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1. 发明申请

WO9830694A3 TUMOR NECROSIS FACTOR RECEPTORS 6 ALPHA AND 6 BETA 审中-公开
标题翻译：肿瘤坏死因子受体6 ALPHA和6 BETA
公开(公告)号：WO9830694A3
公开(公告)日：1998-11-12
申请号：PCT/US9800153
申请日：1998-01-13
申请人： HUMAN GENOME SCIENCES INC , GENTZ REINER L , NI JIAN , EBNER REINHARD , YU GUO LIANG , RUBEN STEVEN M , FENG PING
发明人： GENTZ REINER L , NI JIAN , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , FENG PING
IPC分类号： C12N15/09 , C07K14/705 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/63
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-α and -6β proteins. TNFR-6α and -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α and -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供分离的核酸分子，其编码人TNFR-6α和-6βb; 蛋白质。 TNFR-6α＆-6＆bgr; 还提供多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明进一步涉及鉴定TNFR-6α和-6β的激动剂和拮抗剂的筛选方法。活动。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

2. 发明申请

WO9830693A9 TUMOR NECROSIS FACTOR RECEPTOR 5 审中-公开
标题翻译：肿瘤坏死因子受体5
公开(公告)号：WO9830693A9
公开(公告)日：1999-09-02
申请号：PCT/US9800152
申请日：1998-01-13
申请人： HUMAN GENOME SCIENCES INC , WEI YING FEI , NI JIAN , EBNER REINHARD , YU GUO LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
发明人： WEI YING-FEI , NI JIAN , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P7/00 , A61P9/10 , A61P19/08 , A61P25/16 , A61P25/28 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , A61K38/17 , C12N15/70 , C12N15/85 , C12N15/86
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as "TNFR-5" or "TR5", and now referred to hereinafter as "TRAIL receptor without intracellular domain" or "TRID". TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

3. 发明申请

WO9830693A2 TUMOR NECROSIS FACTOR RECEPTOR 5 审中-公开
标题翻译：肿瘤坏死因子受体5
公开(公告)号：WO9830693A2
公开(公告)日：1998-07-16
申请号：PCT/US9800152
申请日：1998-01-13
申请人： HUMAN GENOME SCIENCES INC , WEI YING FEI , NI JIAN , EBNER REINHARD , YU GUO LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
发明人： WEI YING-FEI , NI JIAN , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , GENTZ REINER L , FENG PING
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/16 , A61P7/00 , A61P9/10 , A61P19/08 , A61P25/16 , A61P25/28 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , A61K38/17 , C12N15/70 , C12N15/85 , C12N15/86
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as "TNFR-5" or "TR5", and now referred to hereinafter as "TRAIL receptor without intracellular domain" or "TRID". TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

4. 发明申请

WO0218622A3 TUMOR NECROSIS FACTOR RECEPTORS 6 AND 6 审中-公开
标题翻译：肿瘤坏死因子受体6和6
公开(公告)号：WO0218622A3
公开(公告)日：2002-08-29
申请号：PCT/US0126396
申请日：2001-08-24
申请人： HUMAN GENOME SCIENCES INC , GENTZ REINER L , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , NI JIAN , FENG PING
发明人： GENTZ REINER L , EBNER REINHARD , YU GUO-LIANG , RUBEN STEVEN M , NI JIAN , FENG PING
IPC分类号： A61K38/17 , C07K14/715 , C12Q1/68 , C07K14/705 , A61K38/00 , A61K39/00 , A61K39/395 , C07H21/04 , C12N5/00 , C12N15/63 , C12P21/02
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/30 , C12Q1/6883
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6 & -6 proteins. TNFR-6 & -6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6 & -6 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6和-6蛋白的分离的核酸分子。还提供了TNFR-6和-6多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TNFR-6和-6活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

