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151. 发明申请

WO1992000398A1 COMBINATION OF AQUEOUS BATHS FOR THE NON-ELECTRICAL DEPOSITION OF GOLD 审中-公开
标题翻译：黄金非电沉积的水溶液组合
公开(公告)号：WO1992000398A1
公开(公告)日：1992-01-09
申请号：PCT/DE1991000498
申请日：1991-06-13
申请人： SCHERING AKTIENGESELLSCHAFT , GESEMANN, Renate , SPINDLER, Jürgen , RICHTER, Falk , BROULIK, Renate , JANOTTA, Klaus , RÜTHER, Robert , DETTKE, Manfred
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C23C18/44
CPC分类号： C23C18/44 , H01L2924/0002 , H01L2924/00
摘要： The invention relates to the combination of aqueous baths for the non-electrical deposition of gold which is preferred for the deposition of gold on nickel and nickel alloy coatings. The combination consists of a preliminary and a main bath, possibly with a pickling solution and a pre-treatment. The gold coating obtained can be bonded to chips and wires.

152. 发明申请

WO1991008324A1 METALLIZATION OF NON-CONDUCTORS 审中-公开
标题翻译：非导体金属化
公开(公告)号：WO1991008324A1
公开(公告)日：1991-06-13
申请号：PCT/DE1990000920
申请日：1990-11-27
申请人： SCHERING AKTIENGESELLSCHAFT , MAHLKOW, Hartmut , BRESSEL, Burkhard
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C25D05/54
CPC分类号： C25D5/54 , C08G61/123 , C25D5/56 , H05K3/424 , H05K3/427 , H05K2201/0329 , H05K2203/0796 , H05K2203/122
摘要： In a process for direct metallization of non-conductors, an aqueous solution of non-conductive derivatives from the group of 5-membered heterocycles, which contains a solubilizer if necessary, is placed in contact with oxidizing agents adsorbed on non-conductors. Insoluble polymer products which adhere strongly to the surface of the non-conductors are precipitated. The electrical conductivity of these polymer products is sufficient to ensure the precipitation of metals from electrolytic baths onto the polymer surface when an electric current is applied.

153. 发明申请

WO1990008534A1 PROCESS FOR PRODUCING AQUEOUS MIXED MICELLE SOLUTIONS 审中-公开
标题翻译：生产水性混合麦芽汁溶液的方法
公开(公告)号：WO1990008534A1
公开(公告)日：1990-08-09
申请号：PCT/DE1990000028
申请日：1990-01-16
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , MICHEL, Heinrich , GÖRITZ, Detlef , RÖSSLING, Georg , TACK, Johannes-Wilhelm
IPC分类号： A61K09/107
CPC分类号： A61K9/1075
摘要： A process for producing aqueous mixed micelle solutions containing mixed micelles formed from lipoids and salts of bile acids, in which, if desired, active substances hardly soluble or insoluble in water are solubilized, is characterized in that the free bile acids are suspended in an aqueous solution possibly containing isotonizing additives and/or water-soluble active substances at a temperature of 40°C to 100°C, the lipoids are dispersed in this suspension at a temperature of 40°C to 100°C and the dispersion obtained is neutralized with bases at a temperature of 0°C to 100°C, provided that, if necessary, the active substances which are hardly soluble or insoluble in water are dispersed together with the lipoids or solubilized in the mixed micelle solution which does not contain these active substances.

154. 发明申请

WO1989012465A1 A METHOD FOR THE VISUAL DISPLAY OF TUMORS USING MONOCLONAL ANTIBODIES 审中-公开
标题翻译：使用单克隆抗体视觉显示肿瘤的方法
公开(公告)号：WO1989012465A1
公开(公告)日：1989-12-28
申请号：PCT/DE1989000393
申请日：1989-06-13
申请人： SCHERING AKTIENGESELLSCHAFT , SPECK, Ulrich , CONRAD, Jürgen
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K49/00
CPC分类号： A61K49/16 , A61K51/1045 , A61K2123/00
摘要： The invention relates to a method for the visual display of tumors using monoclonal antibodies. The remarkable feature of the invention is that the monoclonal antibodies used have no definite specific bonding relations with the antigens associated with the tumor.

