专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2013063526A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE 审中-公开
标题翻译：用于治疗高脂血症和胆汁淤积性疾病的双酸回收抑制剂
公开(公告)号：WO2013063526A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/062303
申请日：2012-10-26
申请人： LUMENA PHARMACEUTICALS, INC.
发明人： GEDULIN, Bronislava , GREY, Michael , O'DONNELL, Niall
IPC分类号： A61K31/385 , A61K31/554 , A61K31/38 , A61P1/16
CPC分类号： C07H13/12 , A61K31/155 , A61K31/38 , A61K31/40 , A61K31/4436 , A61K31/4453 , A61K31/454 , A61K31/495 , A61K31/4995 , A61K31/5377 , A61K31/554 , A61K31/7028 , A61K31/7042 , A61K45/06 , C07C257/10 , C07C279/12 , C07D207/04 , C07D211/06 , C07D211/08 , C07D281/10 , C07D285/36 , C07D295/13 , C07D337/08 , C07D401/12 , C07D413/12 , C07D487/08 , C07H15/18 , C07H15/26 , Y02A50/463 , A61K2300/00
摘要： Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium- dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.
摘要翻译：本文提供了通过向有需要的个体施用治疗有效量的顶端钠依赖性胆汁酸转运蛋白抑制剂（ASBTI）或其药学上可接受的盐来治疗或改善高胆固醇或胆汁淤积性肝病的方法。还提供了用于治疗或改善肝脏疾病，降低血液胆汁酸或肝胆汁酸的水平，治疗或改善瘙痒症，减少肝酶或降低胆红素的方法，其包括向有需要的个体施用治疗有效量的ASBTI 或其药学上可接受的盐。

22. 发明申请

WO2009110002A4 NOVEL EFFLUX PUMP INHIBITORS 审中-公开
标题翻译： NOVEL EFFLUX泵缓冲器
公开(公告)号：WO2009110002A4
公开(公告)日：2009-12-03
申请号：PCT/IN2009000144
申请日：2009-03-03
申请人： COUNCIL SCIENT IND RES , KOUL SURRINDER , THOTA NIRANJAN , MALLEPALLY VENKAT REDDY , SANGWAN PAYARE LAL , TANEJA SUBHASH CHANDRA , KHAN INSHAD ALI , KUMAR ASHWANI , RAJA ALSABA FIDA , SAXENA AJIT KUMAR , AGRAWAL SATYAM KUMAR , JOHRI RAKESH KAMAL , ABDULLAH SHEIKH TASDUQ , SINGH GURDARSHAN , BACHU LAKSHMI NARASAMMA RAO , DHAR AUTAR KRISHAN , PURNIMA BASANT , QAZI GHULAM NABI
发明人： KOUL SURRINDER , THOTA NIRANJAN , MALLEPALLY VENKAT REDDY , SANGWAN PAYARE LAL , TANEJA SUBHASH CHANDRA , KHAN INSHAD ALI , KUMAR ASHWANI , RAJA ALSABA FIDA , SAXENA AJIT KUMAR , AGRAWAL SATYAM KUMAR , JOHRI RAKESH KAMAL , ABDULLAH SHEIKH TASDUQ , SINGH GURDARSHAN , BACHU LAKSHMI NARASAMMA RAO , DHAR AUTAR KRISHAN , PURNIMA BASANT , QAZI GHULAM NABI
IPC分类号： A61K31/435 , A61K31/165 , A61K31/40 , A61K31/4164 , A61K31/495 , A61K31/5375 , A61P31/04 , C07C233/11 , C07C233/15 , C07C233/29 , C07C233/55 , C07C235/32 , C07D207/06 , C07D211/16 , C07D211/46 , C07D233/64 , C07D295/03 , C07D295/185
CPC分类号： C07C233/11 , C07C233/15 , C07C233/29 , C07C233/55 , C07C235/32 , C07D207/06 , C07D211/06 , C07D211/46 , C07D233/60 , C07D295/185
摘要： This invention relates to compounds, which are in general potentiators of antiinfeective agents and inhibitors of bacterial efflux pumps in particular. These novel compounds i.e. substituted dihydronaphtalene derivatives and tetralin derivatives and/or their salts are useful against antibiotic-resistant microbial pathogens, for treating microbial infections by reducing the extrusion of a co-administered antimicrobial agent. This invention also provides processes for the preparation of such efflux pump inhibitors and their compositions with anti infective agents and methods for treatment of microbial infections.
摘要翻译：本发明涉及化合物，其通常是抗感染剂的增效剂和特别是细菌外排泵的抑制剂。这些新型化合物，即取代的二氢萘衍生物和四氢化萘衍生物和/或它们的盐可用于抗抗生素抗微生物病原体，用于通过减少共同施用的抗微生物剂的挤出来治疗微生物感染。本发明还提供了制备这种外排泵抑制剂及其组合物与抗感染剂的方法以及治疗微生物感染的方法。

