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21. 发明申请

WO2005105141A2 COMBINED MENINGOCOCCAL CONJUGATES WITH COMMON CARRIER PROTEIN 审中-公开
标题翻译：与普通携带蛋白质组合的联合化疗联合用药
公开(公告)号：WO2005105141A2
公开(公告)日：2005-11-10
申请号：PCT/IB2005/001536
申请日：2005-04-29
申请人： CHIRON SRL , COSTANTINO, Paulo
发明人： COSTANTINO, Paulo
IPC分类号： A61K39/095
CPC分类号： A61K47/4833 , A61K39/095 , A61K39/116 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/70 , Y02A50/466
摘要： Carrier-induced epitopic suppression is of particular concern where multiple conjugates with the same carrier protein are administered simultaneously. To avoid the suppression, the invention minimises the amount of unconjugated carrier protein in a vaccine. The invention provides a composition for immunising a patient against a disease caused by Neisseria meningitidis, wherein (1) the composition comprises conjugates for at least two of the four meningococcal serogroups A, C, W135 and Y, where at least two of the conjugates have a common carrier protein; and (2) the composition includes the common carrier in an unconjugated form at less than 10 μg/ml.
摘要翻译：载体诱导的表位抑制在与同一载体蛋白的多重缀合物同时施用时尤为重要。为了避免抑制，本发明使疫苗中未缀合的载体蛋白的量最小化。本发明提供了用于免疫患者免受脑膜炎奈瑟菌引起的疾病的组合物，其中（1）组合物包含四种脑膜炎球菌血清群A，C，W135和Y中的至少两种的缀合物，其中至少两种缀合物具有普通载体蛋白; 和（2）组合物以小于10ug / ml的不结合形式包含共同的载体。

22. 发明申请

WO2004067030A2 INJECTABLE VACCINES AGAINST MULTIPLE MENINGOCOCCAL SEROGROUPS 审中-公开
标题翻译：可注射疫苗对抗多种MENINGOCOCCAL血清组织
公开(公告)号：WO2004067030A2
公开(公告)日：2004-08-12
申请号：PCT/IB2004/000651
申请日：2004-01-30
申请人： CHIRON SRL , COSTANTINO, Paolo
发明人： COSTANTINO, Paolo
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K9/0019 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/292 , A61K39/385 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/575 , A61K2039/6037 , A61K2039/62 , A61K2039/627 , A61K2039/70 , C07K14/22
摘要： An injectable immunogenic composition comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of Neisseria meningitidis, wherein said capsular saccharides are conjugated to carrier protein(s) and/or are oligosaccharides, and wherein (i) the composition comprises B N.meningitidis; (b) Haemophilus influenzae type B; and/or (c) Streptococcus pneumoniae. Saccharide antigens in the compositions are generally conjugated to a carrier.
摘要翻译：一种可注射的免疫原性组合物，其包含来自脑膜炎奈瑟氏球菌血清组A，C，W135和Y中的至少两种的荚膜糖，其中所述荚膜糖与载体蛋白缀合）和/或（ii）所述组合物每个剂量包含50μg脑膜炎球菌糖，和/或（ii）所述组合物还包含来自以下一种或多种的抗原：（a）血清组， B脑膜炎奈瑟球菌; （b）流感嗜血杆菌B型; 和/或（c）肺炎链球菌。组合物中的糖抗原通常缀合到载体上。

23. 发明申请

WO01037863A2 COMPOSITIONS COMPRISING NEISSERIA MENINGITIDIS ANTIGENS FROM SEROGROUPS B AND C 审中-公开
标题翻译：包含NEISSERIA MENINGITIDIS的组合物来自SEROGROUPS B和C的抗原
公开(公告)号：WO01037863A2
公开(公告)日：2001-05-31
申请号：PCT/IB2000/001940
申请日：2000-11-29
IPC分类号： A61K39/35 , A61K39/05 , A61K39/08 , A61K39/09 , A61K39/095 , A61K39/10 , A61K39/102 , A61K39/106 , A61K39/116 , A61K39/29 , A61K39/385 , A61P31/04 , A61K39/00
CPC分类号： A61K39/095 , A61K39/116 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068
摘要： International patent application WO99/61053 discloses immunogenic compositions that comprise N.meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N.meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms ( e.g. Haemophilus influenzae , DTP, HBV, etc. ).
摘要翻译：国际专利申请WO99 / 61053公开了包含与载体结合的脑膜炎奈瑟氏球菌血清群C寡糖与脑膜炎奈瑟氏球菌B膜外膜蛋白结合的免疫原性组合物。这些在本申请中与另外的奈瑟氏蛋白和/或其它病原体（例如流感嗜血杆菌，DTP，HBV等）的蛋白质和/或保护性抗原结合在一起公开。的）。

