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11. 发明申请

WO2012021792A2 CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES 审中-公开
标题翻译：临床和/或消费者技术和设备
公开(公告)号：WO2012021792A2
公开(公告)日：2012-02-16
申请号：PCT/US2011/047565
申请日：2011-08-12
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. III. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
发明人： CHICKERING, Donald, E. III. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
IPC分类号： A61M5/142
CPC分类号： A61M37/0015 , A61B5/117 , A61B5/14514 , A61B5/150984 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/96 , A61B90/98 , A61B2560/0412 , A61M5/14248 , A61M37/00 , A61M2037/0023 , A61M2037/0061 , A61M2205/3576 , A61M2205/6009 , A61M2205/6072 , A61N1/30 , A61N1/325
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.
摘要翻译：本发明一般涉及用于递送和/或接受来自受试者，例如来自皮肤和/或来自身体的其它组织的物质或物质例如血液的系统和方法。在一些情况下，该装置可以包含诸如针或微针的物质转移组件，其可以插入到皮肤或另一个器官中以从受试者输送和/或接收流体或其他物质。在一些实施方案中，该装置可以包括构造和布置成将一种或多种物质转移组分插入皮肤或其它器官中的活化剂。在某些情况下，该装置还可以包括用于接收从受试者接收的流体的储存室。

12. 发明申请

WO2011163347A2 SAMPLING DEVICES AND METHODS INVOLVING RELATIVELY LITTLE PAIN 审中-公开
标题翻译：采用相关的轻度疼痛的装置和方法
公开(公告)号：WO2011163347A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041430
申请日：2011-06-22
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
发明人： CHICKERING, Donald, E., III , BERNSTEIN, Howard , DAVIS, Shawn , HAGHGOOIE, Ramin , LEVINSON, Douglas, A. , MICHELMAN, Mark , GONG, Ping
IPC分类号： A61M37/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150091 , A61B5/150099 , A61B5/150106 , A61B5/150129 , A61B5/150145 , A61B5/15016 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150969 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15125 , A61B5/15134 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B5/154 , A61B5/157 , A61B17/00234 , A61B2010/0225 , A61B2562/0238 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或接受诸如血液的物质或物质从受试者例如皮肤和/或从皮肤接收的系统和方法。一方面，本发明一般涉及使用包括物质转移组件（其可以包含例如一个或多个微针）的装置从例如皮肤接收血液的装置和方法，以及存储室在接收血液之前具有小于大气压的内部压力。在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。可以评估疼痛，例如使用诸如Wong-Baker FACES Pain Scale的疼痛量表。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者接收血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，可以从装置接收血液，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于接收血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

13. 发明申请

WO2011053788A2 RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：相对较小的装置适用于皮肤，模块化系统及其使用方法
公开(公告)号：WO2011053788A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054725
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E. , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E. , LEVINSON, Douglas, A. , WALT, David, R. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61M5/32 , A61B5/151 , A61B5/157
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.
摘要翻译：在某些方面，本发明一般涉及应用于皮肤的相对较小的装置，模块化系统及其使用方法。在一些方面，该装置被构造并布置成具有多于一个模块。例如，该装置可以具有用于向皮肤和/或皮肤下方递送和/或抽出流体的模块和用于传输指示输送到皮肤和/或从皮肤抽出的流体的信号的模块，以及 /或在受试者的皮肤下方，用于分析从皮肤和/或受试者的皮肤下面抽出的流体的模块等。在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，连接和/或分离可在装置与对象接触时执行，例如在固定到对象时。在一些实施例中，该装置可以重复地适用于受试者的皮肤，以例如在相同的位置处或者在受试者的皮肤上的不同位置向受试者的皮肤和/或皮肤下方递送流体和/ 受试者的皮肤。在一些方面中，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，装置的尺寸可以是可穿戴的和/或能够由对象携带。例如，该装置可以具有允许装置被对象携带或佩戴不同时间段的质量和/或尺寸，例如至少约一小时，至少约一天，至少约一周等，或不超过约一小时，不超过约十分钟等。

