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1. 发明申请

WO1997011682A2 EMULSION AND MICELLAR FORMULATIONS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES TO CELLS 审中-公开
标题翻译：用于向细胞输送生物活性物质的乳液和胶囊制剂
公开(公告)号：WO1997011682A2
公开(公告)日：1997-04-03
申请号：PCT/US1996015388
申请日：1996-09-26
申请人： UNIVERSITY OF PITTSBURGH
发明人： UNIVERSITY OF PITTSBURGH , LIU, Dexi , LIU, Feng , YANG, Jing-Ping , HUANG, Leaf
IPC分类号： A61K09/107
CPC分类号： A61K9/1075 , Y10S514/938
摘要： New emulsion and micelle formulations are described as are complexes of these formulations with biologically active substances. The novel formulations are different from cationic lipid vectors such as cationic liposomes in that the complexes formed between biologically active substances and the emulsion and micellar formulations of this invention are physically stable and their transfection activity is resistant to the presence of serum. These novel formulations are disclosed to be useful in areas such as gene therapy or vaccine delivery.
摘要翻译：本发明涉及乳液和胶束制剂以及将这些制剂与生物活性物质组合的复合物。与用作载体，如阳离子脂质体的阳离子脂质相比，本发明的制剂的区别在于生物活性物质和乳化和胶束制剂之间形成的复合物是物理稳定的，并且它们的转染活性是抵抗血清的存在。本发明的制剂适用于诸如基因治疗或疫苗递送等领域。

2. 发明申请

WO1997003651A1 LIPID VEHICLE DRUG DELIVERY COMPOSITION CONTAINING VITAMIN E 审中-公开
标题翻译：含有维生素E的脂车辆输送组合物E
公开(公告)号：WO1997003651A1
公开(公告)日：1997-02-06
申请号：PCT/GB1996001758
申请日：1996-07-22
申请人： DANBIOSYST UK LIMITED , ILLUM, Lisbeth , WASHINGTON, Clive , LAWRENCE, Simon , WATTS, Peter
发明人： DANBIOSYST UK LIMITED
IPC分类号： A61K09/107
CPC分类号： A61K9/1075 , A61K9/127 , A61K47/22
摘要： The present invention provides a drug delivery composition comprising a lipid vehicle containing a drug and Vitamin E to enhance the solubility of the active drug in the lipid vehicle. The composition is particularly useful for drugs which are poorly soluble. The composition may be in the form of a liposome or an oil-in-water emulsion. The Vitamin E may be mixed with a pharmaceutically acceptable oil such as a marine oil or a vegetable oil.
摘要翻译：本发明提供一种药物递送组合物，其包含含有药物的脂质载体和维生素E，以增强活性药物在脂质载体中的溶解度。该组合物对于难溶性的药物特别有用。组合物可以是脂质体或水包油乳剂的形式。维生素E可以与药学上可接受的油例如海洋油或植物油混合。

3. 发明申请

WO1996039120A2 MIXED LIPID-BICARBONATE COLLOIDAL PARTICLES FOR DELIVERING DRUGS OR CALORIES 审中-公开
标题翻译：用于递送药物或卡路里的混合脂质 - 二碳酸钙胶体颗粒
公开(公告)号：WO1996039120A2
公开(公告)日：1996-12-12
申请号：PCT/US1996009031
申请日：1996-06-06
申请人： BIOMOLECULAR PRODUCTS, INC.
发明人： BIOMOLECULAR PRODUCTS, INC. , YESAIR, David, W.
IPC分类号： A61K09/107
CPC分类号： A61K9/1075
摘要： A composition of mixed lipid colloidal particles is disclosed containing nonesterified fatty acids having 8-24 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, monoglycerides which are monoesters of glycerol and fatty acids having 8-24 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, lysophosphatidylcholine in which the fatty acid moiety has 8-24 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid and a titrating agent. The compositions can optionally also contain bile salts and/or other biologically compatible surfactants. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable and sustained absorption of fats, sources of readily absorbable polyunsaturated fat and/or choline, and as particles for topical application to the skin. Methods of making these particles are also described. Also disclosed are the use of the compositions in the manufacture of medicamenets and the use of the compositions for the delivery of choline (and fats).
摘要翻译：公开了混合脂质胶体颗粒的组合物，其含有饱和，不饱和和多不饱和脂肪酸8-24个碳原子的非酯化脂肪酸，甘油单酯和具有8-24个碳原子的饱和，不饱和和多不饱和脂肪酸的单酯酸，溶脂磷脂酰胆碱，其中脂肪酸部分具有8-24个碳原子的饱和，不饱和和多不饱和脂肪酸和滴定剂。组合物还可任选地含有胆汁盐和/或其它生物相容的表面活性剂。这些组合物形成亚微米尺寸的胶体颗粒，并且可以作为运输口服药物的载体，以卡路里的容易吸收和持续吸收的形式，容易吸收的多不饱和脂肪和/或胆碱的来源，以及用于局部应用的颗粒到皮肤。还描述了制备这些颗粒的方法。还公开了组合物在制备药片中的用途以及用于递送胆碱（和脂肪）的组合物的用途。