155. 发明申请

WO1988001867A1 TOPICAL AGENT CONTAINING PROSTACYCLINE DERIVATIVES 审中-公开
标题翻译：含有前体衍生物的局部药剂
公开(公告)号：WO1988001867A1
公开(公告)日：1988-03-24
申请号：PCT/DE1987000401
申请日：1987-09-01
申请人： SCHERING AKTIENGESELLSCHAFT , EKERDT, Roland , RAPTIS, Georg , PAULS, Alfred
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/557
CPC分类号： A61K31/34 , A61K31/557
摘要： A dermal application form is disclosed for prostacycline derivatives having the formula (I), in which R1 is hydrogen or alkyl having 1-10 C atoms, A is a -CH2-CH2-, trans-CH=CH- or -C=C- group, W is a free hydroxymethyl group or a hydroxymethyl group functionally transformed at the hydroxy group, the OH group being in the alpha or beta position, X is a CH2 group or an oxygen atom, Z is hydrogen or a cyano group, D is a straight chain or branched saturated alkylene group having 1-5 C atoms, E is a -C=C- bond or a direct bond, R2 is a straight or branched chain, saturated alkyl group having 1-7 C atoms, R3 is a free or functionally transformed hydroxy group, and, if R1 represents a hydrogen atom, its salts with physiologically compatible bases. This application form is used to treat ulcerations caused by embolism-linked diseases, and other skin diseases.

156. 发明申请

WO1987006932A1 PROCESS FOR E/Z STEREOSELECTIVE SYNTHESIS OF HOMOCHIRAL FIVE- AND SIX-RING INTERMEDIATES 审中-公开
标题翻译：用于E / Z的方法合成五和六环中间体
公开(公告)号：WO1987006932A1
公开(公告)日：1987-11-19
申请号：PCT/DE1987000231
申请日：1987-05-18
申请人： SCHERING AKTIENGESELLSCHAFT , GAIS, Hans-Joachim , ERDELMEIER, Irene , BIRK, Rolf
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C161/00
CPC分类号： C07D317/12 , C07F7/1804
摘要： Process for the production of asymmetrical olefines from prochiral symmetrical ketones by addition of lithiosulfoximin from n-butyllithium and N-substituted S-methyl-S-phenyl-sulfoximine derivatives and subsequent reaction with n-butyllithium/trimethylchlorosilane.
摘要翻译：通过从正丁基锂和N-取代的S-甲基-S-苯基 - 亚磺酰亚胺衍生物中加入二硫代氨基甲酸酯并随后与正丁基锂/三甲基氯硅烷的反应，从前手性对称酮生产不对称烯烃的方法。

157. 发明申请

WO1987005940A1 PROCESS FOR THE PRODUCTION OF 17a'alpha'-HYDROXY-D-HOMO-1,4-PREGNADIENE-3,20-DION 审中-公开
标题翻译：制备17aα-羟基-D-羟基-1,4-丙二醛-3,20-二酮的方法
公开(公告)号：WO1987005940A1
公开(公告)日：1987-10-08
申请号：PCT/DE1987000143
申请日：1987-04-01
申请人： SCHERING AKTIENGESELLSCHAFT , WEBER, Alfred , KENNECKE, Mario
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C12P33/02
CPC分类号： C12P33/02 , C07J63/008
摘要： Process for the production of 17a alpha -hydroxy-D-homo-1,4-pregnadiene-3,20-dion of formula (I) characterized by the fact that 3 beta ,17a alpha -dihydroxy-D-homo-5-pregnene-20-one of formula (II) is fermented with Bacillus lentus ATCC 13805.
摘要翻译：制备式（I）的17αα-羟基-D-高-1,4-孕二烯-3,20-二酮的方法，其特征在于3β，17αα-二羟基-D-均-5-孕烯醇式（II）-20-one用迟缓芽孢杆菌ATCC 13805发酵。

