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1. 发明申请

WO2006029887A3 VACCINES COMPRISING PLASMODIUM ANTIGENS 审中-公开
标题翻译：包含PLASMODIUM抗原的疫苗
公开(公告)号：WO2006029887A3
公开(公告)日：2006-05-11
申请号：PCT/EP2005009995
申请日：2005-09-14
申请人： GLAXOSMITHKLINE BIOLOG SA , COHEN JOSEPH D , TORNIEPORTH NADIA GABRIELA
发明人： COHEN JOSEPH D , TORNIEPORTH NADIA GABRIELA
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075
摘要： The present invention relates to a novel use of a malaria antigen to immunise against malarial disease. The invention relates in particular to the use of sporozoite antigens, in particular circumsporozoite (CS) protein or fragments thereof, to immunise against severe malarial disease.
摘要翻译：本发明涉及疟疾抗原对疟疾疾病进行免疫的新用途。本发明特别涉及子孢子抗原，特别是环子孢子（CS）蛋白或其片段在免疫严重疟疾疾病中的应用。

2. 发明申请

WO2004037189A2 METHODS FOR VACCINATING AGAINST MALARIA 审中-公开
标题翻译：用于疟疾疫苗的方法
公开(公告)号：WO2004037189A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/033462
申请日：2003-10-22
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , THE UNITED STATES OF AMERICA represented by THE SECRETARY OF THE NAVY , HOFFMAN, Stephen, L. , WANG, Ruobing , EPSTEIN, Judith, E. , COHEN, Joseph, D.
发明人： HOFFMAN, Stephen, L. , WANG, Ruobing , EPSTEIN, Judith, E. , COHEN, Joseph, D.
IPC分类号： A61K
CPC分类号： A61K39/015 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C07K14/445 , Y02A50/412 , Y02A50/58
摘要： The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine and boosting that response with a protein-based vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.
摘要翻译：本发明涉及通过疫苗接种来防止疟疾感染的方法。本发明的方法包括用基于DNA的疫苗引发抗疟疾免疫应答，并用基于蛋白质的疫苗提高该反应。本发明的方法还涉及通过用基于蛋白质的疫苗进行加强来扩大产生的免疫应答。

3. 发明申请

WO2009080803A1 VACCINES FOR MALARIA 审中-公开
标题翻译：疟疾疫苗
公开(公告)号：WO2009080803A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/068130
申请日：2008-12-22
申请人： GlaxoSmithKline Biologicals s.a. , COHEN, Joseph, D. , MARCHAND, Martine
发明人： COHEN, Joseph, D. , MARCHAND, Martine
IPC分类号： A61K39/015 , C07K14/445
CPC分类号： C07K14/445 , A61K39/015 , A61K2039/5258 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , C07K2319/40 , C12N7/00 , C12N2730/10123 , Y02A50/412
摘要： The present invention relates to a novel protein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. Furthermore, particles with the specific ratio can be prepared by employing yeast, Saccharomyces cerevisiae or Pichia pastoris . In particular it relates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P.vivax and the S antigen of Hepatitis B (CSV-S), and b. S antigen derived from Hepatitis B virus, and characterised in that the ratio of S to CSV-S is in the range 0.1 to 1. Suitably, the ratio of S to CSV-S is in the range 0.19 to 0.30 or 0.68 to 0.80.
摘要翻译：本发明涉及一种新的蛋白质颗粒，其制备和纯化方法，其在药物中的用途，特别是在预防疟疾感染中，含有颗粒的组合物/疫苗或针对蛋白质颗粒的抗体，例如单克隆抗体或多克隆抗体，以及使用相同，特别是在治疗中。此外，具有特定比例的颗粒可以通过使用酵母，酿酒酵母或巴斯德毕赤酵母来制备。尤其涉及包含以下单体的免疫原性蛋白质颗粒：a。包含衍生自P.vivax的CS蛋白的序列和乙型肝炎的S抗原（CSV-S）的融合蛋白，以及b。 S抗原来自乙型肝炎病毒，其特征在于S与CSV-S的比例在0.1〜1的范围内.S与CSV-S的比例在0.19〜0.30或0.68〜0.80的范围内。

