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11. 发明申请

WO1997028465A1 SUSCEPTIBILITY MATCHED NMR MICROSCOPY MICROCOILS 审中-公开
标题翻译：可见性匹配NMR显微镜
公开(公告)号：WO1997028465A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001348
申请日：1997-01-28
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , PECK, Timothy, L. , OLSON, Dean, L. , SWEEDLER, Jonathan, V. , WEBB, Andrew, G. , MAGIN, Richard, L.
IPC分类号： G01V03/00
CPC分类号： G01R33/56536 , G01R33/302 , G01R33/34053 , G01R33/341 , G01R33/5604
摘要： An apparatus and method for compensation of magnetic susceptibility variation in NMR microspectroscopy detection microcoils. NMR detection microcoils are formed with side-by-side windings (18) in order to approximate a uniform cylindrical sheet coil. The wire may have a thin layer of insulation in order to prevent shorting between adjacent turns, or (if the wire diameter is small enough) uninsulated wire may be wound with the adjacent turns touching without fear of shorting between coil turns. Additionally, a susceptibility matching medium (40), such as a perfluorinated hydrocarbon, may be placed around the microcoil to minimize susceptibility-induced variations in the B0 magnetic field (10).
摘要翻译： NMR显微光谱检测微线圈磁化率变化的装置和方法。 NMR检测微线圈由并排绕组（18）形成，以便接近均匀的圆柱形片状线圈。导线可以具有薄的绝缘层，以防止相邻匝之间的短路，或者（如果导线直径足够小），非绝缘线可以在相邻匝之间缠绕而不用担心线圈匝之间的短路。此外，诸如全氟化烃的敏感性匹配介质（40）可以放置在微线圈周围以最小化磁化率诱导的B0磁场（10）中的变化。

12. 发明申请

WO2017011393A1 MAGNETIC RESONANCE SPECTROMETER 审中-公开
标题翻译：磁共振光谱仪
公开(公告)号：WO2017011393A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/041760
申请日：2016-07-11
申请人： STC.UNM , ACOSTA, Victor , JARMOLA, Andrejs , BUDKER, Dmitry , BOUGAS, Lykourgos
发明人： ACOSTA, Victor , JARMOLA, Andrejs , BUDKER, Dmitry , BOUGAS, Lykourgos
IPC分类号： G01N24/08 , G01N24/10 , C30B33/08
CPC分类号： G01R33/323 , C30B33/08 , G01N24/08 , G01N24/10 , G01R33/302 , G01R33/441 , G01R33/46 , G01R33/60
摘要： Technologies relating to a magnetic resonance spectrometer are disclosed. The magnetic resonance spectrometer may include a doped nanostructured crystal. By nanostructuring the surface of the crystal, the sensor-sample contact area of the crystal can be increased. As a result of the increased sensor-sample contact area, the output fluorescence signal emitted from the crystal is also increased, with corresponding reductions in measurement acquisition time and requisite sample volumes.
摘要翻译：公开了与磁共振光谱仪有关的技术。磁共振光谱仪可以包括掺杂的纳米结构晶体。通过纳米结晶的表面，可以提高晶体的传感器样品接触面积。由于增加的传感器 - 样品接触面积，从晶体发出的输出荧光信号也增加，相应地降低了测量采集时间和必要的样品体积。

