会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 16. 发明申请
    • PROCESS FOR PREPARING (2R,3S)-3-(SUBSTITUTED OR UNSUBSTITUTED PHENYL)GLYCIDAMIDE COMPOUNDS BY ASYMMETRIC AMIDATION
    • 通过不对称氨基酸制备(2R,3S)-3-(取代或未取代的苯基)甘氨酰胺化合物的方法
    • WO99007875A1
    • 1999-02-18
    • PCT/JP1998/003453
    • 1998-08-04
    • C07D281/10C07D303/48C12P17/02C12P41/00
    • C12P17/02C07D281/10C07D303/48C12P41/006
    • A novel process for preparing (2R,3S)-3-(substituted or unsubstituted phenyl)glycidamide compounds, characterized by reacting a racemic trans-3-(substituted or unsubstituted phenyl)glycidic ester compound with ammonia or an amine compound in the presence of an enzyme having a capability of asymmetrically amidating glycidic ester compounds to amidate the (2R,3S)-isomer, and separating and harvesting the resultant (2R,3S)-amide compound from the reaction solution; and a process for preparing (2R,3S)-1,5-benzothiazepine derivatives useful as a pharmaceutical, by reacting the (2R,3S)-glycidamide compound prepared above with a 2-aminothiophenol derivative and subjecting the product to ring closure.
    • 一种制备(2R,3S)-3-(取代或未取代的苯基)缩水甘油酰胺化合物的新方法,其特征在于使外消旋反式-3-(取代或未取代的苯基)缩水甘油酯化合物与氨或胺化合物在 具有不对称酰氨基化缩水甘油酯化合物以使(2R,3S) - 异构体酰胺化的能力,并从反应溶液中分离和收获所得(2R,3S) - 酰胺化合物的酶; 以及通过使上述制备的(2R,3S) - 缩水甘油酰胺化合物与2-氨基苯硫酚衍生物反应并使产物闭环来制备可用作药物的(2R,3S)-1,5-苯并硫氮杂衍生物的方法。