专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO02072763A3 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO02072763A3
公开(公告)日：2003-02-27
申请号：PCT/US0206990
申请日：2002-03-08
申请人： HUMAN GENOME SCIENCES INC , SHI YANGGU , NI JIAN , RUBEN STEVEN M
发明人： SHI YANGGU , NI JIAN , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新型蛋白质。更具体地，提供编码新型多肽的分离的核酸分子。提供结合这些多肽的新型多肽和抗体。还提供了载体，宿主细胞，以及用于产生人多核苷酸和/或多肽的抗体的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与这些新型多肽相关的疾病的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

22. 发明申请

WO0118021A9 B7-LIKE POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES 审中-公开
标题翻译： B7样多核苷酸，多肽和抗体
公开(公告)号：WO0118021A9
公开(公告)日：2002-11-28
申请号：PCT/US0023792
申请日：2000-08-30
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , CHEN LIEPING , MAYO FOUNDATION , BAKER KEVIN , NI JIAN
发明人： RUBEN STEVEN M , CHEN LIEPING , BAKER KEVIN , NI JIAN
IPC分类号： G01N33/50 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K31/713 , A61K35/76 , A61K38/00 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/00 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P7/08 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P15/08 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/14 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07K14/47 , C07K14/705 , C07K14/725 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C07K14/46 , C07K14/52 , C12N15/00 , C12N15/63
CPC分类号： C07K14/70532 , A61K38/00
摘要： The present invention relates to novel human B7-like polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human B7-like polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human B7-like polypeptides.
摘要翻译：本发明涉及新的人B7样多肽和含有编码这些多肽的基因的编码区的分离的核酸。还提供了用于生产人类B7样多肽的载体，宿主细胞，抗体和重组方法。本发明进一步涉及用于诊断和治疗与这些新型人类B7样多肽有关的病症的诊断和治疗方法。

23. 发明申请

WO0218622A3 TUMOR NECROSIS FACTOR RECEPTORS 6 AND 6 审中-公开
标题翻译：肿瘤坏死因子受体6和6
公开(公告)号：WO0218622A3
公开(公告)日：2002-08-29
申请号：PCT/US0126396
申请日：2001-08-24
申请人： HUMAN GENOME SCIENCES INC , GENTZ REINER L , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , NI JIAN , FENG PING
发明人： GENTZ REINER L , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , NI JIAN , FENG PING
IPC分类号： A61K38/17 , C07K14/715 , C12Q1/68 , C07K14/705 , A61K38/00 , A61K39/00 , A61K39/395 , C07H21/04 , C12N5/00 , C12N15/63 , C12P21/02
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/30 , C12Q1/6883
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6 & -6 proteins. TNFR-6 & -6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6 & -6 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6和-6蛋白的分离的核酸分子。还提供了TNFR-6和-6多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TNFR-6和-6活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

24. 发明申请

WO0142506A9 T1 RECEPTOR-LIKE LIGAND II AND USES THEREOF 审中-公开
标题翻译： T1受体相似配体II及其用途
公开(公告)号：WO0142506A9
公开(公告)日：2002-08-22
申请号：PCT/US0033389
申请日：2000-12-08
申请人： HUMAN GENOME SCIENCES INC , NI JIAN , GENTZ REINER L , RUBEN STEVEN M
发明人： NI JIAN , GENTZ REINER L , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/54 , C12N5/06 , C12Q1/68
CPC分类号： A61K38/202 , A61K35/15 , A61K35/17 , A61K38/1709 , A61K38/1793 , A61K38/193 , A61K45/06 , A61K48/00 , C07K14/54 , C12N2799/026 , G01N33/6869 , G01N2333/545 , A61K2300/00
摘要： The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.
摘要翻译：本发明涉及一种新颖的T1受体（T1R）样配体II蛋白。特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。本发明还涉及包含T1R样配体II的药物组合物和制剂。还提供了用于治疗和诊断目的的T1R样配体II多核苷酸，多肽，抗体或激动剂/拮抗剂的方法。还提供诊断试剂盒。

25. 发明申请

WO9831818A9 TACE-LIKE AND MATRILYSIN-LIKE POLYPEPTIDES 审中-公开
标题翻译：类似TACE和类似MATRILYSIN的多聚体
公开(公告)号：WO9831818A9
公开(公告)日：2001-06-14
申请号：PCT/US9800783
申请日：1998-01-20
申请人： HUMAN GENOME SCIENCES INC , NI JIAN , RUBEN STEVEN M , BREWER LAURIE , GENTZ REINER , ROSEN CRAIG A
发明人： NI JIAN , RUBEN STEVEN M , BREWER LAURIE , GENTZ REINER , ROSEN CRAIG A
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K14/735 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/57 , C12N1/19 , C12N5/10
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , C12N2799/026
摘要： The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译：本发明涉及新型金属蛋白酶样蛋白质。特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

