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    • 15. 发明申请
    • CLEANING COMPOSITIONS CONTAINING MULTIPLY-SUBSTITUTED PROTEASE VARIANTS
    • 含有多取代蛋白质变体的清洁组合物
    • WO9920727A9
    • 1999-09-02
    • PCT/US9822588
    • 1998-10-23
    • PROCTER & GAMBLEGENENCOR INTGHOSH CHANCHAL KUMARBAECK ANDRE CESAROHTANI RYOHEIBUSCH ALFREDSHOWELL MICHAEL STANFORDSCHELLENBERGER VOLKERKELLIS JAMES T JRPAECH CHRISTIANNADHERNY JOANNENAKI DONALD PCOLLIER KATHERINE DCALDWELL ROBERT MPOULOSE AYROOKARAN J
    • GHOSH CHANCHAL KUMARBAECK ANDRE CESAROHTANI RYOHEIBUSCH ALFREDSHOWELL MICHAEL STANFORDSCHELLENBERGER VOLKERKELLIS JAMES T JRPAECH CHRISTIANNADHERNY JOANNENAKI DONALD PCOLLIER KATHERINE DCALDWELL ROBERT MPOULOSE AYROOKARAN J
    • A23G4/00A23G4/12A61K8/66A61Q11/00C11D1/74C11D3/37C11D3/386C12N9/54A23G3/30A61K7/28A61K7/48
    • A23G4/123A61K8/66A61Q11/00C11D1/74C11D3/3776C11D3/386C12N9/54C12Y304/21062
    • The present invention relates to cleaning compositions comprising a protease variant. One cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin; and one or more cleaning adjunct materials. Another cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of DOLLAR (Bacillus amyloliquefaciens) subtilisin; and one or more cleaning adjunct materials. Methods for using the cleaning compositions are also provided.
    • 本发明涉及包含蛋白酶变体的清洁组合物。 一种清洁组合物包含蛋白酶变体,其包括氨基酸残基与对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置103的氨基酸残基处的另一个天然存在的氨基酸残基的取代,以及氨基酸残基与另一天然存在的 一个或多个对应于1,2,3,4,8,9,10,12,13,16,17,18,19,20,21,22,24,27,33, 37,38,42,43,48,55,57,58,61,62,68,72,75,76,77,78,79,86,87,89,97,98,99,101,102, 104,106,107,109,111,114,116,117,119,121,123,126,128,130,131,133,134,137,140,141,142,146, 160,166,167,170,173,174,177,181,182,183,184,185,188,192,194,198,203,204,205,206,209,210,211,212,213, 214,215,216,217,218,222,224,227,228,222,224,227,228,230,232,236,237,238,240,242,243,244,245,246,247,248,249,251,252,225,216,217,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224,227,218,222,224 253,254,25 5,256,257,258,259,260,261,262,263,265,268,269,270,271,272,274和275的解淀粉芽孢杆菌枯草杆菌蛋白酶; 其中当所述蛋白酶变体包括对位置103和76的氨基酸残基置换时,还有一个或多个除对应于位置27,99的氨基酸残基位置之外的氨基酸残基的氨基酸残基的取代 ,解淀粉芽孢杆菌枯草杆菌蛋白酶的101,104,107,109,123,128,166,204,206,210,216,217,218,222,260,265或274; 和一种或多种清洁辅助材料。 另一种清洁组合物包含蛋白酶变体,其包括氨基酸残基与对应于DOLLAR(解淀粉芽孢杆菌)的位置62,212,230,232,252和257的一个或多个氨基酸残基处的另一个天然存在的氨基酸残基取代, 枯草杆菌蛋白酶; 以及一种或多种清洁辅助材料。 还提供了使用清洁组合物的方法。