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    • 13. 发明申请
    • HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS
    • 生物组分的混合分光光度法监测
    • WO2012096825A3
    • 2012-09-07
    • PCT/US2012020319
    • 2012-01-05
    • O2 MEDTECH INCZHANG WEIYU ZENGPINWANG SHIH-PING
    • ZHANG WEIYU ZENGPINWANG SHIH-PING
    • A61B5/1477
    • A61B5/1455
    • Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.
    • 基于相位调制分光光度法(PMS)和连续波分光光度法(CWS)的混合组合,用于非侵入式近红外分光光度(NIRS)监测总血红蛋白水平和/或其他血液成分水平的系统,方法和相关计算机程序产品, 被描述。 处理包括用于确定至少三个不同波长中的每一个的吸收特性的非脉动分量的振幅和相位信息的基于PMS的测量值,以计算至少部分表示散射特性的PMS导出的中间信息。 结合PMS导出的中间信息处理包括幅度信息的基于CWS的测量值,以计算吸收特性的脉动分量。 从至少三个波长处的吸收特性的脉动分量计算代表至少一个发色团水平的量度,例如总血红蛋白水平,并显示在输出显示器上。