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1. 发明申请

WO2021222015A1 SIMULTANEOUS TOP-DOWN AND ROTATIONAL SIDE-VIEW FLUORESCENCE IMAGER FOR EXCISED TISSUE 审中-公开
公开(公告)号：WO2021222015A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/028816
申请日：2021-04-23
申请人： LI-COR, INC.
发明人： WANG, Han-Wei , MIDDENDORF, Lyle R.
IPC分类号： G01N23/223 , G01N21/17 , G01N21/64 , G01N23/04 , G06F3/0354
摘要： An imager for simultaneously taking full color pictures and fluorescence images from the same perspectives, top-down and side views, is presented that uses multiple cameras looking at the same stage through a beamsplitter and light sources for each view. The imager is configured to work with a particular fluorophore, or at least a predetermined fluorescence excitation wavelength and emission wavelength. A broadband white light source projects through a shortpass or other filter with a cut-off wavelength either lower than or between the excitation and emission wavelengths. Another shortpass or other filter is in front of a color camera with a cut-off wavelength below that of the emission wavelength, while a monochrome fluorescence camera may or may not have additional filters to bring out the fluorescence. These filters may be built into a dichroic mirror of the beamsplitter. In addition, digital processing may boost frequencies in the color image that were dampened by the filters.

2. 发明申请

WO2020263803A1 DYNAMIC AND REAL-TIME CORRECTION OF DIFFERENTIAL MEASUREMENT OFFSETS IN A GAS ANALYSIS SYSTEM 审中-公开
公开(公告)号：WO2020263803A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039097
申请日：2020-06-23
申请人： LI-COR, INC.
发明人： WELLES, Jon , SAATHOFF, Aaron
IPC分类号： G01N21/3504 , G01N33/00 , G01N21/3518
摘要： Systems and method for automatically determining offset correction values in a differential measurement system, and for correcting measurement offsets between two measurement devices in the differential measurement system. A method for determining real-time offset corrections in a gas analysis system having first and second gas analyzers includes for each of a plurality of gas concentrations within a range of gas concentrations: a) supplying the concentration of gas to the first and second gas analyzers through first and second gas flow lines, respectively; b) measuring a first gas concentration value using the first gas analyzer; and c) measuring a second gas concentration value using the second gas analyzer. The method may also include determining an offset value between each corresponding first and second gas concentration value, and determining a functional relationship between the offset values and gas concentration measurements of the first gas analyzer.

3. 发明申请

WO2020146369A1 LASER LINE ILLUMINATION USING COMBINED SINGLE-MODE AND MULTI-MODE LASER SOURCES 审中-公开
公开(公告)号：WO2020146369A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/012559
申请日：2020-01-07
申请人： LI-COR, INC.
发明人： NICHOLLS, Irma , BOUZID, Ahmed , LESIAK, Christopher
IPC分类号： G02B27/10 , G02B3/00 , G02B26/10 , H01S5/40
摘要： Systems for combining multi-mode (MM) and single-mode (SM) illumination beams of differing wavelengths together and creating a uniform, multi-wavelength laser line at a sample plane with minimal or no loss of optical power. A system includes correction optics configured to reduce the beam waist size of the MM illumination beam to substantially the same size as the beam waist size of the SM illumination beam, and beam-combining optics configured to combine the SM illumination beam and the MM illumination beam into a combined illumination beam along a first light path.

4. 发明申请

WO2019213543A1 2-[2-[4-[BIS(2-SULFOETHYL)AMINO]PHENYL]ETHENYL]-1-BUTYL-3,3-DIMETHYL-3H-INDOLIUM HEMICYANINE DYES FOR THE DETECTION OF ANTIBODIES AND OTHER BIOMOLECULES 审中-公开
公开(公告)号：WO2019213543A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030631
申请日：2019-05-03
申请人： LI-COR, INC.
发明人： SANCHINI, Silvano , SKOPP, Rose , ELITZIN, Vassil , PADHYE, Nisha , URLACHER, Teresa
IPC分类号： C07D209/14 , C07D403/12 , C09B23/01 , C09B23/10 , G01N33/483
摘要： The present disclosure embodies hemicyanine dyes, methods, and kits that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting. The invention relates in particular to 2-[2-[4-[bis(2-sulfoethyl) amino]phenyl]ethenyl]-l-butyl-3,3-dimethyl-3H-indolium derivatives and related compounds as hemicyanine dyes for the detection of antibodies and other biomolecules.

