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11. 发明申请

WO99020589A1 MEDICINAL USES OF PHENYLALKANOLS AND DERIVATIVES 审中-公开
标题翻译：苯丙醇和衍生物的药物用途
公开(公告)号：WO99020589A1
公开(公告)日：1999-04-29
申请号：PCT/AU1998/000870
申请日：1998-10-20
IPC分类号： A61K31/05 , A61K31/085 , A61K31/12 , C07C43/23 , C07C45/29 , C07C45/62 , C07C45/66 , C07C45/67 , C07C45/71 , C07C45/72 , C07C45/73 , C07C45/74 , C07C49/245 , C07C49/255 , C07C49/84 , C07D317/54 , C07C49/248 , C07C39/18 , C12P7/22
CPC分类号： C07D317/54 , A61K31/05 , A61K31/085 , A61K31/12 , C07C43/23 , C07C45/292 , C07C45/62 , C07C45/66 , C07C45/673 , C07C45/71 , C07C45/72 , C07C45/73 , C07C45/74 , C07C49/245 , C07C49/255 , C07C49/84 , C07C47/575 , C07C47/277
摘要： A compound of formula (I), a pharmaceutically acceptable derivative thereof, wherein Ph is a phenyl radical R1 is H, OH, OC1-4alkyl, NO2; R2 is OH, OC1-4alkyl, OC=OC1-4alkyl or OC=OPh where the Ph can be optionally substituted by halogen, C1-3 alkyl or NO2; R1 and R2 along with the two carbon atoms of the phenyl ring to which they are attached can combine to form a 5 or 6 membered heterocyclic ring comprising 1 or 2 heteroatoms selected from O, S or N; R3 is an optionally substituted hydrocarbyl radical; R4 is H, CH3, OH or =O; when R4 is =O, then the carbon to which R4 is attached is not bonded to H; W is C(=O)-CH2, CH=CH-, CH2CO, CH(OH)-CH2, C(CH3)(OH)CH2, CH2CH(OH), CH2C(CH3)OH, CO, CHOH, C(CH3)(OH), CH2, CH2CH2; X is -CH-OH, C(CH3)OH, CH2, CH(CH3) or -C=O; Y is -CH-OH, C(CH3)OH, CH2, CH(CH3) or -C=O; provided that one of W, X or Y has an OH group.
摘要翻译：式（I）化合物，其药学上可接受的衍生物，其中Ph是苯基R1是H，OH，OC1-4烷基，NO2; R 2是OH，OC 1-4烷基，OC = OC 1-4烷基或OC = OPh，其中Ph可以任选地被卤素，C 1-3烷基或NO 2取代; R1和R2与它们所连接的苯环的两个碳原子一起可以结合形成包含1或2个选自O，S或N的杂原子的5或6元杂环; R3是任选取代的烃基; R4是H，CH3，OH或= O; 当R 4为= O时，R 4所连接的碳不与H结合; W是C（= O）-CH 2，CH = CH-，CH 2 CO，CH（OH）-CH 2，C（CH 3）（OH）CH 2，CH 2 CH（OH），CH 2 C（CH 3）OH，CO，CHOH，C（ CH3）（OH），CH2，CH2CH2; X是-CH-OH，C（CH 3）OH，CH 2，CH（CH 3）或-C = O; Y是-CH-OH，C（CH 3）OH，CH 2，CH（CH 3）或-C = O; 条件是W，X或Y中的一个具有OH基团。

12. 发明申请

WO2002072522A1 IMPROVED PROCESS FOR THE PREPARATION OF 6-METHYLHEPTANONE 审中-公开
标题翻译：改进6-甲基吗啉的制备方法
公开(公告)号：WO2002072522A1
公开(公告)日：2002-09-19
申请号：PCT/EP2002/000928
申请日：2002-01-30
申请人： DEGUSSA AG
发明人： KRILL, Steffen , KRETZ, Stephan , SCHNEIDER, Achim
IPC分类号： C07C45/73
CPC分类号： C07C49/04 , C07C45/73
摘要： The present invention relates to an improved process for the preparation of methylheptanone and corresponding homologous methyl ketones, in particular phytone and tetrahydrogeranyl acetone, by aldolization of isovaleraldehyde or Prenal or of the corresponding aldehydes with acetone in the presence of a polyhydric alcohol or, in the simplest instance water itself, containing the aldolization catalyst and the heterogeneous hydrogenation catalyst, wherein non-polar auxiliary solvents are utilized in order to increase the yield and selectivity.
摘要翻译：本发明涉及一种改进的制备甲基庚酮和相应的同系甲基酮，特别是植物酮和四氢笨香基丙酮的方法，通过在多元醇的存在下将异戊醛或Prenal或相应的醛与丙酮醛化，或在最简单的实例水本身，含有醛醇化催化剂和非均相氢化催化剂，其中使用非极性的辅助溶剂以提高产率和选择性。