24. 发明申请

WO2016066095A1 预防肺炎链球菌感染性疾病的免疫原性组合物及制备方法审中-公开
公开(公告)号：WO2016066095A1
公开(公告)日：2016-05-06
申请号：PCT/CN2015/093056
申请日：2015-10-28
申请人：天津康希诺生物技术有限公司
发明人：朱涛 , 段磊 , 杨鸣鸣 , 邵忠琦 , 宇学峰 , 毛慧华 , 邱东旭
IPC分类号： A61K39/116 , A61P31/04 , A61K39/09
CPC分类号： A61K39/116 , A61K39/09
摘要：本发明提供了一种用于预防肺炎链球菌感染性疾病的免疫原性组合物，包括PspA-mRX1、PspA-EF5668、PspA-EF3296和PlyL460D，其中，所述各组分的含量均为10-100μg/ml；通过向铝佐剂中加入相应剂量的PspA-mRX1、PspA-EF5668、PspA-EF3296和PlyL460D四种原液并混匀制得。

25. 发明申请

WO2016044773A1 BROAD SPECTRUM CONJUGATE VACCINE TO PREVENT KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA INFECTIONS 审中-公开
标题翻译：广谱荧光素联合疫苗预防克氏杆菌肺炎和PSEUDOMONAS AERUGINOSA感染
公开(公告)号：WO2016044773A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/051032
申请日：2015-09-18
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , SIMON, Raphael , CROSS, Alan , TENNANT, Sharon
发明人： SIMON, Raphael , CROSS, Alan , TENNANT, Sharon
IPC分类号： A61K39/00 , A61K39/104 , A61K39/108 , C12N1/20 , C12N1/21 , C12R1/22 , C12R1/42
CPC分类号： C07K14/26 , A61K39/0266 , A61K39/104 , A61K39/116 , A61K47/4833 , A61K47/61 , A61K47/646 , A61K2039/70 , C07K14/21 , C07K2319/00
摘要： The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.
摘要翻译：本发明涉及包含与一种或多种克雷伯氏菌表面多糖抗原如来自血清型O1，O2a，O2a，c，O3，O4的肺炎克雷伯杆菌O多糖连接的假单胞菌鞭毛蛋白或其抗原性片段或衍生物的缀合物和疫苗组合物，O5，O7，O8和012.本发明还提供血清型试剂菌株以产生缀合物和疫苗组合物以及用缀合物和疫苗组合物诱导免疫应答的方法。

26. 发明申请

WO2015192216A1 EXOTOXIN/THERMOLYSIN COMPOSITIONS AND METHODS AND USES FOR TREATING OR PREVENTING LAMINITIS 审中-公开
标题翻译： EXOTOXIN / THERMOLYSIN组合物及其处理或预防层压体的方法和用途
公开(公告)号：WO2015192216A1
公开(公告)日：2015-12-23
申请号：PCT/CA2015/000399
申请日：2015-06-19
申请人： UNIVERSITY OF SASKATCHEWAN
发明人： WILSON, David G.
IPC分类号： A61K39/02 , A61P37/04
CPC分类号： A61K39/092 , A61K39/02 , A61K39/116 , A61K2039/545 , A61K2039/552 , A61K2039/57 , A61K2039/58 , A61K2039/70
摘要： The disclosure relates to immunogenic and vaccine compositions comprising Streptococcus exotoxins and/or bacterial thermolysins from M4 protease family. Also provided are kits, methods and uses of said compositions for treating or preventing laminitis in a hooved animal.
摘要翻译：本公开涉及包含来自M4蛋白酶家族的链球菌外毒素和/或细菌嗜热菌蛋白酶的免疫原性和疫苗组合物。还提供了用于治疗或预防蹄动物中的扁桃体炎的所述组合物的试剂盒，方法和用途。

