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11. 发明申请

WO1995013113A1 DEVICE FOR TREATING CANCER AND NON-MALIGANT TUMORS AND METHODS 审中-公开
标题翻译：用于治疗癌症和非恶性肿瘤的装置和方法
公开(公告)号：WO1995013113A1
公开(公告)日：1995-05-18
申请号：PCT/US1994012842
申请日：1994-11-08
申请人： ZOMED INTERNATIONAL, INC. , EDWARDS, Stuart, D. , LAX, Ronald, G. , SHARKEY, Hugh, R.
发明人： ZOMED INTERNATIONAL, INC.
IPC分类号： A61N05/02
CPC分类号： A61B18/1477 , A61B18/14 , A61B18/1402 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2018/00011 , A61B2018/00196 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00761 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/162 , A61B2218/002 , A61M3/0279 , A61M25/007 , A61N5/02 , A61N5/04 , A61N5/045
摘要： A method of this invention for treating body tissues containing cancerous cells or non-malignant tumors with RF ablation, alone or in combination with systemic or localized chemotherapy comprising introducing a stylet comprising an electrode surface and a sleeve longitudinally moveable thereon into the vicinity of the body tissues, retracting the sleeve from a portion of the electrode surface, and supplying RF power to the electrode surface sufficient to heat the tissue to a temperature of above about 45 DEG C for a time to cause reduction of tissue mass in the vicinity of the electrode. The RF power supplied to the electrode surface is sufficient to effect a desiccated fluid diffusion barrier capsule surrounding the body tissue being treated. The stylet can include a hollow tube having fluid distribution ports therein, and the method can include the step of passing fluid through one or more distribution ports into the body tissue being treated. The fluid can be saline or a chemotherapeutic fluid such as liquid or gas containing a cytotoxic agent, for example. The fluid can be administered in a variety of procedures. The fluid can be passed through a distribution port into the body tissue before, during and/or after the RF power is supplied to the electrode surface, for example. Preferably, the fluid is introduced after a barrier capsule has been formed. The devices comprises electrodes having a hollow core and a closed sharpened distal tip. The electrode has a plurality of fluid distribution ports therein for distribution of fluid treatment agents into the tissue.
摘要翻译：本发明的方法，用于单独或与全身或局部化疗组合，用RF消融治疗含有癌细胞或非恶性肿瘤的身体组织，包括将包含电极表面和纵向可移动到其上的套管引入身体附近组织，从电极表面的一部分缩回套筒，并将RF功率提供给电极表面，足以将组织加热到高于约45℃的温度一段时间，以引起电极附近的组织块的减少。提供给电极表面的RF功率足以实现围绕被处理的身体组织的干燥的流体扩散阻挡胶囊。探针可以包括其中具有流体分配端口的中空管，并且该方法可以包括使流体通过一个或多个分配端口进入被处理的身体组织的步骤。流体可以是例如盐水或化疗液体，例如含有细胞毒性剂的液体或气体。流体可以以各种方法给药。例如，在将RF功率提供给电极表面之前，期间和/或之后，流体可以通过分配端口进入身体组织。优选地，在形成阻挡胶囊之后引入流体。该装置包括具有中空芯和封闭的锋利的远端的电极。电极在其中具有多个流体分配端口，用于将流体处理剂分配到组织中。

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