日：1992-09-07
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ...
发明人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ... , REDEMANN, Norbert , ULLRICH, Axel
IPC分类号： C12N09/12
CPC分类号： C07K14/71 , A61K38/00 , A61K48/00
摘要： Mutated receptor tyrosine kinases are useful as medicaments. These mutated growth factor receptors are particularly advantageous for treating cancerous diseases, in particular those types of cancer in which the overactivity of growth factor receptors play a role in the formation of the cancer, as well as for treating other diseases caused by receptor overactivity. Mutants of the EGF receptors in which the tyrosine kinase activity of the wild type receptor has been eliminated by punctual mutation or deletion in the tyrosine kinase domain are particularly effective medicaments for treating cancer.

25. 发明申请

WO1984004329A1 ENZYME EXTRACTION AND PURIFICATION PROCESSES 审中-公开
标题翻译：酶提取和纯化方法
公开(公告)号：WO1984004329A1
公开(公告)日：1984-11-08
申请号：PCT/AU1984000069
申请日：1984-04-19
申请人： LA TROBE UNIVERSITY , SCOPES, Robert, Kerry
发明人： LA TROBE UNIVERSITY
IPC分类号： C12N09/12
CPC分类号： C12N9/0006 , C12N9/00 , C12N9/12 , Y10S435/814
摘要： A process for the preparation of an enzyme extract containing glucose 6-phosphate dehydrogenase, glucokinase, pyruvate kinase and fructokinase, derived from microorganism cells, by subjecting Zymomonas mobilis bacterium cells to extraction with an extraction medium comprising a partially water-miscible organic solvent; a non-ionic surfactant; and lysozyme; under neutral to alkaline pH conditions to provide an extract containing said enzymes. The process can be integrated with a process for the sequential isolation of the glucose 6-phosphate dehydrogenase, glucokinase, pyruvate kinase and fructokinase, present in the enzyme extract, by sequentially contacting the extract in a buffer with a plurality of affinity chromatography adsorbents each of which is a protein-binding dye bound to a support matrix and selective with respect to said enzymes so that glucose 6-phosphate dehydrogenase and glucokinase are isolated from the extract by the correspondingly selective adsorbent, followed by isolation of pyruvate kinase and fructokinase by the correspondingly selective adsorbents, then elution to recover each enzyme from the correspondingly selective adsorbent of said plurality of adsorbents, with optional purification of each enzyme.
摘要翻译：一种制备含有来自微生物细胞的葡萄糖-6-磷酸脱氢酶，葡萄糖激酶，丙酮酸激酶和果糖激酶的酶提取物的方法，通过使运动发酵单胞菌细胞用含有部分水混溶性有机溶剂的提取介质进行提取; 非离子表面活性剂; 和溶菌酶; 在中性至碱性pH条件下提供含有所述酶的提取物。该方法可以与用于顺序分离存在于酶提取物中的葡萄糖-6-磷酸脱氢酶，葡萄糖激酶，丙酮酸激酶和果糖激酶的方法，通过将缓冲液中的提取物与多个亲和层析吸附剂顺序接触，其是与支持基质结合的蛋白质结合染料并且相对于所述酶具有选择性，从而通过相应的选择性吸附剂从提取物中分离葡萄糖-6-磷酸脱氢酶和葡萄糖激酶，然后相应地分离丙酮酸激酶和果糖激酶选择性吸附剂，然后洗脱以从所述多个吸附剂的相应选择性吸附剂中回收每种酶，并可任选地纯化每种酶。

26. 发明申请

WO1998024891A1 M. TUBERCULOSIS RNA POLYMERASE ALPHA SUBUNIT 审中-公开
标题翻译： M.TUBERCULOSIS RNA POLYMERASE ALPHA SUBUNIT
公开(公告)号：WO1998024891A1
公开(公告)日：1998-06-11
申请号：PCT/US1997022216
申请日：1997-11-03
申请人： SCRIPTGEN PHARMACEUTICALS, INC. , HEALY, Judith, M. , BODOROVA, Jana , LAM, Kelvin, T. , LESOON, Andrea, J.
发明人： SCRIPTGEN PHARMACEUTICALS, INC.
IPC分类号： C12N09/12
CPC分类号： C12N9/1247
摘要： The present invention provides isolated nucleic acids encoding RNA polymerase alpha subunit from M. tuberculosis, vectors comprising the nucleic acids, cells comprising the vectors, and methods for producing M. tuberculosis alpha subunit. The invention also provides in vitro and in vivo methods for high-throughput screening to identify inhibitors of M. tuberculosis RNA polymerase.
摘要翻译：本发明提供了编码来自结核分枝杆菌的RNA聚合酶α亚基的分离的核酸，包含核酸的载体，包含载体的细胞，以及产生结核分枝杆菌α亚基的方法。本发明还提供用于鉴定结核分枝杆菌RNA聚合酶抑制剂的高通量筛选的体外和体内方法。

