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    • 96. 发明申请
    • TEMPORARY IMPLANT COMPRISING TWO ACTIVE SUBSTANCES
    • 包含两种活性物质的临时植入物
    • WO2007099232A3
    • 2007-12-27
    • PCT/FR2007000367
    • 2007-03-01
    • CERAVIC SASLEONARD ALAINLAVERNE CLAUDINEOGLAZA JEAN-FRANCOIS
    • LEONARD ALAINLAVERNE CLAUDINEOGLAZA JEAN-FRANCOIS
    • A61F2/30
    • A61F2/30A61F2/36A61F2/3662A61F2/4637A61F2002/3021A61F2002/30332A61F2002/30616A61F2002/30672A61F2002/30677A61F2002/3611A61F2002/3625A61F2002/3631A61F2002/365A61F2002/4681A61F2220/0033A61F2230/0067A61F2310/00011A61F2310/00353
    • The present invention relates to a spacer device made of polymer cement ready for use as a replacement for a permanent articular prosthesis during a two-stage revision, comprising a rod that can be fixed to the support bone, and a head that can be placed in the articular zone, said spacer device being composed of two complementary elements that comprise means for rigid assembly to each other, the first element being charged with a first active substance, and the second element being charged with a second active substance. According to a preferred embodiment of the invention, the first and second active substances are antibiotics chosen, for example, from among gentamicin, tobramycin, vancomycin, erythromycin, fucidin, tetracycline, or other suitable antibiotics. The temporary articular implant according to the invention is intended, on the one hand, to maintain a suitable space for the length of time necessary for the replacement of a permanent prosthesis, in order to ensure that the tissues do not occupy the space freed by the removal of the permanent prosthesis, and, on the other hand, to ensure effective treatment of resistant infections by local treatment of the articular zone by at least two different active substances, such as two antibiotics.
    • 本发明涉及一种由聚合物水泥制成的间隔装置,可在两阶段修订期间用作永久性关节假体的替代物,包括可固定在支撑骨上的杆,以及能够放置在其中的头部 所述间隔装置由两个互补元件组成,所述互补元件包括用于彼此刚性组装的装置,所述第一元件装有第一活性物质,所述第二元件装有第二活性物质。 根据本发明的优选实施方案,第一和第二活性物质是选自例如庆大霉素,妥布霉素,万古霉素,红霉素,fucidin,四环素或其它合适的抗生素的抗生素。 根据本发明的临时关节植入物一方面旨在维持替换永久性假体所需的时间长度的适当空间,以确保组织不占据由 去除永久假体,另一方面,通过至少两种不同的活性物质如两种抗生素局部治疗关节区,确保有效治疗耐药性感染。