13. 发明申请

WO02022542A1 PROCESS FOR THE PRODUCTION OF MIBK USING CD TECHNOLOGY 审中-公开
标题翻译：使用CD技术生产MIBK的方法
公开(公告)号：WO02022542A1
公开(公告)日：2002-03-21
申请号：PCT/US2001/028417
申请日：2001-09-13
IPC分类号： C07C45/00 , C07C45/73 , C07C45/45
CPC分类号： C07C45/00 , C07C45/73 , Y02P20/127 , C07C49/04
摘要： A process for producing methyl isobutyl ketone includes introducing acetone into a catalytic distillation. Some of the acetone is converted to mesityl alcohol ('MSO'), water and, optionally, diacetone alcohol ('DAA') and/or other by-products. A product stream comprising MSO, water, and, optionally, DAA, other by-products and/or unreacted acetone is withdrawn from the catalytic distillation zone. When the product stream includes DAA, other by-products and/or unreacted acetone, it is treated in a treatment zone to remove at least some of the DAA, other by-products and/or the unreacted acetone therefrom. The products stream and hydrogen are fed into a reaction zone in which MSO present in the product stream and hydrogen react to form methyl isobutyl ketone ('MIBK'). A MIBK rich product stream is withdrawn from this reaction zone.
摘要翻译：一种生产甲基异丁基酮的方法包括将丙酮引入催化蒸馏。一些丙酮被转化为均三甲醇（“MSO”），水和任选的双丙酮醇（“DAA”）和/或其它副产物。从催化蒸馏区取出包含MSO，水和任选的DAA，其它副产物和/或未反应的丙酮的产物流。当产物流包含DAA，其它副产物和/或未反应的丙酮时，在处理区中处理至少一些DAA，其他副产物和/或未反应的丙酮。将产物流和氢气进料到产物流中存在MSO的反应区，氢反应形成甲基异丁基酮（“MIBK”）。从该反应区中取出富含MIBK的产物流。

14. 发明申请

WO02008164A1 SECONDARY C10-18 SURFACTANT ALCOHOLS 审中-公开
标题翻译： SECONDARY C10-C18醇的表面活性剂
公开(公告)号：WO02008164A1
公开(公告)日：2002-01-31
申请号：PCT/EP2001/008197
申请日：2001-07-16
IPC分类号： B01F17/02 , B01F17/14 , B01F17/38 , C07B61/00 , C07C29/145 , C07C29/17 , C07C31/125 , C07C41/03 , C07C43/11 , C07C45/50 , C07C45/62 , C07C45/73 , C07C45/74 , C07C49/04 , C07C305/06 , C07C305/10 , C07F9/09 , C07F9/11 , C08G65/28 , C11D1/14 , C11D1/16 , C11D1/29 , C11D1/34 , C11D1/72
CPC分类号： C11D1/72 , C07C29/175 , C07C31/125 , C07C41/03 , C07C45/50 , C07C45/62 , C07C45/73 , C07C45/74 , C07C305/06 , C07C305/10 , C07F9/091 , C07F9/11 , C11D1/146 , C11D1/29 , C11D1/345 , C07C47/02 , C07C47/21 , C07C43/11
摘要： The invention relates to secondary C10 to C18 surfactant alcohols of the general formula (I), wherein R represents methyl or ethyl and R' represents a linear or branched alkyl group with 6-13 C atoms, excepting 5-ethyl-2-nonanol and 6-ethyl-3-decanol, in addition to fatty alcohol alkoxylates, alkyl phosphates, alkyl sulphates, alkyl ether phosphates and alkyl ether sulphates. The secondary C10 to C18 surfactant alcohols can be produced by a simple aldol condensation of linear or branched saturated or unsaturated C7-C14 aldehydes, excepting 2-ethyl hexanal, with acetone or methyl ethyl ketone and the subsequent hydrogenation of the condensation product. In the preferred method, the aldol condensation is heterogenically catalysed under hydrogenation conditions and the saturated ketone that has been formed is subsequently hydrogenated.
摘要翻译：次级C10至C18的通式（I）的表面活性剂的醇，其中R是甲基或乙基，R“是直链或支链烷基与6-13个碳原子的，比其它5-乙基-2-壬醇和6-乙基-3- 癸醇，以及这些可用的脂肪醇，烷基磷酸盐，硫酸盐，烷基醚磷酸盐和硫酸盐的混合物。到表面活性剂C18醇二次C10可以通过简单的线性的醛醇缩合来制备或支链饱和或不饱和的C 7 -C 14 - 醛，除了2-乙基己醛，准备丙酮或甲基乙基酮和氢化的缩合产物。的方法，其中所述醛醇缩合下多相催化氢化条件下进行的，并形成随后氢化饱和酮是优选的。

