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1. 发明申请

WO2012154735A3 THERMOSTABLE CARBONIC ANHYDRASES AND METHODS OF USE THEREOF 审中-公开
标题翻译：热稳定性碳酸酐及其使用方法
公开(公告)号：WO2012154735A3
公开(公告)日：2013-02-07
申请号：PCT/US2012036932
申请日：2012-05-08
申请人： DANISCO US INC , GE JING , HUA LING , POULOSE AYROOKARAN J
发明人： GE JING , HUA LING , POULOSE AYROOKARAN J
IPC分类号： C12N9/88 , C07K14/195 , C07K14/37 , C07K17/02 , C12N15/52 , C12N15/63 , C12P5/02
CPC分类号： C12N9/88 , B01D53/62 , B01D53/84 , B01D2251/95 , B01D2258/0283 , C02F3/342 , C12N11/14 , C12Y402/01001 , Y02E50/343
摘要： The present compositions and methods relate to a thermostable carbonic anhydrases, polynucleotides encoding the carbonic anhydrase, and methods of make and/or use thereof. Formulations containing the carbonic anhydrase are suitable for use in extracting carbon dioxide.
摘要翻译：本发明的组合物和方法涉及热稳定性碳酸酐酶，编码碳酸酐酶的多核苷酸，以及制备和/或使用它们的方法。含有碳酸酐酶的制剂适用于提取二氧化碳。

2. 发明申请

WO2010056635A1 COMPOSITIONS AND METHODS COMPRISING A SUBTILISIN VARIANT 审中-公开
标题翻译：包含色氨酸变体的组合物和方法
公开(公告)号：WO2010056635A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/063799
申请日：2009-11-10
申请人： DANISCO US INC. , ESTELL, David, A. , GOEDEGEBUUR, Frits , POULOSE, Ayrookaran, J.
发明人： ESTELL, David, A. , GOEDEGEBUUR, Frits , POULOSE, Ayrookaran, J.
IPC分类号： C12N9/54
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38681 , C11D3/3942 , C12N9/54 , C12Y304/21062
摘要： The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides automatic dishwashing compositions comprising this serine protease variant.
摘要翻译：本发明提供芽孢杆菌属枯草杆菌蛋白酶变体。此外，本发明提供了包含该丝氨酸蛋白酶变体的自动餐具洗涤组合物。

3. 发明申请

WO2008106215A1 CLEANING ENZYMES AND MALODOR PREVENTION 审中-公开
标题翻译：清洁酶和恶性肿瘤预防
公开(公告)号：WO2008106215A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002682
申请日：2008-02-27
申请人： DANISCO US, INC., GENENCOR DIVISION , MCAULIFFE, Joseph C. , MIKKELSEN, Jorn Dalgaard , POULOSE, Ayrookaran J. , SOE, Jorn Borch
发明人： MCAULIFFE, Joseph C. , MIKKELSEN, Jorn Dalgaard , POULOSE, Ayrookaran J. , SOE, Jorn Borch
IPC分类号： C11D3/386
CPC分类号： C11D3/38636
摘要： The present invention provides compositions comprising an acyltransferase and an alcohol substrate for the acyltransferase. In some particularly preferred embodiments, the composition finds use in production of a fragrant ester. In some other embodiments, the composition finds use in laundry detergents to clean stains that contain at least one triglyceride. In some further embodiments, the compositions are used to produce compounds with cleaning properties (e.g., a surfactant ester).
摘要翻译：本发明提供了包含酰基转移酶和酰基转移酶的醇底物的组合物。在一些特别优选的实施方案中，该组合物用于生产芳香酯。在一些其它实施方案中，组合物可用于衣物洗涤剂中以清洁含有至少一种甘油三酯的污渍。在一些另外的实施方案中，组合物用于产生具有清洁性能的化合物（例如表面活性剂酯）。

4. 发明申请

WO2008063400A1 ENZYME FOR THE PRODUCTION OF LONG CHAIN PERACID 审中-公开
标题翻译：用于长链生产的酶
公开(公告)号：WO2008063400A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/023327
申请日：2007-11-05
申请人： DANISCO US, INC., GENENCOR DIVISION , AMIN, Neelam, S. , BOTT, Richard, R. , CERVIN, Marguerite, A. , POULOSE, Ayrookaran, J. , WEYLER, Walter
发明人： AMIN, Neelam, S. , BOTT, Richard, R. , CERVIN, Marguerite, A. , POULOSE, Ayrookaran, J. , WEYLER, Walter
IPC分类号： C12N15/55 , C12N9/16 , C11D3/386
CPC分类号： C12N9/16 , C11D3/38636
摘要： The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embodiments of the present invention find particular use in applications involving cleaning, bleaching and disinfecting.
摘要翻译：本发明提供包含至少一种用于清洁和其它应用的过水解酶的方法和组合物。在一些实施方案中，本发明提供用于产生长链过酸的方法和组合物。本发明的某些实施方案特别用于涉及清洁，漂白和消毒的应用中。