5. 发明申请

WO2018031479A1 MULTI-SHEATH FLOW AND ON-CHIP TERMINATING ELECTRODE FOR MICROFLUIDIC DIRECT-BLOTTING 审中-公开
标题翻译：微流控直接印刷用多层流动和片式端接电极
公开(公告)号：WO2018031479A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/045774
申请日：2017-08-07
申请人： LI-COR, INC.
发明人： FURTAW, Michael D. , LAMB, Donald T. , MIDDENDORF, Lyle R.
IPC分类号： G01N27/447 , G01N30/72 , B01L3/00
CPC分类号： B01L3/502753 , B01L3/0268 , B01L3/5027 , B01L3/50273 , B01L3/502776 , B01L2200/0631 , B01L2200/0636 , B01L2300/06 , B01L2300/0681 , B01L2300/069 , B01L2300/0867 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , G01N1/405 , G01N27/44739 , G01N27/44756 , G01N27/44791
摘要： Devices and methods are provided for the separation and dispensing of material using a microfluidic separation column connected via an exit channel to one or more sheath flow channels. The flow of separated material through the separation column is at least partially driven by a voltage potential between a first electrode within the separation column and a terminating electrode within at least one of the sheath flow channels. The separation column, exit channel, sheath flow channels, and electrodes are all within a single monolithic chip. The presence of an on-chip terminating electrode allows for separated material to be entrained in the sheath fluids and ejected onto a surface that can be non-conductive. The presence of multiple sheath flows allows for sheath flow fluids to have different compositions from one another, while reducing the occurrence of sheath flow fluids entering the separation column.
摘要翻译：提供了使用通过出口通道连接到一个或多个鞘流通道的微流体分离柱来分离和分配材料的设备和方法。分离的物质通过分离柱的流动至少部分地由分离柱内的第一电极与至少一个鞘流动通道内的终端电极之间的电压驱动。分离柱，出口通道，鞘流通道和电极都在一个单片芯片内。片上端接电极的存在允许将分离的材料夹带在鞘液中并喷射到可以不导电的表面上。多鞘流的存在允许鞘液流体具有彼此不同的组成，同时减少鞘液流体进入分离柱的发生。

6. 发明申请

WO2017223378A1 COMPLEMENTARY COLOR FLASHING FOR MULTICHANNEL IMAGE PRESENTATION 审中-公开
标题翻译：用于多通道图像呈现的补色闪烁
公开(公告)号：WO2017223378A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038860
申请日：2017-06-22
申请人： LI-COR, INC.
发明人： WANG, Han-Wei
IPC分类号： G06T11/00
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/0646 , A61B5/0073 , A61B6/032 , A61B6/5247 , G01N1/30 , G06K2209/05 , G06T11/00 , G06T11/001 , G06T2207/30004 , G06T2210/41
摘要： Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.
摘要翻译：
提供了通过交替具有互补色彩的图像来突出显示合成图像中的特征的方法。具有感兴趣特征的图像用于生成一个或多个伪彩色图像。然后交替地显示一系列伪彩色图像和一个或多个附加伪彩色或原始彩色图像，使得一系列图像中的不同彩色区域容易被操作员识别。不同颜色的区域具有彼此互补的色调。这些方法对于使用两个或更多个成像模态和通道显示信息特别有用，例如对于某些医学应用的情况，其中将具有较深红色或蓝色脉管系统的粉红色或浅红色组织的自然光图像重叠与另一个功能图像。在这些情况下，功能图像中存在的特征可以在与来自另一个成像模式或通道的基础图像进行复合叠加显示时更容易被感知。

7. 发明申请

WO2017200801A1 X-RAY BIOPSY SPECIMEN IMAGER AND METHODS 审中-公开
标题翻译： X射线活检标本成像仪和方法
公开(公告)号：WO2017200801A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/031740
申请日：2017-05-09
申请人： LI-COR, INC.
发明人： WANG, Han-Wei
IPC分类号： A61B6/00 , G01N23/04 , G01N23/083 , B01L3/00 , A61B6/03 , A61B5/00
CPC分类号： G03B42/026 , A61B5/0071 , A61B6/032 , A61B6/035 , A61B6/4417 , A61B6/466 , A61B6/486 , A61B6/5205 , A61B6/5247 , A61B6/545 , A61B6/547 , G01N23/046 , G01N23/223 , G01N33/4833 , G01N2223/04 , G01N2223/041 , G01N2223/071 , G01N2223/309 , G01N2223/3306 , G01N2223/612 , G01N2223/6126 , G03B42/02
摘要： Methods and devices are disclosed for the tomographic imaging of a biological sample from almost all rotational perspectives in three-dimensional space and with multiple imaging modalities. A biological sample is positioned on an imaging stage that is capable of nearly full 360-degree rotation in at least one of two substantially orthogonal axes. Positioned about the stage is an X-ray imaging module enabling the recording of a series of images. A reflected light imaging module can also be positioned about the stage to enable recording of black and white or color white light images. A computer can use the images to construct three-dimensional models of the sample and to render images of the sample conveying information from one or more imaging channels.
摘要翻译：公开了用于来自三维空间中的几乎所有旋转视角和具有多个成像模态的生物样品的层析成像的方法和设备。生物样品位于成像台上，该成像台能够在两个基本上正交的轴中的至少一个中几乎完全360度旋转。定位在舞台上的是一个X射线成像模块，可以记录一系列图像。反射光成像模块也可以放置在舞台的周围，以便记录黑白或彩色白光图像。计算机可以使用这些图像来构建样本的三维模型并且呈现来自一个或多个成像通道的样本的图像传输信息。