27. 发明申请

WO1998020114A1 NOVEL RECEPTOR TYROSINE KINASES 审中-公开
标题翻译：新型受体TYROSINE KINASES
公开(公告)号：WO1998020114A1
公开(公告)日：1998-05-14
申请号：PCT/US1997019646
申请日：1997-10-29
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH
发明人： LUDWIG INSTITUTE FOR CANCER RESEARCH , REITH, Alastair , RUEGG, Markus
IPC分类号： C12N09/12
CPC分类号： C07K14/71
摘要： A novel family of receptor tyrosine kinases is disclosed. These molecules, the nucleic acid molecules encoding them, and the uses of these, are features of the disclosed invention.
摘要翻译：公开了一种新的受体酪氨酸激酶家族。这些分子，编码它们的核酸分子及其用途是本发明的特征。

28. 发明申请

WO1998007838A1 HIGHER ANIMAL TELOMERASE PROTEIN AND GENE ENCODING THE SAME 审中-公开
标题翻译：更高的动物丝氨酸蛋白酶和基因编码它们
公开(公告)号：WO1998007838A1
公开(公告)日：1998-02-26
申请号：PCT/JP1997002904
申请日：1997-08-21
申请人： MITSUBISHI CHEMICAL CORPORATION , ISHIKAWA, Fuyuki , NAKAMURA, Hideo , TAKAHASHI, Kazuhiro , FUJINO, Yasuhiro , HARADA, Naozumi
发明人： MITSUBISHI CHEMICAL CORPORATION
IPC分类号： C12N09/12
CPC分类号： C12N9/1241 , A61K38/00 , C12Q1/48
摘要： A telomerase protein originating in higher animals involving human being. This protein and a gene encoding the same are useful in, for example, the clarification of biological control mechanisms such as cell growth and aging and expected to be applicable to, in particular, the development of remedies for cancer. A method for screening substances acting on the expression of the enzyme activity of the higher animal telomerase protein involves the step of measuring the molecular weight of the telomerase protein contained in cells or tissues in contact with a test substance by, for example, the SDS polyacrylamide electrophoresis method.
摘要翻译：源自涉及人的高等动物的端粒酶蛋白。该蛋白质和编码该蛋白质的基因可用于例如细胞生长和衰老等生物学控制机制的澄清，并且预期特别适用于开发癌症治疗。用于筛选作用于较高动物端粒酶蛋白的酶活性表达的物质的方法包括测量与被检物质接触的细胞或组织中所含的端粒酶蛋白的分子量的步骤，例如通过SDS聚丙烯酰胺电泳法。

29. 发明申请

WO1997042310A1 MUTANT cDNA ENCODING THE p85'alpha' SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE 审中-公开
标题翻译：编码磷酸二氢叶酸3-生长激素的p85α亚基的突变cDNA
公开(公告)号：WO1997042310A1
公开(公告)日：1997-11-13
申请号：PCT/DK1997000200
申请日：1997-05-02
申请人： NOVO NORDISK A/S , HANSEN, Torben , ANDERSEN, Carsten, Bo , PEDERSEN, Oluf, Borbye
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/12
CPC分类号： C12N9/1205 , A01K2217/05 , C12Q1/6883 , C12Q2600/156 , G01N2333/91215
摘要： A nucleic acid sequence comprising a DNA sequence encoding a regulatory subunit of phosphaditylinositol 3-kinase (P13K), the DNA sequence containing a mutation of at least one nucleotide, or comprising a segment of the DNA sequence including said mutation for use as a diagnostic tool, a marker or a probe. Examples of mutations in p85 alpha subunit are: C to T in nucleotide 261; T to G in nucleotide 663; A to G in nucleotide 810; G to A in nucleotide 1020.
摘要翻译：一种核酸序列，其包含编码磷脂酰肌醇3-激酶（P13K）的调节亚基的DNA序列，含有至少一个核苷酸的突变的DNA序列，或包含用于诊断工具的所述突变的DNA序列片段，标记或探针。 p85α亚基突变的实例是：核苷酸261中的C至T; T至G在核苷酸663中; 核苷酸810中的A至G; G至A在核苷酸1020中。

30. 发明申请

WO1997027289A1 BRCA-1 PROTEIN KINASE AND METHOD OF USE 审中-公开
标题翻译： BRCA-1蛋白激酶及其使用方法
公开(公告)号：WO1997027289A1
公开(公告)日：1997-07-31
申请号：PCT/US1997001261
申请日：1997-01-28
申请人： ELI LILLY AND COMPANY , BECKMANN, Richard, P. , BURKE, Teresa, Faye , COCKE, Kimberly, S. , LEMKE, Stephanie, J.
发明人： ELI LILLY AND COMPANY
IPC分类号： C12N09/12
CPC分类号： C12N9/1205
摘要： The present invention describes a novel protein kinase which modulates phosphorylation of BRCA-1 protein. The present invention also describes the use of the BRCA-1 protein kinase as a molecular target for therapeutic intervention and/or as a therapeutic tool for diagnosing and treating breast and/or ovarian cancer.
摘要翻译：本发明描述了调节BRCA-1蛋白磷酸化的新型蛋白激酶。本发明还描述了BRCA-1蛋白激酶作为治疗性干预的分子靶标和/或用作诊断和治疗乳腺和/或卵巢癌的治疗工具的用途。

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