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11. 发明申请

WO2004016729A3 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：控制pH和其他反应器环境条件的系统和方法
公开(公告)号：WO2004016729A3
公开(公告)日：2005-06-30
申请号：PCT/US0325907
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
发明人： MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

12. 发明申请

WO2004069983A9 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A9
公开(公告)日：2005-02-03
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

13. 发明申请

WO2004069983A2 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A2
公开(公告)日：2004-08-19
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

14. 发明申请

WO2004016727B1 DETERMINATION AND/OR CONTROL OF REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：确定和/或控制反应堆环境条件
公开(公告)号：WO2004016727B1
公开(公告)日：2004-07-08
申请号：PCT/US0325956
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
发明人： MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12Q1/00
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, 02 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生物化学反应器芯片和其他反应系统，例如微反应器系统，以及用于构建和使用此类装置的系统和方法。在一个方面，可以构建芯片或其他反应系统以促进其内的细胞生长。在某些实施方案中，本发明的木片或其他反应体系包括一个或多个反应位点。反应位点可以非常小，例如体积小于约1ml。在本发明的一个方面中，芯片能够检测，测量和/或控制与一个或多个反应位点相关的环境因素，例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。另一方面，本发明涉及具有湿度和/或气体控制的材料和系统，例如用于芯片。这样的材料可以具有高的透氧性和/或低的水蒸汽渗透性。再一方面，本发明总体上涉及适用于芯片和其他反应器系统的光交互部件。这些部件可以包括波导，光纤，光源，光电探测器，光学元件等。

15. 发明申请

WO2005120698A2 CONTROL OF REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：反应器环境条件控制
公开(公告)号：WO2005120698A2
公开(公告)日：2005-12-22
申请号：PCT/US2005019914
申请日：2005-06-07
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO A PETER , LEBLANC SEAN J , LEROUX DENIS
发明人： RODGERS SETH T , RUSSO A PETER , LEBLANC SEAN J , LEROUX DENIS
IPC分类号： B01D61/00 , B01J19/00 , B01L3/00 , C12M3/06 , C40B60/14
CPC分类号： B01D61/002 , B01J19/0093 , B01J2219/00317 , B01J2219/00743 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502707 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0887 , B01L2300/10 , B01L2300/12 , B01L2300/163 , B01L2300/1822 , B01L2400/046 , C12P1/00 , C40B60/14
摘要： The present disclosure generally relates to chemical, biological, and/or biochemical reactor chips and/or reaction systems such as microreactor systems, as well as methods for constructing and using such systems. In some cases, humidity control materials are utilized to provide beneficially high rates of gas exchange. The humidity control materials may be used, in certain instances, to provide at least adequate, and in certain embodiments superior, gas exchange for systems having small volumes. In some cases, the currently disclosed materials include certain polymers, e.g., poly(acetylene)s such as poly(alkylacetylene)s. The polymers may be at least partially halogenated (for example, fluorinated) in some instances. In certain embodiments, a chip and/or a reaction system may be constructed so as to promote cell growth within it. In some embodiments, the chips may include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In certain embodiments, a reaction system is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, 02 concentration, relative humidity, pH, etc., associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In certain embodiments, the present disclosure discloses materials and systems having humidity and/or gas control, for example, for use with a reaction system. Such materials may have high oxygen permeability and/or low water vapor permeability. In certain embodiments, the disclosed devices can employ light-interacting components suitable for use in reaction systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本公开一般涉及化学，生物和/或生化反应堆芯片和/或反应系统，例如微反应器系统，以及用于构建和使用这种系统的方法。在一些情况下，使用湿度控制材料来提供有利的高比例的气体交换。在某些情况下，可以使用湿度控制材料，以在具有小体积的系统中提供至少足够的且在某些实施方案中优异的气体交换。在一些情况下，目前公开的材料包括某些聚合物，例如聚（乙炔）如聚（烷基乙炔）。在某些情况下，聚合物可以至少部分卤化（例如氟化）。在某些实施方案中，可以构建芯片和/或反应系统以促进细胞内的细胞生长。在一些实施方案中，芯片可以包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在某些实施方案中，反应体系能够通过以下方式检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等使用一个或多个传感器，致动器，处理器和/或控制系统。在某些实施方案中，本公开公开了具有例如用于反应体系的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧气渗透性和/或低水蒸气渗透性。在某些实施方案中，所公开的装置可以使用适合用于反应系统的光相互作用组分。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