23. 发明申请

WO2004033422A2 MODULATION OF ANXIETY THROUGH BLOCKADE OF ANANDAMIDE HYDROLYSIS 审中-公开
标题翻译：丙二酰胺水解后阻塞的焦虑调节
公开(公告)号：WO2004033422A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031844
申请日：2003-10-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PIOMELLI, Daniele , DURANTI, Andrea , TONTINI, Andrea , MOR, Marco , TARZIA, Georgio
发明人： PIOMELLI, Daniele , DURANTI, Andrea , TONTINI, Andrea , MOR, Marco , TARZIA, Georgio
IPC分类号： C07D
CPC分类号： C07C311/29 , C07C271/56 , C07C275/54 , C07C2601/14 , C07D209/08 , C07D211/06 , C07D215/06 , C07D307/79 , C07D487/04
摘要： Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH 2 , O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unsubstituted biphenylyl, substituted or unsubstituted naphthyl, and substituted or unsubstituted phenyl; substituted or unsubstituted terphenylyl; substituted or unsubstituted cycloalkyl, heteroaryl, or alkyl; and R 1 and R 2 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted phenyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; with the proviso that if Z is O, one of R 1 and R 2 is absent, and that, if Z is N, optionally R 1 and R 2 may optionally be taken together to form a substituted or unsubstituted N -heterocycle or substituted or unsubstituted heteroaryl with the N atom to which they are each attached. Pharmaceutical compositions comprising the compounds of Formula (I) and methods of using them to inhibit FAAH and/or treat appetite disorders, glaucoma, pain, insomnia, and neurological and psychological disorders including anxiety disorders, epilepsy, and depression are provided.
摘要翻译：提供了式（I）的脂肪酸酰胺水解酶抑制剂，其中X是NH，CH 2，O或S; Q是O或S; Z是O或N; R是选自取代或未取代的芳基; 取代或未取代的联苯基，取代或未取代的萘基和取代或未取代的苯基; 取代或未取代的三联苯基; 取代或未取代的环烷基，杂芳基或烷基; 且R 1和R 2独立地选自H，取代或未取代的烷基，取代或未取代的杂烷基和取代或未取代的苯基，取代或未取代的联苯基，取代或未取代的芳基和取代或未取代的杂芳基; 条件是如果Z是O，则R 1和R 2中的一个不存在，并且如果Z是N，则任选地R 1 1 和R 2'可以任选地一起形成取代或未取代的N - 杂环或取代或未取代的与它们各自连接的N原子相连的杂芳基。提供了包含式（I）化合物的药物组合物和使用它们抑制FAAH和/或治疗食欲障碍，青光眼，疼痛，失眠以及神经和心理障碍，包括焦虑症，癫痫和抑郁症的方法。

24. 发明申请

WO1995014027A1 ANTI-VIRAL GUANIDINO-SUBSTITUTED COMPOUNDS 审中-公开
标题翻译：抗病毒药物替代化合物
公开(公告)号：WO1995014027A1
公开(公告)日：1995-05-26
申请号：PCT/CA1994000636
申请日：1994-11-16
申请人： ALLELIX BIOPHARMACEUTICALS INC. , SLASSI, Abdelmalik , RAKHIT, Sumanas
发明人： ALLELIX BIOPHARMACEUTICALS INC.
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , C07C279/16 , C07D211/06 , C07H15/08
摘要： Novel guanidino-substituted compounds are described having general formula (I) or a salt, hydrate or solvate thereof, wherein X is selected from C, O, N and S; R1 is -(W)a-(R4)b-Z, wherein a and b are independently 0 or 1; W is NH, O or S; R4 is C1-8alkylene in which one or two of the carbon atoms thereof is optionally replaced with nitrogen or oxygen; and Z is H, OH or -NH-C(NH)-NH2; R2 and R3 are, independently, C1-8alkylene in which one of the carbon atoms thereof is optionally replaced with nitrogen or oxygen. These compounds have been found to inhibit effectively herpesvirus replication. Particularly preferred compounds in accordance with formula (I) for this purpose are guanidino-substituted sugar derivatives.
摘要翻译：描述了新的胍基取代的化合物，其具有通式（I）或其盐，水合物或溶剂化物，其中X选自C，O，N和S; R1是 - （W）a-（R4）b-Z，其中a和b独立地为0或1; W是NH，O或S; R4是其中一个或两个碳原子任选被氮或氧取代的C1-8亚烷基; 并且Z是H，OH或-NH-C（NH）-NH 2; R2和R3独立地为其中一个碳原子任选被氮或氧代替的C 1-8亚烷基。已经发现这些化合物有效地抑制疱疹病毒复制。特别优选的根据式（I）的化合物是胍基取代的糖衍生物。