5. 发明申请

WO9841629A3 DEATH DOMAIN CONTAINING RECEPTOR 5 审中-公开
标题翻译：死亡细菌受体5
公开(公告)号：WO9841629A3
公开(公告)日：1998-10-29
申请号：PCT/US9805377
申请日：1998-03-17
申请人： HUMAN GENOME SCIENCES INC , NI JIAN , GENTZ REINER L , YU GUO LIANG , SU JEFFREY Y , ROSEN CRAIG A
发明人： NI JIAN , GENTZ REINER L , YU GUO-LIANG , SU JEFFREY Y , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P9/10 , A61P25/28 , A61P35/00 , A61P37/06 , C07K14/715 , C07K16/28 , C12N1/21 , C12N5/10 , C12N15/12 , A61K38/17 , C12N15/62
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

6. 发明申请

WO0066156A8 DEATH DOMAIN CONTAINING RECEPTOR 5 审中-公开
标题翻译：死亡细菌受体5
公开(公告)号：WO0066156A8
公开(公告)日：2001-07-26
申请号：PCT/US0012041
申请日：2000-05-04
申请人： HUMAN GENOME SCIENCES INC , NI JIAN , GENTZ REINER L , YU GUO LIANG , ROSEN CRAIG A
发明人： NI JIAN , GENTZ REINER L , YU GUO-LIANG , ROSEN CRAIG A
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/04 , A61P43/00 , C07K14/705 , C07K17/08 , C07K19/00 , C12N15/09 , C12P21/02 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , A61K39/00 , A01N37/18 , C07K14/52 , C07K14/525 , C07K16/28
CPC分类号： C07K14/70578 , A61K38/00 , A61K39/395 , C07K2319/00 , C07K2319/30 , A61K38/191 , A61K38/19 , A61K38/177 , A61K31/00 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR5 acitivity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。特别地，提供编码人DR5蛋白的分离的核酸分子。还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定DR5活性的激动剂和拮抗剂的筛选方法。

7. 发明申请

WO02077155A3 KERATINOCYTE GROWTH FACTOR-2 审中-公开
公开(公告)号：WO02077155A3
公开(公告)日：2003-01-03
申请号：PCT/US0200101
申请日：2002-01-04
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , JIMENEZ PABLO , DUAN D ROXANNE , RAMPY MARK A , MENDRICK DONNA , ZHANG JUN , NI JIAN , MOORE PAUL A , COLEMAN TIMOTHY A , GRUBER JOACHIM R , DILLON PATRICK J , GENTZ REINER L
发明人： RUBEN STEVEN M , JIMENEZ PABLO , DUAN D ROXANNE , RAMPY MARK A , MENDRICK DONNA , ZHANG JUN , NI JIAN , MOORE PAUL A , COLEMAN TIMOTHY A , GRUBER JOACHIM R , DILLON PATRICK J , GENTZ REINER L
IPC分类号： A61K38/00 , A61K48/00 , C07K14/50 , C12N5/08 , A01N1/00 , A01N43/04 , C07H21/02 , C07K1/00 , C12P21/04
CPC分类号： C07K14/50 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

8. 发明申请

WO9909161A8 PANCREAS-DERIVED PLASMINOGEN ACTIVATOR INHIBITOR 审中-公开
标题翻译：胰蛋白酶衍生的PLASMINOGEN激活剂抑制剂
公开(公告)号：WO9909161A8
公开(公告)日：1999-04-08
申请号：PCT/US9803217
申请日：1998-02-18
申请人： HUMAN GENOME SCIENCES INC , LONG ISLAND JEWISH MEDICAL CT , NI JIAN , GENTZ REINER L , RUBEN STEVEN M , SHI Y ERIC
发明人： NI JIAN , GENTZ REINER L , RUBEN STEVEN M , SHI Y ERIC
IPC分类号： A61K38/00 , A61K48/00 , C07K14/81 , C12N15/12 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/8132 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions, including breast cancer, and diagnostic methods for detecting pathologic disorders.
摘要翻译：本发明涉及纤溶酶原激活物抑制剂蛋白家族的新成员。特别地，提供编码胰腺衍生的纤溶酶原激活物抑制蛋白的分离的核酸分子。还提供了胰腺来源的纤溶酶原激活物抑制剂多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于治疗生理和病理疾病状况的方法，包括乳腺癌，以及用于检测病理障碍的诊断方法。