4. 发明申请

WO1996037192A1 PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SPHINGO- AND GLYCOLIPIDS 审中-公开
标题翻译：含有SPHINGO-和GLYCOLIPIDS的药物和化妆品组合物
公开(公告)号：WO1996037192A1
公开(公告)日：1996-11-28
申请号：PCT/IB1996000493
申请日：1996-05-24
申请人： VESIFACT AG , WEDER, Hans, Georg
发明人： VESIFACT AG
IPC分类号： A61K09/107
CPC分类号： A61Q17/00 , A61K8/11 , A61K8/14 , A61K8/4993 , A61K8/553 , A61K8/68 , A61K9/1075 , A61K45/06 , A61K2800/413 , A61Q17/04 , A61Q19/00 , B82Y5/00
摘要： The invention relates to pharmaceutical or cosmetic compositions for the topical, enteral or parenteral administration of sparingly soluble sphingolipids and glycolipids. The compositions are prepared by the formation of a homogeneous dispersion of nanoparticles.
摘要翻译：本发明涉及用于局部，肠内或非肠道给药微溶性鞘脂和糖脂的药物或化妆品组合物。通过形成纳米颗粒的均匀分散体来制备组合物。

5. 发明申请

WO1996036316A1 SELF-EMULSIFYING FORMULATIONS OF LIPOPHILIC DRUGS 审中-公开
标题翻译： LIPOPHILIC DRUGS的自我制剂配方
公开(公告)号：WO1996036316A1
公开(公告)日：1996-11-21
申请号：PCT/US1996007155
申请日：1996-05-17
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , LIPARI, John, M. , McCHESNEY-HARRIS, Lisa, L. , MEYER, Glenn, A. , WIELAND, John, J.
IPC分类号： A61K09/107
CPC分类号： A61K47/22 , A61K9/4858 , A61K47/14
摘要： Self-emulsifying pharmaceutical pre-concentrate compositions comprising: (a) a lipophilic medicinal compound, (b) d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS), and (c) a lipophilic phase as well as pharmaceutical compositions comprising such pre-concentrates in combination with a sufficient amount of water to produce a stable emulsion.
摘要翻译：自乳化药物预浓缩组合物，其包含：（a）亲脂性药用化合物，（b）d-α-生育酚聚乙二醇1000琥珀酸酯（TPGS），和（c）亲脂相以及药物组合物，浓缩与足够量的水组合以产生稳定的乳液。

6. 发明申请

WO1996019970A1 HEMOLYSIS PREVENTION BY SURFACTANTS AND EMULSIONS 审中-公开
标题翻译：表面活性剂和乳液的预防化学反应
公开(公告)号：WO1996019970A1
公开(公告)日：1996-07-04
申请号：PCT/GB1995002936
申请日：1995-12-15
申请人： MERCK SHARP & DOHME LIMITED , HARRISON, Timothy
发明人： MERCK SHARP & DOHME LIMITED
IPC分类号： A61K09/107
CPC分类号： A61K9/0019 , A61K9/107 , A61K31/20 , A61K31/77 , A61K47/26 , Y10S514/922 , Y10S514/937 , Y10S514/943
摘要： The present invention relates to the use of a non-ionic surface-active agent or an emulsion for the reduction of the hemolytic effects of an amphiphilic compound. There is also provided a method for reducing the hemolytic effects of an amphiphilic compound which comprises formulating said compound with a non-ionic surface-active agent or in the form of an emulsion.
摘要翻译：本发明涉及非离子表面活性剂或乳液用于降低两亲性化合物溶血作用的用途。还提供了减少两亲化合物的溶血作用的方法，其包括用非离子表面活性剂或乳液形式配制所述化合物。