13. 发明申请

WO2016045888A1 EINRICHTUNG ZUR NMR-ANALYSE VON SUBSTANZEN IN EINER PROBE, ATEMGASANALYSEGERÄT, KRAFTSTOFFSENSOR UND VERFAHREN 审中-公开
标题翻译： DEVICE FOR物质在一个样品NMR分析，呼吸气体分析装置，燃料传感器和方法
公开(公告)号：WO2016045888A1
公开(公告)日：2016-03-31
申请号：PCT/EP2015/069143
申请日：2015-08-20
申请人： ROBERT BOSCH GMBH
发明人： LUTZ, Theresa , EINSELE, Florian , LUCKERT, Katrin , ROELVER, Robert
IPC分类号： G01N24/08 , G01R33/32 , A61B5/08 , G01N33/22 , G01R33/30 , G01N24/10 , G01R33/24 , B01L3/00
CPC分类号： G01N24/08 , A61B5/082 , A61B5/097 , G01N21/645 , G01N21/6486 , G01N24/10 , G01N33/22 , G01N33/497 , G01N2021/6471 , G01R33/24 , G01R33/26 , G01R33/302 , G01R33/31 , G01R33/323
摘要： Bei einer Einrichtung (40) zur Analyse von Substanzen in einer Probe auf der Basis einer Messung von magnetischen Kernspinresonanzen umfasst die Einrichtung Mittel (47) zur Erzeugung eines Magnetfeldes. Die Einrichtung (40) ist dadurch gekennzeichnet, dass zur Detektion von Magnetresonanzen, die durch die Erzeugung des Magnetfeldes in der Probe induziert werden, wenigstens ein Magnetfeldsensor vorgesehen ist, der wenigstens eine sensitive Komponente (45) mit Diamantstrukturen umfasst, wobei die Diamantstrukturen Stickstoff-Vakanz-Zentren aufweisen.
摘要翻译：在用于核磁共振的测定的基础上的样品中物质的分析的装置（40），该装置包括用于产生磁场的装置（47）。所述装置（40），其特征在于，磁场传感器提供了一种用于检测样品中诱导的磁场的产生磁共振至少包含具有金刚石结构的至少一个敏感元件（45），其中，所述金刚石结构的氮有空位中心。

14. 发明申请

WO2014149692A3 MEDICAL FLUID SENSORS AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：医用流体传感器及相关系统和方法
公开(公告)号：WO2014149692A3
公开(公告)日：2014-12-18
申请号：PCT/US2014020378
申请日：2014-03-04
申请人： FRESENIUS MED CARE HLDG INC
发明人： JONES ROSS PETER , CHOPRA PRANAV , MENZIES RUPERT , TUCKWELL MARK DAVID , CRNKOVICH MARTIN JOSEPH , JENSEN LYNN , KALASKAR SHASHIKANT DATTATRAYA
IPC分类号： A61B5/055 , A61M1/16 , A61M1/36 , G01N24/08 , G01R33/46
CPC分类号： G01N24/08 , A61B5/055 , A61B5/14546 , A61M1/1607 , A61M1/1609 , A61M1/3609 , A61M1/3621 , A61M2205/12 , A61M2205/3317 , A61M2205/70 , A61M2230/20 , G01R33/302 , G01R33/34053 , G01R33/383
摘要： This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a method includes reading an indicia of a medical fluid cartridge to determine a volume of a fluid passageway of the medical fluid cartridge indicated by the indicia, receiving radio frequency energy generated by excited atoms in medical fluid in the fluid passageway of the medical fluid cartridge, and determining a concentration of a substance in the medical fluid based on the determined volume of the fluid passageway of the medical fluid cartridge indicated by the indicia and the received radio frequency energy generated by the excited atoms in the medical fluid in the fluid passageway of the medical fluid cartridge.
摘要翻译：本公开涉及医疗流体传感器及相关系统和方法。在某些方面，一种方法包括读取医疗流体筒的标记以确定由标记指示的医疗流体筒的流体通道的体积，接收由流体通道中的医疗流体中的激发原子产生的射频能量以及基于由所述标记指示的所述医疗流体筒的所述流体通道的所述确定体积和由所述医疗流体筒中的所述医疗流体中的所述激发原子产生的所接收射频能量来确定所述医疗流体中的物质的浓度医用流体筒的流体通道。

