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1. 发明申请

WO2012040806A2 SYNERGISTIC IMMUNOGENIC COMPOSITIONS BASED ON PROTEIN ANTIGENS COMBINED WITH PERTUSSIS CELL ANTIGEN AND INACTIVATED TOXINS 审中-公开
标题翻译：基于蛋白质抗原与PERTUSSIS细胞抗原及失活毒素协同作用的免疫原性组合物
公开(公告)号：WO2012040806A2
公开(公告)日：2012-04-05
申请号：PCT/BR2011000350
申请日：2011-09-26
申请人： FUNDACAO BUTANTAN , MIYAJI ELIANE NAMIE , RAW ISAIAS , OLIVEIRA MARIA LEONOR SARNO DE , HO PAULO LEE
发明人： MIYAJI ELIANE NAMIE , RAW ISAIAS , OLIVEIRA MARIA LEONOR SARNO DE , HO PAULO LEE
IPC分类号： A61K39/09
CPC分类号： A61K39/116 , A61K39/08 , A61K39/092 , A61K39/099 , A61K2039/521 , A61K2039/543 , A61K2039/70
摘要： The present invention relates to synergistic immunogenic compositions for preventing whooping cough and infections caused by Streptococcus pneumoniae. Additionally, the compositions according to the present invention may protect against infections caused by other pathogenic agents by means of a synergistic combination of antigens thereof. In particular, the present invention provides synergistic immunogenic compositions that comprise at least one cell antigen of inactivated Bordetella pertussis and at least one protein antigen comprising one or more surface proteins A (PspA) of Streptococcus penumoniae or fragments thereof. The present invention further provides synergistic immunogenic compositions comprising at least one cell antigen of inactivated Bordetella pertussis, at least one protein antigen comprising one or more surface proteins A (PspA) of Streptococcus penumoniae or fragments thereof, and one or more diphtheria and/or tetanus toxins. The present invention also relates to the use of one or more synergistic immunogenic compositions according to the present invention for producing combined vaccines for the prevention of whooping cough, tetanus, diphtheria and/or infections caused by Streptococcus pneumoniae. The present invention further relates to the use of the compositions according to the present invention for producing vaccines for the prevention of whooping cough, tetanus, diphtheria and/or infections caused by Streptococcus pneumoniae.
摘要翻译：本发明涉及用于预防由肺炎链球菌引起的百日咳和感染的协同免疫原性组合物。另外，根据本发明的组合物可以通过其抗原的协同组合来防止由其它病原体引起的感染。具体而言，本发明提供了协同免疫原性组合物，其包含至少一种灭活的百日咳博德特氏菌的细胞抗原和至少一种蛋白质抗原，所述蛋白质抗原包含一种或多种penumboniae或其片段的表面蛋白A（PspA）或其片段。本发明进一步提供了协同免疫原性组合物，其包含至少一种灭活的百日咳博德特氏菌的细胞抗原，至少一种蛋白质抗原，其包含一种或多种肺炎链球菌或其片段的表面蛋白A（PspA）或一种或多种白喉和/或破伤风毒素。本发明还涉及根据本发明的一种或多种协同免疫原性组合物用于生产用于预防由肺炎链球菌引起的百日咳，破伤风，白喉和/或感染的组合疫苗的用途。本发明进一步涉及根据本发明的组合物用于生产用于预防由肺炎链球菌引起的百日咳，破伤风，白喉和/或感染的疫苗的用途。

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