专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1989000559A1 9-HALOGEN-(Z)-PROSTAGLANDIN DERIVATIVES, PROCESS FOR MANUFACTURING THEM, AND THEIR USE AS DRUGS 审中-公开
标题翻译： 9-卤代 - （Z）-PROSTAGLANDIN衍生物，其制备方法及其作为药物的用途
公开(公告)号：WO1989000559A1
公开(公告)日：1989-01-26
申请号：PCT/DE1988000452
申请日：1988-07-15
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , BUCHMANN, Bernd , SKUBALLA, Werner , VORBRÜGGEN, Helmut , RADÜCHEL, Bernd , LOGE, Olaf , ELGER, Walter , STÜRZEBECHER, Claus-Steffen , THIERAUCH, Karl-Heinz
IPC分类号： C07C177/00
CPC分类号： C07C405/0016 , C07C405/00 , C07C405/0025
摘要： 9-Halogen-(Z)-prostane derivatives have the formula (I), where Z is one of the residues (a) or (b), Hal is a chorine or fluorine atom in the alpha or beta position, R1 is the residue CH2OH or (c) where R2 is a hydrogen atom or an alkyl, cycloalkyl, aryl, or heterocyclic residue, or R1 is the residue (d) where R3 is an acid residue or the R2 residue, A is a -CH2-CH2-, a trans-CH=CH or a -C=C-group, W is a free or functionally modified hydroxymethylene group or a free or functionally modified (e) group, in which the corresponding OH groups can be in the alpha or beta position, D and E together represent a direct bond or D is a straight-chain alkylene group with 1-10 C-atoms, a branched-chain alkylene group with 2-10 C-atoms, or a cyclic alkylene group with 3-10 C-atoms, which may, if necessary, be substituted by fluorine atoms, and E is an oxygen or sulphur atom, a direct bond, a -C=C- bond, or a -CR6=CR7-group, where R6 and R7 are different and stand for a hydrogen atom, a chlorine atom, or a C1-C4 alkyl group, R4 is a free or functionally modified hydroxy group, R5 is a hydrogen atom, an alkyl group, a halogen-substituted alkyl group, a cycloalkyl group, a heterocyclic or possibly aryl-substituted group. The invention also concerns the salts of these derivatives with physiologically innocuous bases and their cyclodextrin chlathrates, in the case in which R2 is a hydrogen atom. Also described are the process for manufacturing these derivatives and their pharmaceutical use.

2. 发明申请

WO1989004828A1 CYCLODEXTRIN CLATHRATES OF 5-CYANO-PROSTACYCLINE DERIVATIVES AND THEIR USE AS DRUGS 审中-公开
标题翻译： 5-氰基 - 前列环素衍生物的CYCLODEXTRIN CLATHRATES及其作为药物的用途
公开(公告)号：WO1989004828A1
公开(公告)日：1989-06-01
申请号：PCT/DE1988000739
申请日：1988-11-25
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , SKUBALLA, Werner , DAHL, Helmut , VORBRÜGGEN, Helmut , LOGE, Olaf , THIERAUCH, Karl-Heinz
IPC分类号： C07D307/935
CPC分类号： C07D307/937 , A61K31/557 , A61K47/6951 , B82Y5/00 , C08B37/0015
摘要： The invention concerns cyclodextrin clathrates of 5-cyano-prostacycline analogs of general formula (I) where R1 is the OR3 residue, where R3 can be hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue, or the residue NHR4, where R4 is an acid residue, B is a straight-chain or branched-chain alkylene groups with 2 to 10 C atoms, A is a -CH2-CH2, cis-CH=CH-, trans-CH=CH ou -C=C- group, W is a free or functionally modified hydroxymethylene group or a free or functionally modified (a) group, where the OH group can be in the alpha or beta position, D and E together are a direct bond or D is a straight-chain or branched alkylene group with 1 to 5 C atoms, E is an oxygen or sulphur atom or a direct bond, R2 is an alkyl, cycloalkyl, or possibly a substituted aryl or heterocyclic group, R5 is a free or functionally modified hydroxy group and, when R3 is hydrogen, salts thereof with physiologically compatible bases.