27. 发明申请

WO2015192196A1 COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. HYOPNEUMONIAE, GENE SINTÉTICO CODIFICANTE DO COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. HYOPNEUMONIAE, COMPOSIÇÃO ANTIGÊNICA, PROCESSO DE OBTENÇÃO DE UM COMPLEXO DE POLIPROTENAS IMUNOGÊNICAS DE M. HYOPNEUMONIAE, USO DE UMA COMPOSIÇÃO BASEADA NO COMPLEXO DE POLIPROTEÍNAS IMUNOGÊNICAS DE M. HYOPNEUMONIAE 审中-公开
标题翻译：复合型水杨酸的合成复合物，编码水杨酸的免疫原性聚合物复合物的合成基因，免疫组合物，生产水杨酸的免疫原性聚合物复合物的方法，基于复合免疫多糖的组合物的使用 M. HYOPNEUMONIAE
公开(公告)号：WO2015192196A1
公开(公告)日：2015-12-23
申请号：PCT/BR2015/050056
申请日：2015-05-08
申请人： OURO FINO SAÚDE ANIMAL LTDA
发明人： ROMERO RAMOS, Celso Raul , MARROQUIN QUELOPANA, Miryam
IPC分类号： A61K39/02 , A61K39/116 , A61P31/04
CPC分类号： A61K39/0241 , A61K39/02 , A61K39/116 , A61K2039/55566 , A61K2039/55577 , A61K2039/575 , C07K14/195 , C07K14/30 , C07K2319/40
摘要： A presente invenção se refere a um complexo de poliproteínas contendo regiões imunogênicas derivadas dos antígenos P36, P46, HSP, NrdF, P97, MHP271 e P216 de M. hyopneumoniae , regiões estas que estão fusionadas com segmentos das proteínas portadoras Rrp4, Rrp41 e Rrp42 de P. abyssi , formando um complexo único. Outros objetos adicionais da presente invenção proporcionam: (i) um gene codificante do complexo de poliproteínas, dito complexo sendo baseado no exossomo de P. abyssi que porta cópias de antígenos vacinais de M. hyopneumoniae ; (ii) uma composição antigênica compreendendo o complexo de poliproteínas da invenção, opcionalmente um ou mais adjuvantes e/ou aditivos e um veículo farmacologicamente aceitável; (iii) um processo de obtenção do dito complexo de poliproteína; e (iv) usos de dito complexo e de dita composição no tratamento e prevenção de infecções causadas por M. hyopneumoniae .
摘要翻译：本发明涉及含有衍生自猪肺炎支原体的P36，P46，HSP，NrdF，P97，MHP271和P216抗原的免疫原性区域的多蛋白复合物，该区域与Rrp4，Rrp41 e Rrp42载体蛋白的片段融合 abyssi，形成一个单一的复杂。本发明进一步提供以下目的：（i）编码多蛋白复合物的基因，该复合物基于阿维菌素的外来体，携带猪肺炎支原体疫苗抗原的拷贝; （ii）包含本发明的多聚蛋白复合物，任选的一种或多种辅助剂和/或添加剂和药理学上可接受的赋形剂的抗原组合物; （iii）生产所述多蛋白复合物的方法; 和（iv）所述复合物和组合物在治疗和预防由猪肺炎支原体感染引起的疾病中的用途。

28. 发明申请

WO2012117377A1 COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT 审中-公开
标题翻译：组合疫苗与较低剂量的抗原和/或ADJUVANT
公开(公告)号：WO2012117377A1
公开(公告)日：2012-09-07
申请号：PCT/IB2012/050989
申请日：2012-03-02
申请人： NOVARTIS AG , BAUDNER, Barbara , SKIBINSKI, David A.G. , SINGH, Manmohan , O'HAGAN, Derek
发明人： BAUDNER, Barbara , SKIBINSKI, David A.G. , SINGH, Manmohan , O'HAGAN, Derek
IPC分类号： A61K39/095 , A61K39/13 , A61K39/295 , A61K39/00 , A61K33/06 , A61K33/08 , A61K31/4375 , A61K31/66 , A61K39/39 , A61K33/42
CPC分类号： A61K39/0018 , A61K31/4375 , A61K31/66 , A61K33/06 , A61K39/102 , A61K39/116 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/70 , C12N2730/10134 , C12N2770/32634 , Y02A50/466 , A61K2300/00
摘要： Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
摘要翻译：组合疫苗组合物及其制备方法具有相对低量的抗原和/或相对低量的铝，但是它们仍可具有免疫原性，其可与具有相对高量抗原和/或相对较高的铝量。也提供了无铝组合疫苗组合物，例如，用水包油乳剂佐剂佐剂化的组合物。

