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11. 发明申请

WO2013048446A1 DEVICES TO DETECT A SUBSTANCE AND METHODS OF PRODUCING SUCH A DEVICE 审中-公开
标题翻译：检测物质的装置和生产这种装置的方法
公开(公告)号：WO2013048446A1
公开(公告)日：2013-04-04
申请号：PCT/US2011/054283
申请日：2011-09-30
申请人： HEWLET-PACKARD DEVELOPMENT COMPANY, L.P. , WU, Wei , LI, Zhiyong , KIM, Ansoon , HU, Min , STUKE, Michael Josef
发明人： WU, Wei , LI, Zhiyong , KIM, Ansoon , HU, Min , STUKE, Michael Josef
IPC分类号： G01N1/36 , G01N21/64 , G01N21/65 , G01N33/00
CPC分类号： G01N31/22 , B01L3/5085 , B01L3/50853 , B01L2200/141 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B82Y15/00 , G01N21/648 , G01N21/658 , G01N2201/0227 , G01N2201/023 , Y10T436/25
摘要： Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.
摘要翻译：公开了检测物质的装置和制造这种装置的方法。用于检测物质的示例性装置包括限定外部可触及室的壳体和用于封闭室的至少一部分的密封件。该示例性装置还包括基底，其包括位于腔室内的纳米颗粒。纳米颗粒暴露于物质时与物质反应。该示例性装置还包括室内的非分析溶液以保护纳米颗粒免于过早暴露。

12. 发明申请

WO2012161683A1 SURFACE ENHANCED RAMAN SPECTROSCOPY SENSOR, SYSTEM AND METHOD OF SENSING 审中-公开
标题翻译：表面增强拉曼光谱传感器，系统和感测方法
公开(公告)号：WO2012161683A1
公开(公告)日：2012-11-29
申请号：PCT/US2011/037464
申请日：2011-05-20
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY L.P. , KIM, Ansoon , LI, Zhiyong
发明人： KIM, Ansoon , LI, Zhiyong
IPC分类号： G01J3/44 , B82Y15/00
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/44
摘要： A surface enhanced Raman spectroscopy (SERS) sensor, system and method employ nanorods and independent nanoparticles that interact. The sensor includes at least two spaced apart nanorods attached at first ends to a substrate and an independent nanoparticle. Second ends of the nanorods are movable into close proximity to one another and include a Raman active surface. The nanoparticle has a functionalized surface that includes a Raman signal generator. An interaction between the nanoparticle and the nanorod second ends in close proximity is detectable. The system includes the SERS sensor, an illumination source and a Raman signal detector. The method includes illuminating the interaction of the nanoparticle and the nanorods with an analyte, and detecting an effect on a Raman signal caused by the analyte.
摘要翻译：表面增强拉曼光谱（SERS）传感器，系统和方法采用纳米棒和独立纳米粒子相互作用。传感器包括至少两个间隔开的纳米棒，其在第一端附着到基底和独立的纳米颗粒。纳米棒的第二端可以彼此靠近移动并且包括拉曼活性表面。纳米颗粒具有包括拉曼信号发生器的官能化表面。纳米颗粒和纳米棒第二末端之间的相互作用是可以接近的。该系统包括SERS传感器，照明源和拉曼信号检测器。该方法包括用分析物照射纳米颗粒和纳米棒的相互作用，并检测由分析物引起的对拉曼信号的影响。

13. 发明申请

WO2012128762A1 HYBRID NANOSTRUCTURES FOR MOLECULAR ANALYSIS 审中-公开
标题翻译：用于分子分析的混合纳米结构
公开(公告)号：WO2012128762A1
公开(公告)日：2012-09-27
申请号：PCT/US2011/029612
申请日：2011-03-23
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , KIM, Ansoon , LI, Zhiyong , WILLIAMS, R. Stanley
发明人： KIM, Ansoon , LI, Zhiyong , WILLIAMS, R. Stanley
IPC分类号： G01N33/483 , G01N21/65 , B82B1/00
CPC分类号： G01N21/00 , G01N21/554 , G01N21/648 , G01N21/658
摘要： A hybrid nanostructure for molecular analysis is disclosed. The structure includes a plurality of nanofingers wherein each nanofinger is coated with a metal coating, is attached at one end to a substrate, and is freely bendable along its length such that the second ends of each nanofinger are capable of movement toward each other to form a cavity. The structure further includes a nanoparticle trapped in the cavity. An array of hybrid nanostructures and a method for fabricating the hybrid nanostructures are also disclosed.
摘要翻译：公开了用于分子分析的杂化纳米结构。该结构包括多个纳米针，其中每个纳米针涂覆有金属涂层，其一端连接到基底，并且可沿其长度自由弯曲，使得每个纳米针的第二端能够朝向彼此移动以形成一个空腔。该结构还包括捕获在空腔中的纳米颗粒。还公开了一系列混合纳米结构和制备混合纳米结构的方法。