3. 发明申请

WO1993011144A1 NEW METHOD OF PREPARING 2-FLUOROPURINE DERIVATIVES 审中-公开
标题翻译：制备2-氟嘌呤衍生物的新方法
公开(公告)号：WO1993011144A1
公开(公告)日：1993-06-10
申请号：PCT/EP1992002689
申请日：1992-11-23
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , VORBRÜGGEN, Helmut , KROLIKIEWICZ, Konrad , WIRSCHING, Randolph, C. , BAUMAN, John, G.
IPC分类号： C07H19/167
CPC分类号： C07H19/16 , C07H19/20
摘要： The invention concerns a method for the preparation of 2-fluoropurine derivatives from 2-aminopurine derivatives which are transformed into HF/pyridine or HF/pyridine/H2O in the presence of a nitrite.

4. 发明申请

WO1987005294A1 CYCLODEXTRINCLATHRATES OF CARBACYCLINE DERIVATIVES AND THEIR USE AS MEDICINAL DRUGS 审中-公开
标题翻译：碳水化合物衍生物及其作为药物使用的环孢菌素
公开(公告)号：WO1987005294A1
公开(公告)日：1987-09-11
申请号：PCT/DE1987000106
申请日：1987-03-09
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , SKUBALLA, Werner , VORBRÜGGEN, Helmut , DAHL, Helmut , STÜRZEBECHER, Claus-Steffen , THIERAUCH, Karl-Heinz
IPC分类号： C07C177/00
CPC分类号： B82Y5/00 , A61K47/6951 , C07C405/0083 , C08B37/0015
摘要： Cyclodextrinclathrates of carbacycline analogs have general formula (I) in which: R1 is an atom of hydrogen or a straight chain or branched alkyl rest with up to 10 C atoms, A is a trans-CH=CH or -C=C group, W is a free or functionally transformed hydroxymethylene group or a free or functionnally transformed group (II), where the OH group can be alpha or beta stable, D is the group (III) a straight chain, saturated alkylene group with 1-5 C atoms, a branched or a straight chain or a branched unsaturated alkylene group with 2-5 C atoms, which can be if necessary substituted with fluorine atoms, m can represent the numbers 1, 2 or 3, E is a direct link, a -C=C group or a -CR4=CR5 group, in which R4 represents hydrogen or an alkyl group with 1-5 C atoms and R5 represents hydrogen, halogen or an alkyl group with 1-5 C atoms, R2 is an alkyl group with 1-10 C atoms, a cycloalkyl group with 3-10 C atoms or a possibly substituted aryl group with 6-10 C atoms or an heterocyclic group and R3 represents a free or functionally transformed hydroxyl group, n can represent the numbers 1, 2, 3, 4 or 5 and X a -CH2 group or an atom of oxygen.
摘要翻译：通式Ⅰ的碳霉酸类似物的环糊精包合物其中R 1是氢，至多10个碳原子的烷基或链烯基，A是-CH 2 CH 2 - ，反式-CH = CH-或-C 3位C- 基团，W是游离或官能改性的羟基亚甲基基团或游离或官能改性的“IMAGE”，其中OH基团可以在α或β-位，D是亚烷基，或不饱和亚烷基，其各自可以任选被氟原子取代，m为1,2或3，E为直接键，-C 3位C基或-CR 4 = CR 5 - 基，其中R 4为氢或1-5碳烷基原子，R5为氢或1-5个碳原子的烷基，R5为氢，卤素或1-5个碳原子的烷基，R2为至多10个碳原子的烷基或烯基，环烷基为3 -10个碳原子或任选取代的6-10个碳原子的芳基或杂环基，R3是游离或官能改性的羟基，n是1,2,3,4或5，X是-CH 2 - 或氧作为有价值的结晶药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式