14. 发明申请

WO2012021801A2 SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS 审中-公开
标题翻译：用于监测对象的系统和技术
公开(公告)号：WO2012021801A2
公开(公告)日：2012-02-16
申请号：PCT/US2011/047581
申请日：2011-08-12
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , BERNSTEIN, Howard
发明人： LEVINSON, Douglas, A. , BERNSTEIN, Howard
IPC分类号： G06Q50/00 , A61M35/00
CPC分类号： A61B5/4833 , A61B5/1112 , A61B5/145 , A61B5/14503 , A61B5/14514 , A61B5/14546 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150854 , A61B5/150862 , A61B5/150969 , A61B5/150984 , A61B5/15113 , A61B5/15125 , A61B5/15142 , A61B5/154 , A61B5/157 , A61B5/4839 , A61B5/4848 , A61B5/6824 , A61B10/0045 , A61B2010/0009 , A61B2010/008 , A61M5/1723 , A61M37/0015 , A61M2037/0023 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3468 , G06Q20/10 , G06Q30/02 , G06Q30/0207 , G06Q50/22 , G16H40/63 , Y02A90/22 , Y02A90/26
摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.
摘要翻译：本发明总体上涉及用于监测和/或提供对象服用的药物或其他药物的反馈的系统和方法。在一个方面，本发明涉及用于确定受试者皮肤内的物种的装置和方法; 并基于物种的确定向对象产生反馈。反馈可以是例如视觉，听觉，触觉，温度变化等。在一些情况下，关于种类的确定的信息可以被传输到另一个实体，例如健康护理提供者，计算机，亲属等等，然后可以以某种方式向对象提供反馈。在一些情况下，反馈可以直接指示物种，例如物种是否存在，物种的浓度，是否存在涉及物种的反应的副产物，受该物种影响的化合物是否是存在等。但是，在一些实施例中，反馈也可以是间接的。例如，可以向受试者呈现外部奖励，例如基于皮肤内物种的确定。例如，可以基于主体的合规性水平来提供诸如现金，优惠券，歌曲，折扣，个人物品等的奖励。本发明的其他方面通常涉及涉及这种装置（具有或不具有待监测药物）的试剂盒，促进此类系统的方法等。

15. 发明申请

WO2010101626A1 TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING 审中-公开
标题翻译：与血液采样相关的技术和设备
公开(公告)号：WO2010101626A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/000631
申请日：2010-03-02
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Doanld, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , MICHELMAN, Mark
发明人： LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Doanld, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , MICHELMAN, Mark
IPC分类号： A61B5/151
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to a device for withdrawing blood from the skin and/or from beneath the skin of a subject, the device comprising: a fluid transporter, a vacuum chamber having an internal pressure less than atmospheric pressure before blood is withdrawn into the device and a storage chamber for receiving blood withdrawn from the subject through the fluid transporter when a negative presure is applied to the skin of the subject. The device may further comprises one or more microwelles.
摘要翻译：本发明总体上涉及一种用于从皮肤和/或从受试者皮肤下面抽出血液的装置，该装置包括：流体输送器，具有内压低于大气压的真空室，然后血液被抽出到装置和存储室，用于当对受试者的皮肤施加负面压力时，通过流体转运器接收从对象抽出的血液。该装置还可以包括一个或多个微孔。

