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1. 发明申请

WO2017062496A3 ANTI-SAS1B ANTIBODIES, ASSOCIATED METHODS OF USE, AND COMPOSITIONS AND METHODS FOR DETECTING AND TREATING CANCER 审中-公开
标题翻译：抗SAS1B抗体，相关的使用方法以及检测和治疗癌症的组合物和方法
公开(公告)号：WO2017062496A3
公开(公告)日：2017-06-01
申请号：PCT/US2016055557
申请日：2016-10-05
申请人： UNIV VIRGINIA PATENT FOUNDATION , HERR JOHN , PIRES EUSEBIO , D'SOUZA RYAN , MANDAL ARABINDA , ANDERSON-KNAPP KILEY
发明人： HERR JOHN , PIRES EUSEBIO , D'SOUZA RYAN , MANDAL ARABINDA , ANDERSON-KNAPP KILEY
IPC分类号： A61K39/395 , A61K38/17 , A61K39/00 , C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： A61K39/295 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/55 , C07K2317/73 , C07K2317/77 , G01N33/573 , G01N33/57492 , G01N2333/96419
摘要： The present disclosure provides anti-SAS1B antibodies, antigen-binding fragments thereof, and antibody-drug conjugates and methods of their use. This present disclosure also provides an isolated antibody or antigen-binding portion thereof having at least one of SB antibodies binding to surface exposed SAS1B, and 6B1 antibodies identifying at least one set of cancer patients testing positive for SAS1B expression.
摘要翻译：本公开提供了抗SAS1B抗体，其抗原结合片段和抗体 - 药物缀合物及其使用方法。本公开内容还提供了分离的抗体或其抗原结合部分，其具有结合至表面暴露的SAS1B的至少一种SB抗体和识别SAS1B表达检测呈阳性的至少一组癌症患者的6B1抗体。

2. 发明申请

WO2017040265A1 NOROVIRUS VACCINE 审中-公开
公开(公告)号：WO2017040265A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/048940
申请日：2016-08-26
申请人： NANOTHERAPEUTICS, INC. , COBB, Ron , SPRINGER, Michael , NI, Yawei
发明人： COBB, Ron , SPRINGER, Michael , NI, Yawei
IPC分类号： A61K39/12 , A61K39/00
CPC分类号： A61K39/00 , A61K39/12 , A61K39/295 , A61K2039/5258 , A61K2039/55583 , C12N2770/16034
摘要： A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.
摘要翻译：提供一种干粉诺如病毒疫苗，其包含至少两种代表不同基因组的诺如病毒抗原。疫苗可以通过用不同抗原或单价粉末的混合物与每种含有一种抗原的混合物制剂来制备。配制的疫苗适用于粘膜给药，可溶于非肠道给药的水溶液。还提供免疫方法，其包括通过粘膜和/或亲本途径至少一次给予疫苗。免疫可以具有疫苗的多次施用，即通过粘膜途径进行一次或多次免疫，随后通过肠胃外途径进行一次或多次免疫，反之亦然，以最大限度地提高粘膜和全身免疫应答并防止诺如病毒感染。

3. 发明申请

WO2016114676A1 AN IMMUNOGENIC VACCINE AGAINST THE HCV AND/OR HBV 审中-公开
标题翻译：抗生素和/或HBV的免疫原性疫苗
公开(公告)号：WO2016114676A1
公开(公告)日：2016-07-21
申请号：PCT/PL2016/000002
申请日：2016-01-14
申请人： UNIWERSYTET GDAŃSKI
发明人： CZARNOTA, Anna , GRZYB, Katarzyna
IPC分类号： A61K39/29 , C12N15/85 , A61K39/00
CPC分类号： A61K39/295 , A61K39/12 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2770/24222 , C12N2770/24234 , Y02A50/41
摘要： The invention concerns a vaccine containing determinant 'a' of the HBsAg protein of the HBV virus, subtype adw2, and region 412-425 of E2 envelope glycoprotein of the HCV. The invention further concerns isolated chimeric protein in the form of vaccine, a combination containing chimeric protein, and a method of obtaining the vaccine. Furthermore, the invention concerns a composition containing chimeric protein and an expression vector.
摘要翻译：本发明涉及含有HCV病毒的HBsAg蛋白，亚型adw2和E2的E2包膜糖蛋白的区域412-425的决定簇“a”的疫苗。本发明还涉及疫苗形式的分离的嵌合蛋白，含有嵌合蛋白的组合以及获得疫苗的方法。此外，本发明涉及含有嵌合蛋白质和表达载体的组合物。

