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    • 15. 发明申请
    • TARGETED CELLULAR SELECTIVITY OF SURFACE ACTIVE MOLECULES
    • 表面活性分子的靶向细胞选择性
    • WO2009100011A2
    • 2009-08-13
    • PCT/US2009032851
    • 2009-02-02
    • UNIV FLORIDAMOUDGIL BRIJ MVARSHNEY MANOJGROBMYER STEPHEN R
    • MOUDGIL BRIJ MVARSHNEY MANOJGROBMYER STEPHEN R
    • A61K31/765A61K49/06A61P35/00
    • A61K49/0017A61K31/765A61K47/543A61K47/60
    • A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.
    • 用于治疗癌症的方法包括将表面活性剂递送至生物体,其中表面活性剂选择性分配并杀死癌细胞而非健康细胞。 表面活性剂可以是HLB小于29的离子或非离子表面活性剂或HLB小于40的表面活性剂的混合物,其中疏水部分是表面活性剂的较少部分 亲水部分。 检测和定位生物体中的癌细胞的荧光方法涉及递送表面活性剂,其中表面活性剂包括荧光部分,所述荧光部分在表面活性剂选择性分配到癌细胞上并通过辐射源辐射以激发 荧光部分,观察到荧光发射,允许通过相对高强度发射的局部体积检测和定位癌组织。