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11. 发明申请

WO01032212A1 DRUGS, DRINKS OR FOODS 审中-公开
标题翻译：药物，饮料或食品
公开(公告)号：WO01032212A1
公开(公告)日：2001-05-10
申请号：PCT/JP2000/007372
申请日：2000-10-23
IPC分类号： A23F3/16 , A23L1/30 , A23L1/39 , A23L2/52 , A61K9/00 , A61K31/352 , A61K31/353 , A61P5/00 , A61P43/00 , C07D311/60 , C07D311/62 , A61K45/00
CPC分类号： C07D311/60 , A23F3/163 , A23L2/52 , A23L23/00 , A23L33/105 , A23V2002/00 , A61K9/0095 , A61K31/352 , A61K31/353 , C07D311/62 , A23V2250/214
摘要： Remedies or preventives for diseases caused by the binding of agonists (endocrine disruptors, etc.) to the estrogen receptor, characterized by containing, as the active ingredient, antagonists such as catechins (for example, epigallocatechin gallate) having the antagonism to the estrogen receptor agonists.
摘要翻译：激动剂（内分泌干扰物等）与雌激素受体的结合引起的疾病的治疗或预防措施，其特征在于含有拮抗雌激素受体的拮抗剂如儿茶素类（例如表没食子儿茶素没食子酸酯）作为活性成分激动剂。

12. 发明申请

WO99058496A1 NOVEL SUBSTITUTED CYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型取代的环状化合物，其制备方法和含有它们的药物组合物
公开(公告)号：WO99058496A1
公开(公告)日：1999-11-18
申请号：PCT/FR1999/001101
申请日：1999-05-10
IPC分类号： C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00 , C07C311/37 , C07D307/85
CPC分类号： C07D207/27 , C04B35/632 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C275/24 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/14 , C07D209/20 , C07D209/60 , C07D213/70 , C07D221/10 , C07D231/12 , C07D233/42 , C07D233/56 , C07D233/84 , C07D235/06 , C07D249/08 , C07D261/20 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/06 , C07D405/12 , C07D407/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14
摘要： The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R , R , R , v and R are as defined in the description; R' represents a -(CH2)t-R group wherein t and R are as defined in the description.
摘要翻译：本发明涉及式（I）化合物：R-A-R'其中：A如说明书中所定义; R表示基团（V），（VI），（VII）或（VIII），其中E，Q，R 1，R 2，R 3，v和R 4如说明; R'表示 - （CH 2）t -R 5基团，其中t和R 5如说明书中所定义。

13. 发明申请

WO99029682A1 NOVEL WATER SOLUBLE PHOTOCHROMIC COMPOUNDS 审中-公开
标题翻译：新型水溶性光电子化合物
公开(公告)号：WO99029682A1
公开(公告)日：1999-06-17
申请号：PCT/US1998/025858
申请日：1998-12-04
IPC分类号： C07D311/60 , C07D311/92 , C09K9/02 , C08K5/15 , G02B5/23
CPC分类号： C07D311/60 , C07D311/92 , C09K9/02
摘要： Described are novel water soluble photochromic naphthopyran and benzopyran compounds having an alkylaminoalkylamino group on the naphtho- or benzo-portions and/or pyran portions thereof. Theses compounds may be represented by one of graphic formulae (1) or (2) or (3) wherein R1 is an alkylaminoalkylamino group. Articles such as ophthalmic lenses or other plastic transparencies and coating compositions such as paints and inks that incorporate the novel water soluble compounds are also described.
摘要翻译：描述了在萘酚或苯并 - 和/或其吡喃部分上具有烷基氨基烷基氨基的新型水溶性光致变色萘并吡喃和苯并吡喃化合物。这些化合物可以由式（1）或（2）或（3）之一表示，其中R 1是烷基氨基烷基氨基。还描述了诸如眼用透镜或其它塑料透明片的物品以及掺入新型水溶性化合物的涂料组合物如油漆和油墨。

14. 发明申请

WO2016022742A1 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
标题翻译：抗生素双胶体化合物
公开(公告)号：WO2016022742A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043903
申请日：2015-08-06
申请人： MERCK SHARP & DOHME CORP. , CHEN, Helen , COLLETTI, Steven, L. , DEMONG, Duane , GUO, Yan , MILLER, Michael , NAIR, Anilkumar , PLUMMER, Christopher, W. , XIAO, Dong , YANG, De-Yi
发明人： CHEN, Helen , COLLETTI, Steven, L. , DEMONG, Duane , GUO, Yan , MILLER, Michael , NAIR, Anilkumar , PLUMMER, Christopher, W. , XIAO, Dong , YANG, De-Yi
IPC分类号： A61K31/357
CPC分类号： C07D311/60 , A61K31/366 , A61K31/397 , A61K31/4985 , A61K45/06 , C07D405/10 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/08 , C07D491/107 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症。

