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91. 发明申请

WO2010040062A2 NANOPARTICLE LABELING REAGENTS AND METHODS OF USE 审中-公开
标题翻译：纳米标签试剂和使用方法
公开(公告)号：WO2010040062A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/059394
申请日：2009-10-02
申请人： ADVANCED THROUGHPUT LTD.CO. , WENG, Kevin, C.
发明人： WENG, Kevin, C.
IPC分类号： G01N33/58
CPC分类号： G01N33/582 , B82Y15/00 , G01N33/586 , G01N33/587 , G01N33/588
摘要： Compositions and methods for labeling biological targets using a conjugate of a luminescent component and a targeting molecule attached to a nanoparticle core structure are described. The labeling conjugates offer high intensity and low background, and are ideal for histology and pathology.
摘要翻译：描述了使用发光组分和连接于纳米颗粒核心结构的靶向分子的缀合物标记生物学靶标的组合物和方法。标记缀合物提供高强度和低背景，是组织学和病理学的理想选择。

92. 发明申请

WO2006044275A2 METHODS FOR ALTERING SURFACE CHARACTERISTICS OF MICROSPHERES 审中-公开
标题翻译：改善微球表面特性的方法
公开(公告)号：WO2006044275A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/036264
申请日：2005-10-11
申请人： LUMINEX CORPORATION , LUGADE, Ananda, G. , HOFFACKER, Kurt, D.
发明人： LUGADE, Ananda, G. , HOFFACKER, Kurt, D.
IPC分类号： G01N33/543 , G01N33/546 , G01N33/58
CPC分类号： G01N21/645 , G01N33/54313 , G01N33/54353 , G01N33/54393 , G01N33/586 , G01N2021/6421 , G01N2650/00 , Y10T436/13
摘要： Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.
摘要翻译：提供了形成染色微球的各种方法。一种方法包括使用热或光活化与染料偶联的化学结构，以在微球存在下形成反应中间体。反应中间体共价连接到微球的聚合物上，从而将染料偶联到聚合物上并形成染色的微球。提供用于形成耦合到分子的染色微球的其它方法。除了在染色的微球的外表面上合成分子之外，这些方法包括如上所述染色微球。还提供了一批染色微球。群体的每个染色的微球包括通过化学结构连接到每个染色微球的聚合物上的染料。由染料染色的微球体的染料特性的变异系数小于约10％。

93. 发明申请

WO2005084210A3 MULTIPLEX DETECTION PROBES 审中-公开
标题翻译：多重检测探头
公开(公告)号：WO2005084210A3
公开(公告)日：2005-11-10
申请号：PCT/US2005005955
申请日：2005-02-28
申请人： HITACHI CHEMICAL RES CT INC , HITACHI CHEMICAL CO LTD , MURAKAMI TAKU
发明人： MURAKAMI TAKU
IPC分类号： A61K38/00 , C07H21/02 , C07K1/00 , C12N15/11 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6823 , C12Q1/6816 , C12Q1/682 , G01N33/586 , G01N33/6848 , C12Q2537/143 , C12Q2563/161 , C12Q2563/167
摘要： The present invention comprises detection probes utilizing vesicles or soluble bodies to retain multiple mass tag molecules. The detection probes may be used to simultaneously assay a plurality of different biological samples, each comprising a plurality of analytes, by immobilizing the analytes from each of the samples on a surface incubating the surface with a set of the detection probes, each having mass tag molecules with different masses, removing the unbound detection probe, collecting the first and second mass tag molecules from the bound detection probe, and quantifying the first and second mass tag molecules collected.
摘要翻译：本发明包括利用囊泡或可溶性体保留多个质量标签分子的检测探针。检测探针可以用于通过将来自每个样品的分析物固定在表面上孵育表面的一组检测探针来同时分析多个不同的生物样品，每个不同的生物样品包括多个分析物，每个检测探针具有质量标签去除未结合的检测探针，从结合的检测探针收集第一和第二质量标签分子，并量化收集的第一和第二质量标签分子。

94. 发明申请

WO2005084210A2 MULTIPLEX DETECTION PROBES 审中-公开
标题翻译：多重检测探针
公开(公告)号：WO2005084210A2
公开(公告)日：2005-09-15
申请号：PCT/US2005/005955
申请日：2005-02-28
申请人： HITACHI CHEMICAL RESEARCH CENTER, INC. , HITACHI CHEMICAL CO., LTD. , MURAKAMI, Taku
发明人： MURAKAMI, Taku
IPC分类号： A61K38/00 , C07H21/02 , C07K1/00 , C12N15/11 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6823 , C12Q1/6816 , C12Q1/682 , G01N33/586 , G01N33/6848 , C12Q2537/143 , C12Q2563/161 , C12Q2563/167
摘要： The present invention comprises detection probes utilizing vesicles or soluble bodies to retain multiple mass tag molecules. The detection probes may be used to simultaneously assay a plurality of different biological samples, each comprising a plurality of analytes, by immobilizing the analytes from each of the samples on a surface incubating the surface with a set of the detection probes, each having mass tag molecules with different masses, removing the unbound detection probe, collecting the first and second mass tag molecules from the bound detection probe, and quantifying the first and second mass tag molecules collected.
摘要翻译：本发明包括利用囊泡或可溶性物质保留多个质量标签分子的检测探针。检测探针可以用于通过将来自每个样品的分析物固定在用一组检测探针孵育表面的表面上来同时测定多个不同的生物样品，每个生物样品包含多个分析物，每个具有质量标签分离不同质量的组分，去除未结合的检测探针，从结合的检测探针收集第一和第二质量标签分子，并定量收集的第一和第二质量标签分子。