25. 发明申请

WO2016071216A1 PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE 审中-公开
标题翻译：哌嗪基吡唑并嘧啶酮及其用途
公开(公告)号：WO2016071216A1
公开(公告)日：2016-05-12
申请号：PCT/EP2015/075208
申请日：2015-10-30
申请人： BAYER PHARMA AKTIENGESELLSCHAFT
发明人： ELLERMANN, Manuel , VALOT, Gaelle , CANCHO GRANDE, Yolanda , HAßFELD, Jorma , KINZEL, Tom , KÖBBERLING, Johannes , BEYER, Kristin , RÖHRIG, Susanne , SPERZEL, Michael , STAMPFUß, Jan , MEYER, Imke , KÖLLNBERGER, Maria , BURKHARDT, Nils , SCHLEMMER, Karl-Heinz , STEGMANN, Christian , SCHUHMACHER, Joachim , WERNER, Matthias , HEIERMANN, Jörg , HENGEVELD, Willem Jan
IPC分类号： C07D487/04 , A61K31/519 , A61P7/04
CPC分类号： C07D487/04 , A61K31/519 , C07D211/06 , C07D231/00 , C07D247/02 , C07D271/06 , C07D271/10 , C07D403/14 , C07D471/04
摘要： The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
摘要翻译：本申请涉及新的取代的哌啶基吡唑并嘧啶酮，其制备方法，单独使用的化合物或用于治疗和/或预防疾病的方法中的组合，特别是用于治疗和/或预防急性和复发性出血在具有或不具有潜在的遗传性或获得性止血性疾病的患者中，其中所述出血与选自重度月经出血，产后出血，出血性休克，出血性膀胱炎，胃肠道出血，创伤，手术，移植的疾病或医疗干预相关联，中风，肝脏疾病，遗传性血管性水肿，鼻出血和滑膜炎以及关节炎后的软骨损伤。

26. 发明申请

WO2015052283A1 DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译：二氨基胆碱逆转录病毒拮抗剂及其作为药物使用
公开(公告)号：WO2015052283A1
公开(公告)日：2015-04-16
申请号：PCT/EP2014/071654
申请日：2014-10-09
申请人： FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
发明人： GRIMALDI, Benedetto , TORRENTE, Esther , SCARPELLI, Rita , BOTTEGONI, Giovanni , BANDIERA, Tiziano , VERONESI, Marina
IPC分类号： C07D309/14 , C07D211/06 , C07D295/04 , C07D295/185 , C07D487/08 , C07D333/08 , C07D241/38 , C07D471/08 , A61K31/445 , A61K31/495 , A61P35/00
CPC分类号： A61K31/496 , A61K31/445 , A61K31/4453 , A61K31/495 , C07D211/06 , C07D211/58 , C07D241/38 , C07D295/04 , C07D295/08 , C07D295/16 , C07D295/185 , C07D309/14 , C07D333/08 , C07D333/20 , C07D471/08 , C07D487/08
摘要： The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof : It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐或溶剂合物：其还公开了包含式（I）化合物及其作为癌症治疗的抗增殖和促凋亡剂的用途的药物组合物。

27. 发明申请

WO2015024016A2 2-PIPERIDINYL SUBSTITUTED N,3-DIHYDROXYBUTANAMIDES 审中-公开
标题翻译： 2-哌啶基取代的N，3-二羟基丁胺
公开(公告)号：WO2015024016A2
公开(公告)日：2015-02-19
申请号：PCT/US2014/051504
申请日：2014-08-18
申请人： DUKE UNIVERSITY
发明人： ZHOU, Pei , TOONE, Eric, J. , NICHOLAS, Robert, A.
IPC分类号： A61K31/451
CPC分类号： C07D211/06 , A61K31/455 , C07D211/14
摘要： Diclosed are compounds of formulae: (I) and pharmaceutically acceptable salts thereof, wherein the variables, R 1 , R 2 , Y, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
摘要翻译：被定义为式（I）化合物及其药学上可接受的盐，其中变量R1，R2，Y和Z在本文中定义。这些化合物可用于治疗革兰氏阴性菌感染。

