专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0115734A3 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE 审中-公开
标题翻译：高粘度液体控制输送系统和医疗或手术装置
公开(公告)号：WO0115734A3
公开(公告)日：2001-09-13
申请号：PCT/US0023270
申请日：2000-08-24
申请人： SOUTHERN BIOSYSTEMS INC
发明人： GIBSON JOHN W , SULLIVAN STACEY A , MIDDLETON JOHN G , TIPTON ARTHUR J
IPC分类号： C07H13/04 , A61K8/60 , A61K9/00 , A61K9/107 , A61K9/12 , A61K9/14 , A61K9/16 , A61K9/48 , A61K9/50 , A61K9/70 , A61K47/14 , A61K47/18 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/00 , A61L27/54 , A61L31/00 , A61L31/16 , A61L33/00 , A61Q11/00 , C07C69/675 , C07H13/06
CPC分类号： A61K9/0024 , A61K8/60 , A61K9/0014 , A61K9/0019 , A61K9/0073 , A61K9/008 , A61K9/1647 , A61K9/4858 , A61K9/7015 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/0015 , A61L24/0026 , A61L26/0066 , A61L27/54 , A61L31/16 , A61L2300/00 , A61Q5/006 , A61Q11/00 , Y10T428/2985
摘要： The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo , leaving a higher viscosity liquid material.
摘要翻译：本发明涉及形成液体，高粘度材料的新型非聚合物和组合物，其适于以受控的方式递送生物活性物质，并用作医疗或手术装置。该材料可任选地用溶剂稀释以形成较低粘度的材料，使得该材料易于施用。该溶剂可以是水不溶性或水溶性的，其中水溶性溶剂在体内快速扩散或迁移离开材料，留下较高粘度的液体材料。

2. 发明申请

WO0066087A8 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
公开(公告)号：WO0066087A8
公开(公告)日：2001-04-05
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC , GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.

3. 发明申请

WO9913913A3 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AS A DEVICE 审中-公开
标题翻译：高粘度液体控制输送系统作为装置
公开(公告)号：WO9913913A3
公开(公告)日：1999-06-03
申请号：PCT/US9818629
申请日：1998-09-08
申请人： SOUTHERN BIOSYSTEMS INC
发明人： TIPTON ARTHUR J
IPC分类号： A61L27/00 , A61K8/60 , A61K9/00 , A61K45/00 , A61K47/26 , A61L15/20 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/54 , A61L31/16 , A61Q11/00 , A61L25/00
CPC分类号： A61K9/0024 , A61K8/60 , A61K9/0019 , A61K9/0095 , A61K47/26 , A61L15/20 , A61L15/44 , A61L24/0015 , A61L26/0066 , A61L27/54 , A61L31/16 , A61L2300/236 , A61L2300/602 , A61L2300/802 , A61Q11/00 , Y10S436/829 , Y10T428/2987
摘要： A composition as a medical or surgical device is provided that includes: (i) a non-polymeric, non-water soluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37 DEG C that does not crystallize neat under ambient or physiological conditions; and, optionally, (ii) a substance to be delivered.
摘要翻译：提供了一种作为医疗或手术装置的组合物，其包含：（i）在37℃下粘度至少为5,000cP的非聚合非水溶性液体载体材料（HVLCM），其在环境下不会结晶净化或生理状况; 并且可选地，（ii）待递送的物质。

4. 发明申请

WO1996039995A1 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM 审中-公开
标题翻译：高粘度液体控制输送系统
公开(公告)号：WO1996039995A1
公开(公告)日：1996-12-19
申请号：PCT/US1996010055
申请日：1996-06-07
申请人： SOUTHERN BIOSYSTEMS, INC.
发明人： SOUTHERN BIOSYSTEMS, INC. , TIPTON, Arthur, J. , HOLL, Richard, J.
IPC分类号： A61F02/02
CPC分类号： A61K9/0095 , A61K8/60 , A61K9/0019 , A61K9/0024 , A61K47/26 , A61L15/20 , A61L15/44 , A61L24/0015 , A61L26/0066 , A61L27/54 , A61L31/16 , A61L2300/236 , A61L2300/42 , A61L2300/602 , A61L2300/622 , A61L2300/802 , A61Q11/00
摘要： A composition for the controlled release of substances is provided that includes: (i) a non-polymeric, water-insoluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37 DEG C that does not crystallize neat under ambient or physiological conditions; and (ii) a substance to be delivered.
摘要翻译：提供了用于控制释放物质的组合物，其包括：（i）在37℃下粘度为至少5,000cP的非聚合的水不溶性液体载体材料（HVLCM），其在环境或生理学下不结晶条件; 和（ii）待送达的物质。