15. 发明申请

WO2014011940A3 MINIATURIZED MOLECULAR INTERROGATION AND DATA SYSTEM 审中-公开
标题翻译：小型化分子间信息处理和数据系统
公开(公告)号：WO2014011940A3
公开(公告)日：2014-07-31
申请号：PCT/US2013050165
申请日：2013-07-11
申请人： NATIVIS INC
发明人： BUTTERS BENNETT M , BUTTERS JOHN T
IPC分类号： G01R33/24
CPC分类号： G01R33/032 , G01N27/72 , G01N37/005 , G01R33/26 , G01R33/302 , G01R33/326
摘要： A system for analyzing signals produced from a sample is described, where the system includes at least one magnetometer, where the magnetometer is capable of detecting magnetic fields produced by a sample. The magnetometer is positioned proximate to the sample, and is miniaturized (e.g. has a size less than 6 cm per side). A noise producing component is configured to uniformly produce noise surrounding the sample and the magnetometer, where the noise produced is capable of inducing stochastic resonance in the sample to amplify characteristic signals of the sample. At least one shielding structure electromagnetically shields the sample and the first magnetometer from external electromagnetic radiation
摘要翻译：描述了用于分析从样本产生的信号的系统，其中系统包括至少一个磁力计，其中磁力计能够检测由样本产生的磁场。磁力计靠近样品定位，并且小型化（例如，每边尺寸小于6cm）。噪声产生部件被配置为均匀地产生围绕样本和磁强计的噪声，其中产生的噪声能够引起样本中的随机共振以放大样本的特征信号。至少一个屏蔽结构电磁屏蔽样本和第一磁力计免受外部电磁辐射

16. 发明申请

WO2012054639A3 NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES 审中-公开
标题翻译：用于快速检测分析物的NMR系统和方法
公开(公告)号：WO2012054639A3
公开(公告)日：2013-07-04
申请号：PCT/US2011056936
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC , LOWERY THOMAS JAY JR , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
发明人： LOWERY THOMAS JAY JR , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： G01V3/00
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
摘要翻译：本发明的特征在于用于检测分析物的系统和方法及其在治疗和诊断疾病中的用途。

17. 发明申请

WO2012159896A1 DIAMOND SENSORS, DETECTORS, AND QUANTUM DEVICES 审中-公开
标题翻译：钻石传感器，探测器和量子设备
公开(公告)号：WO2012159896A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/058682
申请日：2012-05-10
申请人： ELEMENT SIX LIMITED , TWITCHEN, Daniel, James , MARKHAM, Matthew, Lee
发明人： TWITCHEN, Daniel, James , MARKHAM, Matthew, Lee
IPC分类号： G01N24/10 , G01R33/60 , C30B29/04 , H01L21/04 , G06N99/00 , B82Y10/00 , G01R33/24 , G01R33/30
CPC分类号： H01L29/1602 , B82Y10/00 , C30B29/04 , C30B29/64 , C30B31/22 , C30B33/08 , G01N24/10 , G01R33/24 , G01R33/302 , G01R33/60 , G06N99/002 , H01L21/0405 , H01L29/157 , H01L29/167
摘要： A thin plate of synthetic single crystal diamond material, the thin plate of synthetic single crystal diamond material having: a thickness in a range 100 nm to 50 μιη; a concentration of quantum spin defects greater than 0.1 ppb (parts-per-billion); a concentration of point defects other than the quantum spin defects of below 200 ppm (parts-per-million); and wherein at least one major face of the thin plate of synthetic single crystal diamond material comprises surface termination species which have zero nuclear spin and/or zero electron spin.
摘要翻译：合成单晶金刚石材料的薄板，合成单晶金刚石材料的薄板具有：厚度在100nm至50μΩ的范围内; 量子自旋缺陷的浓度大于0.1ppb（十亿分之一）; 量子自旋缺陷以外的点缺陷浓度低于200ppm（百万分之一）; 并且其中所述合成单晶金刚石材料薄板的至少一个主面包括具有零核自旋和/或零电子自旋的表面终止物质。