4. 发明申请

WO2009071613A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2009071613A2
公开(公告)日：2009-06-11
申请号：PCT/EP2008066762
申请日：2008-12-04
申请人： GLAXOSMITHKLINE BIOLOG SA , COHEN JOSEPH D , MARCHAND MARTINE
发明人： COHEN JOSEPH D , MARCHAND MARTINE
IPC分类号： A61K39/00
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/53 , A61K2039/55572 , A61K2039/55577 , C12N7/00 , C12N15/86 , C12N2710/10343
摘要： The invention relates to a replication deficient simian adenoviral vector C7 encoding a protein comprising CS protein from P. falciparum or a fragment thereof, for example as shown in Seq ID No: 1 or Seq ID No: 3. The invention also relates to processes of preparing said viral vector and use of the viral vector in the treatment/prevention of malaria infection. Compositions, vaccines and kits comprising said viral vector are also described. In one aspect the invention employs a synthetic C7 viral vector. The C7 viral vector according to the invention may be co-administered or co-formulated with a malaria antigen such as RTS,S optionally in the presence of an adjuvant for example comprising 3D-MPL and/or a saponin such as QS21.
摘要翻译：本发明涉及编码包含来自恶性疟原虫或其片段的CS蛋白的蛋白的复制缺陷型猿猴腺病毒载体C7，例如如Seq ID No：1或Seq ID No：3所示。本发明还涉及制备所述病毒载体和使用病毒载体治疗/预防疟疾感染。还描述了包含所述病毒载体的组合物，疫苗和试剂盒。一方面，本发明使用合成的C7病毒载体。根据本发明的C7病毒载体可以任选地在例如包含3D-MPL和/或皂苷例如QS21的佐剂存在下共同施用或与疟疾抗原例如RTS，S共配制。

5. 发明申请

WO2008009650A3 VACCINES FOR MALARIA 审中-公开
标题翻译：疟疾疫苗
公开(公告)号：WO2008009650A3
公开(公告)日：2008-04-10
申请号：PCT/EP2007057296
申请日：2007-07-16
申请人： GLAXOSMITHKLINE BIOLOG SA , US ARMY , COHEN JOSEPH D , MARCHAND MARTINE , OCKENHOUSE CHRISTIAN F , YADAVA ANJALI
发明人： COHEN JOSEPH D , MARCHAND MARTINE , OCKENHOUSE CHRISTIAN F , YADAVA ANJALI
IPC分类号： A61K39/015 , A61K39/29
CPC分类号： A61K39/015 , A61K2039/6075 , C07K14/445 , C07K2319/40
摘要： The present invention relates to a lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. In particular it relates to an immunogenic protein particle comprising the following monomers: a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), and b. a fusion protein comprising sequences derived from CS protein of P. falciparum and S antigen of Hepatitis B (RTS), and c. optionally the S antigen derived from Hepatitis B.
摘要翻译：本发明涉及脂蛋白颗粒，其制备和纯化方法，其在药物中的用途，特别是在预防疟疾感染中，含有颗粒的组合物/疫苗或针对蛋白质颗粒的抗体，例如单克隆或多克隆抗体和使用相同的，特别是在治疗。尤其涉及包含以下单体的免疫原性蛋白质颗粒：a。包含源自间日疟原虫的CS蛋白的序列和乙型肝炎的S抗原（CSV-S）的融合蛋白，以及b。包含衍生自恶性疟原虫的CS蛋白和乙型肝炎（RTS）的S抗原的序列的融合蛋白，以及c。任选地来自乙型肝炎的S抗原。

6. 发明申请

WO2007003384A1 ANTI-MALARIA VACCINE 审中-公开
标题翻译：抗疟疾疫苗
公开(公告)号：WO2007003384A1
公开(公告)日：2007-01-11
申请号：PCT/EP2006/006407
申请日：2006-06-29
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , COHEN, Joseph, D.
发明人： COHEN, Joseph, D.
IPC分类号： A61K39/015 , A61K39/29 , A61K39/39
CPC分类号： C07K14/445 , A61K35/68 , A61K38/164 , A61K39/015 , A61K39/292 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , A61K2039/627 , C07K2319/00 , C12N2730/10122 , Y02A50/412 , A61K2300/00
摘要： There is provided, inter alia , a method for the prophylaxis of productive malaria infection in travelers to endemic regions comprising the administration of suitable amounts of a formulation comprising a Plasmodium antigen or an immunogenic fragment or derivative thereof and an adjuvant, comprising a lipid A derivative and a saponin in a liposome formulation.
摘要翻译：特别地，提供了一种预防在流行地区的旅行者中产生疟疾感染的方法，包括施用合适量的包含疟原虫抗原或其免疫原性片段或其衍生物和佐剂的制剂，其包含脂质A衍生物和脂质体制剂中的皂角苷。

