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11. 发明申请

WO2009100065A2 METHOD OF REMOVING UNDESIRED TISSUE FROM CONNECTIVE TISSUE 审中-公开
标题翻译：从连接组织中去除不良组织的方法
公开(公告)号：WO2009100065A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/032961
申请日：2009-02-03
申请人： ZIMMER ORTHOBIOLOGICS, INC. , XIAN, Hai-Qing , WANG, Hali , LIU, Hui , YAO, Jian, Q. , GAO, Jizong
发明人： XIAN, Hai-Qing , WANG, Hali , LIU, Hui , YAO, Jian, Q. , GAO, Jizong
IPC分类号： A61K38/48
CPC分类号： A61K38/4826 , A61K38/465 , C12Y301/01003 , C12Y304/21004
摘要： A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include a detergent, an enzyme, a salt solution, an organic solvent, and combinations thereof.
摘要翻译：提供从结缔组织中去除不想要的组织的方法，其包括拉伸结缔组织并剥离不想要的组织。一些方法包括在拉伸和/或剥离不想要的组织之前和/或之后将结缔组织浸泡在溶液中。溶液可以包括洗涤剂，酶，盐溶液，有机溶剂及其组合。

12. 发明申请

WO2009073106A1 IN VITRO METHOD OF QUANTIFYING DEMINERALI ZED BONE OSTEOINDUCTIVITY 审中-公开
标题翻译：体外定量分析骨质疏松性骨质疏松的方法
公开(公告)号：WO2009073106A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/013073
申请日：2008-11-24
申请人： ZIMMER ORTHOBIOLOGICS, INC. , AKELLA, Rama , O'CONNELL, Julie, R.
发明人： AKELLA, Rama , O'CONNELL, Julie, R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/158
摘要： The present invention provides an in vitro method for determining the osteoinductive potential of a biomaterial. In particular, the method measures the expression of osterix by osteoblast progenitor cells incubated with the biomaterial. In various embodiments, the biomaterial is demineralized bone (DMB) and the progenitor cells are incubated with DMB or proteins extracted from DMB.
摘要翻译：本发明提供了用于测定生物材料的骨诱导电位的体外方法。特别地，该方法通过与生物材料一起温育的成骨细胞祖细胞来测量奥斯特里克的表达。在各种实施方案中，生物材料是去矿物质骨（DMB），并且祖细胞与DMB或从DMB提取的蛋白质一起温育。

13. 发明申请

WO2009048927A1 VERNONIA OIL POLYOLS 审中-公开
标题翻译： VERNONIA油多元醇
公开(公告)号：WO2009048927A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079167
申请日：2008-10-08
申请人： UNIVERSITY OF SOUTHERN MISSISSIPPI , RAWLINS, James, W. , MENDON, Sharathkumar, K. , LIU, Yuan
发明人： RAWLINS, James, W. , MENDON, Sharathkumar, K. , LIU, Yuan
IPC分类号： C11C1/04 , C11C3/06 , C08G18/00
CPC分类号： C11C3/06 , C08G18/36 , C08G18/6696 , C08G2101/0008 , C08G2101/0025 , C08G2101/005 , C08G2101/0083 , C11C1/04
摘要： The present invention discloses polyols synthesized from vemonia oil. The process for synthesizing a vemonia oil-based polyol involves reducing vernonia oil to vernolic acid; heating the vernolic acid at elevated temperatures to form oligomers; and forming the polyol by transesterification of the oligomers with glycerol. The polyols synthesized according to the present invention have lower viscosity values at similar hydroxyl values compared to polyols synthesized from other vegetable oils. The lower viscosity values are of importance in the synthesis of foams as it promotes foam growth.
摘要翻译：本发明公开了从vemonia油合成的多元醇。合成基于油的多元醇多元醇的方法包括将葵花油降低至戊醛酸; 在升高的温度下加热钒酸以形成低聚物; 并通过低聚物与甘油的酯交换形成多元醇。根据本发明合成的多元醇与其它植物油合成的多元醇相比，具有较低的粘度值。在促进泡沫生长时，较低的粘度值在泡沫的合成中是重要的。