15. 发明申请

WO01082923A1 ESTROGEN RECEPTOR MODULATORS 审中-公开
标题翻译：雌激素受体调节剂
公开(公告)号：WO01082923A1
公开(公告)日：2001-11-08
申请号：PCT/US2001/004831
申请日：2001-02-14
IPC分类号： C07D295/08 , A61K31/05 , A61K31/122 , A61K31/138 , A61K31/15 , A61K31/192 , A61K31/222 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4453 , A61K31/5375 , A61P3/04 , A61P9/00 , A61P13/02 , A61P15/00 , A61P19/08 , A61P19/10 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C39/42 , C07C45/28 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/68 , C07C45/69 , C07C45/71 , C07C45/72 , C07C45/73 , C07C45/74 , C07C45/75 , C07C49/747 , C07C49/755 , C07C49/757 , C07C59/90 , C07C69/63 , C07C205/45 , C07C211/61 , C07C211/63 , C07C251/44 , C07C255/47 , C07D295/092 , C07D295/10 , C07D307/46 , C07D333/22 , A61K31/19 , A61K31/445 , C07C39/23 , C07C49/543 , C07C49/553 , C07C57/03 , C07C251/32 , C07D211/06 , C07D333/04
CPC分类号： C07D295/088 , C07C39/42 , C07C45/28 , C07C45/46 , C07C45/63 , C07C45/65 , C07C45/68 , C07C45/69 , C07C45/71 , C07C45/72 , C07C45/73 , C07C45/74 , C07C45/75 , C07C49/747 , C07C49/755 , C07C59/90 , C07C205/45 , C07C251/44 , C07C255/47 , C07C2603/18 , C07D333/22 , C07C49/84
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
摘要翻译：本发明涉及其化合物及其衍生物，其合成及其作为雌激素受体调节剂的用途。本发明的化合物是雌激素受体的配体，因此可用于治疗或预防与雌激素功能相关的各种病症，包括：骨丢失，骨折，骨质疏松症，软骨退化，子宫内膜异位症，子宫肌瘤病，热特别是乳腺，子宫和前列腺中的LDL胆固醇水平升高，心血管疾病，认知功能障碍，脑退行性疾病，再狭窄，乳腺发育不良，血管平滑肌细胞增殖，肥胖症，失禁和癌症。

16. 发明申请

WO01027061A1 CONTINUOUS METHOD FOR PRODUCTION OF CINNAMALDEHYDE AND DIHYDROCINNAMALDEHYDE DERIVATIVES 审中-公开
标题翻译：连续工艺用于生产和肉桂dihydrocinnamaldehyde衍生品
公开(公告)号：WO01027061A1
公开(公告)日：2001-04-19
申请号：PCT/EP2000/009918
申请日：2000-10-10
IPC分类号： C07B61/00 , C07C45/62 , C07C45/73 , C07C45/74 , C07C47/232 , C07C47/228
CPC分类号： C07C45/74 , C07C45/62 , C07C45/73 , C07C47/228 , C07C47/232
摘要： The invention relates to a continuous method for production of cinnamaldehyde or cinnamaldehyde derivatives comprising continuous reaction of benzaldehyde derivatives with alkanals in the presence of bases and, optionally, as the final step, continuous hydrogenation in a recirculating reactor in the presence of a suspended catalyst and hydrogen to give dihydrocinnamaldehyde derivatives.
摘要翻译：本发明涉及一种用于生产肉桂醛的肉桂醛衍生物或通过苯甲醛与在碱存在链烷醛连续反应，并且如果在悬浮催化剂和氢的存在下，循环反应器适当后续连续氢化，得到dihydrocinnamaldehyde衍生物的连续方法。