8. 发明申请

WO2017184940A1 MULTIMODALITY MULTI-AXIS 3-D IMAGING 审中-公开
标题翻译：多模式多轴三维成像
公开(公告)号：WO2017184940A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028769
申请日：2017-04-21
申请人： LI-COR, INC.
发明人： WANG, Han-Wei
IPC分类号： G01N21/31 , G01B5/00 , G01N29/06 , G01N29/22 , G01N21/47 , G01N21/64 , G01N23/04 , G01N21/17
摘要： Methods and devices are disclosed for the imaging of a biological sample (106) from all rotational perspectives in three-dimensional space and with multiple imaging modalities. A biological sample (106) is positioned on an imaging stage (103) that is capable of full 360- degree rotation in at least one of two orthogonal axes (104,105). Positioned about the stage (103) are imaging modules (102,109,111) enabling the recording of a series of images in multiple modalities, including reflected visible light, fluorescence, X-ray, ultrasound, and optical coherence tomography. A computer can use the images to construct three-dimensional models of the sample (106) and to render images of the sample conveying information from one or more imaging channels. The rendered images can be displayed for an operator who can manipulate the images to present additional information or viewing angles of the sample (106). The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen (700).
摘要翻译：公开了用于从三维空间中的所有旋转视角和多个成像模态成像生物样本（106）的方法和设备。生物样本（106）位于能够在两个正交轴（104,105）中的至少一个轴上完全360度旋转的成像台（103）上。定位在台架（103）周围的是成像模块（102,109,111），其能够以多种模态记录一系列图像，包括反射的可见光，荧光，X射线，超声和光学相干断层扫描。计算机可以使用这些图像来构建样本（106）的三维模型并且呈现来自一个或多个成像通道的样本传送信息的图像。可以为可以操纵图像以呈现样本的附加信息或视角的操作员显示所呈现的图像（106）。图像处理可以通过使用可消毒或一次性触摸笔（700）输入的触摸手势来实现。

9. 发明申请

WO2016210340A1 FLUORESCENCE BIOPSY SPECIMEN IMAGER AND METHODS 审中-公开
标题翻译：荧光生物样本图像和方法
公开(公告)号：WO2016210340A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039382
申请日：2016-06-24
申请人： LI-COR, INC.
发明人： WANG, Han-Wei
IPC分类号： G01N15/14 , G01N21/25 , G01N21/64
CPC分类号： G01N21/6456 , G01N21/6486 , G06F3/03545 , G06F3/04845 , G06F3/04847 , G06F3/0485 , G06F3/04886 , G06T7/55 , G06T2207/10064 , G06T2207/30096 , G06T2207/30204 , H04N5/2251 , H04N5/2256
摘要： An imaging device is described that uses multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.
摘要翻译：描述了一种成像装置，其使用多个相机来将生物样品成像在由白色光沐浴的转台上或由于全身施用的染料而发荧光。在确定样品部分的3-D位置时，可以补偿远离激发光源的荧光。转盘转动并倾斜，以便拍摄足够的图像来准备样品的动画。在图形用户界面中，可以根据用户的手势，触摸，平板电脑倾斜或其他命令来停止，缩放和倾斜动画。图像处理可以是使用可消毒或一次性触摸笔输入的触摸手势。

10. 发明申请

WO2015013722A1 SYSTEMS AND METHODS FOR SETTING INITIAL DISPLAY SETTINGS 审中-公开
标题翻译：用于设置初始显示设置的系统和方法
公开(公告)号：WO2015013722A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/048505
申请日：2014-07-28
申请人： LI-COR, INC.
发明人： HUMPHREY, Patrick G.
IPC分类号： G06T5/00 , G06T5/40
CPC分类号： G06T5/008 , G06T5/007 , G06T5/40 , G06T2207/20024 , G06T2207/20028 , G06T2207/20182 , G06T2207/20208 , G09G5/10 , G09G2320/029 , G09G2320/066 , G09G2320/08
摘要： A method for applying a filter to data to improve data quality and/or reduce file size. In one example, a region of interest of an image is identified. A histogram is generated of pixel intensity values in the region of interest. The histogram is iteratively updated to focus (zoom) in on the highest peak in the histogram. A Gaussian curve is fitted to the updated histogram. A bilateral filter is applied to the images, where parameters of the bilateral filter are based on the parameters of the Gaussian curve.
摘要翻译：将过滤器应用于数据以提高数据质量和/或减小文件大小的方法。在一个示例中，识别图像的感兴趣区域。在感兴趣区域中生成像素强度值的直方图。直方图被迭代地更新，以便在直方图中的最高峰上对焦（缩放）。高斯曲线拟合到更新的直方图。双边滤波器应用于图像，其中双边滤波器的参数基于高斯曲线的参数。

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