16. 发明申请

WO2010101625A2 OXYGEN SENSOR 审中-公开
标题翻译：氧传感器
公开(公告)号：WO2010101625A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/000630
申请日：2010-03-02
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , BERNSTEIN, Howard
发明人： LEVINSON, Douglas, A. , BERNSTEIN, Howard
IPC分类号： A61B5/15 , A61B5/00 , G01N33/49 , G01N33/72
CPC分类号： G01N33/84 , A61B5/021 , A61B5/14532 , A61B5/14542 , A61B5/411 , A61B2560/0412 , A61M5/14244 , G01N33/54366 , G01N33/72
摘要： The present invention generally relates to systems and methods for determining oxygen in a sample, or in a subject. In one aspect, the present invention is generally directed to an article exhibiting a determinable feature responsive to oxygen, such as oxygen-sensitive particles. The particles may exhibit a determinable change with a change in oxygen concentration, and such particles can accordingly be used to determine oxygen. For example, in one set of embodiments, the particles may be at least partially coated with a protein, such as hemoglobin, that is able to interact with oxygen. In some cases, the protein may aggregate under certain conditions (e.g., under relatively low oxygen concentrations), and such protein aggregation may be used, for example, to cause the particles to become aggregated, which can be determined in some way. In some cases, such aggregation may be irreversible; i.e., the degree of aggregation corresponds to the most extreme oxygen concentrations that the proteins were exposed to. Such articles may be used, for example, to determine oxygen within a sample, or within a subject, such as a human subject. For instance, the article may be formed as a skin patch, or administered to the skin of a subject, e.g., on the surface of the skin, within the dermis or epidermis, etc., to determine oxygen within the subject.
摘要翻译：本发明一般涉及用于测定样品或受试者中的氧的系统和方法。一方面，本发明一般涉及一种表现出对氧敏感的颗粒有氧的可确定特征的物品。颗粒可以随着氧浓度的变化而呈现可确定的变化，因此可以使用这样的颗粒来确定氧气。例如，在一组实施方案中，颗粒可以至少部分地涂覆有能够与氧相互作用的蛋白质，例如血红蛋白。在一些情况下，蛋白质可以在某些条件下（例如，在相对低的氧浓度下）聚集，并且可以使用这种蛋白质聚集，例如使颗粒变得聚集，这可以以某种方式确定。在某些情况下，这种聚合可能是不可逆的; 即聚集度对应于蛋白质暴露于最极端的氧浓度。例如，这样的制品可用于测定样品内或受试者（例如人类受试者）内的氧。例如，制品可以形成为皮肤贴片，或者施用于受试者的皮肤，例如皮肤表面，真皮或表皮等内，以确定受试者内的氧。

17. 发明申请

WO2010101620A2 SYSTEMS AND METHODS FOR CREATING AND USING SUCTION BLISTERS OR OTHER POOLED REGIONS OF FLUID WITHIN THE SKIN 审中-公开
标题翻译：用于在皮肤内部创建和使用吸引性疱疹或其他PO液区域的流体的系统和方法
公开(公告)号：WO2010101620A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/000623
申请日：2010-03-02
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , ANDERSON, Richard, Rox , BERNSTEIN, Howard
发明人： LEVINSON, Douglas, A. , ANDERSON, Richard, Rox , BERNSTEIN, Howard
IPC分类号： A61B5/15
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明总体上涉及与诊断，治疗和其他应用（包括皮肤相关应用）相关联的装置和技术，例如用于递送和/或从受试者抽取流体的装置，例如穿过皮。在一些实施方式中，该装置包括用于在进入部位从主体皮肤和/或穿过主体皮肤进入可提取介质的系统，以及由支撑结构支撑的压力调节器，该压力调节器能够在访问网站的至少一部分。在一些情况下，所述装置还可以包括由所述支撑结构支撑的传感器，用于从所述对象确定所述可提取介质的至少一个状态，并且可选地包括由所述支撑结构支撑的信号发生器，用于生成与媒体由传感器确定。

