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91. 发明申请

WO03066815A2 METHOD FOR PRODUCING 2-HYDROXYISOBUTYRIC ACID AND METHACRYLIC ACID FROM ACETONE CYANOHYDRIN 审中-公开
标题翻译：从乙腈氰化物生产2-羟基丁酸和甲基丙烯酸的方法
公开(公告)号：WO03066815A2
公开(公告)日：2003-08-14
申请号：PCT/US0303434
申请日：2003-02-04
申请人： DU PONT , CHAUHAN SARITA , DICOSIMO ROBERT , FALL N ROBERT D , GAVAGAN JOHN E , MANZER LEO E , PAYNE MARK S
发明人： CHAUHAN SARITA , DICOSIMO ROBERT , FALL N ROBERT D , GAVAGAN JOHN E , MANZER LEO E , PAYNE MARK S
IPC分类号： C07C51/377 , C07C51/44 , C12N1/21 , C12N9/78 , C12P7/40 , C12P7/42 , C12R1/19 , C12N
CPC分类号： C12P7/42 , C07C51/377 , C07C51/44 , C12N9/78 , C07C57/04
摘要： The present invention relates to a method for producing 2-hydroxyisobutyric acid where acetone cyanohydrin is converted to 2-hydroxyisobutyric acid using an enzyme catalyst having nitrilase activity, or having a combination of nitrile hydratase and amidase activities. The invention also encompasses production of methacrylic acid wherein the 2-hydroxyisobutyric acid produced with the catalyst described is dehydrated to produce methacrylic acid.
摘要翻译：本发明涉及使用具有腈水解酶活性的酶催化剂或具有腈水合酶和酰胺酶活性的组合将丙酮氰醇转化为2-羟基异丁酸的2-羟基异丁酸的制备方法。本发明还包括甲基丙烯酸的生产，其中用所述催化剂生产的2-羟基异丁酸被脱水以生产甲基丙烯酸。

92. 发明申请

WO0242418A3 3-HYDROXYPROPIONIC ACID AND OTHER ORGANIC COMPOUNDS 审中-公开
标题翻译： 3-羟基丙酸和其他有机化合物
公开(公告)号：WO0242418A3
公开(公告)日：2003-06-26
申请号：PCT/US0143607
申请日：2001-11-20
申请人： CARGILL INC , GOKARN RAVI R , SELIFONOVA OLGA V , JESSEN HOLLY , GORT STEVEN J , SELMER THORSTEN , BUCKEL WOLFGANG
发明人： GOKARN RAVI R , SELIFONOVA OLGA V , JESSEN HOLLY , GORT STEVEN J , SELMER THORSTEN , BUCKEL WOLFGANG
IPC分类号： C12N15/09 , C12N1/19 , C12N1/21 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/18 , C12N9/88 , C12N15/00 , C12N15/52 , C12P7/42 , C12P7/62 , C07H21/04 , C12N1/20 , C12N9/14
CPC分类号： C12P7/42 , C12N9/0004 , C12N15/52 , C12P7/18 , C12P7/40 , C12P7/52 , C12P7/625 , Y02P20/52
摘要： The invention provides methods and materials related to producing 3-HP as well as other organic compounds. Specifically, the invention provides isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds.
摘要翻译：本发明提供了与生产3-HP以及其它有机化合物相关的方法和材料。具体地，本发明提供分离的核酸，多肽，宿主细胞，以及用于生产3-HP和其它有机化合物的方法和材料。

93. 发明申请

WO0229034A3 EXBB-EXBD-TONB GENE CLUSTER OF PSEUDOMONAS PUTIDA DOT-T1E CONFERRING TOLERANCE TO AROMATIC COMPOUNDS AND RESISTANCE TO ANTIBIOTICS 审中-公开
标题翻译： PU PU PU PU PU PU CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS CS
公开(公告)号：WO0229034A3
公开(公告)日：2003-04-10
申请号：PCT/US0131180
申请日：2001-09-28
申请人： DU PONT
发明人： RAMOS JUAN L , BEN-BASSAT ARIE , GODOY PATRICIA , RAMOS-GONZALES M ISABEL , DUQUE ESTRELLA
IPC分类号： C07K14/21 , C12N15/31 , C12N15/52 , C12P7/42
CPC分类号： C07K14/21 , C12N15/52 , C12P7/42
摘要： This invention relates to the isolation of a novel tonB operon from Pseudomonas putida. These genes are useful to render the cells more sensitive to antibiotics, toluene, pHBA, aromatic compounds, parabenes, and aromatic amino acids after inactivation with specific mutant allels or more tolerant to these compounds after overexpression with appropriate expression vector. These findings are important in the field of medicine and biotechnology and biocatalysis. In addition a screen to identify pHBA tolerant genes is provided and strains with significant tolerance to pHBA were identified. These strains are important for pHBA production.
摘要翻译：本发明涉及从恶臭假单胞菌（Pseudomonas putida）中分离出一种新的tonB操纵子。在用适当的表达载体过表达后，这些基因可用于使细胞在特异性突变体等位基因失活后对抗生素，甲苯，pHBA，芳香族化合物，对羟基苯甲酸和芳香族氨基酸更敏感或更耐受这些化合物。这些发现在医学和生物技术和生物催化领域是重要的。另外还提供了一个识别pHBA耐受基因的筛选条件，并鉴定出对pHBA具有显着耐受性的菌株。这些菌株对pHBA生产很重要。