14. 发明申请

WO2008091531A2 ELEMENTS FOR IMPROVED EXPRESSION OF BOVINE SOMATOTROPIN 审中-公开
标题翻译：用于改善牛血清素的表达的元素
公开(公告)号：WO2008091531A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/000633
申请日：2008-01-17
申请人： MONSANTO TECHNOLOGY LLC , BOGOSIAN, Gregg , FRANTZ, Julia, P. , SMITH, Hong, Q.
发明人： BOGOSIAN, Gregg , FRANTZ, Julia, P. , SMITH, Hong, Q.
IPC分类号： C07K14/43
CPC分类号： C07K14/655 , C12N15/67
摘要： The invention allows improved expression of heterologous polypeptides such as bovine somatotropin (bST). Novel compositions and methods are provided for production of bST from a native bST cDNA in transformed host cells such as E. coli. In particular, DNA segments comprising novel ribosome binding sites and adjacent sequences are provided, which in conjunction with a promoter sequence direct high level expression of bST from its native cDNA. The invention also provides expression constructs comprising the ribosome binding sites and methods for the use of such constructs.
摘要翻译：本发明允许异源多肽例如牛生长激素（bST）的改进表达。提供新的组合物和方法用于在转化的宿主细胞如大肠杆菌中从天然bST cDNA生产bST。特别地，提供了包含新的核糖体结合位点和相邻序列的DNA片段，其与来自其天然cDNA的启动子序列直接高水平表达bST。本发明还提供了包含核糖体结合位点的表达构建体和使用这种构建体的方法。

15. 发明申请

WO2006073447A2 ENRICHED PAG-55 FRACTION AND METHODS FOR EARLY DETECTION OF PREGNANCY IN UNGULATE ANIMALS 审中-公开
标题翻译：丰富的PAG-55馏分和早期检测结核病患者妊娠的方法
公开(公告)号：WO2006073447A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/014458
申请日：2005-04-27
申请人： MONSANTO TECHNOLOGY LLC , MATHIALAGAN, Nagappan , MCGRATH, Michael , SCHENKEL, Robert
发明人： MATHIALAGAN, Nagappan , MCGRATH, Michael , SCHENKEL, Robert
CPC分类号： C07K16/18 , C07K14/4715 , G01N33/689 , G01N2800/368 , Y10S424/811
摘要： Disclosed are methods for determining the pregnancy status of an ungulate animal by detecting the level of PAG-55 protein fraction. These methods may involve the detection of PAG-55 enriched proteins in the PAG-55 protein fraction by using novel polyclonal and monoclonal antibodies that have been generated using the PAG-55 enriched protein fraction as an immu1ogen. The novel PAG-55 protein fraction indicates that the animal is pregnant when the acidic PAG-55 protein fraction, or antigenic components thereof, are present at an elevated level in a sample. The present invention also provides for methods of obtaining the PAG-55 enriched protein fraction. The invention provides accurate methods of detecting pregnancy at early stages and has the benefit of allowing early post partum detection of the pregnancy status with fewl false positive results. The antibodies for detecting PAG-55 proteins will also be useful in combination with detecting elevated progesterone levels in the animal, thus providing an even more effective pregnancy detection method. The benefit of this early pregnancy detection is that identifying animals that are not pregnant very shortly after breeding, allows for timely rebreeding and minimizes the amount of time the animal is open. Also disclosed are methods for making a breeding decision for an animal. These methods allow a herd manager to make breeding decisions based on the levels of PAG-55 protein fraction and optionally, progesterone levels detected in a biological sample taken from an animal suspected of being in the early stages of pregnancy.
摘要翻译：公开了通过检测PAG-55蛋白组分的水平来确定有蹄动物的怀孕状态的方法。这些方法可能涉及通过使用已经使用富集了PAG-55的蛋白质部分作为免疫原生成的新型多克隆和单克隆抗体来检测PAG-55蛋白质级分中富含PAG-55的蛋白质。新的PAG-55蛋白部分表明，当酸性PAG-55蛋白部分或其抗原性组分在样品中以升高的水平存在时，动物是怀孕的。本发明还提供了获得富含PAG-55的蛋白质部分的方法。本发明提供了在早期阶段检测妊娠的准确方法，并且具有允许在怀孕状态的早期检测以及几乎没有假阳性结果的益处。用于检测PAG-55蛋白的抗体也可用于检测动物体内升高的孕酮水平，从而提供更有效的妊娠检测方法。这种早期妊娠检测的好处在于，能够在繁殖后立即识别未怀孕的动物，以便及时回避和避免;繁殖并最大限度地缩短动物开放的时间。还公开了用于对动物进行育种决定的方法。这些方法允许牧群管理者基于从疑似处于怀孕早期阶段的动物采集的生物样品中检测到的PAG-55蛋白质级分和任选的孕酮水平作出育种决定。

