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21. 发明申请

WO2006050012A3 MORINDA CITRIFOLIA BASED COMPOSITIONS AND METHODS FOR INHIBITING XANTHINE OXIDASE 审中-公开
标题翻译：基于MORINDA CITRIFOLIA的组合物和抑制XANTHINE氧化酶的方法
公开(公告)号：WO2006050012A3
公开(公告)日：2007-06-28
申请号：PCT/US2005038727
申请日：2005-10-26
申请人： MORINDA INC
发明人： PALU AFA KEHAATI , SU CHEN , ZHOU BING-NAN , JENSEN CLAUDE JARAKAE , ASAY KIM , STORY STEPHEN P
IPC分类号： A61K36/00
CPC分类号： A61K36/73 , A61K36/45 , A61K36/746 , A61K2300/00
摘要： The present invention relates to the inhibition of xanthine oxidase. In particular, the present invention relates to systems and methods for utilizing Morinda citrifolia L. based compositions and methods to inhibit xanthine oxidase activity.
摘要翻译：本发明涉及黄嘌呤氧化酶的抑制。特别地，本发明涉及利用基于烟草柠檬酸的组合物和抑制黄嘌呤氧化酶活性的方法的系统和方法。

22. 发明申请

WO2005091953A2 MORINDA CITRIFOLIA LEAF EXTRACT COMPOSITIONS AND METHODS OF OBTAINING THE SAME 审中-公开
标题翻译： MORINDA CITRIFOLIA LEAF萃取组合物及其获得方法
公开(公告)号：WO2005091953A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/006923
申请日：2005-03-04
申请人： MORINDA, INC. , ZHOU, Bing-Nan , PALU, Afa, Kehaati , SU, Chen , JENSEN, Claude, Jarakae , STORY, Stephen
发明人： ZHOU, Bing-Nan , PALU, Afa, Kehaati , SU, Chen , JENSEN, Claude, Jarakae , STORY, Stephen
CPC分类号： A61K36/746
摘要： Methods and compositions relating to leaf extracts obtained from removing liquids from relatively dry Morinda citrifolia leaves. Methods and compositions relating to a leaf serum created from combining leaf extract and fruit juice from the Morinda citrifolia L . plant. Methods and compositions relating to leaf extract compositions comprising one or more of the leaf extracts and leaf serums.
摘要翻译：与通过从相对干燥的Morinda citrifolia叶中除去液体获得的叶提取物相关的方法和组合物。与叶片提取物和来自Morinda citrifolia L.植物的果汁组合的叶片血清相关的方法和组合物。涉及包含一种或多种叶提取物和叶血清的叶提取物组合物的方法和组合物。

23. 发明申请

WO2004098514A3 MORINDA CITRIFOLIA-BASED FORMULATION FOR INHIBITING METASTASIS OF CARCINOGENIC CELLS 审中-公开
标题翻译：用于抑制致癌细胞分化的基于MORINDA CITRIFOLIA的制剂
公开(公告)号：WO2004098514A3
公开(公告)日：2005-07-14
申请号：PCT/US2004013558
申请日：2004-05-03
申请人： MORINDA INC
发明人： SU CHEN , WEST BRETT , PALU AFA , HIRASUMI-KIM ANNE , JENSEN CLAUDE JARAKAE , STORY STEPHEN
IPC分类号： A61K20060101 , A61K35/78
CPC分类号： A61K36/746
摘要： The present invention features processed ingredients from the Indian mulberry plant, and particularly Morinda citrifolia fruit juice, for inhibiting and preventing metastasis of carcinogenic cells, as well as destroying metastasized cells. At least some implementations of the present invention comprise the consumption of food products or medicinal products or compositions comprising processed Morinda citrifolia.
摘要翻译：本发明涉及来自印度桑树植物的加工成分，特别是Morinda citrifolia果汁，用于抑制和预防致癌细胞的转移，以及破坏转移细胞。本发明的至少一些实施方案包括消费食品或药用产品或包含加工的海巴戟天的组合物。