15. 发明申请

WO2015044229A1 NEW PI3K/AKT/MTOR INHIBITORS AND PHARMACEUTICAL USES THEREOF 审中-公开
标题翻译：新型PI3K / AKT / MTOR抑制剂及其药物用途
公开(公告)号：WO2015044229A1
公开(公告)日：2015-04-02
申请号：PCT/EP2014/070409
申请日：2014-09-24
申请人： UNIVERSITE DE RENNES 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： JEAN, Mickael , FOUQUE, Amélie , LEGEMBRE, Patrick , VAN DE WEGHE, Pierre
IPC分类号： C07D311/60 , C07D311/64 , C07D335/06 , C07D407/04 , C07D409/04 , A61K31/352 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D311/60 , C07D311/64 , C07D335/06 , C07D407/04 , C07D409/04 , C07D493/10 , C07D495/04
摘要： The invention relates to new PI3K/AKT/m TOR inhibitors and their use for the prevention and/or the treatment of a disease selected from the group consisting of: inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancers, transplant rejection, diseases characterized by a premature aging and tuberous sclerosis.
摘要翻译：本发明涉及新的PI3K / AKT / mTOR抑制剂及其用于预防和/或治疗选自以下的疾病的用途：炎症性疾病，自身免疫性疾病，神经变性疾病，癌症，移植排斥，以早衰和结节性硬化症。

16. 发明申请

WO2014162320A3 NOVEL ANALOGUES OF EPICATECHIN AND RELATED POLYPHENOLS 审中-公开
标题翻译： EPICATECHIN和相关多酚的新型模拟物
公开(公告)号：WO2014162320A3
公开(公告)日：2014-12-24
申请号：PCT/IN2014000213
申请日：2014-04-04
申请人： SPHAERA PHARMA PVT LTD
发明人： DUGAR SUNDEEP , MAHAJAN DINESH , RAI KUMAR SANTOSH , SINGH SARBJIT , PATIL ISHWAR RAKESH
IPC分类号： A61K31/353
CPC分类号： C07D311/62 , A23L33/10 , C07C45/71 , C07C45/72 , C07D311/54 , C07D311/60 , C07D405/12
摘要： The present invention provides novel analogues of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.
摘要翻译：本发明提供表儿茶素和相关多酚的新型类似物，它们的各种官能化衍生物，其制备方法，包含这些化合物的组合物及其使用方法。

17. 发明申请

WO2014162320A2 NOVEL ANALOGUES OF EPICATECHIN AND RELATED POLYPHENOLS 审中-公开
标题翻译：新霉素及相关多酚的类似物
公开(公告)号：WO2014162320A2
公开(公告)日：2014-10-09
申请号：PCT/IN2014/000213
申请日：2014-04-04
申请人： SPHAERA PHARMA PVT. LTD.
发明人： DUGAR, Sundeep , MAHAJAN, Dinesh , RAI, Kumar, Santosh , SINGH, Sarbjit , PATIL, Ishwar, Rakesh
CPC分类号： C07D311/62 , A23L33/10 , C07C45/71 , C07C45/72 , C07D311/54 , C07D311/60 , C07D405/12
摘要： The present invention provides novel analogues of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.
摘要翻译：本发明提供了表儿茶素和相关多酚的新类似物，它们的各种官能化衍生物，其制备方法，包含这些化合物的组合物及其使用方法。

