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1. 发明申请

WO2019137951A1 MRI METHOD FOR DETERMINING A MAGNETIC FIELD MAP FROM A BO REFERENCE SCAN AND A WASSR SCAN 审中-公开
公开(公告)号：WO2019137951A1
公开(公告)日：2019-07-18
申请号：PCT/EP2019/050430
申请日：2019-01-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： DE WEERDT, Elwin
IPC分类号： G01R33/24 , G01R33/48 , G01R33/56 , G01R33/561
CPC分类号： G01R33/243 , G01R33/4828 , G01R33/5605 , G01R33/5615
摘要： The invention provides for a medical imaging system (100, 300). The medical imaging system (100, 300) comprises a processor (104). Execution of machine executable instructions(120)causes the processor (104) to: receive magnetic resonance data, wherein the magnetic resonance datacomprises B0 field data (122) of a reference scan for a plurality of voxels and water saturation data (124) of a WASSR scan for a subset of voxels of the plurality of voxels, the water saturation data (124) comprising data of a limited number of sample points; determine a local absolute water saturation frequency (130) for each voxel of the subset using the water saturation data (124) of the WASSR scan; and reconstruct a field map (132) comprising a local absolute water saturation frequency for each voxel of the plurality of voxels, wherein the reconstruction comprises determining relative frequency differences between the voxels using the B0 field data (122) of the reference scan and adding a frequency offset to the relative frequency differences based on the determined local absolute water saturation frequencies (130) of the subset.

2. 发明申请

WO2016124414A1 MR FINGERPRINTING FOR DETERMINING PERFORMANCE DEGRADATION OF THE MR SYSTEM 审中-公开
标题翻译：用于确定MR系统的性能降级的MR指纹
公开(公告)号：WO2016124414A1
公开(公告)日：2016-08-11
申请号：PCT/EP2016/051274
申请日：2016-01-22
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BOERNERT, Peter , DONEVA, Mariya Ivanova , AMTHOR, Thomas Erik , KOKEN, Peter , KEUPP, Jochen
IPC分类号： G01R33/46 , G01R33/54 , G01R33/58 , G06F19/00 , G01R33/48
CPC分类号： G01R33/4625 , G01R33/4828 , G01R33/54 , G01R33/546 , G01R33/58 , G06F19/00 , G16H40/40
摘要： The invention provides for a method of operating a magnetic resonance system for acquiring magnetic resonance data (152) from a phantom (124) within a measurement (zone 108). The phantom comprises a known volume of at least one predetermined substance ((128), 130). The method comprises the step of acquiring (300) the magnetic resonance data by controlling the magnetic resonance system with pulse sequence instructions (150). The pulse sequence instructions cause the magnetic resonance system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The pulse sequence instructions specifiy a train of pulse sequence repetitions. Each pulse sequence repetition has a repetition time chosen from a distribution of repetition times. Each pulse sequence repetition comprises a radio frequency pulse chosen from a distribution of radio frequency pulses. The distribution of radio frequency pulses cause magnetic spins to rotate to a distribution of flip angles. Each pulse sequence repetition comprises a sampling event where the magnetic resonance signal is sampled for a predetermined duration at a sampling time before the end of the pulse sequence repetition. The method further comprises determining (302) one or more performance degradation conditions of the magnetic resonance system by comparing the magnetic resonance data with a magnetic resonance fingerprinting dictionary (154). The magnetic resonance fingerprinting dictionary contains a listing of magnetic resonance signals for a set of system states in response to execution of the pulse sequence instructions for each of the at least one predetermined substance.
摘要翻译：本发明提供一种操作磁共振系统的方法，用于从测量（区域108）内的体模（124）获取磁共振数据（152）。该幻影包括已知体积的至少一种预定物质（（128），130）。该方法包括通过用脉冲序列指令（150）控制磁共振系统来获取（300）磁共振数据的步骤。脉冲序列指令使磁共振系统根据磁共振指纹技术获取磁共振数据。脉冲序列指令指定一系列脉冲序列重复。每个脉冲序列重复具有从重复次数的分布中选择的重复时间。每个脉冲序列重复包括从射频脉冲分布中选出的射频脉冲。射频脉冲的分布导致磁旋转到翻转角分布。每个脉冲序列重复包括采样事件，其中磁共振信号在脉冲序列重复结束之前的采样时间被采样预定的持续时间。该方法还包括通过将磁共振数据与磁共振指纹词典（154）进行比较来确定（302）磁共振系统的一个或多个性能降级条件。磁共振指纹词典包含响应于对于至少一种预定物质中的每一种的脉冲序列指令的执行而针对一组系统状态的磁共振信号的列表。