94. 发明申请

WO02010407A1 BIOPRODUCTION OF PARA-HYDROXYCINNAMIC ACID 审中-公开
标题翻译：生物降解对羟基酸的研究
公开(公告)号：WO02010407A1
公开(公告)日：2002-02-07
申请号：PCT/US2001/002099
申请日：2001-01-23
IPC分类号： C12N15/09 , C12N9/02 , C12N9/88 , C12N15/60 , C12N15/82 , C12P7/40 , C12P7/42 , C12R1/19 , C07K14/39
CPC分类号： C12N9/0042 , C12N9/0077 , C12N9/88 , C12N15/8243 , C12P7/42
摘要： The present invention provides several methods for biological production of para -hydroxycinnamic acid (PHCA). The invention is also directed to the discovery of new fungi and bacteria that possess the ability to convert cinnamate to PHCA. The invention relates to developing of a new biocatalyst for conversion of glucose to PHCA by incorporation of the wild type PAL from the yeast Rhodotorula glutinis into E. coli underlining the ability of the wildtype PAL to convert tyrosine to PHCA. The invention is also directed to developing a new biocatalyst for conversion of glucose to PHCA by incorporation of the wildtype PAL from the yeast Rhodotorula glutinis plus the plant cytochrome P-450 and the cytochrome P-450 reductase into E. coli . In yet another embodiment, the present invention provides for the developing of a new biocatalyst through mutagenesis of the wild type yeast PAL which possesses enhanced tyrosine ammonia-lyase (TAL) activity.
摘要翻译：本发明提供了几种生物制备对羟基肉桂酸（PHCA）的方法。本发明还涉及具有将肉桂酸转化为PHCA的能力的新真菌和细菌的发现。本发明涉及通过将来自酵母红酵母的野生型PAL并入E中而将葡萄糖转化为PHCA的新的生物催化剂的开发。大肠杆菌突出野生型PAL将酪氨酸转化为PHCA的能力。本发明还涉及开发新的生物催化剂，用于将葡萄糖转化为PHCA，将来自酵母红酵母的野生型PAL加上植物细胞色素P-450和细胞色素P-450还原酶我>电子。大肠杆菌的。在另一个实施方案中，本发明提供通过具有增强的酪氨酸氨裂解酶（TAL）活性的野生型酵母PAL的诱变来开发新的生物催化剂。

95. 发明申请

WO01094607A2 HIGH LEVEL PRODUCTION OF P-HYDROXYBENZOIC ACID IN GREEN PLANTS 审中-公开
标题翻译：在绿色植物中高水平生产P-羟基苯甲酸
公开(公告)号：WO01094607A2
公开(公告)日：2001-12-13
申请号：PCT/US2001/016661
申请日：2001-05-22
IPC分类号： A01H5/00 , C07K19/00 , C12N9/88 , C12N15/09 , C12N15/60 , C12N15/82 , C12R1/91 , C12P7/42
CPC分类号： C12N9/88 , C07K2319/00 , C12N15/8243
摘要： The invention relates to high-level production of pHBA in green plants using a unique expression cassette. The latter comprises a chorismate pyruvate lyase (CPL) coding sequence operably linked to a suitable promoter capable of driving protein expression in higher plants. Additionally, the CPL cassette comprises a sequence encoding a chloroplast transit peptide, its natural cleavage site, and a small portion of the transit peptide donor protein fused to the N-terminus of CPL. The chloroplast targeting sequence targets the foreign protein to the chloroplast compartment and aids in its uptake into the organelle. The cleavage site is unique to the transit peptide, and cleavage of the chimeric protein encoded by the cassette at this site releases a novel polypeptide that has full enzyme activity, comprising the mature CPL enzyme and a small portion of the transit peptide donor.
摘要翻译：本发明涉及使用独特的表达盒在绿色植物中高水平生产pHBA。后者包括可操作地连接到能够驱动高等植物中的蛋白质表达的合适的启动子的草酸丙酸裂解酶（CPL）编码序列。此外，CPL盒包含编码叶绿体转运肽，其天然切割位点的序列和与CPL的N末端融合的转运肽供体蛋白的一小部分。叶绿体靶向序列将外来蛋白质靶向叶绿体隔室，并有助于其吸收到细胞器中。切割位点对于转运肽是独特的，并且在该位点处由盒编码的嵌合蛋白质的切割释放出具有完整酶活性的新型多肽，其包含成熟CPL酶和少量转运肽供体。