158. 发明申请

WO1987005294A1 CYCLODEXTRINCLATHRATES OF CARBACYCLINE DERIVATIVES AND THEIR USE AS MEDICINAL DRUGS 审中-公开
标题翻译：碳水化合物衍生物及其作为药物使用的环孢菌素
公开(公告)号：WO1987005294A1
公开(公告)日：1987-09-11
申请号：PCT/DE1987000106
申请日：1987-03-09
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , SKUBALLA, Werner , VORBRÜGGEN, Helmut , DAHL, Helmut , STÜRZEBECHER, Claus-Steffen , THIERAUCH, Karl-Heinz
IPC分类号： C07C177/00
CPC分类号： B82Y5/00 , A61K47/6951 , C07C405/0083 , C08B37/0015
摘要： Cyclodextrinclathrates of carbacycline analogs have general formula (I) in which: R1 is an atom of hydrogen or a straight chain or branched alkyl rest with up to 10 C atoms, A is a trans-CH=CH or -C=C group, W is a free or functionally transformed hydroxymethylene group or a free or functionnally transformed group (II), where the OH group can be alpha or beta stable, D is the group (III) a straight chain, saturated alkylene group with 1-5 C atoms, a branched or a straight chain or a branched unsaturated alkylene group with 2-5 C atoms, which can be if necessary substituted with fluorine atoms, m can represent the numbers 1, 2 or 3, E is a direct link, a -C=C group or a -CR4=CR5 group, in which R4 represents hydrogen or an alkyl group with 1-5 C atoms and R5 represents hydrogen, halogen or an alkyl group with 1-5 C atoms, R2 is an alkyl group with 1-10 C atoms, a cycloalkyl group with 3-10 C atoms or a possibly substituted aryl group with 6-10 C atoms or an heterocyclic group and R3 represents a free or functionally transformed hydroxyl group, n can represent the numbers 1, 2, 3, 4 or 5 and X a -CH2 group or an atom of oxygen.
摘要翻译：通式Ⅰ的碳霉酸类似物的环糊精包合物其中R 1是氢，至多10个碳原子的烷基或链烯基，A是-CH 2 CH 2 - ，反式-CH = CH-或-C 3位C- 基团，W是游离或官能改性的羟基亚甲基基团或游离或官能改性的“IMAGE”，其中OH基团可以在α或β-位，D是亚烷基，或不饱和亚烷基，其各自可以任选被氟原子取代，m为1,2或3，E为直接键，-C 3位C基或-CR 4 = CR 5 - 基，其中R 4为氢或1-5碳烷基原子，R5为氢或1-5个碳原子的烷基，R5为氢，卤素或1-5个碳原子的烷基，R2为至多10个碳原子的烷基或烯基，环烷基为3 -10个碳原子或任选取代的6-10个碳原子的芳基或杂环基，R3是游离或官能改性的羟基，n是1,2,3,4或5，X是-CH 2 - 或氧作为有价值的结晶药物。