16. 发明申请

WO2005103066A1 METHOD FOR ATTACHING MOLECULAR PROBES TO A SOLID SUPPORT 审中-公开
标题翻译：将分子探针连接到固体支持物的方法
公开(公告)号：WO2005103066A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/009962
申请日：2005-03-24
申请人： BURZYNSKI, Stanislaw, R. , WRIGHT, Dennis
发明人： WRIGHT, Dennis
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： Disclosed is a novel method for attaching aldehyde, ketone or carboxyamide derivatives of molecular probes to hydrazide or hydrazine treated solid supports under alkaline conditions. In contrast to chemistries commonly used to attach biologically relevant molecules to a solid support (e.g., thiol or primary amine conjugation chemistry), the hydrazone bonds disclosed here exhibit improved chemical properties (e.g., improved stability in water and resistance to changes in pH and temperature).
摘要翻译：公开了一种在碱性条件下将分子探针的醛，酮或羧酰胺衍生物连接到酰肼或肼处理的固体载体的新方法。与通常用于将生物相关分子附着到固体支持物（例如硫醇或伯胺共轭化学）的化学物质相反，本文公开的腙键显示出改善的化学性质（例如，改善的水中的稳定性和耐pH和温度变化的抗性）。

17. 发明申请

WO2005015989A1 METHOD FOR GENETIC IMPROVEMENT OF TERMINAL BOARS 审中-公开
标题翻译：终端的遗传改良方法
公开(公告)号：WO2005015989A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/024168
申请日：2004-07-26
申请人： MONSANTO TECHNOLOGY LLC , BUTTRAM, Samuel, T. , LOHUIS, Michael, M. , GU, Youping , WAGNER, Christina, M.
发明人： BUTTRAM, Samuel, T. , LOHUIS, Michael, M. , GU, Youping , WAGNER, Christina, M.
IPC分类号： A01K67/02
CPC分类号： A01K67/027 , A01K2227/108
摘要： The methods provided herein relate to swine production. Specifically the instant invention provides methods for the production of terminal parent animals (i.e. terminal sires and terminal dams) for use in swine production herds. Also provided are methods for quickly and efficiently introducing and/or fixing one or more desirable traits or alleles in a swine herd. Alternatively, the present methods may be employed to eliminate a particular undesirable trait or gene. The invention also provides for herds that have been developed using any of the methods described herein. The invention also provides for the use of embryo transfer, including markerassisted embryo transfer to facilitate the transfer of genetic material, particularly when it is desirable to maintain the specific-pathogen free status of a herd.
摘要翻译：本文提供的方法涉及猪的产生。具体地说，本发明提供了用于生产猪生产的终端母体动物（即码头和末端大坝）的方法。还提供了用于在猪群中快速有效地引入和/或固定一种或多种所需性状或等位基因的方法。或者，可以使用本发明的方法来消除特定的不希望的特征或基因。本发明还提供了使用本文所述的任何方法开发的群体。本发明还提供了胚胎移植的使用，包括标记辅助胚胎移植以促进遗传物质的转移，特别是当希望保持牛群的特异性病原体免费状态时。