9. 发明申请

WO0142506A9 T1 RECEPTOR-LIKE LIGAND II AND USES THEREOF 审中-公开
标题翻译： T1受体相似配体II及其用途
公开(公告)号：WO0142506A9
公开(公告)日：2002-08-22
申请号：PCT/US0033389
申请日：2000-12-08
申请人： HUMAN GENOME SCIENCES INC , NI JIAN , GENTZ REINER L , RUBEN STEVEN M
发明人： NI JIAN , GENTZ REINER L , RUBEN STEVEN M
IPC分类号： C12N15/09 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/54 , C12N5/06 , C12Q1/68
CPC分类号： A61K38/202 , A61K35/15 , A61K35/17 , A61K38/1709 , A61K38/1793 , A61K38/193 , A61K45/06 , A61K48/00 , C07K14/54 , C12N2799/026 , G01N33/6869 , G01N2333/545 , A61K2300/00
摘要： The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.
摘要翻译：本发明涉及一种新颖的T1受体（T1R）样配体II蛋白。特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。本发明还涉及包含T1R样配体II的药物组合物和制剂。还提供了用于治疗和诊断目的的T1R样配体II多核苷酸，多肽，抗体或激动剂/拮抗剂的方法。还提供诊断试剂盒。

10. 发明申请

WO9853069A3 GDNF RECEPTORS 审中-公开
标题翻译： GDNF受体
公开(公告)号：WO9853069A3
公开(公告)日：1999-02-25
申请号：PCT/US9810328
申请日：1998-05-20
申请人： HUMAN GENOME SCIENCES INC , NI JIAN , HSU TSU AN , YOUNG PAUL , GENTZ REINER L , RUBEN STEVEN M
发明人： NI JIAN , HSU TSU-AN , YOUNG PAUL , GENTZ REINER L , RUBEN STEVEN M
IPC分类号： A61K38/00 , C07K14/71 , C12N15/12 , A61K38/17
CPC分类号： C07K14/71 , A61K38/00
摘要： The present invention relates to a novel glial cell line-derived neurotrophic factor receptor beta (GDNFR-β) and novel glial cell line-derived neurotrophic factor receptor gamma 1 and 2 (GDNFR-ηl and GDNFR-η2). The receptors of the present invention share high homology with glial cell line-derived neurotrophic factor receptor alpha and have been named GDNFR-β, GDNFR-η1 and GDNFR-η2. More specifically, isolated nucleic acid molecules are provided encoding human GDNFR-β, GDNFR-η1 and GDNFR-η2 receptors. GDNFR-β, GDNFR-η1 and GDNFR-η2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of GDNFR-β, GDNFR-η1 and GDNFR-η2 activity. Also provided are diagnostic and therapeutic methods for disorders and diseases including Parkinson's disease, thyroid tumor, kidney failure and gut dysfunction.
摘要翻译：本发明涉及新型神经胶质细胞系衍生的神经营养因子受体β（GDNFR-β）和新型神经胶质细胞系衍生的神经营养因子受体γ1和2（GDNFR-γ1和GDNFR-γ2）。本发明的受体与神经胶质细胞系衍生的神经营养因子受体α具有高同源性，并且被命名为GDNFR-β，GDNFR-γ1和GDNFR-γ2。更具体地，提供分离的核酸分子，其编码人GDNFR- β，GDNFR-γ1和GDNFR-γ2受体。还提供了GDNFR-β，GDNFR-γ1和GDNFR-γ2多肽，载体，宿主细胞和用于产生它们的重组方法也是如此。本发明还涉及用于鉴定GDNFR-β，GDNFR-γ1和GDNFR-γ2活性的激动剂和拮抗剂的筛选方法。还提供了用于疾病和疾病的诊断和治疗方法，包括帕金森病，甲状腺肿瘤，肾衰竭和肠功能障碍。

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