96. 发明申请

WO0114576B1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF ISOXAZOLECAROXAMIDES AND ANALOGUES 审中-公开
标题翻译：方法和中间体的ISOXAZOLECAROXIDES和类似物的制备
公开(公告)号：WO0114576B1
公开(公告)日：2001-09-27
申请号：PCT/US0023032
申请日：2000-08-23
申请人： AGOURON PHARMA
发明人： TAO JUNHUA , BABU SRINIVASAN , DAGNINO RAYMOND JR , TIAN QINGPING , REMARCHUK TRAVIS PAUL , MCGEE KEVIN SCOTT , NAYYAR NARESH K , MORAN TERENCE JAROLD
IPC分类号： C12P7/42 , A61K31/422 , A61P31/14 , B01J19/24 , C07C69/732 , C07C229/34 , C07C271/22 , C07C303/28 , C07C309/65 , C07D207/26 , C07D261/18 , C07D413/12 , C12M1/12 , C12P17/14 , C07C51/347 , C07C59/56 , C07C229/36 , C12P1/00
CPC分类号： C07D413/12 , B01J19/2435 , B01J19/2475 , B01J2219/00033 , B01J2219/00099 , B01J2219/00103 , B01J2219/00159 , B01J2219/00162 , B01J2219/00177 , C07B2200/07 , C07C69/732 , C07C229/34 , C07C271/22 , C07C303/28 , C07D261/18 , C07C309/65
摘要： Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula (I), particulary (I'), key intermediates useful in those synthetic routes, as well as a continuous membrane reactor useful for those synthetic routes. These compounds of formula (I), as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
摘要翻译：用于制备式（I）的鼻病毒蛋白酶抑制剂（特别是（I'））的有效合成路线，可用于那些合成路线的关键中间体，以及用于那些合成路线的连续膜反应器。这些式（I）化合物以及含有这些化合物的药物组合物适用于治疗感染一种或多种小核糖核酸病毒的患者或宿主。

97. 发明申请

WO01067891A1 BIOLOGICALLY ACTIVE MATERIALS FROM CEREALS AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：来自谷物的生物活性材料及其制备方法
公开(公告)号：WO01067891A1
公开(公告)日：2001-09-20
申请号：PCT/KR2001/000395
申请日：2001-03-14
IPC分类号： A23L1/10 , A23L1/105 , A23L1/30 , C08B30/10 , C08B37/00 , C12P7/42 , C12P19/04 , C12P19/14
CPC分类号： C12P7/42 , A23L7/107 , A23L7/115 , A23L33/105 , C08B30/10 , C08B37/0057 , C12P19/04
摘要： The present invention relates to physiologically active materials separated from the cereals and manufaturing method thereof. Physiologically active materials such as ferulic acid and arabinoxylan present in cereal brans were separated by the extrusion process and the subsequent treatment with plant cell wall hydrolyzing enzymes. This combined process of extrusion and enzyme treatments for cereal brans, compared to the individual treatment, significantly increased the separation efficiency of physiologically active materials in cereal brans, ferulic acid and arabinoxylan, which inherently exist as insoluble materials in the cell wall of cereal bran.
摘要翻译：本发明涉及与谷物分离的生理活性物质及其制造方法。存在于谷物中的生理活性物质如阿魏酸和阿拉伯木聚糖通过挤出方法分离，随后用植物细胞壁水解酶处理。与单独处理相比，这种谷物干燥的挤出和酶处理的这种组合方法显着提高了谷物麸，阿魏酸和阿拉伯木聚糖中的生理活性物质的分离效率，其在谷物麸的细胞壁中固有地作为不溶物质存在。