159. 发明申请

WO1986001204A1 NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS 审中-公开
标题翻译：新的多巴胺衍生物，其生产工艺及其作为医药产品的使用
公开(公告)号：WO1986001204A1
公开(公告)日：1986-02-27
申请号：PCT/DE1985000275
申请日：1985-08-14
申请人： SCHERING AKTIENGESELLSCHAFT , SCHÖLLKOPF, Klaus , ALBRECHT, Rudolf , LEHMANN, Manfred , SCHRÖDER, Gertrud
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D231/56
CPC分类号： C07D285/14 , C07C205/37 , C07C205/44 , C07C275/40 , C07D209/42 , C07D231/56 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/26 , C07D235/28 , C07D235/30 , C07D249/18
摘要： New dopamine-derivatives of general formula (I) are described, where A is a substituted phenyl group of structure (II) in which R and R at the same time or separately represent hydrogen, C1-5 alkyl and allyl, D is a compound according to (III), R4 represents hydrogen, C1-C4-alkyl, CF3, NH2, E is a compound according to (IV), X = OH, NH2, a compound according to (V) and NH-SO2-CF3, when Y = OH, Y = OH, NH2, a compound according to (VI), NH-SO2-CF3 and NH-SO2-CH3, when X = OH, but X and Y do not simultaneously signify OH, with R = C1-4 alkyl and Z = H or OH and if Z signifies the hydroxy group, the group A can also exist in the tautomeric basic form, and their acid addition salts; and a description is given of their production and use as medicinal products with an anti-hypertensive action.
摘要翻译：描述了通式（I）的新的多巴胺衍生物，其中A是结构（II）的取代苯基，其中R 1和R 2同时或分别代表氢，C 1-5烷基和烯丙基，D是根据（III）的化合物，R4代表氢，C1-C4-烷基，CF3，NH2，E是根据（IV）的化合物，X = OH，NH 2，根据（V）和当X = OH时，Y = OH，Y = OH，NH2，根据（Ⅵ）的化合物，NH-SO2-CF3和NH-SO2-CH3，但X和Y不同时表示 OH，其中R 3 = C 1-4烷基，Z = H或OH，并且如果Z表示羟基，则基团A也可以以互变异构碱性形式存在，以及它们的酸加成盐; 并说明其作为具有抗高血压作用的药物的生产和用途。

160. 发明申请

WO1985002187A1 20-ALKYL-7-OXOPROSTACYCLINE DERIVATIVES AND PRODUCTION PROCESS THEREOF 审中-公开
标题翻译： 20-烷基-7-氧代环糊精衍生物及其生产方法
公开(公告)号：WO1985002187A1
公开(公告)日：1985-05-23
申请号：PCT/DE1984000238
申请日：1984-11-08
申请人： SCHERING AKTIENGESELLSCHAFT , NICKOLSON, Robert , VORBRÜGGEN, Helmut , STÜRZEBECHER, Claus - Steffen , HABEREY, Martin
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D307/935
CPC分类号： C07D307/935 , C07C405/00 , C07D307/937
摘要： 20-alkyl-7-oxoprostacycline derivatives having the general formula (I) wherein R1 is either the rest OR3, R3 representing hydrogen or alkyl comprising from 1 to 10 atoms of carbon optionally substituted by halogen, phenyl, alkoxy having from 1 to 4 atoms of carbon or dialkylamino having from 1 to 4 atoms of carbon, cycloalkyl, aryl or a heterocyclic rest, or the rest NHR4, R4 representing hydrogen or an alkanoyl or alkansulphonyl rest having from 1 to 10 atoms of carbon; n is 1 or 2; A is a group-CH2-CH2-, cis -CH=CH- or trans -CH=CH-; W is a groupe (II) or (III) wherein the group OH may be esterified with benzoyl or alkane acid rest having from 1 to 4 atoms of carbon or etherified with a tetrahydropyranol-, tetrahydrofuranyl-, alkoxyalkyl-, or trialkylsilyle rest, the free or esterified OH group being in the alpha or beta position; R2 is a straight or branched chain alkyl comprising from 1 to 6 atoms of carbon; R5 is a hydroxy group esterified with an alkane acid rest having from 1 to 4 atoms of carbon or etherified with tetrahydropyranyl-, tetrahydrofuranyl-, alkoxy alkyl- or trialkylsilyle rest; R6 and R7 are hydrogen or a straight or branched chain alkyl having from 1 to 4 atoms of carbon or R6 and R7 form together a trimethylene radical, R8 and R9 form together a bound, hydrogen or a straight or branched chain alkyl having from 1 to 4 atoms of carbon and if R3 is hydrogen, the salts thereof with physiologically compatible bases; production thereof and utilization thereof as medicine.

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