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1. 发明申请

WO1998015279A1 HORMONAL COMPOSITION CONSISTING OF AN OESTROGEN COMPOUND AND OF A PROGESTATIONAL COMPOUND 审中-公开
标题翻译：雌激素化合物和孕激素组合物的组成
公开(公告)号：WO1998015279A1
公开(公告)日：1998-04-16
申请号：PCT/FR1997001792
申请日：1997-10-08
申请人： LABORATOIRE THERAMEX , LANQUETIN, Michel , PARIS, Jacques , THOMAS, Jean-Louis
发明人： LABORATOIRE THERAMEX
IPC分类号： A61K31/57
CPC分类号： A61K45/06 , A61K31/56 , A61K31/565 , A61K31/57 , Y10S424/811 , Y10S514/841 , Y10S514/843 , A61K2300/00
摘要： The invention concerns the field of chemical therapy and more particularly the field of pharmaceutical hormonal technique. More precisely it concerns novel pharmaceutical hormonal compositions characterised in that they are formed by an oestroprogestational combination consisting of an oestrogen compound and a progestational compound, associated or mixed with one or several non-toxic, inert and pharmaceutically acceptable excipients, for oral administration. The invention also concerns the use of the oestroprogestational mixture in which the oestrogenic constituent and the progestational constituent are administered in combination. The combined association can be prescribed continuously or intermittently, for producing a composition for treating oestrogenic deficiencies, preventing osteoporosis and cardiovascular diseases in the menopausal woman, or still for blocking ovulation in a woman during the period of ovarian activity. The invention also concerns a method for preparing these novel pharmaceutical oestroprogestational compositions.
摘要翻译：本发明涉及化学治疗领域，更具体地涉及药物激素技术领域。更确切地说，它涉及新型药物激素组合物，其特征在于它们由与雌激素化合物和促孕化合物组成的产卵组合形成，其与一种或多种无毒，惰性和药学上可接受的赋形剂相关或混合，用于口服给药。本发明还涉及其中雌激素成分和促孕成分组合施用的产卵药混合物的用途。可以连续或间歇地规定组合关联，用于生产用于治疗雌激素缺乏症，预防绝经妇女的骨质疏松症和心血管疾病的组合物，或仍然在卵巢活动期间阻止女性排卵。本发明还涉及制备这些新型药物产卵药组合物的方法。

2. 发明申请

WO02013842A1 COMPOSITIONS COMPRISING ICARISIDE I AND ANHYDROICARITIN AND METHODS FOR MAKING THE SAME 审中-公开
标题翻译：包含ICARISIDE I和ANHYDROICARITIN的组合物及其制备方法
公开(公告)号：WO02013842A1
公开(公告)日：2002-02-21
申请号：PCT/US2001/022700
申请日：2001-07-19
IPC分类号： A61K31/00 , A61K31/352 , A61K31/70 , A61K36/296 , A61K35/78
CPC分类号： A61K31/7048 , A61K31/00 , A61K31/352 , A61K36/296 , Y10S424/811 , A61K2300/00
摘要： Compositions for maintaining normal sexual function and treating sexual dysfunction in males and females comprising at least 15 % by weight icariside I or at least 3.5 % by weight anhydroicaritin, derived from extracts of plants belonging the Epimedium genus, and methods for preparing the same, are provided. The methods comprise subjecting an Epimedium extract to mild acid hydrolysis. Methods for maintaining normal sexual function and treating sexual dysfunction in both males and females are also provided, comprising oral administration of an effective amount of a novel composition of this invention comprising at least 15 % by weight icariside I or at least 3.5 % by weight anhydroicaritin.
摘要翻译：用于维持男性和女性的正常性功能和治疗性功能障碍的组合物，其包含至少15重量％的伊曲肽I或至少3.5重量％的衍生自属于淫羊藿属的植物提取物的脱水天冬氨酸，以及提供了制备方法。所述方法包括使淫羊藿提取物进行温和的酸水解。还提供了用于维持男性和女性的正常性功能和治疗性功能障碍的方法，其包括口服施用有效量的本发明的新组合物，其包含至少15重量％的碘酸酯I或至少3.5重量％的氢化异。