98. 发明申请

WO01066783A1 NOVEL 7,8-DIHYDRO-XANTHENONE-8-CARBOXYLIC ACID DERIVATIVE AND NOVEL MICROBE PRODUCING THE SAME 审中-公开
标题翻译：新的7,8-二羟基 - 十八烷基-8-羧酸衍生物和生产其的新型微生物
公开(公告)号：WO01066783A1
公开(公告)日：2001-09-13
申请号：PCT/KR2001/000358
申请日：2001-03-08
IPC分类号： C12P7/42 , C07D311/86 , C12P17/06 , A61K31/35 , A61K35/66
CPC分类号： C12R1/66 , C07D311/86 , C12P17/06
摘要： Disclosed are a novel compound represented by the following chemical formula (1), useful for the prophylaxis and treatment of angiogenic diseases, its production, and a novel microorganism producing the same. Aspergillus sp. Y80118 isolated from soil was found to produce 7,8-dihydro-1,7-dihydroxy-3-hydroxymethyl-xanthenone-8-carboxylic acid methylester which inhibits VEGF-induced proliferation of HUVEC, angiogenesis in CAM assay, and tumor growth. The novel compound can be effectively used for the medical treatment of angiogenic diseases, including cancers, rheumatoid arthritis, and diabetic retinopathy.
摘要翻译：公开了由以下化学式（1）表示的新型化合物，其用于预防和治疗血管发生疾病及其制备，以及生产该新化合物的新型微生物。曲霉菌发现从土壤中分离的Y80118产生抑制VEGF诱导的HUVEC增殖，CAM测定中的血管发生和肿瘤生长的7,8-二氢-1,7-二羟基-3-羟甲基 - 呫吨酮-8-羧酸甲酯。该新型化合物可有效地用于治疗血管生成疾病，包括癌症，类风湿性关节炎和糖尿病性视网膜病变。

99. 发明申请

WO0114576A3 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF ISOXAZOLECAROXAMIDES AND ANALOGUES 审中-公开
标题翻译：制备异辛酰胺类和类似物的方法和中间体
公开(公告)号：WO0114576A3
公开(公告)日：2001-08-30
申请号：PCT/US0023032
申请日：2000-08-23
申请人： AGOURON PHARMA
发明人： TAO JUNHUA , BABU SRINIVASAN , DAGNINO RAYMOND JR , TIAN QINGPING , REMARCHUK TRAVIS PAUL , MCGEE KEVIN SCOTT , NAYYAR NARESH K , MORAN TERENCE JAROLD
IPC分类号： C12P7/42 , A61K31/422 , A61P31/14 , B01J19/24 , C07C69/732 , C07C229/34 , C07C271/22 , C07C303/28 , C07C309/65 , C07D207/26 , C07D261/18 , C07D413/12 , C12M1/12 , C12P17/14 , C07C51/347 , C07C59/56 , C07C229/36 , C12P1/00
CPC分类号： C07D413/12 , B01J19/2435 , B01J19/2475 , B01J2219/00033 , B01J2219/00099 , B01J2219/00103 , B01J2219/00159 , B01J2219/00162 , B01J2219/00177 , C07B2200/07 , C07C69/732 , C07C229/34 , C07C271/22 , C07C303/28 , C07D261/18 , C07C309/65
摘要： Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula (I), particulary (I'), key intermediates useful in those synthetic routes, as well as a continuous membrane reactor useful for those synthetic routes. These compounds of formula (I), as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.
摘要翻译：用于制备式（I），特别是（I'）的鼻病毒蛋白酶抑制剂，可用于那些合成途径的关键中间体的有效合成途径，以及用于那些合成途径的连续膜反应器。这些式（I）化合物以及含有这些化合物的药物组合物适用于治疗感染了一种或多种微小核糖核酸病毒的患者或宿主。

100. 发明申请

WO01048175A2 METHODS FOR PRODUCING ENANTIOMERICALLY PURE alpha -SUBSTITUTED CARBOXYLIC ACIDS 审中-公开
标题翻译：生产纯化的α-羟基羧酸的方法
公开(公告)号：WO01048175A2
公开(公告)日：2001-07-05
申请号：PCT/US2000/035555
申请日：2000-12-29
IPC分类号： C12N15/09 , C07C229/36 , C12N9/78 , C12P7/42 , C12P13/04 , C12P13/06 , C12P13/22 , C12P41/00
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： In accordance with the present invention there are provided methods for producing enantiomerically pure alpha -sustituted carboxylic acids, such as, for example, alpha -amino acids and alpha -hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cynohydrin intermediate under conditions sufficient to produce the carboxylic acid.
摘要翻译：根据本发明，提供了制备对映体纯的α-取代的羧酸，例如α-氨基酸和α-羟基酸的方法，所述方法包括将醛或酮与氰化物和氨组合，或在具有腈水解酶活性的腈水解酶或多肽的存在下，在足以产生羧酸的条件下立即选择性水解氨基腈或噌啉中间体的铵盐或胺。

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