16. 发明申请

WO2007014190A3 COMPUTERIZED FACTORIAL EXPERIMENTAL DESIGN AND CONTROL OF REACTION SITES AND ARRAYS THEREOF 审中-公开
标题翻译：计算机工程实验设计与反应场地及其阵列的控制
公开(公告)号：WO2007014190A3
公开(公告)日：2007-07-26
申请号：PCT/US2006028774
申请日：2006-07-25
申请人： BIOPROCESSORS CORP , RODGERS SETH T , ZHANG FAN , SHAHEEN MOHAMED , ALEXANDER BENJAMIN R
发明人： RODGERS SETH T , ZHANG FAN , SHAHEEN MOHAMED , ALEXANDER BENJAMIN R
IPC分类号： C12M3/00 , B01J19/00 , G06F19/28
CPC分类号： C12M41/48 , G06F19/28
摘要： Computer-facilitated design of large-scale, multi-factorial cell culture experiments and the like, and control of reaction sites and/or arrays of reaction sites to perform such experiments using automated devices. In certain cases, the invention is directed to controlling a plurality of cell culture experiments, e.g., using an automated cell culture device. In one set of embodiments, a data structure or a "descriptor" for use with cell culture experiments is provided. The descriptor may be used, for instance, to control one or more cell culture experiments, to identify one or more cell culture experiments, and/or to identify or "tag" data arising from one or more cell culture experiments, e.g., for further analysis or recall.
摘要翻译：大规模，多因素细胞培养实验等的计算机辅助设计，以及反应位点和/或反应位点阵列的控制，以使用自动化装置进行这种实验。在某些情况下，本发明涉及控制多种细胞培养实验，例如使用自动细胞培养装置。在一组实施例中，提供了用于细胞培养实验的数据结构或“描述符”。描述符可以用于例如控制一个或多个细胞培养实验，以鉴定一个或多个细胞培养实验，和/或识别或“标记”由一个或多个细胞培养实验产生的数据，例如进一步分析或召回。

17. 发明申请

WO2005121307A3 GAS CONTROL IN A MICROREACTOR 审中-公开
标题翻译：微生物气体控制
公开(公告)号：WO2005121307A3
公开(公告)日：2006-08-17
申请号：PCT/US2005019969
申请日：2005-06-07
申请人： BIOPROCESSOR CORP , RODGERS SETH T , RUSSO A PETER , JOHNSON TIMOTHY J , LEBLANC SEAN J
发明人： RODGERS SETH T , RUSSO A PETER , JOHNSON TIMOTHY J , LEBLANC SEAN J
IPC分类号： B01L3/00 , B01J19/00 , C12M20060101
CPC分类号： B01J19/0093 , B01J2219/00837 , B01J2219/00862 , B01J2219/00869 , B01J2219/00907 , B01J2219/00952 , B01J2219/00963 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2200/0668 , B01L2200/0684 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2300/0887 , B01L2300/10 , B01L2400/0457 , B01L2400/0688 , B01L2400/086
摘要： Chemical, biological, and/or biochemical reaction systems, including chips or reactors, may be configured so as to restrain immiscible materials such as gas bubbles from interfering with the determination of environmental factors associated with the chip according to one aspect of the invention. In another aspect, a chip or other reaction system may be configured to maintain a gas headspace in the chip or other reaction system. In certain embodiments, impediments such as physical barriers may be used to contain gas bubbles within a gas containing region, or otherwise away from a detection region. In other embodiments, surface tension properties may be used to control the location of gas bubbles. The chip or other reaction systems may include reaction site containers that can be very small, for example, having a volume of less than about 2 ml. In certain embodiments, chips or other reaction systems of the invention include one or more reaction sites, which, in some cases, may be defined by reaction site containers. According to another aspect of the invention, a reaction site container may be shaped to limit the formation of gas bubbles during the filling of the reaction site container with liquid by providing reaction site container shapes that do not include sharp angles or abrupt changes in reaction site container width.
摘要翻译：包括芯片或反应器的化学，生物和/或生物化学反应系统可以被配置为根据本发明的一个方面来抑制诸如气泡的不混溶材料干扰与芯片相关的环境因素的确定。在另一方面，芯片或其它反应系统可以被配置为在芯片或其他反应系统中保持气体顶部空间。在某些实施方案中，阻挡物例如物理屏障可以用于在含气体区域内或以其他方式远离检测区域容纳气泡。在其它实施例中，可以使用表面张力特性来控制气泡的位置。芯片或其他反应系统可以包括可以非常小的反应位点容器，例如具有小于约2ml的体积。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点，其在一些情况下可由反应位点容器限定。根据本发明的另一方面，反应部位容器可以成形为通过提供不包括尖锐角度的反应部位容器形状或反应部位的突然变化来限制在用液体填充反应部位容器期间产生气泡的形成容器宽度。