5. 发明申请

WO2005056782A3 PERHYDROLASE 审中-公开
标题翻译：水解酶
公开(公告)号：WO2005056782A3
公开(公告)日：2006-02-16
申请号：PCT/US2004040438
申请日：2004-12-03
申请人： GENENCOR INT , PROCTER & GAMBLE , AMIN NEELAM S , BOSTON MATTHEW G , BOTT RICHARD R , CERVIN MARGUERITE A , CONCAR EDWARD M , GUSTWILLER MARC E , JONES BRIAN EDWARD , LIEBETON KLAUS , MIRACLE GREGORY S , OH HIROSHI , POULOSE AYROOKARAN J , RAMER SANDRA W , SCHEIBEL JEFFREY J , WEYLER WALTER , WHITED GREGORY M
发明人： AMIN NEELAM S , BOSTON MATTHEW G , BOTT RICHARD R , CERVIN MARGUERITE A , CONCAR EDWARD M , GUSTWILLER MARC E , JONES BRIAN EDWARD , LIEBETON KLAUS , MIRACLE GREGORY S , OH HIROSHI , POULOSE AYROOKARAN J , RAMER SANDRA W , SCHEIBEL JEFFREY J , WEYLER WALTER , WHITED GREGORY M
IPC分类号： C12N9/16 , C11D3/386 , C12N9/50 , C12N9/52
CPC分类号： A01N63/00 , C11D3/38636 , C12N9/16 , C12N9/50 , C12N9/52
摘要： The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions for generation of peracids. The present invention finds particular use in applications involving cleaning, bleaching and disinfecting.
摘要翻译：本发明提供包含至少一种用于清洁和其它应用的过水解酶的方法和组合物。在一些特别优选的实施方案中，本发明提供了用于产生过酸的方法和组合物。本发明特别用于涉及清洗，漂白和消毒的应用。

6. 发明申请

WO2005052161A3 SERINE PROTEASES, NUCLEIC ACIDS ENCODING SERINE ENZYMES AND VECTORS AND HOST CELLS INCORPORATING SAME 审中-公开
标题翻译：丝氨酸蛋白酶，核酸编码丝氨酸酶和载体和宿主细胞
公开(公告)号：WO2005052161A3
公开(公告)日：2005-11-03
申请号：PCT/US2004039006
申请日：2004-11-19
申请人： GENENCOR INT , JONES BRIAN EDWARD , KOLKMAN MARC , LEEFLANG CHRIS , POULOSE AYROOKARAN J , SHAW ANDREW , VAN DER KLEIJ WILHELMUS A H , VAN MARREWIJK LEO
发明人： JONES BRIAN EDWARD , KOLKMAN MARC , LEEFLANG CHRIS , POULOSE AYROOKARAN J , SHAW ANDREW , VAN DER KLEIJ WILHELMUS A H , VAN MARREWIJK LEO
IPC分类号： C11D3/386 , C12N9/52 , C12N9/64 , C12N15/53
CPC分类号： C12N9/52 , C07K2299/00 , C11D3/386
摘要： The present invention provides novel serine proteases, novel genetic material encoding these enzymes, and proteolytic proteins obtained from Micrococcineae spp., including but not limited to Cellulomonas spp. and variant proteins developed therefrom. In particular, the present invention provides protease compositions obtained from a Cellulomonas spp, DNA encoding the protease, vectors comprising the DNA encoding the protease, host cells transformed with the vector DNA, and an enzyme produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising protease(s) obtained from a Micrococcineae spp., including but not limited to Cellulomonas spp. In alternative embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These mutant proteases also find use in numerous applications.
摘要翻译：本发明提供了新的丝氨酸蛋白酶，编码这些酶的新型遗传物质，以及从微球菌属（Micrococcineae spp。）获得的蛋白水解蛋白，包括但不限于纤维单胞菌属（Cellulomonas spp）和从其开发的变体蛋白质。特别地，本发明提供了从纤维单胞菌属（Splulomonas spp）获得的蛋白酶组合物，编码蛋白酶的DNA，包含编码蛋白酶的载体的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物，以及包含从微球菌（Micrococcineae spp。）获得的蛋白酶的纺织和皮革加工组合物，其包括但不限于纤维单胞菌属（Cellulomonas spp）在替代实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。这些突变型蛋白酶也可用于许多应用。