28. 发明申请

WO2014152494A1 PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DESEASES 审中-公开
标题翻译： FUMARATES的原料及其在处理各种不良物质方面的应用
公开(公告)号：WO2014152494A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027401
申请日：2014-03-14
申请人： ALKERMES PHARMA IRELAND LIMITED , ZEIDAN, Tarek, A. , DUNCAN, Scott , HENCKEN, Christopher, P. , WYNN, Thomas, Andrew , SANRAME, Carlos, N.
发明人： ZEIDAN, Tarek, A. , DUNCAN, Scott , HENCKEN, Christopher, P. , WYNN, Thomas, Andrew , SANRAME, Carlos, N.
IPC分类号： C07C219/08 , C07C229/16 , C07C309/18 , C07C229/12 , A61K31/221
CPC分类号： A61K31/225 , C07C219/08 , C07C229/16 , C07C233/18 , C07C233/91 , C07C317/18 , C07C317/28 , C07D207/06 , C07D207/40 , C07D209/52 , C07D211/06 , C07D211/38 , C07D295/088 , C07D491/113
摘要： The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
摘要翻译：本发明提供式（I）化合物及其药物组合物。

29. 发明申请

WO2013174736A1 N- [3- (2 -CARBOXYETHYL) PHENYL] - PIPERIDIN- 1 - YLACETAMID - DERIVATE UND IHRE VERWENDUNG ALS AKTIVATOREN DER LÖSLICHEN GUANYLATCYCLASE 审中-公开
标题翻译： N- [3-（2-羧乙基）苯基] - 哌啶-1 - 基乙酰胺 - 衍生物和它们作为可溶性鸟苷酸环化酶活化剂使用
公开(公告)号：WO2013174736A1
公开(公告)日：2013-11-28
申请号：PCT/EP2013/060222
申请日：2013-05-17
申请人： BAYER PHARMA AKTIENGESELLSCHAFT
发明人： LAMPE, Thomas , HAHN, Michael , STASCH, Johannes-Peter , SCHLEMMER, Karl-Heinz , WUNDER, Frank , EL SHEIKH, Sherif , LI, Volkhart, Min-Jian , BECKER, Eva-Maria , STOLL, Friederike , KNORR, Andreas
IPC分类号： C07D211/06 , C07D211/14 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15 , A61K31/438 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/472 , A61P9/00
CPC分类号： C07D211/14 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/472 , A61K45/06 , C07D211/06 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15
摘要： Die vorliegende Anmeldung betrifft neue, substituierte 2-(Piperidin-1- yl)acetamid-Derivate der Formel (I), in welcher A für einen optional substituierten oder anellierten Piperidin-Ring der Formel (I-a) oder (I-b) steht, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention kardiovaskulärer Erkrankungen.
摘要翻译：本申请涉及是新的取代的2-（哌啶-1-基）的式（I），其中A表示式（Ia）或（Ib）的任选取代的或稠合的哌啶环的乙酰胺衍生物，涉及用于处理它们的制备，它们的使用对于疾病的治疗和/或预防和它们用于制备药物用于疾病的治疗和/或预防的用途，特别是用于治疗心血管疾病的治疗和/或预防。

30. 发明申请

WO2013115486A1 신규한 피페린 유도체 및 그의 용도 审中-公开
标题翻译：新型催化剂及其用途
公开(公告)号：WO2013115486A1
公开(公告)日：2013-08-08
申请号：PCT/KR2012/011548
申请日：2012-12-27
申请人： 한국보건산업진흥원 , 연세대학교 산학협력단
发明人： 박태선 , 정낙신
IPC分类号： C07D317/46 , C07D405/12 , A61K31/36 , A61P3/00
CPC分类号： C07D405/12 , C07D211/06 , C07D295/192 , C07D317/58 , C07D317/60 , C07D317/62
摘要： 본 발명은 신규한 피페린 유도체에 관한 것이다. 본 발명은 피페린 유도체를 유효성분으로 포함하는 비만, 당뇨, 이상지방혈증, 지방간 및 인슐린 저항성 증후군으로 구성된 군으로부터 선택되는 대사질환의 예방 또는 치료용 약제학적 조성물 또는 기능성 식품 조성물을 제공한다. 본 발명의 피페린 유도체는 지방전구세포의 분화를 억제하고 세포내 중성지방의 축적량을 감소시킴으로써 궁극적으로 비만, 당뇨, 이상지방혈증, 지방간 및 인슐린 저항성 증후군으로 구성된 군으로부터 선택되는 대사질환의 예방 또는 치료 활성을 나타내는 의약 또는 기능성 식품 조성물로서 유용하게 이용될 수 있다.
摘要翻译：本发明涉及一种新颖的胡椒苷衍生物。本发明提供一种药物组合物或功能性食品组合物，其包含胡椒碱衍生物作为活性成分，其用于预防或治疗选自肥胖，糖尿病，血脂异常，脂肪肝和胰岛素抵抗综合征的代谢紊乱。本发明的胡椒碱衍生物可以有利地用作抑制脂肪细胞前体细胞分化的医学或功能性食品组合物，并减少在细胞中积累的甘油三酯的量，因此最终在预防或治疗选自由肥胖，糖尿病，血脂异常，脂肪肝和胰岛素抵抗综合征组成的组。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式