18. 发明申请

WO2005121307A9 GAS CONTROL IN A REACTOR 审中-公开
标题翻译：反应器中的气体控制
公开(公告)号：WO2005121307A9
公开(公告)日：2006-04-27
申请号：PCT/US2005019969
申请日：2005-06-07
申请人： BIOPROCESSOR CORP , RODGERS SETH T , RUSSO A PETER , JOHNSON TIMOTHY J , LEBLANC SEAN J
发明人： RODGERS SETH T , RUSSO A PETER , JOHNSON TIMOTHY J , LEBLANC SEAN J
IPC分类号： B01J19/00 , B01L3/00 , C12M20060101 , C12M
CPC分类号： B01J19/0093 , B01J2219/00837 , B01J2219/00862 , B01J2219/00869 , B01J2219/00907 , B01J2219/00952 , B01J2219/00963 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2200/0668 , B01L2200/0684 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2300/0887 , B01L2300/10 , B01L2400/0457 , B01L2400/0688 , B01L2400/086
摘要： Chemical, biological, and/or biochemical reaction systems, including chips or reactors, may be configured so as to restrain immiscible materials such as gas bubbles from interfering with the determination of environmental factors associated with the chip according to one aspect of the invention. In another aspect, a chip or other reaction system may be configured to maintain a gas headspace in the chip or other reaction system. In certain embodiments, impediments such as physical barriers may be used to contain gas bubbles within a gas containing region, or otherwise away from a detection region. In other embodiments, surface tension properties may be used to control the location of gas bubbles. The chip or other reaction systems may include reaction site containers that can be very small, for example, having a volume of less than about 2 ml. In certain embodiments, chips or other reaction systems of the invention include one or more reaction sites, which, in some cases, may be defined by reaction site containers. According to another aspect of the invention, a reaction site container may be shaped to limit the formation of gas bubbles during the filling of the reaction site container with liquid by providing reaction site container shapes that do not include sharp angles or abrupt changes in reaction site container width.
摘要翻译：包括芯片或反应器的化学，生物和/或生物化学反应系统可以被配置为根据本发明的一个方面来抑制诸如气泡的不混溶材料干扰与芯片相关联的环境因素的确定。在另一方面，芯片或其它反应系统可以被配置为在芯片或其他反应系统中保持气体顶部空间。在某些实施方案中，阻挡物例如物理屏障可以用于在含气体区域内或以其他方式远离检测区域容纳气泡。在其它实施例中，可以使用表面张力特性来控制气泡的位置。芯片或其他反应系统可以包括可以非常小的反应位点容器，例如具有小于约2ml的体积。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点，在某些情况下，反应位点可以由反应位点容器限定。根据本发明的另一方面，反应部位容器可以成形为通过提供不包括尖锐角度的反应部位容器形状或反应部位的突然变化来限制在用液体填充反应部位容器期间产生气泡的形成容器宽度。

