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11. 发明申请

WO2004045503A2 IMPROVED HYDROPHILIC MONOLITHIC COLUMNS FOR SEPARATION OF SACCHARIDE MIXTURES 审中-公开
标题翻译：改进的亲水性单层柱分离糖化混合物
公开(公告)号：WO2004045503A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/034089
申请日：2003-10-24
申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. , QUE, Amy, H. , NOVOTNY, Milos, V.
发明人： QUE, Amy, H. , NOVOTNY, Milos, V.
IPC分类号： A61K
CPC分类号： B01J20/261 , B01J20/265 , B01J20/285 , B01J20/291 , B01J2220/54 , B01J2220/82 , G01N2030/285 , G01N2030/528
摘要： Polar, monolithic CEC columns having an amine and/or cyano functional stationary phase are used to separate complex mixtures of saccharides. Using the positive-ion mode of detection for neutral saccharides, detection conditions were optimized to low-femtomole sensitivities with the use of an ion trap mass spectrometer. The described column technology provides a universal system for separating a wide range of carbohydrates: mono- and oligosaccharides with the intact reducing end, as well as saccharide alditols.
摘要翻译：使用具有胺和/或氰基官能固定相的极性单片CEC柱来分离糖类的复杂混合物。使用中性糖的正离子检测模式，使用离子阱质谱仪将检测条件优化为低飞摩尔灵敏度。所描述的色谱柱技术提供了一种通用的分离多种碳水化合物的系统：具有完整还原端的单糖和寡糖以及糖醛糖醇。

12. 发明申请

WO2002063288A1 MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置
公开(公告)号：WO2002063288A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/002927
申请日：2002-01-31
申请人： STAATS, Sau, Lan, Tang
发明人： STAATS, Sau, Lan, Tang
IPC分类号： G01N27/26
CPC分类号： B01L3/0268 , B01J2219/0036 , B01L3/0241 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2200/021 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0822 , B01L2300/0874 , B01L2300/0887 , B01L2400/027 , B01L2400/0421 , B01L2400/0481 , B01L2400/0487 , B81B2201/058 , B81C1/00119 , B81C2201/019 , C07K1/24 , C40B60/14 , G01N27/44773 , G01N27/44782 , G01N27/44791 , G01N30/6026 , G01N30/6095 , G01N30/90 , G01N30/92 , G01N35/1074 , G01N2030/285 , G01N2035/1039 , H01J49/04 , G01N30/463
摘要： Microfluidic devices (7) that form layered structures provide a liquid handling interface with external devices as well as reduce consumption of sample and buffer in analytical operations. These microfluidic devices (7) are suitable for operations designed for lab-on-a-chip functions. The microfluidic devices (7) accomplish sample injection in a single channel (6) without intersecting channels on the same plane. These devices (7) may be formed through injection-molding fabrication methods.
摘要翻译：形成分层结构的微流体装置（7）提供与外部装置的液体处理界面，并减少分析操作中样品和缓冲液的消耗。这些微流体装置（7）适用于为片上实验室功能而设计的操作。微流体装置（7）在单个通道（6）中实现样品注入，而不在同一平面上相交通道。这些装置（7）可以通过注射成型制造方法形成。

13. 发明申请

WO02056991A2 SYSTEMS AND METHODS FOR PERFORMING ELECTROKINETIC CHROMATOGRAPHY 审中-公开
标题翻译：用于执行电动色谱的系统和方法
公开(公告)号：WO02056991A2
公开(公告)日：2002-07-25
申请号：PCT/US0201259
申请日：2002-01-16
申请人： ARQULE INC
发明人： GOETZINGER WOLFGANG K , HONG CAI
IPC分类号： G01N27/447 , G01N30/28 , G01N30/34 , B01D15/00
CPC分类号： G01N30/34 , G01N27/44747 , G01N2030/285
摘要： Reagents and methods for performing electrokinetic chromatography are provided. The reagents of the invention comprise at least one organic acid and at least one organic base, and are substantially free of inorganic ions.
摘要翻译：提供了用于进行电动色谱的试剂和方法。本发明的试剂包含至少一种有机酸和至少一种有机碱，并且基本上不含无机离子。