18. 发明申请

WO2012118442A1 BIOSENSOR, PALM-SIZED DEVICE AND METHOD BASED ON MAGNETIC RESONANCE RELAXOMETRY 审中-公开
标题翻译：生物传感器，PALM尺寸的设备和基于磁共振放大的方法
公开(公告)号：WO2012118442A1
公开(公告)日：2012-09-07
申请号：PCT/SG2012/000056
申请日：2012-02-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PENG, Weng Kung , HAN, Jongyoon , CHEN, Lan
发明人： PENG, Weng Kung , HAN, Jongyoon
IPC分类号： A61B5/055 , G01R33/20
CPC分类号： G01R33/448 , A61B5/055 , G01N24/08 , G01R33/302 , G01R33/3808 , G01R33/383 , G01R33/465 , G01R33/4828 , G01R33/50 , G01R33/543 , G01R33/546
摘要： In accordance with one aspect of this disclosure, there is provided a device for performing magnetic resonance relaxometry. The device comprises a radio-frequency spectrometer comprising at least one field-programmable gate array chip; a power amplifier electrically connected with the radio-frequency spectrometer and amplifying an electrical output of the radio-frequency spectrometer, thereby producing an amplified electrical signal comprising between about 0.1 Watts and about 10 Watts power; a duplexer configured to isolate the radio-frequency spectrometer from the amplified electrical signal during a receiving mode of the device; a radio-frequency detection probe configured to transmit radio-frequency electromagnetic radiation to excite nuclei under resonance during a transmission mode of the device, the radio-frequency detection probe comprising a detection coil comprising an inner diameter of less than about 1 millimeter; and at least one magnet supplying an external magnetic field to a detection region of the radio-frequency detection probe, the external magnetic field being less than about 3 Tesla.
摘要翻译：根据本公开的一个方面，提供了一种用于执行磁共振弛豫测量的装置。该装置包括一个包括至少一个现场可编程门阵列芯片的射频光谱仪; 功率放大器，其与所述射频光谱仪电连接并放大所述射频光谱仪的电输出，从而产生包括约0.1瓦至约10瓦功率之间的放大电信号; 双工器，被配置为在所述设备的接收模式期间将所述射频频谱仪与放大的电信号隔离; 射频检测探头，被配置为在所述设备的传输模式期间传输射频电磁辐射以在谐振下激发核，所述射频检测探针包括包含小于约1毫米的内径的检测线圈; 以及向所述射频检测探针的检测区域提供外部磁场的至少一个磁体，所述外部磁场小于约3特斯拉。

19. 发明申请

WO2012054638A3 NMR SYSTEMS AND METHODS FOR THE DETECTION OF ANALYTES 审中-公开
标题翻译： NMR系统和检测分析物的方法
公开(公告)号：WO2012054638A3
公开(公告)日：2012-07-05
申请号：PCT/US2011056933
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC , LOWERY THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
发明人： LOWERY THOMAS JAY , AUDEH MARK JOHN , BLANCO MATTHEW , CHEPIN JAMES FRANKLIN , DEMAS VASILIKI , DHANDA RAHUL , FRITZEMEIER MARILYN LEE , KOH ISAAC , KUMAR SONIA , NEELY LORI ANNE , MOZELESKI BRIAN , PLOURDE DANIELLA LYNN , RITTERSHAUS CHARLES WILLIAM , WELLMAN PARRIS
IPC分类号： C12Q1/68
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
摘要翻译：本发明描述了用于检测分析物的系统和方法，以及它们在疾病治疗和诊断中的用途。

20. 发明申请

WO2012054588A3 CONDUIT-CONTAINING DEVICES AND METHODS FOR ANALYTE PROCESSING AND DETECTION 审中-公开
标题翻译：用于分析处理和检测的包含装置和方法
公开(公告)号：WO2012054588A3
公开(公告)日：2012-07-05
申请号：PCT/US2011056865
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC , LOWREY THOMAS JAY , WELLMAN PARRIS S , MCDONOUGH JOHN , CHEPIN JAMES FRANKLIN , RITTERSHAUS CHARLES WILLIAM , DEMAS VASILIKI , SKELLEY ALISON
发明人： LOWREY THOMAS JAY , WELLMAN PARRIS S , MCDONOUGH JOHN , CHEPIN JAMES FRANKLIN , RITTERSHAUS CHARLES WILLIAM , DEMAS VASILIKI , SKELLEY ALISON
IPC分类号： C12M1/34
CPC分类号： G01R33/465 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448
摘要： This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
摘要翻译：本发明的特征在于用于分析物处理和检测的装置和方法，以及使用这些方法，例如在疾病的治疗和诊断中或确定病原体的存在。

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