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11. 发明申请

WO1983003061A1 DUAL MICROCAPSULES 审中-公开
标题翻译：双微孔
公开(公告)号：WO1983003061A1
公开(公告)日：1983-09-15
申请号：PCT/US1983000285
申请日：1983-03-02
申请人： BATTELLE DEVELOPMENT CORPORATION
发明人： BATTELLE DEVELOPMENT CORPORATION , GARDNER, David, L.
IPC分类号： B01J13/02
CPC分类号： A61K9/5073 , A01N25/28 , B01J13/025 , B01J13/125
摘要： The outer membrane (10) encapsulates a liquid (12) having one or more smaller microcapsules (mini-microcapsules) suspended therein. The mini-microcapsules contain a complex or a reaction product of a drug which diffuses into the liquid (12) in which mini-microcapsules are suspended. The suspending liquid (12) contains an enzyme which reacts with drug complex or reaction product to regenerate or release the drug. The drug diffuses through the outer membrane (10) into a host.
摘要翻译：外膜（10）封装具有悬浮在其中的一个或多个较小微囊（微型微囊）的液体（12）。微型微胶囊含有扩散到微型微胶囊悬浮液体（12）中的药物的复合物或反应产物。悬浮液（12）含有与药物复合物或反应产物反应以再生或释放药物的酶。药物通过外膜（10）扩散到宿主体内。

12. 发明申请

WO2016003947A1 METHOD OF MANUFACTURING STICK COMPRISING ANTIPERSPIRANT 审中-公开
标题翻译：制造包含抗真菌剂的胶囊的方法
公开(公告)号：WO2016003947A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/038402
申请日：2015-06-30
申请人： THE PROCTER & GAMBLE COMPANY
发明人： CETTI, Jonathan, Robert , DIHORA, Jiten, Odhavji , WITT, Steven, Edward , HENLEY, Eric, Shane
IPC分类号： A61K8/26 , A61K8/28 , A61Q15/00 , A61K8/81 , A61K8/02 , A61K8/11
CPC分类号： A61K8/28 , A61K8/0229 , A61K8/11 , A61K8/25 , A61K8/26 , A61K8/31 , A61K8/33 , A61K8/342 , A61K8/37 , A61K8/42 , A61K8/498 , A61K8/585 , A61K8/60 , A61K8/65 , A61K8/732 , A61K8/738 , A61K8/8147 , A61K8/8152 , A61K8/891 , A61K8/92 , A61K8/922 , A61K2800/31 , A61K2800/412 , A61K2800/56 , A61K2800/592 , A61K2800/652 , A61K2800/654 , A61K2800/805 , A61Q15/00 , B01J13/125
摘要： Methods of making personal care compositions including microcapsules and methods of enhancing the efficacy of the microcapsules in said personal care compositions.
摘要翻译：制备包括微胶囊的个人护理组合物的方法和增强所述个人护理组合物中微胶囊功效的方法。

13. 发明申请

WO2013178802A3 MICROPARTICLES AND A SYSTEM AND METHOD FOR THE SYNTHESIS OF MICROPARTICLES 审中-公开
标题翻译：微量元素和微生物合成的系统和方法
公开(公告)号：WO2013178802A3
公开(公告)日：2014-02-27
申请号：PCT/EP2013061302
申请日：2013-05-31
申请人： UNIV DUBLIN
发明人： LEE GIL , O'MAHONY JAMES , PLATT MARK
IPC分类号： A61K9/50 , B01J13/04
CPC分类号： C01G49/02 , A61B5/055 , A61K9/5094 , B01F3/0811 , B01F3/0853 , B01F3/223 , B01F7/00 , B01F15/0203 , B01F2015/062 , B01J13/043 , B01J13/125 , C01P2004/61 , C01P2006/42 , H01F1/0054
摘要： There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are microparticles of controllable size and morphology formed by the method.
摘要翻译：提供了使用基于乳液的合成途径制备微粒的方法，包括：提供第一流体相和第二流体相，其中第一流体相是连续相，第二流体相是包含分散材料的分散相，其中连续相与分散相不混溶; 在剪切装置中在存在表面活性剂的情况下将第一连续相和第二分散相混合以形成可控尺寸并具有窄液滴尺寸分布的液滴的乳液; 干燥乳液以形成可控尺寸并且具有窄尺寸分布的微粒，并且其中微粒可以包含球形，皱缩的，凹陷的，多孔的或中空的微粒形态。还提供了包括剪切装置和干燥装置的系统。还提供了通过该方法形成的可控尺寸和形态的微粒。

