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1. 发明申请

WO2004091545A3 SELECTIVELY INHIBITING ESTROGEN PRODUCTION AND PROVIDING ESTROGENIC EFFECTS IN THE HUMAN BODY 审中-公开
公开(公告)号：WO2004091545A3
公开(公告)日：2004-10-28
申请号：PCT/US2004/009129
申请日：2004-03-25
申请人： MORINDA, INC. , PALU, Afa, Kehaati
发明人： PALU, Afa, Kehaati , WANG, Mian, Ying , SU, Chen, Xing , WEST, Brett, Justin , WESTENDORF, Johannes, Joseph , JENSEN, Claude, Jarakae , STORY, Stephen, Paul
IPC分类号： A61K33/00
摘要： Implementation is directed to selectively inhibiting estrogen production and providing estrogenic effects in a human body. A dietary supplement includes a processed Morinda citrifolia product that is used to inhibit aromatase or aromatase enzymes that function to convert androgens to estrogens, inhibit receptors from binding with estrogen, and reduce and/or regulate estrogen production, as well as reduce the amount of estrogen produced within the body and regulating such production. The dietary supplement further provides estrogenic effects. The present invention methods and compositions effectively function to treat estrogen-dependent cancers, and particularly inhibit, destroy, and reverse the effects of of estrogendependent cancerous tumors through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, predetermined duration.

2. 发明申请

WO2004041186A2 ANTI-ANGIOGENESIS EFFECTS OF MORINDA CITRIFOLIA 审中-公开
标题翻译：桑叶的抗血管生成作用
公开(公告)号：WO2004041186A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034652
申请日：2003-10-31
申请人： MORINDA, INC.
发明人： PALU, Afa, Kehaati , JENSEN, Claude, Jarakae , LEMUS, David , FUENZALIDA, Marcela , MIHOVILOVIC, Danilo
IPC分类号： A61K
CPC分类号： A61K36/746
摘要： The present invention features a method of inducing an anti-angiogenesis effect within a tumorous region in the body of a mammal, wherein the method comprises the steps of administering, to a patient, a formulation comprising processed Morinda Citrifolia, wherein the processed Morinda citrifolia blocks formation of new blood vessels within a tumorous region by inhibiting tubule elongation and endothelial cell migration. Blocking the growth factors of said endothelial cells within said tumorous region inhibits tubule elongation and endothelial cell migration. In a preferred embodiment, the processed Morinda citrifolia comprises fruit juice and puree juice in various concentrations.
摘要翻译：本发明的特征在于在哺乳动物体内的肿瘤区域内诱导抗血管生成作用的方法，其中所述方法包括以下步骤：向患者施用包含处理过的其中加工的海巴戟天通过抑制小管延长和内皮细胞迁移阻断肿瘤区域内新血管的形成。阻断所述肿瘤区域内的所述内皮细胞的生长因子抑制小管延长和内皮细胞迁移。在一个优选的实施方案中，加工的巴戟天包含各种浓度的果汁和果泥汁。

3. 发明申请

WO2006050012A2 MORINDA CITRIFOLIA BASED COMPOSITIONS AND METHODS FOR INHIBITING XANTHINE OXIDASE 审中-公开
标题翻译：基于MORINDA CITRIFOLIA的组合物和抑制XANTHINE氧化酶的方法
公开(公告)号：WO2006050012A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038727
申请日：2005-10-26
申请人： MORINDA, INC.
发明人： PALU, Afa, Kehaati , SU, Chen , ZHOU, Bing-Nan , JENSEN, Claude, Jarakae , ASAY, Kim , STORY, Stephen, P.
IPC分类号： A61K36/45 , A61K36/73 , A61K36/746
CPC分类号： A61K36/73 , A61K36/45 , A61K36/746 , A61K2300/00
摘要： The present invention relates to the inhibition of xanthine oxidase. In particular, the present invention relates to systems and methods for utilizing Morinda citrifolia L. based compositions and methods to inhibit xanthine oxidase activity.
摘要翻译：本发明涉及黄嘌呤氧化酶的抑制。特别地，本发明涉及利用基于烟草柠檬酸的组合物和抑制黄嘌呤氧化酶活性的方法的系统和方法。

4. 发明申请

WO2005086834A3 METHODS AND COMPOSITIONS FOR REACTIVATING ACETYLCHOLINESTERASE 审中-公开
公开(公告)号：WO2005086834A3
公开(公告)日：2005-09-22
申请号：PCT/US2005/007662
申请日：2005-03-09
申请人： MORINDA, INC. , PALU, Afa, Kehaati , WEST, Brett , ZHOU, Bing-Nan , JENSEN, Jarakae , STORY, Stephen
发明人： PALU, Afa, Kehaati , WEST, Brett , ZHOU, Bing-Nan , JENSEN, Jarakae , STORY, Stephen
IPC分类号： A61K35/78
摘要： The present invention relates to methods and compositions for reactivating Acetylcholinesterase in living organisms using contents from the Morinda citrifolia L. plant. More particularly, the present invention relates to methods and compositions involving the reactivation of Acetylcholinesterase using fruit juice obtained from the Morinda citrifolia L. plant.