14. 发明申请

WO01051163A1 CHROMATOGRAPHIC AND ELECTROPHORETIC SEPARATION OF CHEMICALS USING ELECTRICALLY CONDUCTIVE POLYMERS 审中-公开
标题翻译：使用电导体聚合物的化学品的色谱和电泳分离
公开(公告)号：WO01051163A1
公开(公告)日：2001-07-19
申请号：PCT/US2001/000973
申请日：2001-01-11
IPC分类号： B01D15/20 , B01D15/36 , B01D69/14 , B01D71/40 , B01D71/72 , B01J20/281 , G01N27/447 , G01N30/28 , G01N30/50 , B01D15/08
CPC分类号： B01D15/20 , B01D15/36 , B01D69/141 , B01D71/40 , B01D71/72 , B01J20/281 , B01J2220/54 , G01N27/44747 , G01N27/44752 , G01N30/48 , G01N30/50 , G01N2030/285 , G01N30/34 , G01N30/96
摘要： A separation system comprising a stationary phase, a double stranded conductive polymer system contacting the stationary phase and means to place a mobile phase carrying a component to be separated from the mobile into contacting relationship with the polymer system whereby the component is captured by the polymer. The double stranded polymer is comprised of a conjugated polymer and a polyelectrolyte.
摘要翻译：一种分离系统，其包括固定相，与固定相接触的双股导电聚合物体系，以及将携带要从所述移动体分离的组分的流动相放置成与所述聚合物体系成接触关系的装置，由此所述组分被所述聚合物捕获。双链聚合物由共轭聚合物和聚电解质组成。

15. 发明申请

WO01037960A1 PRECISE ELECTROKINETIC DELIVERY OF MINUTE VOLUMES OF LIQUID(S) 审中-公开
标题翻译：精密电子液体输送量（S）
公开(公告)号：WO01037960A1
公开(公告)日：2001-05-31
申请号：PCT/US2000/031570
申请日：2000-11-17
IPC分类号： B01L3/02 , C40B60/14 , F04B17/00 , F04B19/00 , G01N30/28 , G01N30/32 , B01D15/08
CPC分类号： B01L3/0244 , B01J2219/00371 , B01J2219/00378 , C40B60/14 , F04B17/00 , F04B19/006 , G01N2030/285 , G01N2030/326
摘要： Femtoliter to milliliter volumes of one or a plurality of different liquids are accurately dispensed electrokinetically without any direct electrical contact with such liquid(s). This is accomplished with apparatus which creates an electric field over dispensing receptacles to discharge such liquid(s) into receiver reservoirs or scientific apparatus. Two electrically-conductive plates are insulated from each other so that a field polarizes the liquid and forces movement without faradaic processes or joule heating. One of the plates is charged, whereas the other is grounded. Liquid to be dispensed is placed between the two plates and is dispensed on applying the charge to the charged plate.
摘要翻译：将一毫升体积的一种或多种不同液体的薄荷体电动地精确地分配，而不会与这种液体直接电接触。这是通过在分配容器上产生电场以将这种液体排放到接收器储存器或科学装置中的装置来实现的。两个导电板彼此绝缘，使得场对液体进行极化，并且迫使运动没有法拉第过程或焦耳加热。其中一个板是充电的，而另一个是接地的。要分配的液体放置在两个板之间，并且在将电荷施加到带电板上时被分配。

16. 发明申请

WO00049396A1 ELECTROKINETIC CONCENTRATION OF CHARGED MOLECULES 审中-公开
标题翻译：充电分子的电化学浓度
公开(公告)号：WO00049396A1
公开(公告)日：2000-08-24
申请号：PCT/US2000/004616
申请日：2000-02-22
IPC分类号： B01J4/04 , B01J19/00 , B01J19/24 , G01N1/40 , G01N27/447 , G01N30/00 , G01N30/28 , G01N27/26
CPC分类号： G01N30/00 , B01J4/04 , B01J19/2475 , G01N1/40 , G01N27/44743 , G01N2030/0035 , G01N2030/285
摘要： A method for separating and concentrating charged species from uncharged or neutral species regardless of size differential. The method uses reversible electric field induced retention (135 and 130) of charged species, that can include molecules and molecular aggregates such as dimers, polymers, multimers, colloids, micelles, and liposomes, in volumes and on surfaces of porous materials (120). The retained charged species are subsequently quantitatively removed from the porous material by a pressure driven flow that passes through the retention volume and is independent of direction, thus, a multi-directional flow field is not required. Uncharged species pass through the system unimpeded thus effecting a complete separation of charged and uncharged species and making possible concentration factors greater than 1000-fold.
摘要翻译：一种用于从不带电荷或中性物质分离和浓缩带电物质的方法，而不考虑大小差异。该方法在多孔材料的体积和表面上使用电荷种类的可逆电场诱导保留（135和130），其可以包括分子和分子聚集体，例如二聚体，聚合物，多聚体，胶体，胶束和脂质体（120）。随后通过通过保持体积并且不依赖于方向的压力驱动流从多孔材料中定量地除去保留的带电物质，因此不需要多方向流场。不带电荷的物质无阻碍地通过系统，从而完全分离带电荷和不带电荷的物质，并使得可能的浓度因子大于1000倍。