14. 发明申请

WO2010140987A1 MULTI-PHASE MICROPARTICLES AND METHOD OF MANUFACTURING MULTI-PHASE MICROPARTICLES 审中-公开
标题翻译：多相微阵列和制备多相微阵列的方法
公开(公告)号：WO2010140987A1
公开(公告)日：2010-12-09
申请号：PCT/SG2010/000215
申请日：2010-06-07
申请人： NANYANG TECHNOLOGICAL UNIVERSITY , LOO, Say Chye Joachim , LEE, Wei Li
发明人： LOO, Say Chye Joachim , LEE, Wei Li
IPC分类号： B01J13/04 , A01N25/28 , A61K9/50 , A61K9/58 , B01J13/06 , C08J3/09
CPC分类号： B01J13/125 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61K9/5089 , A61K31/192 , C08J3/126 , C08J3/14 , C08J3/16 , C08J2300/16 , C08J2367/04 , C08J2467/04 , C09B67/0097
摘要： The invention relates to a method of manufacturing multi-phase microparticles. The method comprises dissolving at least three different polymers in a volatile organic solvent to obtain a first solution. The first solution comprises at least two cloud points, wherein the second cloud point is higher than the first cloud point. Viscosity of the first solution and the first and second cloud point are selected such that the at least three different polymers are immiscible with each other in the first solution. The first solution is dispersed into an aqueous continuous phase which comprises a surfactant to obtain an emulsion. The volatile organic solvent is evaporated from the emulsion. The total concentration of the at least three different polymers together in the emulsion before evaporation is below the first cloud point, or is above the first cloud point and below the second cloud point or is above the second cloud point. The invention relates also to a multi-phase microparticle made by the method and a pharmaceutical composition comprising the multi-phase microparticle.
摘要翻译：本发明涉及制造多相微粒的方法。该方法包括将至少三种不同的聚合物溶解在挥发性有机溶剂中以获得第一溶液。第一解决方案包括至少两个浊点，其中第二浊点高于第一浊点。选择第一溶液和第一和第二浊点的粘度，使得至少三种不同的聚合物在第一溶液中彼此不混溶。将第一溶液分散到包含表面活性剂以获得乳液的含水连续相中。挥发性有机溶剂从乳液中蒸发掉。在蒸发之前乳液中至少三种不同聚合物的总浓度低于第一浊点，或高于第一浊点并低于第二浊点或高于第二浊点。本发明还涉及通过该方法制备的多相微粒和包含多相微粒的药物组合物。

15. 发明申请

WO2009093812A3 DOUBLE LAYERED POLYMER CAPSULES FOR THE STABILIZATION OF CAROTENOIDS, THE PROCESS FOR PREPARING THE SAME, AND THE COSMETIC COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：用于稳定类胡萝卜素的双层聚合物胶囊，其制备方法以及含有相同成分的化妆品组合物
公开(公告)号：WO2009093812A3
公开(公告)日：2009-10-15
申请号：PCT/KR2008007645
申请日：2008-12-24
申请人： AMOREPACIFIC CORP , KIM YONG JIN , AN JI HYE , PARK CHANG HOON , CHO JUN CHEOL
发明人： KIM YONG JIN , AN JI HYE , PARK CHANG HOON , CHO JUN CHEOL
IPC分类号： C08J3/12
CPC分类号： A61Q19/08 , A61K8/11 , A61K8/8117 , A61K8/8147 , A61K8/8152 , A61K2800/412 , A61K2800/63 , B01J13/125 , B01J13/22
摘要： The present invention relates to a double-layered polymer capsule for stabilizing a carotenoid such as ß- carotin and a method for preparing the same, and a cosmetic composition comprising the same, and more particularly, to a polymer capsule prepared by preparing a cationic polymer capsule containing a carotenoid and coating the surface of the capsule with an anionic polymer. The double-layered polymer capsule according to the present invention is a stabilizing system to preventing degeneration of an active material by the outside destructive environment and effective on materials susceptible to oxidation.
摘要翻译：本发明涉及用于稳定类胡萝卜素如β-胡萝卜素的双层聚合物胶囊及其制备方法，以及包含其的化妆品组合物，并且更具体地涉及通过制备阳离子聚合物胶囊含有类胡萝卜素并用阴离子聚合物涂覆胶囊表面。根据本发明的双层聚合物胶囊是用于防止由外部破坏性环境引起的活性物质退化并且对易于氧化的材料有效的稳定体系。