24. 发明申请

WO2005048919A2 PREVENTATIVE EFFECTS OF MORINDA CITRIFOLIA ON MAMMARY BREAST CANCER 审中-公开
标题翻译： MORINDA CITRIFOLIA对乳腺癌的预防作用
公开(公告)号：WO2005048919A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/026253
申请日：2004-08-11
申请人： MORINDA, INC.
发明人： WANG, Mian-Ying , JENSEN, Claude, Jarakae , SU, Chen
IPC分类号： A61K
CPC分类号： A61K36/746
摘要： The present invention features a novel use of processed ingredients from the Indian mulberry plant. More specifically, the present invention features a novel use of processed Morinda citrifolia, namely Morinda citrifolia fruit juice, puree, or puree juice for treating breast cancer, and particularly for inhibiting and/or preventing the metastasis of carcinogenic cells within the mammary region of the breast, as well as destroying metastasized mammary or breast cancer cells. The present invention comprises the consumption of food products or medicinal products or compositions comprising processed Morinda citrifolia, in either puree or fruit juice form. The present invention also features a method of inhibiting carcinogen-mediated conversion of mammary cells and protecting DNA against carcinogen-mediated damage by administering a composition comprising water soluble Morinda citrifolia.
摘要翻译：本发明的特征在于使用来自印度桑树植物的加工成分。更具体地，本发明的特征在于加工的海巴戟天（Morinda citrifolia）的新颖应用，即莫利达柠檬酸果汁，泥浆或果泥汁用于治疗乳腺癌，特别是用于抑制和/或预防乳腺癌中乳腺癌中的致癌细胞的转移乳房，以及破坏转移性乳腺癌或乳腺癌细胞。本发明包括以酱油或果汁形式消费食品或医药产品或包含加工的海巴戟天的组合物。本发明还涉及一种抑制致癌物介导的乳腺细胞转化和保护DNA免受致癌物介导的损伤的方法，该方法是通过施用包含水溶性的海巴戟天的组合物。

25. 发明申请

WO2004098514A2 MORINDA CITRIFOLIA-BASED FORMULATION FOR INHIBITING METASTASIS OF CARCINOGENIC CELLS 审中-公开
标题翻译：用于抑制致癌细胞分化的基于MORINDA CITRIFOLIA的制剂
公开(公告)号：WO2004098514A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/013558
申请日：2004-05-03
申请人： MORINDA, INC.
发明人： SU, Chen , WEST, Brett , PALU, Afa , HIRASUMI-KIM, Anne , JENSEN, Claude, Jarakae , STORY, Stephen
IPC分类号： A61K
CPC分类号： A61K36/746
摘要： The present invention features processed ingredients from the Indian mulberry plant, and particularly Morinda citrifolia fruit juice, for inhibiting and preventing metastasis of carcinogenic cells, as well as destroying metastasized cells. At least some implementations of the present invention comprise the consumption of food products or medicinal products or compositions comprising processed Morinda citrifolia .
摘要翻译：本发明的特征是来自印度桑树植物的加工成分，特别是Morinda citrifolia果汁，用于抑制和预防致癌细胞的转移，以及破坏转移细胞。本发明的至少一些实施方案包括消费食品或医药产品或包含加工的Morinda citrifolia的组合物。

26. 发明申请

WO2004091545A2 SELECTIVELY INHIBITING ESTROGEN PRODUCTION AND PROVIDING ESTROGENIC EFFECTS IN THE HUMAN BODY 审中-公开
标题翻译：选择性抑制雌激素在人体内的生产和提供雌激素作用
公开(公告)号：WO2004091545A2
公开(公告)日：2004-10-28
申请号：PCT/US2004009129
申请日：2004-03-25
申请人： MORINDA INC , PALU AFA KEHAATI
发明人： PALU AFA KEHAATI , WANG MIAN YING , SU CHEN XING , WEST BRETT JUSTIN , WESTENDORF JOHANNES JOSEPH , JENSEN CLAUDE JARAKAE , STORY STEPHEN PAUL
IPC分类号： A61K31/353 , A61K36/00 , A61K36/746 , A61K
CPC分类号： A61K36/746 , A61K31/353
摘要： Implementation is directed to selectively inhibiting estrogen production and providing estrogenic effects in a human body. A dietary supplement includes a processed Morinda citrifolia product that is used to inhibit aromatase or aromatase enzymes that function to convert androgens to estrogens, inhibit receptors from binding with estrogen, and reduce and/or regulate estrogen production, as well as reduce the amount of estrogen produced within the body and regulating such production. The dietary supplement further provides estrogenic effects. The present invention methods and compositions effectively function to treat estrogen-dependent cancers, and particularly inhibit, destroy, and reverse the effects of of estrogendependent cancerous tumors through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, predetermined duration.
摘要翻译：实施的目的是选择性地抑制雌激素产生并在人体内提供雌激素作用。膳食补充剂包括加工的Morinda citrifolia产品，其用于抑制将雄激素转化成雌激素，抑制受体与雌激素结合的芳香酶或芳香酶，以及减少和/或调节雌激素的产生以及减少雌激素的量在体内生产并调节这种生产。膳食补充剂进一步提供雌激素作用。本发明的方法和组合物有效地用于治疗雌激素依赖性癌症，特别是抑制，破坏和逆转雌激素依赖性癌性肿瘤的作用通过引入体内（例如摄取）安全的预定剂量的药物配制或包含一种或多种加工的Morinda citrifolia产品的组合物用于安全的，预定的持续时间。