3. 发明申请

WO2016075020A1 MAGNETIC RESONANCE FINGERPRINTING USING A SPIN-ECHO PULSE SEQUENCE WITH AN ADDITIONAL 180 DEGREE RF PULSE 审中-公开
标题翻译：使用附加180度RF脉冲的旋转脉冲序列指向磁性共振
公开(公告)号：WO2016075020A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/075775
申请日：2015-11-05
申请人： KONINKLIJKE PHILIPS N.V.
发明人： AMTHOR, Thomas Erik , DONEVA, Mariya Ivanova , KOKEN, Peter , KEUPP, Jochen , BOERNERT, Peter
IPC分类号： G01R33/46 , G01R33/465 , G01R33/50 , G01R33/54 , G01R33/565 , A61B5/055
CPC分类号： G01R33/4828 , A61B5/055 , G01R33/4625 , G01R33/465 , G01R33/50 , G01R33/54 , G01R33/56563
摘要： The invention provides for a magnetic resonance system (100) for acquiring a magnetic resonance data from a subject (118) within a measurement zone (108) according to a magnetic resonance fingerprinting technique. The pulse sequence comprises a train of pulse sequence repetitions (302, 304). Each pulse sequence repetition has a repetition time chosen from a distribution of repetition times. Each pulse sequence repetition comprises a radio frequency pulse (306) chosen from a distribution of radio frequency pulses. The distribution of radio frequency pulses cause magnetic spins to rotate to a distribution of flip angles, and each pulse sequence repetition comprises a sampling event (310) at a sampling time chosen from a distribution of sampling times. Each pulse sequence repetition of the pulse sequence comprises a first 180 degree RF pulse (308) performed at a first temporal midpoint between the radio frequency pulse and the sampling event to refocus the magnetic resonance signal. Each pulse sequence repetition of the pulse sequence comprises a second 180 degree RF pulse (309) performed at a second temporal midpoint between the sampling event and the start of the next pulse repetition.
摘要翻译：本发明提供一种磁共振系统（100），用于根据磁共振指纹技术从测量区域（108）内的对象（118）获取磁共振数据。脉冲序列包括一系列脉冲序列重复（302,304）。每个脉冲序列重复具有从重复次数的分布中选择的重复时间。每个脉冲序列重复包括从射频脉冲的分布中选择的射频脉冲（306）。射频脉冲的分布导致磁旋转到翻转角分布，并且每个脉冲序列重复包括从采样时间分布中选出的采样时间的采样事件（310）。脉冲序列的每个脉冲序列重复包括在射频脉冲和采样事件之间的第一时间中点执行的第一180度RF脉冲（308），以重新聚焦磁共振信号。脉冲序列的每个脉冲序列重复包括在采样事件和下一个脉冲重复的开始之间的第二时间中点执行的第二180度RF脉冲（309）。

4. 发明申请

WO2015134918A1 METHODS AND SYSTEMS OF ASSESSING TISSUE VASCULAR PERMEABILITY USING NON-LABELED DEXTRAN 审中-公开
标题翻译：使用非标记的DEXTRAN评估组织血管渗透性的方法和系统
公开(公告)号：WO2015134918A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/019272
申请日：2015-03-06
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： LIU, Guanshu , VAN ZIJL, Peter C.M. , LI, Yuguo
IPC分类号： G01N33/50 , G01R33/48
CPC分类号： G01R33/5601 , G01R33/4828 , G01R33/50 , G01R33/5605 , G01R33/56366
摘要： A method of assessing tissue vascular permeability for nanotherapeutics using non-labeled dextran can include: receiving a non-labeled, physiologically-tolerable dextran solution by a subject; acquiring a plurality of magnetic resonance images of a distribution of the dextran solution within at least one region of interest of the subject for a corresponding plurality of times; and assessing a tissue vascular permeability of the at least one region of interest to dextran particles in the dextran solution based on differences between the plurality of magnetic resonance images, wherein the dextran solution is a substantially mono-disperse solution of dextran particles of one size.
摘要翻译：使用非标记的葡聚糖来评估纳米治疗剂的组织血管渗透性的方法可以包括：受试者接受未标记的，生理上可容忍的葡聚糖溶液; 在所述对象的感兴趣的至少一个区域内获取所述葡聚糖溶液分布的多个磁共振图像多次; 并且基于所述多个磁共振图像之间的差异来评估所述葡聚糖溶液中的所述至少一个感兴趣区域的组织血管渗透性，其中所述葡聚糖溶液是一种尺寸的葡聚糖颗粒的基本上单分散溶液。

