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1. 发明申请

WO1998005761A1 AGE-1 POLYPEPTIDES AND RELATED MOLECULES AND METHODS 审中-公开
标题翻译： AGE-1多肽和相关分子和方法
公开(公告)号：WO1998005761A1
公开(公告)日：1998-02-12
申请号：PCT/US1997013914
申请日：1997-08-07
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , RUVKUN, Gary , MORRIS, Jason , TISSENBAUM, Heidi
IPC分类号： C12N09/12
CPC分类号： C12N9/1205
摘要： Disclosed are substantially pure AGE-1 polypeptides and purified DNAs, vectors, and cells encoding those polypeptides. Also disclosed are methods for determining longevity and isolating antagonists using the AGE-1 sequence.
摘要翻译：公开了基本上纯的AGE-1多肽和纯化的DNA，载体和编码那些多肽的细胞。还公开了使用AGE-1序列确定寿命和分离拮抗剂的方法。

2. 发明申请

WO1998001541A1 TRAF2-ASSOCIATED PROTEIN KINASE AND ASSAYS 审中-公开
标题翻译： TRAF2相关蛋白激酶和测定
公开(公告)号：WO1998001541A1
公开(公告)日：1998-01-15
申请号：PCT/US1997011981
申请日：1997-07-08
申请人： TULARIK, INC.
发明人： TULARIK, INC. , SONG, Ho, Yeong , ROTHE, Mike
IPC分类号： C12N09/12
CPC分类号： C12N9/1205 , C07K14/7151
摘要： The invention provides methods and compositions relating to a novel human tumor necrosis factor receptor associated factor number two associated kinase protein. The invention provides hybridization probes and primers capable of hybridizing with the disclosed gene, nucleic acid encoding the kinase, methods of making the kinase proteins, and methods of using the compositions in diagnosis and drug screening.
摘要翻译：本发明提供了与新型人类肿瘤坏死因子受体相关的第二因子相关激酶蛋白相关的方法和组合物。本发明提供能够与所公开的基因杂交的杂交探针和引物，编码激酶的核酸，制备激酶蛋白的方法，以及在诊断和药物筛选中使用该组合物的方法。

3. 发明申请

WO1997039113A1 BIOLOGICALLY ACTIVE FRAGMENT OF BACILLUS STEAROTHERMOPHILUS DNA POLYMERASE 审中-公开
标题翻译： BACILLUS STEAROTHERMOPHILUS DNA聚合酶的生物活性片段
公开(公告)号：WO1997039113A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006235
申请日：1997-04-16
申请人： MOLECULAR BIOLOGY RESOURCES, INC.
发明人： MOLECULAR BIOLOGY RESOURCES, INC. , SWAMINATHAN, Neela , WILKOSZ, Richard, K.
IPC分类号： C12N09/12
CPC分类号： C12N9/1252
摘要： The present invention is directed to an isolated and purified DNA encoding a biologically active fragment of a thermostable, full length DNA polymerase I enzyme of Bacillus stearothermophilus. More particularly, the invention is directed to a DNA encoding an approximately 66,000 dalton DNA polymerase that lacks 273 amino acids from the N-terminus of the approximately 96,000 dalton B. stearothermophilus DNA polymerase I, and to the protein encoded thereby which has been designated the B. stearothermophilus DNA polymerase I exo-fragment. The enzyme fragments are useful in DNA sequencing, cDNA preparations, thermophilic Strand Displacement Amplification and other molecular biology applications.
摘要翻译：本发明涉及编码嗜热脂肪芽孢杆菌的热稳定的全长DNA聚合酶I酶的生物活性片段的分离和纯化的DNA。更具体地，本发明涉及编码大约66,000道尔顿DNA聚合酶的DNA，其缺乏来自约96,000道尔顿嗜热脂肪芽孢杆菌DNA聚合酶I的N末端的273个氨基酸，以及由此编码的蛋白质，其被命名为嗜热脂肪芽孢杆菌DNA聚合酶I外切片段。酶片段可用于DNA测序，cDNA制备，嗜热链位移扩增和其他分子生物学应用。