7. 发明申请

WO1994021234A1 SOLUBILIZING, THICKENING AND EMULSIFYING COSMETIC COMPOSITION AND PROCESS FOR PREPARATION OF SAME 审中-公开
标题翻译：溶解，增稠和乳化化妆品组合物及其制备方法
公开(公告)号：WO1994021234A1
公开(公告)日：1994-09-29
申请号：PCT/US1994003174
申请日：1994-03-18
申请人： COLLABORATIVE LABORATORIES , VICHROSKI, Thomas, J. , COSTA, Regina, A. , HAYWARD, James, A.
发明人： COLLABORATIVE LABORATORIES
IPC分类号： A61K09/107
CPC分类号： A61K8/33 , A61K8/8147 , A61K2800/262 , A61Q13/00 , A61Q19/00 , Y10S514/937 , Y10S514/944
摘要： A cosmetic composition includes (a) ether alcohols conforming to the general formula C(n)H(2n+2)O(n/2), where n is an integer which ranges from 4 to 12; (b) a homopolymer of acrylic acid cross-linked with an allyl ether of pentaerythritol or an allyl ether of sucrose, or copolymers of acrylic acid or acrylate derivative/acrylonitrile copolymers, or polyacrylic acid; (c) a fragrance oil or oils, or cosmetically acceptable oils or oily-type materials; and (d) water.
摘要翻译：化妆品组合物包括（a）符合通式C（n）H（2n + 2）O（n / 2）的醚醇，其中n为4-12的整数; （b）与季戊四醇或蔗糖烯丙基醚的烯丙基醚交联的丙烯酸均聚物，或丙烯酸或丙烯酸酯衍生物/丙烯腈共聚物或聚丙烯酸的共聚物; （c）香料油或油，或化妆品可接受的油或油性物质; 和（d）水。

8. 发明申请

WO1994014418A1 FREEZE-DRIED EMULSION CONTAINING AN ACTIVE SUBSTANCE 审中-公开
标题翻译： LYOPILISIERTE，含有活性乳液
公开(公告)号：WO1994014418A1
公开(公告)日：1994-07-07
申请号：PCT/DE1993001188
申请日：1993-12-10
申请人： SCHWARZ PHARMA AG , SCHÜTZ, Andreas , MIKA, Hans-Jürgen , SIEVERT, Frank , EMSCHERMANN, Bernhard
发明人： SCHWARZ PHARMA AG
IPC分类号： A61K09/107
CPC分类号： A61K9/1075 , A61K9/19
摘要： The invention concerns a freeze-dried emulsion composition containing an active substance and which can be reconstituted using water to give the original emulsion, plus a method of producing the freeze-dried composition. The reconstituted emulsion is suitable for parenteral use.

9. 发明申请

WO1994010979A1 COMPOSITIONS OF INSOLUBLE FILM-FORMING POLYMERS AND USES THEREFOR 审中-公开
标题翻译：不溶性膜形成聚合物的组合物及其用途
公开(公告)号：WO1994010979A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010881
申请日：1993-11-11
申请人： ISP INVESTMENTS INC.
发明人： ISP INVESTMENTS INC. , NARAYANAN, Kolazi, S.
IPC分类号： A61K09/107
CPC分类号： A01N25/24 , A01N25/22 , A01N43/36 , A01N63/00 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/445 , A61K8/4913 , A61K8/8182 , A61Q17/04 , Y10S514/937 , Y10S514/938 , A01N2300/00 , A01N25/10 , A01N25/04
摘要： A composition comprising a long-chain alkylpyrrolidone, a surfactant, and film-forming water-soluble polymer wherein the amounts of the components are such that on dilution with water, a clear liquid is formed. The composition may be used as a medium for agriculturally active ingredients as well as other active ingredients which are suitable for film formation, e.g., wood protectants, and the like. Also, emulsion concentrates of water-insoluble film-forming polymers are disclosed which can be utilized to form water-resistant films of active ingredients, such as, agriculturally active chemicals. Methods for preparation and use of the emulsion concentrates are disclosed.
摘要翻译：包含长链烷基吡咯烷酮，表面活性剂和成膜水溶性聚合物的组合物，其中组分的量使得在用水稀释时形成透明液体。该组合物可以用作农业活性成分的介质以及适用于成膜的其它活性成分，例如木材保护剂等。此外，公开了可用于形成活性成分例如农业活性化学品的防水膜的水不溶性成膜聚合物的乳液浓缩物。公开了制备和使用乳液浓缩物的方法。

10. 发明申请

WO1994009759A2 INHIBITION OF FOOD PATHOGENS BY HOP ACIDS 审中-公开
标题翻译：食物病原体抑制作用
公开(公告)号：WO1994009759A2
公开(公告)日：1994-05-11
申请号：PCT/US1993010249
申请日：1993-10-26
申请人： BIO-TECHNICAL RESOURCES LP
发明人： BIO-TECHNICAL RESOURCES LP , MILLIS, James, R. , SCHENDEL, Mark, J.
IPC分类号： A61K09/107
CPC分类号： A23L3/3499 , A23B4/10 , A23B4/12 , A23B4/20 , A23C19/10 , A23L3/3472 , A23L3/3481
摘要： The protection of food products from contamination by food pathogens, particularly Listeria monocytogenes, by incorporation of 6 to 50 ppm and preferably 6 to 15 ppm of beta-acids, as extracted from hops, into such food products.
摘要翻译：通过将从啤酒花中提取的6至50ppm，优选6至15ppm的β-酸掺入食品病原体，特别是李斯特氏菌的食品中，保护食品免受这种食品的侵害。

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