27. 发明申请

WO2004041186A3 ANTI-ANGIOGENESIS EFFECTS OF MORINDA CITRIFOLIA 审中-公开
标题翻译：莫桑比克的抗血管生成作用
公开(公告)号：WO2004041186A3
公开(公告)日：2004-07-15
申请号：PCT/US0334652
申请日：2003-10-31
申请人： MORINDA INC
发明人： PALU AFA KEHAATI , JENSEN CLAUDE JARAKAE , LEMUS DAVID , FUENZALIDA MARCELA , MIHOVILOVIC DANILO
IPC分类号： A61K20060101 , A61K36/746 , A61K35/78
CPC分类号： A61K36/746
摘要： The present invention features a method of inducing an anti-angiogenesis effect within a tumorous region in the body of a mammal, wherein the method comprises the steps of administering, to a patient, a formulation comprising processed Morinda Citrifolia, wherein the processed Morinda citrifolia blocks formation of new blood vessels within a tumorous region by inhibiting tubule elongation and endothelial cell migration. Blocking the growth factors of said endothelial cells within said tumorous region inhibits tubule elongation and endothelial cell migration. In a preferred embodiment, the processed Morinda citrifolia comprises fruit juice and puree juice in various concentrations.
摘要翻译：本发明的特征在于在哺乳动物体内的肿瘤区域内诱导抗血管生成作用的方法，其中所述方法包括向患者施用包含加工的Morinda Citrifolia的制剂的步骤，其中加工的Morinda citrifolia块通过抑制小管伸长和内皮细胞迁移，在肿瘤区域内形成新的血管。阻断所述肿瘤区内的所述内皮细胞的生长因子抑制小管延长和内皮细胞迁移。在优选的实施方案中，加工的Morinda citrifolia包含各种浓度的果汁和酱汁。

28. 发明申请

WO0245654A9 CANCER PREVENTATIVE EFFECT OF MORINDA CITRIFOLIA 审中-公开
标题翻译：癌症的预防效果
公开(公告)号：WO0245654A9
公开(公告)日：2004-02-12
申请号：PCT/US0146835
申请日：2001-12-05
申请人： MORINDA INC , SU CHEN XING , JENSEN CLAUD JARAKAE , STORY STEPHEN P , WANG MIAN-YING
发明人： SU CHEN XING , JENSEN CLAUD JARAKAE , STORY STEPHEN P , WANG MIAN-YING
IPC分类号： A23L1/30 , A23L2/02 , A61K36/60 , A61K36/746 , A61P35/00 , A61K35/78
CPC分类号： A61K36/746 , A23L2/02 , A23L33/105 , A61K2300/00
摘要： Providing and using a dietary supplement to inhibit cancer and/or to otherwise provide a cancer preventative effect at the initiation stage of carcinogenesis. The dietary supplement includes reconstituted Morinda citrifolia fruit juice from pure juice puree of French Polynesia, and may include other natural juices, such as a natural grape juice concentrate, natural blueberry juice concentrate, and/or another natural juice concentrate. The dietary supplement reduces the DMBA-DNA adduct formation in various organs, such as the heart, kidneys, lungs, and liver. The DNA adduct formation in various organs, such as the heart, kidneys, lungs, and liver. The DNA adduct formation furthers chemical carcinogenesis. The use of the dietary supplement protects cells and/or lipids from oxidative modification mediated by SAR. As such, the use of the dietary supplement contributes to cancer inhibitation.
摘要翻译：提供和使用膳食补充剂来抑制癌症和/或以其他方式在癌发生的起始阶段提供癌症预防效果。膳食补充剂包括来自法属波利尼西亚的纯果汁的重建的Morinda citrifolia果汁，并且可以包括其它天然果汁，例如天然葡萄汁浓缩物，天然蓝莓汁浓缩物和/或另一种天然浓缩汁。膳食补充剂减少了各种器官如心脏，肾脏，肺和肝脏中的DMBA-DNA加合物形成。各种器官中的DNA加合物形成，如心脏，肾脏，肺和肝脏。 DNA加合物形成进一步促进化学致癌作用。膳食补充剂的使用保护细胞和/或脂质免受SAR介导的氧化修饰。因此，使用膳食补充剂有助于癌症抑制。