4. 发明申请

WO1997033981A1 PURIFIED PORCINE KIDNEY L-FUCOSE KINASE 审中-公开
标题翻译：纯化的PORCINE KIDNEY L-FUCOSE KINASE
公开(公告)号：WO1997033981A1
公开(公告)日：1997-09-18
申请号：PCT/US1997003771
申请日：1997-03-11
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
发明人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , ELBEIN, D., Alan
IPC分类号： C12N09/12
CPC分类号： C12N9/1205
摘要： L-fucokinase has been isolated from porcine kidney in homogeneously purified form. The enzyme has a native molecular weight of about 260 kDa based on gel filtration, a subunit molecular weight of about 45 kDa based on SDS PAGE, and an optimal pH of about 8.0. The enzyme catalyzes the phosphorylation of L-fucose, but does not phosphorylate D-glucose, D-galactose or D-mannose.
摘要翻译：已经从均匀纯化形式的猪肾中分离出L-丝菌蛋白酶。该酶基于凝胶过滤具有约260kDa的天然分子量，基于SDS PAGE的约45kDa的亚基分子量和约8.0的最佳pH。该酶催化L-岩藻糖磷酸化，但不磷酸化D-葡萄糖，D-半乳糖或D-甘露糖。

5. 发明申请

WO1997012033A1 RECOMBINANT HEPATITIS C VIRUS RNA REPLICASE 审中-公开
标题翻译：重组HEPATITIS C病毒RNA替代物
公开(公告)号：WO1997012033A1
公开(公告)日：1997-04-03
申请号：PCT/US1996015571
申请日：1996-09-27
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , HAGEDORN, Curt, H. , AL, Reinoldus, H.
IPC分类号： C12N09/12
CPC分类号： C12N9/127
摘要： A recombinant RNA-dependent RNA polymerase of hepatitis C virus (r-HCV-RDRP) coding DNA was cloned and expressed yielding active enzyme in vitro. The r-HCV-RDRP can include up to 20 added amino acids and up to nine deleted or substituted amino acids at the NH2-terminus of the encoded amino acid sequence. The invention provides method to solubilize r-HCV-RDRP from a host cell lysate and purified r-HCV-RDRP. Methods for screening for inhibitors of r-HCV-RDRP in vitro, for making stably transfected mammalian cells expressing r-HCV-RDRP and for in vivo testing of r-HCV-RDRP inhibitors in vivo are disclosed. The invention provides antibodies to r-HCV-RDRP and methods for detecting antibodies to HCV-RDRP in serum of human patients.
摘要翻译：克隆并表达丙型肝炎病毒（r-HCV-RDRP）编码DNA的重组RNA依赖性RNA聚合酶，并在体外产生活性酶。 r-HCV-RDRP可以在编码的氨基酸序列的NH 2 - 末端包含多达20个添加的氨基酸和至多9个缺失或取代的氨基酸。本发明提供从宿主细胞裂解物和纯化的r-HCV-RDRP中溶解r-HCV-RDRP的方法。公开了用于在体内筛选r-HCV-RDRP抑制剂的方法，用于制备表达r-HCV-RDRP的稳定转染的哺乳动物细胞和体内r-HCV-RDRP抑制剂的体内测试。本发明提供了对r-HCV-RDRP的抗体以及用于检测人类患者血清中HCV-RDRP抗体的方法。

6. 发明申请

WO1993003148A2 TAU/NEUROFILAMENT PROTEIN KINASES PK40 AND PK36 审中-公开
标题翻译： TAU / NEUROFILAMENT蛋白激酶PK40和PK36
公开(公告)号：WO1993003148A2
公开(公告)日：1993-02-18
申请号：PCT/US1992005825
申请日：1992-07-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , INGRAM, Vernon, M. , RODER, Hanno, M.
IPC分类号： C12N09/12
CPC分类号： C12N15/86 , C07K16/40 , C12N9/12 , C12N2710/10343 , C12N2710/10345
摘要： Novel TAU/neurofilament protein kinases, PK40 and PK36, are essentially purified and characterized. Novel immunoassays relating to the kinases and inhibitors for the kinases also are provided. Finally, DNA sequences encoding the kinases and cell lines relating to the kinases are provided.
摘要翻译：新型TAU /神经丝蛋白激酶PK40和PK36基本上是纯化和表征的。还提供了与激酶和激酶抑制剂有关的新型免疫测定。最后，提供编码与激酶相关的激酶和细胞系的DNA序列。