4. 发明申请

WO2015095499A1 CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS 审中-公开
标题翻译： CAP260，CAP174和K0224 HIV-1包膜，肽和组合物
公开(公告)号：WO2015095499A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071117
申请日：2014-12-18
申请人： DUKE UNIVERSITY , LOS ALAMOS NATIONAL SECURITY, LLC
发明人： HAYNES, Barton, F. , KORBER, Bette, T.
IPC分类号： C07K14/155 , C12N15/49 , C12N15/63 , C12N15/863 , A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/545 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
摘要： The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1 V2 env region of clade C HIV-1.
摘要翻译：本发明涉及HIV-1包膜蛋白和肽，以及包含其的组合物，以增加进化枝C HIV-1的V1 V2 env区域的疫苗覆盖范围的广度。

5. 发明申请

WO2012104821A1 IMMUNOGENIC BORDETELLA BRONCHISEPTICA COMPOSITIONS 审中-公开
标题翻译：免疫原BORDETELLA BRONCHISEPTICA组合物
公开(公告)号：WO2012104821A1
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050512
申请日：2012-02-03
申请人： PFIZER INC. , ABDELMAGID, Omar, Yousif , BRICKER, Joseph, Michael , SHIELDS, Shelly, Lynn , GALVIN, Jeffrey, E.
发明人： ABDELMAGID, Omar, Yousif , BRICKER, Joseph, Michael , SHIELDS, Shelly, Lynn , GALVIN, Jeffrey, E.
IPC分类号： A61K39/295 , C07K14/235 , A61K39/10
CPC分类号： A61K39/099 , A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/55577 , A61K2039/70 , C07K14/235 , C12N2710/10034 , C12N2760/16134 , C12N2760/18634 , C12N2770/20034
摘要： Provided herein are compositions, combinations, and methods comprising Bordetella bronchiseptica and isoiated pertactin, which are effective in treating or preventing respiratory infections, such as kennel cough, in animals.
摘要翻译：本文提供的组合物，组合和方法包括支气管炎博德特氏菌和分离的百日咳杆菌，它们在动物中有效治疗或预防呼吸道感染，如狗窝咳嗽。

6. 发明申请

WO2012089749A1 SALMONID ALPHAVIRUS PROTEIN E2 审中-公开
标题翻译：沙门氏菌ALPHAVIRUS蛋白E2
公开(公告)号：WO2012089749A1
公开(公告)日：2012-07-05
申请号：PCT/EP2011/074121
申请日：2011-12-28
申请人： INTERVET INTERNATIONAL B.V. , VILLOING, Stephane
发明人： VILLOING, Stephane
IPC分类号： C07K14/18 , A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/295 , A61K2039/552 , A61K2039/55566 , C12N7/00 , C12N2770/36122 , C12N2770/36134 , C12N2770/36151
摘要： The present invention relates to Salmonid alphavirus E2 -protein expressed in a bacterial expression system, its use in medicine, vaccines comprising such protein, methods for the preparation of such proteins and methods for the preparation of vaccines comprising such proteins.
摘要翻译：本发明涉及在细菌表达系统中表达的鲑鱼病毒E2-蛋白质，其在医药中的应用，包含这种蛋白质的疫苗，用于制备这种蛋白质的方法以及制备包含这种蛋白质的疫苗的方法。

7. 发明申请

WO2012083445A1 VIRUS LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译：病毒粒子在植物中的生产
公开(公告)号：WO2012083445A1
公开(公告)日：2012-06-28
申请号：PCT/CA2011/001427
申请日：2011-12-22
申请人： MEDICAGO INC. , D'AOUST, Marc-Andre , COUTURE, Manon , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe
发明人： D'AOUST, Marc-Andre , COUTURE, Manon , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe
IPC分类号： C12N15/00 , A61K39/295 , A61P31/16 , A61P37/04 , C07K19/00 , C12N15/62 , C12N15/82 , C12N7/00 , C07K14/005 , C07K14/11
CPC分类号： A61K39/295 , A61K2039/5258 , C07K14/005 , C07K2319/03 , C12N7/00 , C12N15/8257 , C12N15/8258 , C12N2710/16723 , C12N2710/16751 , C12N2740/16023 , C12N2740/16034 , C12N2740/16051 , C12N2740/16134 , C12N2760/14123 , C12N2760/14134 , C12N2760/14151 , C12N2760/16123 , C12N2760/20123 , C12N2760/20134 , C12N2760/20151 , C12N2770/20023 , C12N2770/20034 , C12N2770/20051
摘要： A method of producing a virus like particle (VLP) in a plant, and compositions comprising VLPs, are provided. The method involves introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a chimeric nucleotide sequence encoding, in series, an ectodomain from a virus trimeric surface protein or fragment thereof, fused to an influenza transmembrane domain and cytoplasmic tail, into the plant, or portion of the plant, the ectodomain is from a non- influenza virus trimeric surface protein and heterologous with respect to the influenza transmembrane domain, and the cytoplasmic tail. The plant or portion of the plant are incubated under conditions that permit the expression of the nucleic acid, thereby producing the VLP. A VLP produced by this method are also provided.
摘要翻译：提供了在植物中产生病毒样颗粒（VLP）的方法和包含VLP的组合物。所述方法包括将包含在植物中有活性的调节区的核酸引入，并与编码融合至流感跨膜结构域和细胞质尾的病毒三聚体表面蛋白或其片段的胞外域串联编码的嵌合核苷酸序列可操作地连接，进入植物或植物的部分中，胞外域来自非流感病毒三聚体表面蛋白并且相对于流感跨膜结构域和细胞质尾部是异源的。在允许核酸表达的条件下孵育植物或植物部分，从而产生VLP。还提供了由此方法生成的VLP。