7. 发明申请

WO1991006313A1 PROTECTION OF GROWING CROPS FROM PATHOGENS BY TREATMENT WITH ENZYMES 审中-公开
标题翻译：通过用酶处理保护来自病原体的作物
公开(公告)号：WO1991006313A1
公开(公告)日：1991-05-16
申请号：PCT/US1990006086
申请日：1990-10-26
申请人： GENENCOR INTERNATIONAL INC. , KOLATTUKUDY, Pappachan, E. , O'NEILL, Roger, A. , POULOSE, Ayrookaran, J.
发明人： GENENCOR INTERNATIONAL INC.
IPC分类号： A61K37/54
CPC分类号： A01N63/00 , A01N61/00 , A01N25/30 , A01N2300/00
摘要： A method is disclosed for protecting a growing crop from pathogens comprising applying to the growing crop and to any pathogen present thereon a compound capable of generating an active oligomer elicitor in the crop or the pathogen. The compound is applied with a penetrating agent which aids in the entry of the compound into the cuticle layer of the growing crop or the pathogen. The elicitor is generated in the crop or the pathogen in an amount effective to elicit production in the crop of an anti-pathogenic agent. When the elicitor is generated in a pathogen present on the harvested crop, the elicitor is generated in sufficient amount to transfer into the crop, which transfer may be aided by the presence of said penetrating agent, in order to produce the desired phytoalexins in the harvested crop. Also disclosed is a composition comprising the above compound and a penetrating agent for the compound as well as a growing crop treated with the above composition.
摘要翻译：公开了一种用于保护生长的作物免受病原体的方法，其包括施用于生长的作物和存在于其上的任何病原体上能够在作物或病原体中产生活性寡聚体诱发剂的化合物。该化合物施用有助于化合物进入生长作物或病原体的角质层的渗透剂。激发剂在作物或病原体中以有效引起作物中抗生素剂产生的量产生。当引诱剂在收获的作物上存在的病原体中产生时，产生足够量的诱发子以转移到作物中，所述转移可以通过所述渗透剂的存在来辅助，以便在收获的作物中产生所需的植物抗坏血酸作物。还公开了包含上述化合物和用于该化合物的渗透剂以及用上述组合物处理的生长作物的组合物。

8. 发明申请

WO2011140364A1 COMPOSITIONS AND METHODS COMPRISING SUBTILISIN VARIANTS 审中-公开
标题翻译：包含色氨酸变体的组合物和方法
公开(公告)号：WO2011140364A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035389
申请日：2011-05-05
申请人： DANISCO US INC. , THE PROCTER AND GAMBLE COMPANY , ALEKSEYEV, Viktor Yuryevich , AMIN, Neelam, S. , AUGUSTYN, Katherine , CASCAO-PEREIRA, Luis Gustavo , COLLIER, Katherine, D. , ESTELL, David, A. , KELLIS, JR., James, T. , POULOSE, Ayrookaran, J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
发明人： ALEKSEYEV, Viktor Yuryevich , AMIN, Neelam, S. , AUGUSTYN, Katherine , CASCAO-PEREIRA, Luis Gustavo , COLLIER, Katherine, D. , ESTELL, David, A. , KELLIS, JR., James, T. , POULOSE, Ayrookaran, J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
IPC分类号： C12N9/54 , C11D3/386 , C11D3/39
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译：本发明提供了丝氨酸蛋白酶变体。具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。

9. 发明申请

WO2011072099A2 COMPOSITIONS AND METHODS COMPRISING PROTEASE VARIANTS 审中-公开
标题翻译：包含蛋白酶变体的组合物和方法
公开(公告)号：WO2011072099A2
公开(公告)日：2011-06-16
申请号：PCT/US2010/059628
申请日：2010-12-09
申请人： DANISCO US INC. , BASLER, Joshua Roy , CASCAO-PEREIRA, Luis Gustavo , ESTELL, David A. , KELLIS, James T. , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , TORRES-PAZMINO, Daniel
发明人： BASLER, Joshua Roy , CASCAO-PEREIRA, Luis Gustavo , ESTELL, David A. , KELLIS, James T. , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , TORRES-PAZMINO, Daniel
IPC分类号： C12N9/64
CPC分类号： C12N9/54 , C11D3/386 , C12N9/52 , C12N9/64 , C12Y304/21062
摘要： The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions.
摘要翻译：本发明提供了蛋白酶变体，包含蛋白酶变体的组合物，以及使用这些蛋白酶变体和组合物的方法。

10. 发明申请

WO2008153925A9 METHODS FOR IMPROVING MULTIPLE PROTEIN PROPERTIES 审中-公开
公开(公告)号：WO2008153925A9
公开(公告)日：2008-12-18
申请号：PCT/US2008/007103
申请日：2008-06-06
申请人： DANISCO US, INC., GENENCOR DIVISION , CASCAO-PEREIRA, Luis, Gustavo , ESTELL, David, A. , KELLIS, James, T., Jr. , POULOSE, Ayrookaran, J.
发明人： CASCAO-PEREIRA, Luis, Gustavo , ESTELL, David, A. , KELLIS, James, T., Jr. , POULOSE, Ayrookaran, J.
IPC分类号： C12N15/10 , C12N15/01 , C12N15/52
摘要： The present invention provides efficient methods for obtaining a protein with one or more beneficial attributes in industrial, consumer or pharmaceutical applications. In some preferred embodiments, the present invention provides methods for producing superior enzymes for a given application through screening an abbreviated set of candidate enzymes.

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