29. 发明申请

WO2012040806A2 SYNERGISTIC IMMUNOGENIC COMPOSITIONS BASED ON PROTEIN ANTIGENS COMBINED WITH PERTUSSIS CELL ANTIGEN AND INACTIVATED TOXINS 审中-公开
标题翻译：基于蛋白质抗原与PERTUSSIS细胞抗原及失活毒素协同作用的免疫原性组合物
公开(公告)号：WO2012040806A2
公开(公告)日：2012-04-05
申请号：PCT/BR2011000350
申请日：2011-09-26
申请人： FUNDACAO BUTANTAN , MIYAJI ELIANE NAMIE , RAW ISAIAS , OLIVEIRA MARIA LEONOR SARNO DE , HO PAULO LEE
发明人： MIYAJI ELIANE NAMIE , RAW ISAIAS , OLIVEIRA MARIA LEONOR SARNO DE , HO PAULO LEE
IPC分类号： A61K39/09
CPC分类号： A61K39/116 , A61K39/08 , A61K39/092 , A61K39/099 , A61K2039/521 , A61K2039/543 , A61K2039/70
摘要： The present invention relates to synergistic immunogenic compositions for preventing whooping cough and infections caused by Streptococcus pneumoniae. Additionally, the compositions according to the present invention may protect against infections caused by other pathogenic agents by means of a synergistic combination of antigens thereof. In particular, the present invention provides synergistic immunogenic compositions that comprise at least one cell antigen of inactivated Bordetella pertussis and at least one protein antigen comprising one or more surface proteins A (PspA) of Streptococcus penumoniae or fragments thereof. The present invention further provides synergistic immunogenic compositions comprising at least one cell antigen of inactivated Bordetella pertussis, at least one protein antigen comprising one or more surface proteins A (PspA) of Streptococcus penumoniae or fragments thereof, and one or more diphtheria and/or tetanus toxins. The present invention also relates to the use of one or more synergistic immunogenic compositions according to the present invention for producing combined vaccines for the prevention of whooping cough, tetanus, diphtheria and/or infections caused by Streptococcus pneumoniae. The present invention further relates to the use of the compositions according to the present invention for producing vaccines for the prevention of whooping cough, tetanus, diphtheria and/or infections caused by Streptococcus pneumoniae.
摘要翻译：本发明涉及用于预防由肺炎链球菌引起的百日咳和感染的协同免疫原性组合物。另外，根据本发明的组合物可以通过其抗原的协同组合来防止由其它病原体引起的感染。具体而言，本发明提供了协同免疫原性组合物，其包含至少一种灭活的百日咳博德特氏菌的细胞抗原和至少一种蛋白质抗原，所述蛋白质抗原包含一种或多种penumboniae或其片段的表面蛋白A（PspA）或其片段。本发明进一步提供了协同免疫原性组合物，其包含至少一种灭活的百日咳博德特氏菌的细胞抗原，至少一种蛋白质抗原，其包含一种或多种肺炎链球菌或其片段的表面蛋白A（PspA）或一种或多种白喉和/或破伤风毒素。本发明还涉及根据本发明的一种或多种协同免疫原性组合物用于生产用于预防由肺炎链球菌引起的百日咳，破伤风，白喉和/或感染的组合疫苗的用途。本发明进一步涉及根据本发明的组合物用于生产用于预防由肺炎链球菌引起的百日咳，破伤风，白喉和/或感染的疫苗的用途。

30. 发明申请

WO2009021931A1 VACCINES 审中-公开
标题翻译：疫苗
公开(公告)号：WO2009021931A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/060505
申请日：2008-08-11
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BALLOU, William, Ripley , COHEN, Joseph, D
发明人： BALLOU, William, Ripley , COHEN, Joseph, D
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K39/0017 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K2039/5258 , A61K2039/55 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , A61K2039/70 , C12N2730/10134 , Y02A50/412
摘要： The invention relates to use of an antigen derived from the circumsporozoite protein (CS) protein of Plasmodium falciparum which is expressed at the pre-erythrocytic stage of malarial infection in combination with a pharmaceutically acceptable adjuvant, in the manufacture of a medicament for vaccinating infants against malaria.
摘要翻译：本发明涉及来自恶性疟原虫的环孢子蛋白（CS）蛋白的抗原，其在疟疾感染的红细胞前期与药学上可接受的佐剂组合在制造用于疫苗接种婴儿的药物中的用途疟疾。

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