5. 发明申请

WO2003000156A1 ZERO-ORDER PROLONGED RELEASE COAXIAL IMPLANTS 审中-公开
标题翻译：零轴释放同轴植入物
公开(公告)号：WO2003000156A1
公开(公告)日：2003-01-03
申请号：PCT/US2002/019475
申请日：2002-06-20
申请人： SOUTHERN BIOSYSTEMS, INC.
发明人： GIBSON, John, W. , TIPTON, Arthur, J. , HOLL, Richard, J. , MEADOR, Stacey
IPC分类号： A61F2/02
CPC分类号： A61K9/0002 , A61F2/02 , A61F2250/0067 , A61K9/0024
摘要： A coaxial implant has been developed using entirely biodegradable polymeric materials. As referred to herein, a coaxial implant is a device having a core containing drug, surrounded by a semi-permeable membrane that controls the rate of release from the core. The device is formed by extrusion, using a pre-milling and extruding step to maximize uniformity of drug dispersion within the polymeric material. In one embodiment, the polymer is processed to yield a semi-crystalline polymer, rather than an amorphous polymer. The core containing the drug and the polymer membrane(s) can be the same or different polymer. The polymer can be the same or different composition (i.e., both polycaprolactone, or both poly(lactide-co-glycolide) of different monomer ratios, or polycaprolactone outside of a core of poly(lactide)), of the same or different molecular weights, and of the same or different chemical structure (i.e., crystalline, semi-crystalline or amorphous). The core acts as a reservoir of drug, which partitions from the core polymer to form a saturated solution of at least 10% drug at the polymer membrane.
摘要翻译：已经开发了使用完全可生物降解的聚合材料的同轴植入物。如本文所提及的，同轴植入物是具有含核心的药物的装置，被半透膜隔开，半透膜控制从核心释放的速率。该装置通过挤出形成，使用预研磨和挤出步骤以最大化聚合物材料内药物分散的均匀性。在一个实施方案中，加工聚合物以产生半结晶聚合物，而不是无定形聚合物。含有药物和聚合物膜的核心可以是相同或不同的聚合物。聚合物可以具有相同或不同的组成（即，不同单体比的聚己内酯或聚（丙交酯 - 共 - 乙交酯）或聚（丙交酯）核心外的聚己内酯）具有相同或不同分子量，以及相同或不同的化学结构（即结晶，半结晶或无定形）。核心作为药物储存器，其与芯聚合物分隔开，以在聚合物膜上形成至少10％药物的饱和溶液。

6. 发明申请

WO0066087A2 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
标题翻译：基于乳液的制备微生物的方法
公开(公告)号：WO0066087A2
公开(公告)日：2000-11-09
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.
摘要翻译：提供了制备微粒，优选含有活性剂的方法。在优选的实施方案中，该方法包括制备（1）在聚合物和第一溶剂的溶液中含有试剂的分散相; （2）含有表面活性剂的连续相，与第一溶剂完全或部分不混溶的第二溶剂和足够的第一溶剂使连续相饱和; 和（3）作为聚合物的非溶剂的萃取相，连续相成分的溶剂和第一溶剂的溶剂，其中第一溶剂在萃取相中的溶解度为约0.1％至25 重量％。然后，将分散相和连续相混合以形成乳液，然后将乳液与适量的萃取相短暂混合以在分散相和连续相的界面处诱导皮肤形成。通过蒸发处理步骤除去剩余的溶剂。乳化和溶剂去除步骤优选以连续方法进行。在蒸发之前的简单萃取步骤使得活性剂从微粒中的损失最小化，与其它基于萃取的方法相比，减少提取阶段所需的体积。还提供了交替乳化方法和溶剂去除方法，例如增量萃取，低温萃取或膜分离，并且可以以各种组合使用以制备微粒。

7. 发明申请

WO0066087A9 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
标题翻译：基于乳液的微粒制备工艺
公开(公告)号：WO0066087A9
公开(公告)日：2001-07-12
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC , GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.
摘要翻译：提供了制造优选含有活性剂的微粒的方法。在一个优选的实施方案中，该方法涉及制备（1）在聚合物和第一溶剂的溶液中含有试剂的分散相; （2）含有表面活性剂，与第一溶剂完全或部分不混溶的第二溶剂和足以使连续相饱和的第一溶剂的连续相; 和（3）作为聚合物的非溶剂的萃取相，连续相组分的溶剂和第一溶剂的溶剂，其中第一溶剂在萃取相中的溶解度为约0.1％至25％重量％。然后，将分散相和连续相混合形成乳液，然后将乳液与适量的萃取相短暂混合，以在分散相和连续相的界面处诱导皮肤形成。剩余溶剂通过蒸发工艺步骤除去。乳化和溶剂去除步骤优选以连续方法进行。与其他基于提取的方法相比，在蒸发之前的简单提取步骤使来自微粒的活性剂的损失最小化，并且减少了所需的提取相体积。还提供了替代乳化方法和溶剂去除方法，如增量提取，深冷提取或膜分离，并且可以以各种组合使用以制造微粒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式