17. 发明申请

WO1997033152A1 METHOD AND DEVICE FOR DETERMINING THE MOLECULAR DIFFUSION COEFFICIENT IN A POROUS MEDIUM 审中-公开
标题翻译：用于确定多孔介质中分子扩散系数的方法和装置
公开(公告)号：WO1997033152A1
公开(公告)日：1997-09-12
申请号：PCT/BE1997000026
申请日：1997-03-04
申请人： STUDIECENTRUM VOOR KERNENERGIE, INSTELLING VAN OPENBAAR NUT , MOORS, Hugo
发明人： STUDIECENTRUM VOOR KERNENERGIE, INSTELLING VAN OPENBAAR NUT
IPC分类号： G01N15/08
CPC分类号： G01N15/082 , G01N30/00 , G01N30/89 , G01N2030/285
摘要： Device for measuring the molecular diffusion coefficient, characterized in that it contains a holder (1-2) of non-conductive material for the porous medium (4), a buffer receptacle (5) on two ends of the holder (1-2) situated opposite one another, two electrodes (6 and 7), namely one in each buffer receptacle, and a source to generate a potential gradient (9) between the electrodes (6 and 7). The method is characterized in that a potential gradient is applied to an amount of the porous medium, so that the diffusion process is accelerated.
摘要翻译：用于测量分子扩散系数的装置，其特征在于，其包含用于多孔介质（4）的非导电材料的保持器（1-2），在所述保持器（1-2）的两端上的缓冲容器（5）位于彼此相对的位置，两个电极（6和7），即每个缓冲容器中的一个，以及在电极（6和7）之间产生电位梯度（9）的源。该方法的特征在于，对一定量的多孔介质施加电位梯度，从而加速扩散过程。

18. 发明申请

WO1997003351A1 METHOD AND SILICATE COMPOSITION FOR CONDITIONING SILICA SURFACES 审中-公开
标题翻译：用于调节二氧化硅表面的方法和硅酸盐组合物
公开(公告)号：WO1997003351A1
公开(公告)日：1997-01-30
申请号：PCT/US1996011400
申请日：1996-07-10
申请人： THE PERKIN-ELMER CORPORATION , DEMOREST, David, M. , MORING, Stephen, E. , CHIESA, Claudia
发明人： THE PERKIN-ELMER CORPORATION
IPC分类号： G01N27/447
CPC分类号： G01N27/44752 , G01N30/6052 , G01N2030/285
摘要： Disclosed is a method for increasing the electroosmotic flow rate available for a silica surface. In the method, there is provided an electrophoretic channel which is defined by one or more silica surfaces. The surface(s) are contacted with an alkaline aqueous solution containing a solubilized silicate-monovalent metal complex in an amount effective to increase the acidity of the silica surfaces(s), as evidenced by a reduction in the average bulk pKa of the surface(s). The achieved increase in acidity is greater than would be obtained using an otherwise identical solution lacking said silicate. In one preferred embodiment, the monovalent metal used in the solution is Li , Na , or K . Also disclosed is a method for increasing the acidity of a silica surface, by contacting the surface with an alkaline aqueous solution of the type noted above.
摘要翻译：公开了一种增加可用于二氧化硅表面的电渗流速的方法。在该方法中，提供了由一个或多个二氧化硅表面限定的电泳通道。表面与含有溶解的硅酸盐 - 一价金属络合物的碱性水溶液以有效增加二氧化硅表面的酸度的量接触，这通过表面的平均体积pKa的降低来证明（ S）。实现的酸度增加大于使用其它相同的不含所述硅酸盐的溶液所获得的增加。在一个优选实施方案中，溶液中使用的一价金属是Li +，Na +或K +。还公开了通过使表面与上述类型的碱性水溶液接触来提高二氧化硅表面的酸度的方法。