3. 发明申请

WO1987005516A1 A METHOD FOR CONTRACEPTION BY IMMUNIZATION AGAINST THE ZONA PELLUCIDA 审中-公开
标题翻译：通过对ZONA PELLUCIDA进行免疫接种的方法
公开(公告)号：WO1987005516A1
公开(公告)日：1987-09-24
申请号：PCT/US1987000587
申请日：1987-03-16
申请人： APHTON CORPORATION
发明人： APHTON CORPORATION , GRIMES, Stephen , BENJAMINI, Elizer , GEVAS, Philip
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , C07K16/4208 , Y10S424/811 , Y10S530/861 , Y10S530/864
摘要： A method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies, which anti-idiotypic antibodies express internal images of zona pellucida antigenic determinants capable of eliciting a contraceptive response.
摘要翻译：一种避孕方法，其包括使用包含有效量的抗透明带抗体形成的有效量的抗独特型抗体的组合物，使雌性哺乳动物免受透明带的活性免疫，所述抗独特型抗体表达透明带抗原决定簇的内部图像，其能够引起避孕反应。

4. 发明申请

WO2009062034A1 METHODS, COMPOSITIONS, AND SEQUENCES OF ZP-BINDING PEPTIDES FOR IMMUNOCONTRACEPTION OF DOGS AND OTHER ANIMALS 审中-公开
标题翻译： ZP结合肽对狗和其他动物免疫调节的方法，组成和序列
公开(公告)号：WO2009062034A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082800
申请日：2008-11-07
申请人： AUBURN UNIVERSITY , SAMOYLOVA, Tatiana, I. , BAKER, Henry, J. , GRIFFIN, Brenda , PENDERGRASS, Kristina , GLOBA, Ludmila, P. , GIVENS, M., Daniel , RIDDEL, Kay, P. , COX, Nancy
发明人： SAMOYLOVA, Tatiana, I. , BAKER, Henry, J. , GRIFFIN, Brenda , PENDERGRASS, Kristina , GLOBA, Ludmila, P. , GIVENS, M., Daniel , RIDDEL, Kay, P. , COX, Nancy
IPC分类号： A61K39/00 , C07K14/705 , A61P15/00
CPC分类号： C12N15/1037 , A61K39/0006 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/6081 , C07K7/08 , G01N33/5044 , Y10S424/811 , Y10S530/853
摘要： Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include pharmaceutical compositions.
摘要翻译：公开了用于犬和其他动物的免疫避孕的方法，组合物和透明带结合肽和多肽。所公开的组合物可以包括药物组合物。

5. 发明申请

WO1991008226A1 SPERM ANTIGEN CORRESPONDING TO A SPERM AUTOANTIGENIC EPITOPE AND METHODS OF USING THE SAME 审中-公开
标题翻译：与SPERM自动抗生素相关的SPERM抗原及其使用方法
公开(公告)号：WO1991008226A1
公开(公告)日：1991-06-13
申请号：PCT/US1990006868
申请日：1990-11-23
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , O'RAND, Michael, G. , WIDGREN, Esther, E.
IPC分类号： C07K07/06
CPC分类号： C07K14/4713 , A61K39/00 , G01N33/564 , G01N33/56966 , G01N2800/24 , Y10S424/811 , Y10S514/841
摘要： Disclosed is a synthetic peptide, useful as an immunocontraceptive agent and for the diagnosis of autoimmune infertility, which corresponds to an autoantigenic epitope of rabbit Sperm Membrane Autoantigen (RSA). The synthetic peptide is selected from the group consisting of the decapeptide NH2-pro-gly-gly-gly-thr-leu-pro-pro-ser-gly-COOH and the antigenic equivalents thereof. Also disclosed is a method of diagnosing autoimmune infertility in a human subject. The method comprises the step of, first, contacting an immune sera sample from the subject with an antigen, the antigen selected from the group consisting of RSA, other proteins which bind selection antibodies which bind to RSA, and derivatives thereof which bind selection antibodies which bind to RSA. The next step is to detect the presence of antibodies from the immune sera sample bound to the antigen, the presence of antibodies bound to the antigen suggesting the subject is afflicted with autoimmune infertility. A preferred group of antigens is the decapeptide NH2-pro-gly-gly-gly-thr-leu-pro-pro-ser-gly-COOH and the antigenic equivalents thereof.