29. 发明申请

WO2003099310A1 ANTIFUNGAL EFFECTS OF MORINDA CITRIFOLIA 审中-公开
标题翻译：莫里达咖喱的抗菌效果
公开(公告)号：WO2003099310A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/015912
申请日：2003-05-21
申请人： MORINDA, INC.
发明人： GERSON, Scott , PALU, Afa, Kehaati , ZHOU, Bing-Nan , SU, Chen , JENSEN, Claude, Jarakae , STORY, Stephen, P.
IPC分类号： A61K35/78
CPC分类号： A61K36/746
摘要： The present invention relates to antifungal and antibacterial activity of processed Morinda citrifolia products, as well as from various fractions of extracts from these processed products and the Morinda citrifolia L . plant, and related methods to determine mean inhibitory concentrations. In particular, the present invention relates to ethanol, methanol and ethyl acetate extracts from Morinda citrifolia L . and their inhibitory activities on common fungi and bacteria and the identification of mean inhibitory concentrations.
摘要翻译：本发明涉及加工的海巴戟天产品的抗真菌和抗菌活性，以及来自这些加工产品的提取物和Morinda citrifolia L.植物的各种级分，以及确定平均抑制浓度的相关方法。特别地，本发明涉及来自海巴戟天的乙醇，甲醇和乙酸乙酯提取物及其对常见真菌和细菌的抑制活性以及平均抑制浓度的鉴定。

30. 发明申请

WO0243664A2 REDUCING CELLULAR DAMAGE IN THE HUMAN BODY 审中-公开
标题翻译：减少人体内的细胞损伤
公开(公告)号：WO0243664A2
公开(公告)日：2002-06-06
申请号：PCT/US0147203
申请日：2001-12-03
申请人： MORINDA INC
发明人： SU CHEN XING , JENSEN CLAUDE JARAKAE , STORY STEPHEN PAUL
IPC分类号： A23L1/30 , A61K31/375 , A61K36/00 , A61K36/15 , A61K36/18 , A61K36/746 , A61K36/87 , A61P3/10 , A61P9/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P31/12 , A61P35/00 , A61P39/06 , A61P43/00 , A61K
CPC分类号： A61K36/746 , A23L33/105 , A61K36/15 , A61K36/87 , A61K2300/00
摘要： Providing and using a dietary supplement to reduce cellular damage within the human body. The dietary supplement includes reconstituted Morinda citrifolia fruit juice from pure juice puree of French Polynesia, and may include other natural juices, such as a natural grape juice concentrate, a natural blueberry juice concentrate, and/or another natural juice concentrate. The dietary supplement includes a combination of compounds that work at the cellular level to increase the positive functionality of cells in the body, including cell regeneration and cell function, to increase the ability of cells to absorb and utilize nutrients, such as vitamins and minerals, and to. Furthermore, the dietary supplement scavenges lipid hydroperoxides and superoxide anion free radicals within the body to reduce cellular damage.
摘要翻译：提供和使用膳食补充剂以减少人体内的细胞损伤。膳食补充剂包括来自法属波利尼西亚的纯果汁的重组的莫利达柠檬酸果汁，并且可以包括其它天然果汁，例如天然葡萄汁浓缩物，天然蓝莓汁浓缩物和/或另一种天然果汁浓缩液膳食补充剂包括在细胞水平上起作用以增加体内细胞的阳性功能的化合物的组合，包括细胞再生和细胞功能，以增加细胞吸收和利用营养物质如维生素和矿物质的能力，并。此外，膳食补充剂清除体内脂质氢过氧化物和超氧化物阴离子自由基，以减少细胞损伤。

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