95. 发明申请

WO0102551A3 VIRUS LIKE PARTICLES, PREPARATION AND USE IN SCREENING AND FUNCTIONAL GENOMICS 审中-公开
标题翻译：病毒样颗粒，制备和使用筛选和功能基因组学
公开(公告)号：WO0102551A3
公开(公告)日：2001-11-08
申请号：PCT/EP0006144
申请日：2000-06-30
申请人： EVOTEC BIOSYSTEMS AG , HUNT NICHOLAS
发明人： HUNT NICHOLAS
IPC分类号： G01N33/483 , A61K45/00 , A61K47/42 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/15 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/71 , C07K14/82 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/09 , C12N15/62 , C12N15/86 , C12N15/87 , C12Q1/68 , C12Q1/70 , G01N27/447 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , G01N33/58 , G01N37/00
CPC分类号： C07K14/4722 , A61K2039/525 , A61K2121/00 , C07K14/005 , C07K14/705 , C07K14/71 , C07K14/82 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/73 , C07K2319/735 , C12N7/00 , C12N15/62 , C12N15/87 , C12N2740/13022 , C12N2740/13023 , C12N2740/16122 , C12Q1/6897 , G01N33/586 , G01N2333/005
摘要： The invention relates to virus like particles, their preparation and their use in pharmaceutical screening and functional genomics. The particles are produced by co-expressing in cells a target molecule and a signal molecule wherein the signal and target molecules functionally operate in a non-covalent manner so as to incorporate or encapsulate said target molecules into said virus-like particles.
摘要翻译：本发明涉及病毒样颗粒，其制备及其在药物筛选和功能基因组学中的应用。通过在细胞中共表达靶分子和信号分子来产生颗粒，其中信号和靶分子以非共价方式功能地操作，以便将所述靶分子掺入或包封到所述病毒样颗粒中。

96. 发明申请

WO01002551A2 VIRUS LIKE PARTICLES, THEIR PREPARATION AND THEIR USE PREFERABLY IN PHARMACEUTICAL SCREENING AND FUNCTIONAL GENOMICS 审中-公开
标题翻译：病毒样颗粒，其制备及其在药物筛选和功能基因组学中的优先使用
公开(公告)号：WO01002551A2
公开(公告)日：2001-01-11
申请号：PCT/EP2000/006144
申请日：2000-06-30
IPC分类号： G01N33/483 , A61K45/00 , A61K47/42 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/15 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/71 , C07K14/82 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/09 , C12N15/62 , C12N15/86 , C12N15/87 , C12Q1/68 , C12Q1/70 , G01N27/447 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , G01N33/58 , G01N37/00 , C12N15/00
CPC分类号： C07K14/4722 , A61K2039/525 , A61K2121/00 , C07K14/005 , C07K14/705 , C07K14/71 , C07K14/82 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/73 , C07K2319/735 , C12N7/00 , C12N15/62 , C12N15/87 , C12N2740/13022 , C12N2740/13023 , C12N2740/16122 , C12Q1/6897 , G01N33/586 , G01N2333/005
摘要： The invention relates to virus like particles, their preparation and their use in pharmaceutical screening and functional genomics. The invention further provides a variety of assay formats to be used with said virus like particles.
摘要翻译：本发明涉及病毒样颗粒，其制备及其在药物筛选和功能基因组学中的应用。本发明还提供了与所述病毒样颗粒一起使用的各种测定形式。

97. 发明申请

WO99066328A1 NOVEL NON-ENZYMATIC METHODS OF GENERATING CHEMILUMINESCENCE FROM ACRIDAN ALKENES 审中-公开
标题翻译：从ACRIDAN ALKENES产生CHEMILUMINESCENCE的新型非酶解方法
公开(公告)号：WO99066328A1
公开(公告)日：1999-12-23
申请号：PCT/US1999/006560
申请日：1999-05-03
IPC分类号： G01N33/532 , C12Q1/28 , C12Q1/32 , G01N21/76 , G01N33/52 , G01N33/533 , G01N33/546 , G01N33/58 , G01N33/543
CPC分类号： G01N33/533 , G01N33/52 , G01N33/582 , G01N33/586 , Y10S435/968 , Y10S436/80 , Y10S436/805
摘要： Methods of generating chemiluminescence rapidly without the use of enzymes are provided. The methods utilize chemiluminescent compounds comprising an acridan ring bearing an exocyclic double bond in a reaction with an acid, an oxidant and a base. The chemiluminescent methods are useful in assays to detect the amount of an analyte in a sample. The chemiluminescent compounds may be supplied as a label on an analyte or a specific binding partner or may be encapsulated within a liposome or latex particle.
摘要翻译：提供了不使用酶快速产生化学发光的方法。所述方法利用化学发光化合物，其包含与酸，氧化剂和碱的反应中带有环外双键的吖啶环。化学发光方法可用于检测样品中分析物的量的测定中。化学发光化合物可以作为分析物或特异性结合配偶体上的标记提供，或者可以包封在脂质体或胶乳颗粒内。