6. 发明申请

WO1990003182A1 METHOD AND COMPOSITION FOR PREVENTING CONCEPTION 审中-公开
标题翻译：用于预防概念的方法和组合
公开(公告)号：WO1990003182A1
公开(公告)日：1990-04-05
申请号：PCT/US1989003870
申请日：1989-09-07
申请人： PITMAN-MOORE, INC.
发明人： PITMAN-MOORE, INC. , MIAS, Abdus, S.
IPC分类号： A61K37/43
CPC分类号： A61K38/09 , Y10S424/811 , Y10S514/80 , Y10S530/807 , A61K38/04 , A61K2300/00
摘要： A method for preventing conception in mammals which comprises administering to the mammals a composition comprising (1) free LHRH or its analog and (2) an immunogenic conjugate between LHRH or its analog and a carrier protein. Free LHRH or its analog acts to prevent conception in the mammal during the period from administration to about 6 weeks; the immunogenic conjugate acts to prevent conception during the period from about 6 weeks after administration until the LHRH antibodies formed in response to the conjugate are metabolized, generally about 0.5-2 years.

7. 发明申请

WO1989003399A1 METHOD OF PREPARATION AND USE FOR ZONA PELLUCIDA ANTIGENS AND ANTIBODIES FOR STERILIZATION AND CONTRACEPTION 审中-公开
标题翻译：制备和使用ZONA PELLUCIDA抗原的方法和用于灭菌和收缩的抗体
公开(公告)号：WO1989003399A1
公开(公告)日：1989-04-20
申请号：PCT/US1988003285
申请日：1988-09-23
申请人： ZONAGEN, INC.
发明人： ZONAGEN, INC. , DUNBAR, Bonita, Sue
IPC分类号： C07K15/14
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/18 , Y10S424/811 , Y10S530/806 , Y10S530/808 , Y10S530/85 , Y10S530/853
摘要： The invention relates to antigenic preparations useful for inducing the production of antibodies in an individual which will bind to epitopes on zona pellucida. Also disclosed are immunogenic compositions and methods for immunizing an individual to enable the production of antibodies to zona pellucina antigens. Also disclosed are the use of these recombinant molecules and monoclonal antibodies thereto for immunocontraception or sterilization.

8. 发明申请

WO2007126391A8 INVESTIGATION OF MUCOSA DRYNESS CONDITIONS 审中-公开
标题翻译：调查干旱条件
公开(公告)号：WO2007126391A8
公开(公告)日：2009-07-23
申请号：PCT/SG2007000118
申请日：2007-04-26
申请人： SINGAPORE HEALTH SERVICES PTE , AGENCY SCIENCE TECH & RES , BEUERMAN ROGER , ZHOU LEI , LIU SHOUPING , YANG HE , TAN DONALD
发明人： BEUERMAN ROGER , ZHOU LEI , LIU SHOUPING , YANG HE , TAN DONALD
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
摘要： The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.
摘要翻译：本发明涉及医疗条件的诊断和/或治疗。本发明涉及诊断受试者中干燥粘膜状况的新方法。病情可能是干眼症。本发明还提供了一种监测干性粘膜病症治疗功效，干性粘膜病症治疗方法和/或用于干性粘膜病症的诊断试剂盒的方法。