18. 发明申请

WO2013093007A1 SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS 审中-公开
标题翻译： C4植物的磷酸苯酯羧酸的选择性抑制
公开(公告)号：WO2013093007A1
公开(公告)日：2013-06-27
申请号：PCT/EP2012/076648
申请日：2012-12-21
申请人： HEINRICH HEINE UNIVERSITÄT DÜSSELDORF
发明人： GROTH, Georg
IPC分类号： A01N37/04 , A01N43/16 , A01P13/00 , A01N37/38 , A01N37/40 , A01N43/42 , A01N43/88
CPC分类号： A01N43/60 , A01N37/40 , A01N37/46 , A01N43/16 , A01N43/42 , A01N43/82 , A01N43/90 , A01N45/00 , C07D241/42 , C07D311/28 , C07D311/60 , C40B30/02 , G01N33/573 , G01N2333/988 , G01N2500/04 , G01N2500/20 , G06F19/18
摘要： The present invention relates to the use of a compound, a salt or solvate thereof as C4 plant selective herbicide wherein said compound comprises a cyclic alkyl, aryl, heterocycloalkyl or heteroaryl group, and wherein said compound further comprises a) at least a functional group Z being -C(=Y z )R 1 , wherein Y z is selected from the group consisting of O, NH and S, preferably wherein Y z is O, and wherein R 1 is selected from the group consisting of H, OH and N(R 2 R 3 ), -O(R 2 ) and -S(R 2 ), wherein R 2 and R 3 , are independently of each other, selected from the group consisting of H, Alkyl, cycolalkyl, aryl and heteroaryl and a functional group Q which is -C(=Y Q )R 4 , wherein Y Q is selected from the group consisting of O, NH and S, preferably wherein Y Q is O, and wherein R 4 is selected from the group consisting of H, OH and NR 4# R 5# , OR 4# , SR 4# wherein R 4# and R 5# , are independently of each other, selected from the group consisting of H, alkyl, cycloalkyl, aryl and heteroaryl, or b) at least one electron donating group selected from the group consisting of OH, -SH, -O-R p , -S-R p -NR p R q and O-C(=Y p )R r , wherein R p and R q are, independently of each other, selected from the group consisting of H, alkyl, cycloalkyl and heteroaryl, and wherein R r is -OH, -NH 2 , -NH-Alkyl, -O-Alkyl or -NH-Alkyl, and wherein Y p is selected from the group consisting of -S-, -O-, -NH, said compound being capable of binding to the malate binding site comprised by a phosphoenolpyruvate carboxylase from a C4 plant, thereby inhibiting said phosphoenolpyruvate carboxylase, and wherein the cyclic alkyl, aryl, heterocycloalkyl or heteroaryl group inhibits binding to the malate binding site of a phosphoenolpyruvate carboxylase from a C3 plant.
摘要翻译：本发明涉及化合物，其盐或溶剂合物作为C4植物选择性除草剂的用途，其中所述化合物包括环烷基，芳基，杂环烷基或杂芳基，并且其中所述化合物还包含a）至少一个官能团Z 是-C（= Yz）R1，其中Yz选自O，NH和S，优选其中Yz是O，并且其中R1选自H，OH和N（R2R3）， - O（R 2）和-S（R 2），其中R 2和R 3彼此独立地选自H，烷基，环烷基，芳基和杂芳基，和官能团Q是-C（= YQ） R4，其中YQ选自O，NH和S，优选其中YQ是O，并且其中R4选自H，OH和NR4＃R5＃，OR4＃，SR4＃，其中R4＃和R5＃彼此独立地选自H，烷基，环烷基，芳基和杂芳基，或b）至少一个ele 选自OH，-SH，-O-Rp，-S-Rp -NRpRq和OC（= Yp）Rr的取代基，其中Rp和Rq彼此独立地选自由以下组成的组： H，烷基，环烷基和杂芳基，其中Rr是-OH，-NH2，-NH-烷基，-O-烷基或-NH-烷基，其中Yp选自-S-，-O- ，-NH，所述化合物能够结合来自C4植物的由磷酸烯醇丙酮酸羧化酶包含的苹果酸结合位点，从而抑制所述磷酸烯醇丙酮酸羧化酶，并且其中环状烷基，芳基，杂环烷基或杂芳基抑制与苹果酸结合位点的结合的来自C3植物的磷酸烯醇丙酮酸羧化酶。

19. 发明申请

WO2013025498A1 NEUROPROTECTIVE POLYPHENOL ANALOGS 审中-公开
标题翻译：神经保护性聚苯酚类似物
公开(公告)号：WO2013025498A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/050324
申请日：2012-08-10
申请人： SCHUBERT, David R. , MAHER, Pamela A. , CHIRUTA, Chandramouli
发明人： SCHUBERT, David R. , MAHER, Pamela A. , CHIRUTA, Chandramouli
IPC分类号： A01N37/10
CPC分类号： A61K31/47 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/4025 , A61K31/4709 , A61K45/06 , C07C49/835 , C07C49/84 , C07D215/233 , C07D295/112 , C07D311/30 , C07D311/60 , C07D311/62 , C07D311/78
摘要： The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzherimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.
摘要翻译：本发明提供神经保护性多酚化合物，其可以是维生素E，黄芩苷或绿原酸的合成类似物，其保持神经保护，抗炎，谷胱甘肽促进和/或抗氧化性质。神经保护性多酚化合物可用于促进，增强和/或增加神经元保护，生长和/或再生。多酚化合物进一步用于增加和/或维持细胞内谷胱甘肽（GSH）水平。多酚化合物还可用于治疗，预防，缓解和/或延缓神经变性疾病，包括糖尿病，帕金森病，亨廷顿病，阿尔茨海默病，非阿尔茨海默氏痴呆，多发性硬化，创伤性脑损伤，脊髓损伤或ALS。

20. 发明申请

WO2012089051A1 苯并吡喃酮类雌激素受体调节剂审中-公开
公开(公告)号：WO2012089051A1
公开(公告)日：2012-07-05
申请号：PCT/CN2011/084321
申请日：2011-12-21
申请人：北京盛诺基医药科技有限公司 , 丁红霞 , 孟坤 , 李靖
发明人：丁红霞 , 孟坤 , 李靖
IPC分类号： C07D311/30 , C07D311/54 , C07D311/60 , C07D311/76 , A61K31/352 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： C07D311/28 , C07D311/30 , C07D311/54 , C07D311/60 , C07D311/76 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04

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