16. 发明申请

WO0066087A9 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
标题翻译：基于乳液的微粒制备工艺
公开(公告)号：WO0066087A9
公开(公告)日：2001-07-12
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC , GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.
摘要翻译：提供了制造优选含有活性剂的微粒的方法。在一个优选的实施方案中，该方法涉及制备（1）在聚合物和第一溶剂的溶液中含有试剂的分散相; （2）含有表面活性剂，与第一溶剂完全或部分不混溶的第二溶剂和足以使连续相饱和的第一溶剂的连续相; 和（3）作为聚合物的非溶剂的萃取相，连续相组分的溶剂和第一溶剂的溶剂，其中第一溶剂在萃取相中的溶解度为约0.1％至25％重量％。然后，将分散相和连续相混合形成乳液，然后将乳液与适量的萃取相短暂混合，以在分散相和连续相的界面处诱导皮肤形成。剩余溶剂通过蒸发工艺步骤除去。乳化和溶剂去除步骤优选以连续方法进行。与其他基于提取的方法相比，在蒸发之前的简单提取步骤使来自微粒的活性剂的损失最小化，并且减少了所需的提取相体积。还提供了替代乳化方法和溶剂去除方法，如增量提取，深冷提取或膜分离，并且可以以各种组合使用以制造微粒。

17. 发明申请

WO1994002106A1 THERAPEUTIC AND DIAGNOSTIC USE OF MODIFIED POLYMERIC MICROCAPSULES 审中-公开
标题翻译：改性聚合物微胶囊的治疗和诊断用途
公开(公告)号：WO1994002106A1
公开(公告)日：1994-02-03
申请号：PCT/US1993006675
申请日：1993-07-16
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , WALLACE, Sidney , YANG, David , WALLACE, Michael , LI, Chun , LI-REN, Kuang
IPC分类号： A61K09/50
CPC分类号： A61K9/1647 , A61K9/1641 , A61K9/1652 , A61K9/167 , A61K9/1694 , A61K47/6925 , A61K49/048 , A61K51/1251 , A61K2123/00 , B01J13/125 , B01J13/20 , Y10T428/2985
摘要： The present invention relates to a highly efficient method of preparing modified microcapsules exhibiting selective targeting. These microcapsules are suitable for encapsulation or surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of hydrophilic radiodiagnostic agents in 1 (my)m capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 (my)m capsules for chemoembolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules. The invention also includes hydrophilic microcapsules surface modified with hydroxyl groups. Various agents such as estrone may be attached to the microcapsules and effectively targeted to selected organs.
摘要翻译：本发明涉及一种制备显示出选择性靶向的改性微胶囊的高效方法。这些微胶囊适用于治疗和诊断剂的包封或表面附着。在本发明的一个方面，通过将氨基酸酯与聚合物缀合来改变聚合物材料的表面电荷，从而提供封装剂对特定组织细胞的改进靶向。实例包括将亲水性放射性诊断剂包封在1（my）m胶囊中，以提供改进的不透明化和包封细胞毒性剂在100（my）m胶囊中用于化疗栓塞过程。微胶囊适合于连接广泛范围的靶向剂，包括抗体，类固醇和药物，其可在形成适当大小的微胶囊之前或之后附着于微胶囊聚合物。本发明还包括用羟基表面改性的亲水性微胶囊。可以将诸如雌酮的各种试剂连接到微胶囊上并且有效地靶向选定的器官。

18. 发明申请

WO1993002712A1 PREPARATION OF MICROPARTICLES 审中-公开
标题翻译：微波炉的制备
公开(公告)号：WO1993002712A1
公开(公告)日：1993-02-18
申请号：PCT/GB1992001421
申请日：1992-08-03
申请人： DANBIOSYST UK LIMITED , ILLUM, Lisbeth , JOHNSON, Olufunmiloyo, Lilly
发明人： DANBIOSYST UK LIMITED
IPC分类号： A61K49/00
CPC分类号： B82Y15/00 , A61K9/1694 , A61K9/5036 , A61K9/5052 , A61K9/5089 , A61K49/223 , A61K49/225 , B01J13/125
摘要： Solid microspheres or hollow (i.e. gas or vapour filled) microcapsules, for example of amylodextrin are prepared by forming a shell from a water-soluble starch derivative around a solid or liquid core and subsequently removing the core. The core may be a volatile oil such as perfluorohexane. The microspheres or microcapsules may be made by an oil/water/oil double emulsion followed by chemical or heat hardening to render them water-insoluble. The microspheres can be used for nasal delivery systems and the microcapsules for echocardiography.
摘要翻译：通过在固体或液体核心周围由水溶性淀粉衍生物形成壳并随后除去核心来制备固体微球体或中空（即气体或蒸气填充的）微胶囊，例如淀粉糊精。核心可以是挥发性油，例如全氟己烷。微球或微胶囊可以由油/水/油双重乳液制成，随后进行化学或热硬化，使其不溶于水。微球可用于鼻输送系统和用于超声心动图的微胶囊。