9. 发明申请

WO2007126391A1 INVESTIGATION OF MUCOSA DRYNESS CONDITIONS 审中-公开
标题翻译：调查干旱条件
公开(公告)号：WO2007126391A1
公开(公告)日：2007-11-08
申请号：PCT/SG2007/000118
申请日：2007-04-26
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , YANG, He , TAN, Donald
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , YANG, He , TAN, Donald
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
摘要： The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.
摘要翻译：本发明涉及医疗条件的诊断和/或治疗。本发明涉及诊断受试者中干燥粘膜状况的新方法。病情可能是干眼症。本发明还提供了一种监测干性粘膜病症治疗功效，干性粘膜病症治疗方法和/或用于干性粘膜病症的诊断试剂盒的方法。

10. 发明申请

WO2006073447A3 ENRICHED PAG-55 FRACTION AND METHODS FOR EARLY DETECTION OF PREGNANCY IN UNGULATE ANIMALS 审中-公开
标题翻译：丰富的PAG-55分离和早期检测放射性动物中的孕妇的方法
公开(公告)号：WO2006073447A3
公开(公告)日：2006-12-21
申请号：PCT/US2005014458
申请日：2005-04-27
申请人： MONSANTO TECHNOLOGY LLC , MATHIALAGAN NAGAPPAN , MCGRATH MICHAEL , SCHENKEL ROBERT
发明人： MATHIALAGAN NAGAPPAN , MCGRATH MICHAEL , SCHENKEL ROBERT
IPC分类号： G01N33/68 , C07K14/47 , C07K16/00
CPC分类号： C07K16/18 , C07K14/4715 , G01N33/689 , G01N2800/368 , Y10S424/811
摘要： Disclosed are methods for determining the pregnancy status of an ungulate animal by detecting the level of PAG-55 protein fraction. These methods may involve the detection of PAG-55 enriched proteins in the PAG-55 protein fraction by using novel polyclonal and monoclonal antibodies that have been generated using the PAG-55 enriched protein fraction as an immu1ogen. The novel PAG-55 protein fraction indicates that the animal is pregnant when the acidic PAG-55 protein fraction, or antigenic components thereof, are present at an elevated level in a sample. The present invention also provides for methods of obtaining the PAG-55 enriched protein fraction. The invention provides accurate methods of detecting pregnancy at early stages and has the benefit of allowing early post partum detection of the pregnancy status with fewl false positive results. The antibodies for detecting PAG-55 proteins will also be useful in combination with detecting elevated progesterone levels in the animal, thus providing an even more effective pregnancy detection method. The benefit of this early pregnancy detection is that identifying animals that are not pregnant very shortly after breeding, allows for timely rebreeding and minimizes the amount of time the animal is open. Also disclosed are methods for making a breeding decision for an animal. These methods allow a herd manager to make breeding decisions based on the levels of PAG-55 protein fraction and optionally, progesterone levels detected in a biological sample taken from an animal suspected of being in the early stages of pregnancy.
摘要翻译：公开了通过检测PAG-55蛋白质级分的水平来确定有蹄动物的怀孕状态的方法。这些方法可能涉及通过使用已经使用富含PAG-55的蛋白质级分作为免疫原产生的新型多克隆和单克隆抗体来检测PAG-55蛋白质级分中的PAG-55富集的蛋白质。新型PAG-55蛋白质级分表明当样品中升高的水平存在酸性PAG-55蛋白质级分或其抗原性组分时，该动物是怀孕的。本发明还提供了获得富含PAG-55的蛋白质级分的方法。本发明提供了在早期阶段检测怀孕的准确方法，并且具有允许早期产后检测怀孕状态的益处，具有少量假阳性结果。用于检测PAG-55蛋白的抗体也可用于检测动物中升高的孕酮水平，从而提供更有效的妊娠检测方法。这种早期妊娠检测的好处是识别在繁殖后不久怀孕的动物，允许及时重新种植，并最大限度地减少动物开放的时间。还公开了用于为动物进行育种决定的方法。这些方法允许畜牧经理基于PAG-55蛋白质级分的水平进行育种决定，并且任选地，在从怀疑怀孕早期阶段的动物取得的生物样品中检测到孕酮水平。

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