98. 发明申请

WO99038009A1 DETECTION SYSTEM USING LIPOSOMES AND SIGNAL MODIFICATION 审中-公开
标题翻译：检测系统使用脂质体和信号修饰
公开(公告)号：WO99038009A1
公开(公告)日：1999-07-29
申请号：PCT/GB1999/000208
申请日：1999-01-21
IPC分类号： G01N21/64 , G01N15/14 , G01N33/52 , G01N33/542 , G01N33/543 , G01N33/544 , G01N33/58
CPC分类号： G01N33/542 , G01N33/52 , G01N33/5432 , G01N33/586 , Y10S435/808 , Y10S435/81 , Y10S435/975 , Y10S436/823 , Y10S436/829 , Y10T428/2982 , Y10T428/2984
摘要： A process for detecting an analyte which process comprises (a) contacting a sample suspected of containing said analyte with a containment means comprising a barrier which separates signal generating reagents from said sample, in the presence of an element which interacts specifically with said analyte, under conditions whereby interaction between the analyte and the said element results in activation of the signal generating reagents within the containment means on the side of the barrier opposite to the sample, and (b) detecting any signal generated and retained within the containment means from the sample side of the barrier. The process of the invention provides for sensitive detection of very small numbers of analyte materials using measurement techniques which include counting methods such as flow cytometry.
摘要翻译：一种用于检测分析物的方法，该方法包括（a）将怀疑含有所述分析物的样品与含有所述样品分离信号产生试剂的屏障的容纳装置接触，所述屏障在与所述分析物特异性相互作用的元件的存在下，分析物与所述元件之间的相互作用的条件导致在与样品相反的屏障一侧的容纳装置内的信号产生试剂的活化，和（b）从样品中检测产生并保留在容纳装置内的任何信号一边的障碍。本发明的方法使用包括诸如流式细胞术在内的计数方法的测量技术来提供非常少量的分析物质的敏感检测。

99. 发明申请

WO1998008097A1 SIGNAL AMPLIFICATION METHOD 审中-公开
标题翻译：信号放大方法
公开(公告)号：WO1998008097A1
公开(公告)日：1998-02-26
申请号：PCT/GB1997002254
申请日：1997-08-22
申请人： ECLAGEN LIMITED , CARR, Frank
发明人： ECLAGEN LIMITED
IPC分类号： G01N33/58
CPC分类号： G01N33/531 , G01N33/586 , Y10S436/829
摘要： The present invention relates to a method for the amplification of or creation of a signalling event for detection of a probe which reacts with a test substance, the method comprising causing the test substance to react with the probe and identifying the reaction of the test substance with the probe by the release of a signalling moiety from a vesicle. Preferably the signalling moiety is in an active but ineffective form and/or the signalling moiety is deposited on a solid phase in the vicinity of the probe. The invention also relates to a kit for the detection of a probe which reacts with a test substance, the kit comprising a vesicle which contains a signalling moiety.
摘要翻译：本发明涉及用于扩增或产生用于检测与测试物质反应的探针的信号事件的方法，所述方法包括使测试物质与探针反应并鉴定测试物质与通过从囊泡释放信号传导部分的探针。优选地，信号传导部分处于活性但无效的形式和/或信号传导部分沉积在探针附近的固相上。本发明还涉及用于检测与测试物质反应的探针的试剂盒，该试剂盒包含含有信号传导部分的囊泡。

100. 发明申请

WO1996041178A1 MICELLE PROTECTION ASSAY 审中-公开
标题翻译： MICELLE保护测定
公开(公告)号：WO1996041178A1
公开(公告)日：1996-12-19
申请号：PCT/US1996006919
申请日：1996-05-14
申请人： GEN-PROBE INCORPORATED
发明人： GEN-PROBE INCORPORATED , BECKER, Michael, McClellan
IPC分类号： G01N33/542
CPC分类号： G01N33/5432 , C12Q1/6816 , G01N33/586
摘要： Methods and compositions for selectively detecting analytes in a homogeneous assay, a heterogeneous assay, or a mixture of the two by contacting a labeled probe:analyte complex with one or more amphiphiles. The invention is also useful for increasing the signal to noise ratio when used in conjunction with other assay systems. In preferred embodiments, the analyte and probe are nucleic acids or proteins.
摘要翻译：通过使标记的探针：分析物复合物与一种或多种两亲物接触，在均相测定，异质测定或两者的混合物中选择性地检测分析物的方法和组合物。当与其他测定系统结合使用时，本发明也可用于增加信噪比。在优选的实施方案中，分析物和探针是核酸或蛋白质。

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