19. 发明申请

WO03104384B1 REACTOR SYSTEMS HAVING A LIGHT-INTERACTING COMPONENT 审中-公开
标题翻译：具有光交互组件的反应器系统
公开(公告)号：WO03104384B1
公开(公告)日：2004-02-26
申请号：PCT/US0318240
申请日：2003-06-05
申请人： BIOPROCESSORS CORP
发明人： MILLER SCOTT , LEBLANC SEAN J , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： B01L3/00 , G01N21/47 , G01N21/63 , G01N21/64 , G01N21/77 , G01N33/543 , C12M1/34 , B01J19/00 , C12M3/00 , G01N21/01 , G01N33/487
CPC分类号： B01L3/502715 , B01J2219/00317 , B01J2219/00704 , B01J2219/00743 , B01L3/5025 , B01L3/502707 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/0861 , B01L2300/163 , B01L2300/1838 , B01L2400/046 , B01L2400/0487 , B01L2400/086 , G01N21/47 , G01N21/64 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/635
摘要： Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light to or from the reaction site. The chip may contain a reaction site having a volume of less than about 1 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, or more than one reaction site.
摘要翻译：本发明的各个方面涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。如果使用波导，则它们可以从能够将光透射到反应位点的任何材料形成。芯片可以含有体积小于约1ml的反应位点。在一些实施例中，芯片可以以能够支撑活细胞的方式构造。该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。其他促进反应可能包括化学或生物物种的生产或消费。在一些实施方案中，芯片可以包括多于一种组分或组分类型，或多于一个反应位点。

20. 发明申请

WO03103813A2 MATERIALS AND REACTOR SYSTEMS HAVING HUMIDITY AND GAS CONTROL 审中-公开
标题翻译：具有湿度和气体控制的材料和反应器系统
公开(公告)号：WO03103813A2
公开(公告)日：2003-12-18
申请号：PCT/US0317816
申请日：2003-06-05
申请人： BIOPROCESSORS CORP
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD , ZARUR ANDREY J
IPC分类号： C12M1/04 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/26 , B01D71/28 , B01D71/32 , B01D71/70 , B01J19/00 , B01L3/00 , C12M3/06 , C12N5/06 , C40B60/14 , C12M1/00
CPC分类号： C12M29/04 , B01D69/02 , B01D69/12 , B01J19/0093 , B01J2219/00317 , B01J2219/00743 , B01J2219/00783 , B01J2219/00833 , B01J2219/00907 , B01J2219/00957 , B01J2219/00981 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/10 , B01L2400/046 , C12M23/12 , C12M23/22 , C12M23/24 , C12M25/02 , C12M41/34 , C40B60/14
摘要： The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.
摘要翻译：本发明涉及具有湿气和/或气体控制的材料和反应器系统。该材料可能具有高的透氧性和/或低水蒸气渗透性。在一些情况下，该材料可具有足够的渗透性和/或渗透性，以允许细胞培养在使用该材料的芯片或其它反应器系统中发生。在某些实施方案中，材料可以位于与芯片或反应器内的反应位置相邻或邻接的位置; 在其它实施方案中，材料可以被定位成使其与反应部位流体连通。在某些情况下，材料也可以是多孔的和/或透明的。在一组实施方案中，材料包括分支的聚合物和/或包含允许聚合物具有更开放结构的庞大的侧基。在一些情况下，材料可以包括两层或更多层。每个层可以具有期望的性质，其可以包括例如渗透性，透明度，细胞毒性，生物亲和力，亲水性或结构特征。在一些实施方案中，可以选择材料以促进芯片或反应器内的细胞生长。

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