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21. 发明申请

WO2022040412A1 MULTI-MODAL IMAGING SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2022040412A1
公开(公告)日：2022-02-24
申请号：PCT/US2021/046660
申请日：2021-08-19
申请人： LI-COR, INC.
发明人： RAGATZ, Andrew , FIEDLER, Mark
IPC分类号： G01N21/15 , G01N21/85
摘要： Multi-modality imaging systems and methods for enabling controllable and/or automated switching between different imaging systems or modes. An imaging system includes a base plate having a first exposed region and a second region, a sample stage configured to hold a sample platform, and a first translation mechanism configured to translate the sample stage on the base plate along a first axis between a first position and a second position. In the first position the sample stage is positioned proximal to the first exposed region, and in the second position, the sample stage is positioned proximal to the second region. An illumination device is configured to illuminate a portion of the first exposed region, and a second translation mechanism is configured to translate the illumination device along a second axis substantially perpendicular to the first axis.

22. 发明申请

WO2019195464A1 AUTOMATED REFERENCE LIST BUILDER 审中-公开
公开(公告)号：WO2019195464A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/025642
申请日：2019-04-03
申请人： LI-COR, INC.
发明人： GRIESSBAUM, Frank , FRATINI, Gerardo , BURBA, George
IPC分类号： G06Q10/10 , G06F17/24
摘要： A device for managing a reference list. The device includes one or more processors, which alone or in combination are configured to facilitate performing: (a) running one or more applications; (b) selecting the reference list; (c) monitoring activities in the one or more applications to identify citable processes; (d) receiving citable information from the one or more applications based on the citable processes; (e) determining a type of citable information received; and (f) modifying the reference list based on the type of citable information received.

23. 发明申请

WO2019018393A1 SPECTRAL RESPONSE SYNTHESIS ON TRACE DATA 审中-公开
公开(公告)号：WO2019018393A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/042484
申请日：2018-07-17
申请人： LI-COR, INC.
发明人： HUMPHREY, Patrick G.
IPC分类号： G06K9/00
摘要： Systems and methods for detecting, decoupling and quantifying unresolved signals in trace signal data in the presence of noise with no prior knowledge of the signal characteristics (e.g., signal peak location, intensity and width) of the unresolved signals. The systems and methods are useful for analyzing any trace data signals having one or multiple constituent signals, including overlapping constituent signals, and particularly useful for analyzing data signals which often contain an unknown number of constituent signals with varying signal characteristics, such as peak location, peak intensity and peak width, and varying resolutions. A general signal model function is assumed for each unknown, constituent signal in the trace signal data.

24. 发明申请

WO2018200261A1 TOP-DOWN AND ROTATIONAL SIDE VIEW BIOPSY SPECIMEN IMAGER AND METHODS 审中-公开
公开(公告)号：WO2018200261A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/027978
申请日：2018-04-17
申请人： LI-COR, INC.
发明人： WANG, Han-Wei , MIDDENDORF, Lyle R.
IPC分类号： G06T1/00
摘要： Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.

25. 发明申请

WO2017156321A1 MULTIPLE LASER OPTICAL FEEDBACK ASSISTED CAVITY ENHANCED ABSORPTION SPECTOSCOPY SYSTEMS AND METHODS 审中-公开
标题翻译：多激光器光学反馈辅助腔增强的吸收光学镜系统和方法
公开(公告)号：WO2017156321A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021657
申请日：2017-03-09
申请人： LI-COR, INC.
发明人： KOULIKOV, Serguei
IPC分类号： G01J3/443 , G01N21/39
摘要： Systems and methods for detecting trace gases utilize a resonance optical cavity and one, two or more coherent light sources coupled to the cavity through one or more cavity coupling mirrors, whereby two or more optical cavities may share the same gas volume.
摘要翻译：用于检测痕量气体的系统和方法利用共振光学腔和通过一个或多个腔耦合反射镜耦合到腔的一个，两个或更多个相干光源，由此两个或更多个光学腔可以共享相同的气体量。