14. 发明申请

WO2010030057A1 APPARATUS AND METHOD FOR DETECTING BIOMOLECULES 审中-公开
标题翻译：检测生物分子的装置和方法
公开(公告)号：WO2010030057A1
公开(公告)日：2010-03-18
申请号：PCT/KR2008/006843
申请日：2008-11-20
申请人： ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE , AH, Chil-Seong , KIM, Ansoon , PARK, Chan-Woo , AHN, Chang-Geun , YANG, Jong-Heon , BAEK, In-Bok , KIM, Taeyoub , YANG, HyeKyoung , SUNG, Gun-Yong , PARK, Seon-Hee , YU, Han-Young , JANG, Moon-Gyu
发明人： AH, Chil-Seong , KIM, Ansoon , PARK, Chan-Woo , AHN, Chang-Geun , YANG, Jong-Heon , BAEK, In-Bok , KIM, Taeyoub , YANG, HyeKyoung , SUNG, Gun-Yong , PARK, Seon-Hee , YU, Han-Young , JANG, Moon-Gyu
IPC分类号： G01N27/06
CPC分类号： G01N33/54373 , B01L3/502761 , B01L2200/143 , B01L2300/0636 , B01L2300/0645 , B01L2300/0867 , B01L2300/163 , B01L2400/0415 , G01N27/4145
摘要： Provided are an apparatus and method for detecting biomolecules. The apparatus includes a FET having a substrate, a source electrode, a drain electrode, a channel region between the source and drain electrodes, and probe molecules fixed to the channel region, wherein the source and drain electrodes are separated on the substrate, a microfluid supplier selectively supplying one of a reference buffer solution of low ionic concentration and a reaction solution of high ionic concentration containing target molecules, to the channel region of the FET to which the probe molecules are fixed, and a biomolecule detector detecting the target molecules by measuring a first current value of the channel region of the FET, and a second current value of the channel region of the FET to which the target molecules and the probe molecules that bind to each other in the reaction solution of high ionic concentration are fixed.
摘要翻译：提供了用于检测生物分子的装置和方法。该装置包括具有基板，源电极，漏电极，源极和漏极之间的沟道区以及固定到沟道区的探针分子的FET，其中源电极和漏电极在衬底上分离，微流体供应商选择性地将低离子浓度的参考缓冲溶液和含有靶分子的高离子浓度的反应溶液中的一种提供给探针分子固定的FET的通道区域，以及通过测量来检测靶分子的生物分子检测器 FET的沟道区域的第一电流值和在高离子浓度的反应溶液中彼此结合的靶分子和探针分子的FET的沟道区域的第二电流值是固定的。

15. 发明申请

WO2008069477A1 BIOSENSOR AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：生物传感器及其制造方法
公开(公告)号：WO2008069477A1
公开(公告)日：2008-06-12
申请号：PCT/KR2007/005908
申请日：2007-11-22
申请人： ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE , AHN, Chang-Geun , LEE, Seongjae , YANG, Jong-Heon , BAEK, In-Bok , YU, Han-Young , AH, Chil-Seong , KIM, Ansoon , PARK, Chan-Woo , PARK, Seon-Hee , ZYUNG, Taehyoung
发明人： AHN, Chang-Geun , LEE, Seongjae , YANG, Jong-Heon , BAEK, In-Bok , YU, Han-Young , AH, Chil-Seong , KIM, Ansoon , PARK, Chan-Woo , PARK, Seon-Hee , ZYUNG, Taehyoung
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G01N33/5438 , G01N27/4145
摘要： Provided is a biosensor which can detect a specific biomaterial by an interaction between target molecules and probe molecules, and a manufacturing method thereof. The biosensor includes: a first conductive semiconductor substrate; a second conductive doping layer formed on the semiconductor substrate; an electrode formed on top of both opposite ends of the doping layer; and probe molecules immobilized on the doping layer.
摘要翻译：本发明提供能够通过靶分子和探针分子之间的相互作用检测特定生物材料的生物传感器及其制造方法。生物传感器包括：第一导电半导体衬底; 形成在所述半导体衬底上的第二导电掺杂层; 形成在所述掺杂层的两相对端的顶部上的电极; 和固定在掺杂层上的探针分子。

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