26. 发明申请

WO0073323A3 ADAM POLYNUCLEOTIDES AND POLYPEPTIDES 审中-公开
标题翻译： ADAM多核苷酸和多肽
公开(公告)号：WO0073323A3
公开(公告)日：2001-03-22
申请号：PCT/US0014308
申请日：2000-05-25
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , WEI PING , NI JIAN , HASTINGS GREGG A , SHI YANGGU
发明人： RUBEN STEVEN M , WEI PING , NI JIAN , HASTINGS GREGG A , SHI YANGGU
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/08 , A61P9/10 , A61P17/00 , A61P25/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , G01N33/15 , G01N33/53 , G01N37/00 , A61K38/43 , C12N15/57 , C12N15/74 , C12N15/79 , C12Q1/37
CPC分类号： C12N9/6489 , A61K38/00
摘要： The present invention relates to novel human ADAM polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human ADAM polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human ADAM polypeptides.
摘要翻译：本发明涉及新型人ADAM多肽和含有编码这些多肽的基因的编码区的分离的核酸。还提供了用于产生人ADAM多肽的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人ADAM多肽相关的疾病的诊断和治疗方法。

27. 发明申请

WO9845712A3 20 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 20人类分泌蛋白
公开(公告)号：WO9845712A3
公开(公告)日：1998-12-03
申请号：PCT/US9806801
申请日：1998-04-07
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M , YU GUO LIANG , NI JIAN , FENG PING
发明人： ROSEN CRAIG A , RUBEN STEVEN M , YU GUO-LIANG , NI JIAN , FENG PING
IPC分类号： G01N33/53 , A61K31/711 , A61K35/36 , A61K38/00 , A61K48/00 , A61P7/00 , A61P17/02 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/68 , A61K31/70 , A61K38/17 , C07K19/00 , C12N15/11 , C12N15/12 , C12N15/62 , C12Q1/48 , G01N33/60
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to 20 human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these human secreted proteins.

28. 发明申请

WO0061614A8 UNCOUPLING PROTEINS 审中-公开
标题翻译：消除蛋白质
公开(公告)号：WO0061614A8
公开(公告)日：2007-09-13
申请号：PCT/US0009534
申请日：2000-04-06
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , NI JIAN , KOMATSOULIS GEORGE , ROSEN CRAIG A , SOPPET DANIEL R
发明人： RUBEN STEVEN M , NI JIAN , KOMATSOULIS GEORGE , ROSEN CRAIG A , SOPPET DANIEL R
IPC分类号： C07K14/00 , G01N33/50 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/06 , C12Q1/68 , G01N33/15
CPC分类号： C07K14/47 , A61K38/00

29. 发明申请

WO0132910A2 27 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 27人类分泌蛋白
公开(公告)号：WO0132910A2
公开(公告)日：2001-05-10
申请号：PCT/US0029362
申请日：2000-10-25
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , KOMATSOULIS GEORGE A , BIRSE CHARLES E , NI JIAN , SOPPET DANIEL R
发明人： RUBEN STEVEN M , KOMATSOULIS GEORGE A , BIRSE CHARLES E , NI JIAN , SOPPET DANIEL R
IPC分类号： C12N15/09 , A61K31/713 , A61K38/00 , A61P1/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/06 , A61P17/04 , A61P21/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12Q
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

30. 发明申请

WO9962934A9 INTERFERON RECEPTOR HKAEF92 审中-公开
标题翻译：干扰素受体HKAEF92
公开(公告)号：WO9962934A9
公开(公告)日：2000-05-04
申请号：PCT/US9912156
申请日：1999-06-03
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , NI JIAN
发明人： RUBEN STEVEN M , NI JIAN
IPC分类号： A61K38/00 , C07K14/715 , C07K1/00 , C07H21/04
CPC分类号： C07K14/7156 , A61K38/00
摘要： The present invention relates to a novel Interferon receptor "INFR-HKAEF92" protein which is a member of the Interferon/IL-10 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human INFR-HKAEF92 protein. INFR-HKAEF92 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of INFR-HKAEF92 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为干扰素/ IL-10受体家族成员的新型干扰素受体“INFR-HKAEF92”蛋白。特别地，提供编码人INFR-HKAEF92蛋白的分离的核酸分子。还提供了INFR-HKAEF92多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定INFR-HKAEF92活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式