18. 发明申请

WO2005032523A1 INJECTABLE, ORAL, OR TOPICAL SUSTAINED RELEASE PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：可注射，口服或局部持续释放药物制剂
公开(公告)号：WO2005032523A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/031570
申请日：2004-09-27
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , HUANG, Eric, K. , NARASIMHAN, Sridhar , REESE, Shaina , STRAUB, Julie, A.
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , HUANG, Eric, K. , NARASIMHAN, Sridhar , REESE, Shaina , STRAUB, Julie, A.
IPC分类号： A61K9/16
CPC分类号： A61K9/1647 , A61K9/1617
摘要： Pharmaceutical formulations and methods are provided for the sustained delivery of a pharmaceutical agent to a patient by injection, by oral administration or by topical administration. The injectable formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein upon injection of the formulation a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 24 hours. The oral formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 2 hours following oral administration. The topical formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles for at least 2 hours following topical administration.
摘要翻译：提供药物制剂和方法用于通过注射，口服给药或通过局部给药将药剂持续递送至患者。可注射制剂包括包含药剂和基质材料的多孔微粒，其中在注射制剂时，治疗或预防有效量的药剂从微粒释放至少24小时。口服制剂包括包含药剂和基质材料的多孔微粒，其中在口服给药后至少2小时将治疗或预防有效量的药剂从微粒释放至少2小时。局部制剂包括包含药剂和基质材料的多孔微粒，其中治疗或预防有效量的药剂在局部给药后从微粒释放至少2小时。

19. 发明申请

WO2012154362A1 DEVICES AND METHODS FOR DELIVERY AND/OR WITHDRAWAL OF FLUIDS AND PRESERVATION OF WITHDRAWN FLUIDS 审中-公开
标题翻译：用于输送和/或取出流体和保存流体的装置和方法
公开(公告)号：WO2012154362A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/032846
申请日：2012-04-10
申请人： SEVENTH SENSE BIOSYSEMS, INC. , BERNSTEIN, Howard , BLICHARZ, Timothy M.
发明人： BERNSTEIN, Howard , BLICHARZ, Timothy M.
IPC分类号： A61B17/14 , A61B17/06 , A61B10/02
CPC分类号： A61B5/1519 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/15105 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15123 , A61B5/15125 , A61B50/30 , A61B2010/008 , A61M2037/0023
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽出或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是独立的，并且在某些情况下，可将该装置应用于皮肤并被激活以从受试者中抽出血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

20. 发明申请

WO2007070851A2 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PULMONARY OR NASAL ADMINISTRATION 审中-公开
标题翻译：制备基于粒子的药物制剂用于肺癌或鼻咽管理的方法
公开(公告)号：WO2007070851A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/062093
申请日：2006-12-14
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , BRITO, Shaina , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , STRAUB, Julie, A.
发明人： BERNSTEIN, Howard , BRITO, Shaina , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , STRAUB, Julie, A.
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/0043 , A61K9/0073 , A61K9/143 , A61K9/145
摘要： Dry powder pharmaceutical formulations for pulmonary or nasal administration are made to provide an improved respired dose. These formulations may be blends of milled blends and may include a phospholipid, alone or Ên combination with other excipient materials. In one case, the process includes the steps of (a) providing particles which comprise a pharmaceutical agent; (b) blending the particles with particles of at least one first excipient to form a first powder blend; (c) railling the first powder blend to form a milled blend which comprises microparticies or nanoparticles of the pharmaceutical agent; and (d) blending the milled blend with particles of a second excipient to form a blended dry powder blend pharmaceutical formulation suitable for pulmonary or nasal administration.
摘要翻译：制备用于肺或鼻给药的干粉药物制剂以提供改善的呼吸剂量。这些制剂可以是研磨的共混物的混合物，并且可以包括单独的磷脂或与其它赋形剂材料组合的磷脂。在一种情况下，该方法包括以下步骤：（a）提供包含药剂的颗粒; （b）将颗粒与至少一种第一赋形剂的颗粒混合以形成第一粉末混合物; （c）冲击第一粉末混合物以形成包含药剂的微粒或纳米颗粒的研磨混合物; 和（d）将研磨的共混物与第二赋形剂的颗粒混合以形成适于肺或鼻施用的混合的干粉混合药物制剂。

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