19. 发明申请

WO1992020771A1 POLYMERIC COMPOSITIONS 审中-公开
标题翻译：聚合物组合物
公开(公告)号：WO1992020771A1
公开(公告)日：1992-11-26
申请号：PCT/GB1992000867
申请日：1992-05-14
申请人： ALLIED COLLOIDS LIMITED , LANGLEY, John, Graham , SYMES, Kenneth Charles , MISTRY, Kishor, Kumar
发明人： ALLIED COLLOIDS LIMITED
IPC分类号： C11D03/386
CPC分类号： C12N11/04 , A01N25/10 , A01N25/28 , A01N33/18 , A01N43/90 , A01N47/30 , A01N57/16 , A61K9/1635 , A61K9/5026 , A61K9/5073 , B01J13/10 , B01J13/125 , B01J13/14 , C11D3/3769 , C11D3/38663 , C11D3/38672 , C11D17/0039 , A01N2300/00
摘要： A particulate composition comprises particles having a substantially anhydrous core comprising a matrix polymer containing active ingredient, a layer of hydrophobic oil around the core and a shell of polymer around the oil layer, wherein the solid matrix polymer is sufficiently hydrophobic that it will partition preferentially into the oil rather than into water. The composition can be a powder or a stable liquid dispersion. The active ingredient is preferably a detergent enzyme and the composition can therefore be a stable liquid laundry detergent. The composition can be made by providing an aqueous solution of encapsulating polymer, providing a substantially anhydrous dispersion in oil of particles of a matrix polymer containing active ingredient, dispersing this dispersion into the aqueous solution and causing a solid polymer shell to form around the droplets of the matrix particles.
摘要翻译：颗粒组合物包含具有基本上无水的芯的颗粒，其包含含有活性成分的基质聚合物，芯周围的疏水油层和油层周围的聚合物壳，其中固体基质聚合物足够疏水以使其优先分配成油而不是进水。组合物可以是粉末或稳定的液体分散体。活性成分优选为洗涤剂酶，因此组合物可以是稳定的液体衣物洗涤剂。组合物可以通过提供包封聚合物的水溶液制备，在含有活性成分的基质聚合物的颗粒的油中提供基本上无水的分散体，将该分散体分散在水溶液中，并使固体聚合物壳形成在基质颗粒。

20. 发明申请

WO2015059179A1 CAPSULE, NAMELY NANOCAPSULE, MICROCAPSULE OR MACROCAPSULE, HAVING A VERY LOW OXYGEN PERMEABILITY 审中-公开
标题翻译：胶囊，纳米颗粒，微胶囊或微胶囊，具有非常低的氧气渗透性
公开(公告)号：WO2015059179A1
公开(公告)日：2015-04-30
申请号：PCT/EP2014/072622
申请日：2014-10-22
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , UNIVERSITY OF COPENHAGEN (UC)
发明人： LANDFESTER, Katharina , BALOUCHEV, Stanislav , RISBO, Jens , HANNER, Anna Justina
IPC分类号： B01J13/12 , B01J13/14 , A23P1/04 , A61K9/50 , C09B67/02
CPC分类号： B01J13/14 , A23D9/06 , A23L29/262 , A23P10/30 , A61K9/5161 , B01J13/125 , C09B3/14 , C09B47/00 , C09B67/0097
摘要： A capsule, namely a nanocapsule, microcapsule or macrocapsule, comprises a shell and a core, wherein the core contains at least one compound being at least at any temperature between more than 0°C and 80°C at 101,325 kPa a liquid, and wherein the shell comprises semicrystalline cellulose nanofibers and/or semicrystalline cellulose nanocrystals having each a crystallinity index of at least 30%. These capsules have in particular a very low oxygen permeability and thus protects the liquid included in its core from oxygen. Accordingly, these capsules may be used for protecting for example food or food ingredients from oxygen. In addition, these capsules may be used to protect photoactive compounds from oxygen, such as phosphorescent compounds and photon upconversion compositions, in particular triplet-triplet annihilation upconversion compositions.
摘要翻译：胶囊，即纳米胶囊，微胶囊或大胶囊，包括壳和芯，其中所述芯包含至少一种化合物，其至少在101,325kPa至少在0℃至80℃之间的任何温度下为液体，并且其中该壳包含半结晶纤维素纳米纤维和/或半结晶纤维素纳米晶体，其结晶度指数至少为30％。这些胶囊特别具有非常低的氧气渗透性，因此保护其核心中所含的液体免于氧气。因此，这些胶囊可以用于保护例如食物或食物成分的氧气。此外，这些胶囊可用于保护光活性化合物免受氧，例如磷光化合物和光子上转换组合物，特别是三重重结构三联体湮灭上转换组合物。

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