18. 发明申请

WO2004095033A3 COMPOSITIONS AND METHODS FOR ACCURATE EARLY PREGNANCY DIAGNOSIS IN UNGULATES 审中-公开
公开(公告)号：WO2004095033A3
公开(公告)日：2004-11-04
申请号：PCT/US2004/011456
申请日：2004-04-14
申请人： MOSANTO TECHNOLOGY LLC , MATHIALAGAN, Nagappan
发明人： MATHIALAGAN, Nagappan
IPC分类号： G01N33/68
摘要： This invention provides improved methods for early detection of ungulate (e.g., bovine) pregnancy, and novel antibodies useful in such assays. The antibodies are generated by using specific amino acid sequences within ubiquitin cross-reactive protein (UCRP) as immunogens. Elevated levels of UCRP proteins, when detected in a sample (e.g., bodily fluid) of the animal from days 15-30, and especially days 15-28 after insemination, indicate that the animal is pregnant. The invention can be employed to increase efficiency of commercial farm animal breeding programs.

19. 发明申请

WO2004015068A9 IDENTIFICATION OF SEEDS OR PLANTS USING PHENOTYPIC MARKERS 审中-公开
公开(公告)号：WO2004015068A9
公开(公告)日：2004-02-19
申请号：PCT/US2003/024489
申请日：2003-08-06
申请人： MONSANTO TECHNOLOGY LLC
发明人： PENNER, Greg, A. , BLEDIG, Stefan, A. , CONNER, Timothy, W. , CONCIBIDO, Vergel, C.
IPC分类号： A01H1/02 , A01H1/04 , A01H5/10 , C12N15/82

20. 发明申请

WO2002064803A2 IDENTIFICATION OF SEEDS OR PLANTS USING PHENOTYIC MARKERS 审中-公开
标题翻译：使用原始标记识别种子或植物
公开(公告)号：WO2002064803A2
公开(公告)日：2002-08-22
申请号：PCT/US2002/003545
申请日：2002-02-08
申请人： MONSANTO TECHNOLOGY LLC
发明人： PENNER, Greg, A. , BLEDIG, Stefan, A. , CONNER, Timothy, W.
IPC分类号： C12N15/82
CPC分类号： A01H1/02 , A01H1/04 , A01H5/10 , C12N15/8209 , C12N15/8274
摘要： Utilizing phenotypic markers in seeds or plants to allow qualitative detection of a proprietary trait in the harvest, to allow a quantitative calculation of the amount of the trait, and to facilitate the calculation and collection of fees for the trait. The phenotypic markers of the seeds can be the seed coat color, and said seeds can be homozygous or heterozygous for the phenotypic difference of seed coat color. Commercial cultivars of seeds with the phenotypic difference of seed color may be grown to include several different seed colors. Trait fees may be assessed on all grain with the proprietary trait, whether the grain was produced from purchased seed or from seed saved from a previous harvest.
摘要翻译：在种子或植物中利用表型标记物，以允许定性检测收获中的专有性状，以便定量计算性状的数量，并便于计算和收集性状的费用。种子的表型标记可以是种皮颜色，并且所述种子对于种皮颜色的表型差异可以是纯合的或杂合的。具有种子颜色表型差异的种子的商业品种可以生长以包括几种不同的种子颜色。可以对具有专有性状的所有粮食评估特征费用，无论粮食是从购买的种子生产还是从以前的收获中节省的种子生产。

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