26. 发明申请

WO2017136284A1 CAPILLARY ELECTROPHORESIS INKJET DISPENSING 审中-公开
标题翻译：毛细管电泳喷墨分配
公开(公告)号：WO2017136284A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/015657
申请日：2017-01-30
申请人： LI-COR, INC.
发明人： FURTAW, Michael D. , LAMB, Donald T.
IPC分类号： H01J49/04 , H01J49/16 , B01D57/02 , G01N27/26 , G01N27/447
CPC分类号： G01N27/44739 , G01N27/44791
摘要： Devices, systems, and methods of using them are disclosed that position an end of a capillary electrophoresis tube within an internal tapered nozzle region of an inkjet print head or other microfluidic pump. The capillary electrophoresis tube can extend through an inlet of the microfluidic pump and leave space for a sheath liquid to enter the pump and mix with separated analytes eluted from the capillary electrophoresis tube. The small volume of mixed sheath liquid and analyte can then be jetted through the nozzle at a moving surface, either continuously or as discrete droplets. Relative positions on the surface can indicate separation distances of dispensed analytes.
摘要翻译：公开了使用它们的设备，系统和方法，其将毛细管电泳管的末端定位在喷墨印刷头或其他微流体泵的内部锥形喷嘴区域内。毛细管电泳管可以延伸穿过微流体泵的入口并且留出鞘液的空间以进入泵并与从毛细管电泳管洗脱的分离的分析物混合。然后可以将小体积的混合鞘液和分析物连续或作为离散液滴通过喷嘴在移动表面喷射。表面上的相对位置可以指示分配的分析物的分离距离。

27. 发明申请

WO2015183931A1 STABILIZED CHEMILUMINESCENT SYSTEM 审中-公开
标题翻译：稳定的CHEMILUMINESCENT系统
公开(公告)号：WO2015183931A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/032641
申请日：2015-05-27
申请人： LI-COR, INC.
发明人： KUNDU, Kousik , WANG, Ying , PADHYE, Nisha
IPC分类号： G01N21/76 , G01N33/53 , G01N33/535
CPC分类号： G01N33/573 , G01N33/533 , G01N33/582 , G01N2333/908
摘要： The present invention relate to formulations, systems, kits and methods for chemiluminescence assays to detect the catalytic activity of a peroxidase. The present invention provides formulations and methods for chemiluminescence reactions that have significantly improved signal duration, which signal lasts for hours.
摘要翻译：本发明涉及用于检测过氧化物酶的催化活性的化学发光测定的制剂，系统，试剂盒和方法。本发明提供具有明显改善的信号持续时间的化学发光反应的制剂和方法，该信号持续数小时。

28. 发明申请

WO2013044156A1 APPLICATION OF REDUCED DYES IN IMAGING 审中-公开
标题翻译：减少染色体在成像中的应用
公开(公告)号：WO2013044156A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056739
申请日：2012-09-21
申请人： LI-COR, INC. , KUNDU, Kousik , PADHYE, Nisha , VOLCHECK, William
发明人： KUNDU, Kousik , PADHYE, Nisha , VOLCHECK, William
IPC分类号： C07D403/08
CPC分类号： C09B23/164 , C07D209/08 , C09B23/0008 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B23/107 , G01N33/574 , G01N33/582
摘要： The present invention provides novel compounds and methods for hydrocyanines derived from near-infrared cyanine dyes, as reactive oxygen species probes in imaging. In certain embodiments, the present invention provides reduced dyes as substrates for ELISA and Western blots. In certain instances, the compounds are useful for detecting reactive oxygen species (ROS) probes for in vivo applications.
摘要翻译：本发明提供了新型化合物和衍生自近红外花青染料的氢氰酸的新型化合物和方法，作为成像中的活性氧探针。在某些实施方案中，本发明提供还原染料作为用于ELISA和Western印迹的底物。在某些情况下，该化合物可用于检测用于体内应用的活性氧（ROS）探针。

