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1. 发明申请

WO2006053259A3 FLUORESCENT MUTATION DETECTION WITH MISMATCH CUTTING DNA ENDONUCLEASES 审中-公开
标题翻译：荧光检测用错配切割DNA内切酶
公开(公告)号：WO2006053259A3
公开(公告)日：2007-04-19
申请号：PCT/US2005041056
申请日：2005-11-14
申请人： TRANSGENOMIC INC , SHI YANGGU , GERARD GARY F
发明人： SHI YANGGU , GERARD GARY F
IPC分类号： C07H21/04 , C12P19/34
CPC分类号： C12Q1/683 , C12Q2563/107 , C12Q2537/113 , C12Q2521/514 , C12Q2549/119 , C12Q2525/161 , C12Q2525/155
摘要： Methods and kits are provided with DNA substrates having a fluorescent label positioned at a nucleotide internal from its 5' end for use with CEL nuclease to determine whether a DNA sequence contains mutations or polymorphic changes.
摘要翻译：提供方法和试剂盒具有荧光标记的DNA底物，荧光标记位于其5'末端的核苷酸处，以与CEL核酸酶一起使用以确定DNA序列是否含有突变或多态性变化。

2. 发明申请

WO2004042000A3 157 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 157人类分泌蛋白
公开(公告)号：WO2004042000A3
公开(公告)日：2005-10-06
申请号：PCT/US0315439
申请日：2003-05-16
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M , OLSEN HENRIK , BAKER KEVIN P , FISCELLA MICHELE , WEI PING , BIRSE CHARLES E , KOMATSOULIS GEORGE , CHOI GIL H , MOORE PAUL A , GUPTA RAM , SHI YANGGU
发明人： ROSEN CRAIG A , RUBEN STEVEN M , OLSEN HENRIK , BAKER KEVIN P , FISCELLA MICHELE , WEI PING , BIRSE CHARLES E , KOMATSOULIS GEORGE , CHOI GIL H , MOORE PAUL A , GUPTA RAM , SHI YANGGU
IPC分类号： C07K14/47 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

3. 发明申请

WO0134767A3 22 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 22人分泌蛋白
公开(公告)号：WO0134767A3
公开(公告)日：2002-05-02
申请号：PCT/US0030036
申请日：2000-11-01
申请人： HUMAN GENOME SCIENCES INC , SOPPET DANIEL R , KOMATSOULIS GEORGE , SHI YANGGU , OLSEN HENRIK S , RUBEN STEVEN M
发明人： SOPPET DANIEL R , KOMATSOULIS GEORGE , SHI YANGGU , OLSEN HENRIK S , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61P1/16 , A61P5/14 , A61P7/06 , A61P11/00 , A61P11/08 , A61P13/12 , A61P17/02 , A61P21/06 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/02 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/68 , C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C12N15/63 , C12N15/85 , C12N15/86 , C12P21/06
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及新的人分泌蛋白和含有编码这些蛋白的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白的载体，宿主细胞，抗体和重组方法。本发明进一步涉及诊断和治疗方法，用于诊断和治疗与这些新的人类分泌蛋白相关的疾病，病症和/或病症。

4. 发明申请

WO2012118802A1 KIT AND METHOD FOR SEQUENCING A TARGET DNA IN A MIXED POPULATION 审中-公开
标题翻译：用于在混合人群中测序目标DNA的套件和方法
公开(公告)号：WO2012118802A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/026938
申请日：2012-02-28
申请人： TRANSGENOMIC, INC. , RICHARDSON, Katherine , LEGENDRE, Benjamin , SHI, Yanggu
发明人： RICHARDSON, Katherine , LEGENDRE, Benjamin , SHI, Yanggu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/708 , C12Q2527/107 , C12Q2535/113 , C12Q2537/163
摘要： Methods and kits for sequencing a target DNA sequence in a sample having a related reference sequence are provided herein. In particular, kits and methods for sequencing cancer and cancer therapy associated mutations are described. Also provided are kits and methods for detecting mitochondrial mutations and for differentiating between closely related viral strains.
摘要翻译：本文提供了用于测序具有相关参考序列的样品中的靶DNA序列的方法和试剂盒。具体地，描述了用于测序癌症和癌症治疗相关突变的试剂盒和方法。还提供了用于检测线粒体突变和用于区分密切相关的病毒株之间的试剂盒和方法。