8. 发明申请

WO2012037078A3 IMMUNOGENIC RESPIRATORY SYNCYTIAL VIRUS GLYCOPROTEIN-CONTAINING VLPS AND RELATED COMPOSITIONS, CONSTRUCTS, AND THERAPEUTIC METHODS 审中-公开
标题翻译：免疫抑制剂同源病毒含有GLYCOPROTEIN的VLPS及相关组合物，构造和治疗方法
公开(公告)号：WO2012037078A3
公开(公告)日：2012-06-21
申请号：PCT/US2011051330
申请日：2011-09-13
申请人： STC UNM , CHACKERIAN BRYCE C , PEABODY DAVID S
发明人： CHACKERIAN BRYCE C , PEABODY DAVID S
IPC分类号： A61K38/16 , A61K39/12 , A61K47/42 , A61K47/48 , A61K48/00 , A61P11/00 , A61P31/12
CPC分类号： A61K39/155 , A61K39/12 , A61K39/295 , A61K47/48776 , A61K47/48884 , A61K47/6901 , A61K47/6929 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , A61K2039/6075 , C07K14/005 , C07K2319/40 , C12N7/00 , C12N2760/18523 , C12N2760/18534 , C12N2795/00023
摘要： The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of Respiratory Syncytial Virus (RSV) infections and related disorders, including bronchiolitis and viral pneumonia. Related compositions (e.g, vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against RSV. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against RSV infection, confer immunity against RSV infection, protect against RSV infection, and reduce the likelihood of infection by RSV infection.
摘要翻译：本发明提供了可用于治疗和预防呼吸道合胞病毒（RSV）感染和相关疾病（包括细支气管炎和病毒性肺炎）的免疫治疗和预防性噬菌体病毒样颗粒（VLP）。还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。本发明的VLP和相关组合物诱导针对RSV的高效价抗体应答。 VLP，含VLP的组合物和本发明的治疗方法诱导针对RSV感染的免疫原性应答，赋予针对RSV感染的免疫，防止RSV感染，并降低RSV感染感染的可能性。

9. 发明申请

WO2012078484A1 COMPOSITIONS AND METHODS FOR VACCINATING CATTLE 审中-公开
标题翻译：组合物和方法用于吸虫
公开(公告)号：WO2012078484A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063219
申请日：2011-12-05
申请人： BOEHRINGER INGELHEIM VETMEDICA, INC. , RINEHART, Carol
发明人： RINEHART, Carol
IPC分类号： A61K39/02
CPC分类号： A61K39/295 , A61K39/02 , A61K39/0225 , A61K39/12 , A61K2039/521 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C12N2710/16734 , C12N2760/18534 , C12N2760/18634 , C12N2770/24334 , Y10S424/813 , Y10S424/823
摘要： The present invention relates to compositions, uses thereof, and methods of vaccinating cattle, particularly cows and heifers, against Leptospira borgpetersenii serovar hardjo (type hardjo-bovis ) by using Leptospira interrogans serovar hardjo (type hardjoprajitno ).
摘要翻译：本发明涉及使用钩端螺旋体血清型硬链球菌（hardjoprajitno型）使牛，特别是牛和小母牛接种针对钩端螺旋体血清型（Heptospira borgpetersenii serovar hardjo）的组合物，用途和方法。

10. 发明申请

WO2012038454A1 BVDV VACCINE 审中-公开
公开(公告)号：WO2012038454A1
公开(公告)日：2012-03-29
申请号：PCT/EP2011/066377
申请日：2011-09-21
申请人： INTERVET INTERNATIONAL B.V. , BEER, Martin , REIMANN, Ilona , KOENIG, Patricia
发明人： BEER, Martin , REIMANN, Ilona , KOENIG, Patricia
IPC分类号： A61K39/295 , C07K14/18 , A61K39/12 , C12N7/00 , C12N7/04
CPC分类号： A61K39/12 , A61K39/295 , A61K39/40 , A61K39/42 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N2770/24322 , C12N2770/24334 , C12N2770/24362
摘要： The present invention relates to BVD virus and to its uses, to vaccines and combination vaccines comprising such a virus, their use as a medicament, their use in the treatment of Bovine Viral Diarrhoea and to methods for the preparation of such vaccines.
摘要翻译：本发明涉及BVD病毒及其用途，包含这种病毒的疫苗和组合疫苗，它们作为药物的用途，其用于治疗牛病毒性腹泻的用途以及用于制备这种疫苗的方法。

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