29. 发明申请

WO2012166954A2 SYSTEMS AND METHODS FOR ESTIMATING PHOTOSYNTHETIC CARBON ASSIMILATION 审中-公开
标题翻译：用于估计光合碳协同的系统和方法
公开(公告)号：WO2012166954A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/040255
申请日：2012-05-31
申请人： LI-COR, INC. , MC DERMITT, Dayle K. , MORGAN, Patrick B. , AVENSON, Tom
发明人： MC DERMITT, Dayle K. , MORGAN, Patrick B. , AVENSON, Tom
IPC分类号： G01N33/00 , G01N33/52 , G01N21/64
CPC分类号： G01N33/0098 , A01G7/02 , A01G9/18 , G01N21/3504 , G01N21/6486 , G01N2021/354 , G01N2021/635 , G01N2021/6493 , G01N2021/8466 , G01N2201/0627
摘要： Methods, devices, and systems for measuring carbon assimilation based on simultaneous or near-simultaneous measurements of chlorophyll fluorescence and stomatal conductance of plant. A sample containing chlorophyll, such as a plant leaf, is illuminated with light, e.g., in the form of a single saturating pulse or multiple pulses, and chlorophyll fluorescence and stomatal conductance of the chlorophyll sample are measured. A porometer or infra-red gas analyzer is used to measure stomatal conductance and a photodetector is used to measure fluorescence. A carbon assimilation value for the chlorophyll sample is determined using the measured chlorophyll fluorescence and the measured stomatal conductance.
摘要翻译：基于同时或近同时测量植物的叶绿素荧光和气孔导度来测量碳同化的方法，装置和系统。含有叶绿素（如植物叶）的样品用光照射，例如以单一饱和脉冲或多个脉冲的形式照射，并且测量叶绿素样品的叶绿素荧光和气孔导度。使用孔径计或红外气体分析仪来测量气孔导度，并使用光电探测器来测量荧光。使用测量的叶绿素荧光和测量的气孔导度确定叶绿素样品的碳同化值。

30. 发明申请

WO2012040439A3 GAS EXCHANGE SYSTEM FLOW CONFIGURATION 审中-公开
标题翻译：气体交换系统流量配置
公开(公告)号：WO2012040439A3
公开(公告)日：2012-06-14
申请号：PCT/US2011052724
申请日：2011-09-22
申请人： LI COR INC , JOHNSON MARK A , PARR ANDREW S , ECKLES ROBERT D
发明人： JOHNSON MARK A , PARR ANDREW S , ECKLES ROBERT D
IPC分类号： G01N21/37 , G01N33/00 , G01N33/24
CPC分类号： G01N33/0009 , B33Y70/00 , B33Y80/00 , G01N21/05 , G01N21/3504 , G01N33/004 , G01N33/0098 , G01N2021/8466
摘要： System flow path designs that minimize the impact of gas diffusion sources and sinks. By reducing the magnitude of parasitic sources and sinks, lower rates of photosynthesis and transpiration can be more accurately measured, e.g., without the need for extensive empirical compensation. According to one aspect, a gas exchange analysis system includes a sample chamber defining a measurement volume for analysis of a sample, the sample chamber having an inlet and an outlet, and a flow splitting mechanism located proximal to the sample chamber, the mechanism configured to split a gas flow received at an input port from a remote source to a first output port and to a second output port, wherein the first output port is coupled with the inlet of the sample chamber. The internal surface(s) of the chamber defining the measurement volume can be metal plated. The system also can include a source of gas coupled with the inlet of the sample chamber and a gas analyzer coupled with the outlet of the sample chamber and configured to measure a concentration of one or more gases exiting the chamber, whereby metal plated internal surface(s) of the chamber can reduce sorption of the one or more gases within the chamber, and a second gas analyzer coupled with the second output port of the flow splitting mechanism and configured to measure a concentration of the one or more gases. Advantageously, gas diffusion sources and sinks are reduced due to the proximity of the flow splitting mechanism with the sample chamber and gas analyzers as well as the metal plating.
摘要翻译：系统流路设计，尽量减少气体扩散源和水槽的影响。通过减少寄生源和汇的幅度，可以更准确地测量较低的光合作用和蒸腾速率，例如，不需要广泛的经验补偿。根据一个方面，一种气体交换分析系统包括：样本室，其限定用于分析样品的测量体积，所述样品室具有入口和出口;以及位于所述样品室附近的分流机构，所述机构被配置为将从输入端口接收的气流从远程源分解到第一输出端口和第二输出端口，其中第一输出端口与样品室的入口耦合。限定测量体积的室的内表面可以是金属镀覆的。该系统还可以包括与样品室的入口耦合的气体源和与样品室的出口耦合的气体分析器，并且被配置为测量离开室的一种或多种气体的浓度，由此金属镀覆的内表面 s）可以减少腔室内的一种或多种气体的吸附，以及与分流机构的第二输出端口耦合并被配置成测量一种或多种气体的浓度的第二气体分析器。有利的是，由于流动分离机构与样品室和气体分析仪以及金属镀层的接近，气体扩散源和水槽被减少。

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