7. 发明申请

WO2009021931A1 VACCINES 审中-公开
标题翻译：疫苗
公开(公告)号：WO2009021931A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/060505
申请日：2008-08-11
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BALLOU, William, Ripley , COHEN, Joseph, D
发明人： BALLOU, William, Ripley , COHEN, Joseph, D
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K39/0017 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/102 , A61K39/116 , A61K39/12 , A61K2039/5258 , A61K2039/55 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , A61K2039/70 , C12N2730/10134 , Y02A50/412
摘要： The invention relates to use of an antigen derived from the circumsporozoite protein (CS) protein of Plasmodium falciparum which is expressed at the pre-erythrocytic stage of malarial infection in combination with a pharmaceutically acceptable adjuvant, in the manufacture of a medicament for vaccinating infants against malaria.
摘要翻译：本发明涉及来自恶性疟原虫的环孢子蛋白（CS）蛋白的抗原，其在疟疾感染的红细胞前期与药学上可接受的佐剂组合在制造用于疫苗接种婴儿的药物中的用途疟疾。

8. 发明申请

WO2006029887A2 VACCINES 审中-公开
标题翻译：疫苗
公开(公告)号：WO2006029887A2
公开(公告)日：2006-03-23
申请号：PCT/EP2005/009995
申请日：2005-09-14
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , COHEN, Joseph, D , TORNIEPORTH, Nadia, Gabriela
发明人： COHEN, Joseph, D , TORNIEPORTH, Nadia, Gabriela
IPC分类号： A61K39/15 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/6075 , Y02A50/412
摘要： The present invention relates to a novel use of a malaria antigen to immunise against malarial disease. The invention relates in particular to the use of sporozoite antigens, in particular circumsporozoite (CS) protein or fragments thereof, to immunise against severe malarial disease.
摘要翻译：本发明涉及疟疾抗原对疟疾疾病进行免疫的新用途。本发明特别涉及子孢子抗原，特别是环子孢子（CS）蛋白或其片段在免疫严重疟疾疾病中的应用。

9. 发明申请

WO9919649A3 MULTIPORT CONVERSION SYSTEM FOR BUTTERFLY VALVE 审中-公开
标题翻译：用于蝶阀的多重转换系统
公开(公告)号：WO9919649A3
公开(公告)日：1999-06-24
申请号：PCT/US9821469
申请日：1998-10-09
申请人： UNIVALVE LLC , COHEN JOSEPH D
发明人： COHEN JOSEPH D
IPC分类号： F16K11/052 , F16K27/02
CPC分类号： F16K27/0218 , F16K11/0525 , Y10T137/86839 , Y10T137/86863
摘要： A serviceable multiport conversion system (40) for a conventional butterfly valve includes two fittings (31, 32). A first "T" fitting (32) contains two passageways (81, 82) which join at an internal common bore adjacent a separating wall (84), the wall defining a secondary seat (88) of the multiport valve. Circumscribing the common bore is an annular flange. A second fitting may be a similar "T" fitting or an "L" fitting. The "L" fitting contains a single passageway which terminates at an internal bore circumscribed by an annular flange. In use, the butterfly valve is removably positioned in sealing engagement between two fittings, with the flanges releasably attached and the inner diameters of the flanges co-extensive with the butterfly valve bore.
摘要翻译：用于传统蝶阀的可使用的多端口转换系统（40）包括两个配件（31,32）。第一“T”配件（32）包含两个通道（81,82），该通道连接在与隔离壁（84）相邻的内部公共孔中，该壁限定多端口阀的次级座（88）。环形通孔是环形法兰。第二配件可以是类似的“T”配件或“L”配件。 “L”配件包含单个通道，其终止于由环形凸缘限定的内孔。在使用中，蝶阀可拆卸地定位在两个配件之间的密封接合中，其中凸缘可释放地附接并且凸缘的内径与蝶形阀孔共同扩展。

10. 发明申请

WO2009071613A3 VACCINE 审中-公开
公开(公告)号：WO2009071613A3
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066762
申请日：2008-12-04
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , COHEN, Joseph, D. , MARCHAND, Martine
发明人： COHEN, Joseph, D. , MARCHAND, Martine
IPC分类号： C12N15/861 , A61K39/015 , A61P33/06
摘要： The invention relates to a replication deficient simian adenoviral vector C7 encoding a protein comprising CS protein from P. falciparum or a fragment thereof, for example as shown in Seq ID No: 1 or Seq ID No: 3. The invention also relates to processes of preparing said viral vector and use of the viral vector in the treatment/prevention of malaria infection. Compositions, vaccines and kits comprising said viral vector are also described. In one aspect the invention employs a synthetic C7 viral vector. The C7 viral vector according to the invention may be co-administered or co-formulated with a malaria antigen such as RTS,S optionally in the presence of an adjuvant for example comprising 3D-MPL and/or a saponin such as QS21.

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