5. 发明申请

WO2005120538A1 MORINDA CITRIFOLIA-BASED FORMULATION 5-LOX AND 15-LOX 审中-公开
标题翻译：基于MORINDA CITRIFOLIA的配方5-LOX和15-LOX
公开(公告)号：WO2005120538A1
公开(公告)日：2005-12-22
申请号：PCT/US2004/019781
申请日：2004-06-18
申请人： MORINDA, INC.
发明人： PALU, Afa, Kehaati , ZHOU, Bing-Nan , SU, Chen , JENSEN, Claude, Jarakae , STORY, Stephen
IPC分类号： A61K35/78
CPC分类号： A23L2/02 , A23L33/105 , A61K36/746 , A61K2300/00
摘要： The present invention is directed to methods and formulations for inhibiting Lipoxygenase enzymes that function to biosynthesize or metabolize arachidonic acid into its intermediate Leukotriene constituents, as well as a method and formulation for treating and preventing diseases, including inflammatory diseases, and the symptoms associated with such diseases. The present invention methods and formulations effectively function as such through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, predetermined duration, wherein the processed Morinda citrifolia product may comprise one or more isolated active ingredients.
摘要翻译：本发明涉及用于抑制作用于将花生四烯酸生物合成或代谢为其中间白细胞三烯成分的脂氧合酶的方法和制剂，以及用于治疗和预防包括炎性疾病在内的疾病的方法和制剂，以及与之相关的症状疾病。本发明的方法和制剂通过引入身体（例如摄入）安全，预定剂量的与一种或多种经加工的Morinda citrifolia产品配制或包含一种或多种加工的Morinda citrifolia产品的安全，预定的持续时间，有效地起作用，其中加工的Morinda citrifolia产品可以包含一种或多种分离的活性成分。

6. 发明申请

WO2005086937A3 METHODS AND COMPOSITIONS FOR INHIBITING MONOAMINE OXIDASE AND CATECHOL-L-METHYLTRANSFERASE 审中-公开
公开(公告)号：WO2005086937A3
公开(公告)日：2005-09-22
申请号：PCT/US2005/008069
申请日：2005-03-09
申请人： MORINDA, INC. , PALU, Afa, Kehaati , ZHOU, Bing-Nan , JENSEN, Claude, Jarakae , STORY, Stephen
发明人： PALU, Afa, Kehaati , ZHOU, Bing-Nan , JENSEN, Claude, Jarakae , STORY, Stephen
IPC分类号： A01N65/00
摘要： The present invention relates to methods and compositions for inhibiting Monoamine Oxidase and/or Catechol-O-Methyltransferase in living organisms. More particularly, the present invention relates to methods and compositions involving the inhibition of Monoamine Oxidase and/or Catechol-O-Methyltransferase using processed Morinda citrifolia L. plant products.

7. 发明申请

WO2005091953A2 MORINDA CITRIFOLIA LEAF EXTRACT COMPOSITIONS AND METHODS OF OBTAINING THE SAME 审中-公开
标题翻译： MORINDA CITRIFOLIA LEAF萃取组合物及其获得方法
公开(公告)号：WO2005091953A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/006923
申请日：2005-03-04
申请人： MORINDA, INC. , ZHOU, Bing-Nan , PALU, Afa, Kehaati , SU, Chen , JENSEN, Claude, Jarakae , STORY, Stephen
发明人： ZHOU, Bing-Nan , PALU, Afa, Kehaati , SU, Chen , JENSEN, Claude, Jarakae , STORY, Stephen
CPC分类号： A61K36/746
摘要： Methods and compositions relating to leaf extracts obtained from removing liquids from relatively dry Morinda citrifolia leaves. Methods and compositions relating to a leaf serum created from combining leaf extract and fruit juice from the Morinda citrifolia L . plant. Methods and compositions relating to leaf extract compositions comprising one or more of the leaf extracts and leaf serums.
摘要翻译：与通过从相对干燥的Morinda citrifolia叶中除去液体获得的叶提取物相关的方法和组合物。与叶片提取物和来自Morinda citrifolia L.植物的果汁组合的叶片血清相关的方法和组合物。涉及包含一种或多种叶提取物和叶血清的叶提取物组合物的方法和组合物。

8. 发明申请

WO2003099310A1 ANTIFUNGAL EFFECTS OF MORINDA CITRIFOLIA 审中-公开
标题翻译：莫里达咖喱的抗菌效果
公开(公告)号：WO2003099310A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/015912
申请日：2003-05-21
申请人： MORINDA, INC.
发明人： GERSON, Scott , PALU, Afa, Kehaati , ZHOU, Bing-Nan , SU, Chen , JENSEN, Claude, Jarakae , STORY, Stephen, P.
IPC分类号： A61K35/78
CPC分类号： A61K36/746
摘要： The present invention relates to antifungal and antibacterial activity of processed Morinda citrifolia products, as well as from various fractions of extracts from these processed products and the Morinda citrifolia L . plant, and related methods to determine mean inhibitory concentrations. In particular, the present invention relates to ethanol, methanol and ethyl acetate extracts from Morinda citrifolia L . and their inhibitory activities on common fungi and bacteria and the identification of mean inhibitory concentrations.
摘要翻译：本发明涉及加工的海巴戟天产品的抗真菌和抗菌活性，以及来自这些加工产品的提取物和Morinda citrifolia L.植物的各种级分，以及确定平均抑制浓度的相关方法。特别地，本发明涉及来自海巴戟天的乙醇，甲醇和乙酸乙酯提取物及其对常见真菌和细菌的抑制活性以及平均抑制浓度的鉴定。

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