19. 发明申请

WO2008061222A2 METHOD AND SYSTEM FOR SEPARATING ANALYTES 审中-公开
标题翻译：用于分离分析的方法和系统
公开(公告)号：WO2008061222A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084940
申请日：2007-11-16
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , NUROK, David , NOVOTNY, Allyson, Jennifer , STACHOWIAK, Timothy , SVEC, Frantisek
发明人： NUROK, David , NOVOTNY, Allyson, Jennifer , STACHOWIAK, Timothy , SVEC, Frantisek
IPC分类号： G01N30/32
CPC分类号： G01N30/92 , B01D15/38 , B01J20/261 , B01J20/285 , B01J2220/82 , G01N27/44747 , G01N2030/285 , G01N2030/906
摘要： A method and device for performing chromatography includes placing a monolithic polymer layer in contact with a liquid mobile phase. The monolithic polymer layer may be neutral, positively charged, or negatively charged. A first electrode and second electrode are coupled to the monolithic polymer layer. An electrical potential is created between the first electrode and the second electrode. In some embodiments, the monolithic polymer layer may be placed in a sealed chamber, which may have a pressure greater than atmospheric pressure. Additionally, in some embodiments, the mobile phase is advanced through the monolithic polymer layer via one of a number of forced flow techniques.
摘要翻译：用于执行色谱的方法和装置包括将单片聚合物层放置成与液体流动相接触。单块聚合物层可以是中性的，带正电的或带负电荷的。第一电极和第二电极连接到单片聚合物层。在第一电极和第二电极之间产生电势。在一些实施例中，单片聚合物层可以放置在密封室中，该密封室可以具有大于大气压的压力。另外，在一些实施方案中，通过多种强制流动技术中的一种使流动相前进通过单块聚合物层。

20. 发明申请

WO2004101151A1 SAMPLE PREPARATION FOR PARALLEL CHROMATOGRAPHY 审中-公开
标题翻译：用于平行色谱的样品制备
公开(公告)号：WO2004101151A1
公开(公告)日：2004-11-25
申请号：PCT/US2004/014148
申请日：2004-05-07
申请人： NANOSTREAM, INC. , O'CONNOR, Stephen, D. , DANTSKER, Eugene , KARP, Christoph, D. , LEE, Mike, S. , VAJJHALA, Surekha
发明人： O'CONNOR, Stephen, D. , DANTSKER, Eugene , KARP, Christoph, D. , LEE, Mike, S. , VAJJHALA, Surekha
IPC分类号： B01L3/00
CPC分类号： B01L3/5025 , B01L3/502715 , B01L3/502753 , B01L3/565 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N30/10 , G01N30/461 , G01N30/466 , G01N30/6043 , G01N30/6047 , G01N30/606 , G01N30/6095 , G01N30/88 , G01N2030/085 , G01N2030/146 , G01N2030/285 , G01N2030/565 , G01N2030/8881 , G01N30/06
摘要： Systems and methods are provided for preparing samples for chromatographic separations and then chromatographically separating the prepared samples, preferably in a high-throughput fashion utilizing multiple parallel first (fluid) processing regions in fluid communication with multiple parallel second (fluid) processing regions wherein the each second processing region includes a chromatography column. One or more common fluid supplies may be utilized in each of the sample preparation and separation steps to minimize the number of requisite fluid connections and external components such as pumps, reservoirs, pulse dampers, flow controllers, and the like.
摘要翻译：提供了用于制备用于色谱分离的样品的系统和方法，然后以优选以高通量方式色谱分离制备的样品，利用与多个平行的第二（流体）处理区域流体连通的多个平行的第一（流体）处理区域，其中，第二处理区域包括色谱柱。可以在每个样品制备和分离步骤中使用一种或多种常见的流体供应，以使需要的流体连接和外部组件（例如泵，储存器，脉冲阻尼器，流量控制器等）的数量最小化。

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