7. 发明申请

WO1992003539A1 VIRUS RESISTANCE IN PLANTS 审中-公开
标题翻译：植物病毒抗性
公开(公告)号：WO1992003539A1
公开(公告)日：1992-03-05
申请号：PCT/GB1991001423
申请日：1991-08-22
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , BUCK, Kenneth, William , HAYES, Robert, James
发明人： IMPERIAL CHEMICAL INDUSTRIES PLC
IPC分类号： C12N09/12
CPC分类号： C12N9/2411 , C07K14/415 , C07K16/16 , C07K16/40 , C12N9/127 , C12N9/2408 , C12N15/8283
摘要： An RNA-dependent replicase (RdRp) comprises polypeptides P1a and P2a of cucumber mosaic virus and polypeptide P50 of tobacco. It may also contain other minor polypeptide constituents. Each polypeptide may be substituted by another from a similar source having equivalent function. Also disclosed is recombinant plant genome having virus resistance comprising a gene expressing a product which inhibits expression of or inhibits the catalytic activity of viral RNA replicase. This product may be for example (1) an antibody directed against a protein constituent of the replicase or (2) RNA in antisense orientation to RNA encoding a protein constituent of the replicase.
摘要翻译： RNA依赖性复制酶（RdRp）包含黄瓜花叶病毒的多肽P1a和P2a以及烟草的多肽P50。它还可能含有其他次要多肽成分。每个多肽可以被具有等同功能的相似来源的另一个取代。还公开了具有病毒抗性的重组植物基因组，其包含表达抑制病毒RNA复制酶的催化活性的表达或抑制其的催化活性的产物的基因。该产物可以是例如（1）针对复制酶的蛋白质成分的抗体或（2）反义方向的RNA，其编码复制酶的蛋白质成分。

8. 发明申请

WO1998049274A1 THERMOSTABLE DNA POLYMERASE AND INTEINS OF THE THERMOCOCCUS FUMICOLANS SPECIES 审中-公开
标题翻译：热稳定性DNA聚合酶和热熔化菌体物种的浓度
公开(公告)号：WO1998049274A1
公开(公告)日：1998-11-05
申请号：PCT/FR1997000761
申请日：1997-04-29
申请人： APPLIGENE-ONCOR , QUERELLOU, Joël , CAMBON, Marie-Anne
发明人： APPLIGENE-ONCOR
IPC分类号： C12N09/12
CPC分类号： C12N9/1252
摘要： The invention concerns a purified thermostable DNA polymerase, thermostable archae bacteria DNA polymerase of the Thermococcus fumicolans species having a molecular weight of the order of 89000 daltons and its thermostable inteins.
摘要翻译：本发明涉及一种纯化的热稳定性DNA聚合酶，分子量为89000道尔顿的Thermococcus fumicolans物种的热稳定的古细菌DNA聚合酶及其耐热内含物。

9. 发明申请

WO1998015618A1 MAP KINASES: POLYPEPTIDES, POLYNUCLEOTIDES AND USES THEREOF 审中-公开
标题翻译：地图动物：多糖，多核苷酸及其用途
公开(公告)号：WO1998015618A1
公开(公告)日：1998-04-16
申请号：PCT/GB1997002779
申请日：1997-10-09
申请人： MEDICAL RESEARCH COUNCIL , COHEN, Philip , GOEDERT, Michel
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N09/12
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40
摘要： A substantially pure stress-activated protein kinase comprising the amino acid sequence (I) or a variant, fragment, fusion or derivative thereof, or a fusion of a said variant or fragment or derivative. The above stress-activated protein kinase and the related stress-activated protein kinase SAPK3 are useful in screening assays for drugs.
摘要翻译：包含氨基酸序列（I）或其变体，片段，融合物或衍生物或所述变体或片段或衍生物的融合物的基本上纯的应激活化蛋白激酶。上述应激活化蛋白激酶和相关应激活化蛋白激酶SAPK3可用于药物筛选试验。

10. 发明申请

WO1998001542A1 HUMAN TELOMERASE 审中-公开
标题翻译：人类TELOMERASE
公开(公告)号：WO1998001542A1
公开(公告)日：1998-01-15
申请号：PCT/US1997012296
申请日：1997-07-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , COLLINS, Kathleen
IPC分类号： C12N09/12
CPC分类号： C12N9/1241 , C07K14/70503 , C12P19/34
摘要： The invention provides methods and compositions relating to a human telomerase and related nucleic acids, including four distinct human telomerase subunit proteins called p140, p105, p48 and p43 having human telomerase-specific activity. The proteins may be produced recombinantly from transformed host cells from the disclosed telomerase encoding nucleic acids or purified from human cells. Also included are human telomerase RNA components, as well as specific, functional derivatives thereof. The invention provides isolated telomerase hybridization probes and primers capable of specifically hybridizing with the disclosed telomerase gene, telomerase-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与人端粒酶和相关核酸相关的方法和组合物，包括具有人端粒酶特异性活性的称为p140，p105，p48和p43的四种不同的人端粒酶亚基蛋白。可以从所公开的编码端粒酶的核酸转化的宿主细胞重组产生蛋白质，或从人细胞纯化。还包括人端粒酶RNA组分以及其具体的功能性衍生物。本发明提供了能够与所公开的端粒酶基因，端粒酶特异性结合剂如特异性抗体特异性杂交的分离的端粒酶杂交探针和引物，以及在诊断，治疗和生物制药工业中制备和使用该主题组合物的方法。

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