17. 发明申请

WO1999014177A1 MANUFACTURE OF METHYL ISOBUTYL AND DIISOBUTYL KETONE 审中-公开
标题翻译：甲基异丁基酮和二异丁基酮的制备
公开(公告)号：WO1999014177A1
公开(公告)日：1999-03-25
申请号：PCT/US1997016340
申请日：1997-09-16
申请人： UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION , BASSETT, Mark, R. , KEEN, Brian, T.
发明人： UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION
IPC分类号： C07C45/73
CPC分类号： C07C45/73 , C07C49/04
摘要： A method for the catalytic manufacture of MIBK and DIBK from DMK and/or IPA (optionally in the presence of water) while obtaining improved control over the ratio of DIBK to MIBK in the product stream, comprising reacting, in the presence of an aldol condensation catalyst, a reactant mixture comprising DMK and/or IPA and an effective amount of an additional reactant selected from the group consisting of mesityl oxide (MSO) and methyl isobutyl carbinol (MIBC) and mixtures thereof. Reaction temperature may also be changed to affect the product ratio obtained. The preferred catalyst is copper-based. An overall excess of hydrogen is desired, and this may be achieved by introducing or recycling hydrogen, and/or by balancing exothermic and endothermic reactions. By this invention, the product ratio of DIBK to MIBK is altered such that, as DMK and/or IPA conversion is increased, a lesser amount of DIBK than normal is produced, resulting in improved ability to control the product ratio of these materials.
摘要翻译：一种从DMK和/或IPA（任选地在水存在下）催化制备MIBK和DIBK的方法，同时获得对产物流中DIBK与MIBK比例的改进控制，包括在醛醇缩合物催化剂，包含DMK和/或IPA的反应物混合物和有效量的选自意大利氧化物（MSO）和甲基异丁基甲醇（MIBC）的其它反应物及其混合物。也可以改变反应温度以影响获得的产物比例。优选的催化剂是铜基。需要全部过量的氢气，并且这可以通过引入或循环氢气和/或通过平衡放热和吸热反应来实现。通过本发明，改变了DIBK与MIBK的产物比例，使得当DMK和/或IPA转化率增加时，产生比正常量少的DIBK，从而提高了控制这些材料的产物比例的能力。

18. 发明申请

WO2009017970A1 PROCESS FOR THE PRODUCTION OF MIBC AND/OR IBHK PLUS TMN USING COPPER-BASED CATALYSTS 审中-公开
标题翻译：使用基于铜的催化剂生产MIBC和/或IBHK PLUS TMN的方法
公开(公告)号：WO2009017970A1
公开(公告)日：2009-02-05
申请号：PCT/US2008070262
申请日：2008-07-17
申请人： DOW GLOBAL TECHNOLOGIES INC , SAWREY JEFFREY SCOTT
发明人： SAWREY JEFFREY SCOTT
IPC分类号： C07C29/145 , C07C29/38 , C07C45/73
CPC分类号： C07C29/145 , C07C45/73 , C07C49/04 , C07C31/125
摘要： MIBC and/or a mixture of IBHK and TMN is produced from MlBK by a process comprising the step of contacting MIBK with hydrogen under condensation/hydrogenation/dehydration reactive conditions and in the presence of a catalytic amount of a Cu-based condensation/hydrogenation/dehydration catalyst. The relative amounts of MIBC and the mixture of IBHK and TMN are controlled by the reaction temperature, a lower temperature, e.g., 130C, favoring MIBC alone, and a higher temperature, e.g., 200C, favoring a mixture of MIBC and IBHK plus TMN.
摘要翻译： MIBC和/或IBHK和TMN的混合物由MlBK通过包括在缩合/氢化/脱水反应条件下和在催化量的Cu基缩合/氢化/脱氢反应条件存在下将MIBK与氢接触的步骤制备，脱水催化剂。 MIBC和IBHK和TMN的混合物的相对量由反应温度，较低温度（例如130℃，单独使用MIBC）以及较高温度（例如200℃）控制，有利于MIBC和IBHK加TMN的混合物。