5. 发明申请

WO2007101028A2 METHOD TO PRODUCE ENZYMATICALLY ACTIVE RECOMBINANT ENDONUCLEASES 审中-公开
标题翻译：生产酶促活性重组体内切酶的方法
公开(公告)号：WO2007101028A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062468
申请日：2007-02-21
申请人： TRANSGENOMIC, INC. , SHI, Yanggu , GERARD, Gary, F.
发明人： SHI, Yanggu , GERARD, Gary, F.
CPC分类号： C12N9/22
摘要： Methods for recombinant production of functionally active endonucleases by supplementing the cell culture media with Zn++ are provided. Functionally active, recombinantly expressed endonucleases produced in accordance with these methods are also provided.
摘要翻译：提供了通过用Zn ++补充细胞培养基来重组生产功能活性核酸内切酶的方法。还提供了根据这些方法生产的功能活性的重组表达的内切核酸酶。

6. 发明申请

WO2007021494A2 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2007021494A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/029391
申请日：2006-07-31
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig , BELL, Adam , MOORE, Paul , SHI, Yanggu , LAFLEUR, David , LAIRD, Michael , HASELTINE, William , WOODS, Douglas , BOCK, Jason , SUBRAMANIAN, Mani
发明人： ROSEN, Craig , BELL, Adam , MOORE, Paul , SHI, Yanggu , LAFLEUR, David , LAIRD, Michael , HASELTINE, William , WOODS, Douglas , BOCK, Jason , SUBRAMANIAN, Mani
IPC分类号： C07K14/765
CPC分类号： C07K14/765 , A61K47/643 , C07K2319/00
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，以及含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括含有白蛋白融合蛋白的药物组合物和使用本发明的白蛋白融合蛋白治疗，预防或改善疾病，病症或病症的方法。

7. 发明申请

WO2004042000A2 157 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 157人类分泌蛋白
公开(公告)号：WO2004042000A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/015439
申请日：2003-05-16
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , RUBEN, Steven, M. , OLSEN, Henrik , BAKER, Kevin, P. , FISCELLA, Michele , WEI, Ping , BIRSE, Charles, E. , KOMATSOULIS, George , CHOI, Gil, H. , MOORE, Paul, A. , GUPTA, Ram , SHI, Yanggu
发明人： ROSEN, Craig, A. , RUBEN, Steven, M. , OLSEN, Henrik , BAKER, Kevin, P. , FISCELLA, Michele , WEI, Ping , BIRSE, Charles, E. , KOMATSOULIS, George , CHOI, Gil, H. , MOORE, Paul, A. , GUPTA, Ram , SHI, Yanggu
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

8. 发明申请

WO2005077042A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2005077042A3
公开(公告)日：2006-11-30
申请号：PCT/US2005004041
申请日：2005-02-09
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A , MOORE PAUL A , BOCK JASON B , BELL ADAM , SHI YANGGU , LAFLEUR DAVID
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A , MOORE PAUL A , BOCK JASON B , BELL ADAM , SHI YANGGU , LAFLEUR DAVID
IPC分类号： A61K38/38 , C07K14/76 , C07K14/765 , C12N15/62
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

9. 发明申请

WO2002072763A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO2002072763A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/006990
申请日：2002-03-08
申请人： HUMAN GENOME SCIENCES, INC. , SHI, Yanggu , NI, Jian , RUBEN, Steven, M.
发明人： SHI, Yanggu , NI, Jian , RUBEN, Steven, M.
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新蛋白质。更具体而言，提供了编码新多肽的分离的核酸分子。提供了与这些多肽结合的新多肽和抗体。还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

10. 发明申请

WO2002068628A1 70 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 70人类分泌蛋白
公开(公告)号：WO2002068628A1
公开(公告)日：2002-09-06
申请号：PCT/US2002/005301
申请日：2002-02-21
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig, A. , KOMATSOULIS, George , BAKER, Kevin, P. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping , DUAN, D., Roxanne , SHI, Yanggu , GUPTA, Ram
发明人： ROSEN, Craig, A. , KOMATSOULIS, George , BAKER, Kevin, P. , FISCELLA, Michele , MOORE, Paul, A. , WEI, Ping , DUAN, D., Roxanne , SHI, Yanggu , GUPTA, Ram
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

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