19. 发明申请

WO2007038440B1 METHOD TO MAKE METHYL ISOBUTYL KETONE AND DIISOBUTYL KETONE 审中-公开
标题翻译：制备甲基异丁基酮和二异丁基酮的方法
公开(公告)号：WO2007038440B1
公开(公告)日：2007-05-31
申请号：PCT/US2006037266
申请日：2006-09-26
申请人： UNION CARBIDE CHEM PLASTIC , DOW GLOBAL TECHNOLOGIES INC , SAWREY JEFFREY S , WEGMAN RICHARD W
发明人： SAWREY JEFFREY S , WEGMAN RICHARD W
IPC分类号： C07C45/73 , C07C45/74 , C07C49/04
CPC分类号： C07C45/68 , B01J23/44 , B01J23/868 , C07C45/62 , C07C45/66 , C07C45/72 , C07C45/73 , C07C49/04 , C07C49/203 , C07C49/17
摘要： An improved method for the manufacture of MIBK and DIBK from DMK and/or IPA, by reacting, in the presence of an aldol condensation catalyst, a gaseous mixture comprising hydrogen and DMK and/or IPA. The improvement is the use of a reaction pressure greater than 207 kPa (30 psig) to increase the ratio of MIBK to DIBK. In addition a method for the manufacture of MIBK and DIBK by reacting, in the presence of an aldol condensation catalyst, a gaseous mixture consisting essentially of DMK and/or IPA and optionally water.
摘要翻译：通过在醇醛缩合催化剂存在下，使包含氢气和DMK和/或IPA的气体混合物反应，由DMK和/或IPA制备MIBK和DIBK的改进方法。改进是使用大于207kPa（30psig）的反应压力来增加MIBK与DIBK的比例。此外，通过在醇醛缩合催化剂存在下使基本上由DMK和/或IPA和任选的水组成的气体混合物反应来制造MIBK和DIBK的方法。

20. 发明申请

WO2006072785A2 BASE STABLE IONIC LIQUIDS 审中-公开
标题翻译：基本稳定的离子液体
公开(公告)号：WO2006072785A2
公开(公告)日：2006-07-13
申请号：PCT/GB2006000021
申请日：2006-01-04
申请人： UNIV BELFAST , EARLE MARTYN JOHN , FROHLICH UTE , HUQ SUSANNE , KATDARE SUHAS , LUKASIK RAFAL MARCIN , BOGEL EWA , PLECHKOVA NATALIA VLADIMIROVNA , SEDDON KENNETH RICHARD
发明人： EARLE MARTYN JOHN , FROHLICH UTE , HUQ SUSANNE , KATDARE SUHAS , LUKASIK RAFAL MARCIN , BOGEL EWA , PLECHKOVA NATALIA VLADIMIROVNA , SEDDON KENNETH RICHARD
IPC分类号： B01J31/02 , C07C45/66 , C07C45/67 , C07C45/72 , C07C45/73 , C07C45/74 , C07C211/63 , C07C215/40 , C07C217/08 , C07C221/00 , C07C225/12 , C07D211/14 , C07D231/12 , C07D487/04
CPC分类号： B01J31/0288 , B01J31/0202 , B01J31/0204 , B01J31/0224 , B01J31/0225 , B01J31/0227 , B01J31/0237 , B01J31/0277 , B01J31/0278 , B01J31/0279 , B01J31/0282 , B01J31/0284 , B01J31/0285 , B01J31/0298 , B01J2231/10 , B01J2231/20 , B01J2231/30 , B01J2231/341 , B01J2231/342 , B01J2231/346 , B01J2231/348 , B01J2231/40 , B01J2231/4261 , B01J2231/50 , B01J2231/60 , B01J2231/70 , B01J2531/90 , C07C45/66 , C07C45/67 , C07C45/72 , C07C45/73 , C07C45/74 , C07C211/63 , C07C215/40 , C07C217/08 , C07C221/00 , C07C2601/14 , C07D211/14 , C07D231/12 , C07D487/04 , Y02P20/542 , Y02P20/582 , C07C49/637 , C07C49/203 , C07C49/647 , C07C49/603 , C07C49/597 , C07C49/17 , C07C49/493 , C07C49/497 , C07C49/403 , C07C225/12
摘要： The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.
摘要翻译：本发明涉及新型碱稳定离子液体及其作为化学反应中的溶剂的用途，特别是碱催化的化学反应和包括使用强碱的反应。

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