5. 发明申请

WO2015102169A1 MAGNETIC RESONANCE IMAGING METHOD CANCELING ARTIFACTS AND UNDESIRED SIGNALS 审中-公开
标题翻译：磁共振成像方法取消了艺术家和不符合的信号
公开(公告)号：WO2015102169A1
公开(公告)日：2015-07-09
申请号：PCT/KR2014/004765
申请日：2014-05-28
申请人： GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： CHUNG, Jun Young , PARK, Hyun Wook
IPC分类号： A61B5/055
CPC分类号： G01R33/56563 , G01R33/4828 , G01R33/4838 , G01R33/485 , G01R33/543 , G01R33/5605 , G01R33/5607
摘要： A first off resonance radio frequency (RF) pulse and a second off resonance RF pulse having a phase difference of 180 degrees from the first off resonance RF pulse are applied, one or more auxiliary gradient magnetic fields for offsetting inhomogeneity of a main magnetic field generated by applying the first and second off resonance RF pulses are applied, and magnitudes and signs of the auxiliary gradient magnetic fields are appropriately adjusted. Therefore, artifacts generated due to inhomogeneity of a main magnetic field in an imaging method using an off resonance RF pulse may be removed. When this method is applied to an imaging method using a spatial pre-saturation RF pulse, the phenomenon in which spins excited by the pre-saturation RF pulse are excited again by the off resonance RF pulse to return signals, such that undesired signals overlap and appear in an ultimately-obtained signal, may be removed.
摘要翻译：施加与第一截止共振RF脉冲相差180度的第一次共振射频（RF）脉冲和第二截止共振RF脉冲，一个或多个辅助梯度磁场用于抵消产生的主磁场的不均匀性通过施加第一和第二截止的共振RF脉冲，并且适当地调整辅助梯度磁场的量值和符号。因此，可以去除使用截止共振RF脉冲的成像方法中由于主磁场的不均匀性而产生的假象。当将该方法应用于使用空间预饱和RF脉冲的成像方法时，由预饱和RF脉冲激发的自旋再次被截止共振RF脉冲激励以返回信号的现象，使得不期望的信号重叠，并且出现在最终获得的信号中，可以被去除。

6. 发明申请

WO2014151596A3 SYSTEM AND METHOD FOR INHOMOGENEOUS MAGNETIZATION TRANSFER MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于非均匀磁化转移磁共振成像的系统和方法
公开(公告)号：WO2014151596A3
公开(公告)日：2014-11-13
申请号：PCT/US2014026077
申请日：2014-03-13
申请人： BETH ISRAEL HOSPITAL , ALSOP DAVID , VARMA GOPAL
发明人： ALSOP DAVID , VARMA GOPAL
IPC分类号： A61B5/055
CPC分类号： G01R33/5605 , A61B5/055 , A61B5/4041 , A61B5/7278 , G01R33/4828 , G01R33/50 , G01R33/5659
摘要： A system and method for producing a report about a subject from data collected from the subject using a magnetic resonance imaging (MRI] system. The method includes directing the MRI system to perform a pulse sequence to manipulate exchangeable magnetization in the subject and acquiring, with the MRI system, imaging data from the subject in response to the pulse sequence. The method also includes analyzing the effects of the frequencies of applied RF energy on the imaging data to identify inhomogeneous lines formed by a summation of multiple sublines centered at multiple different frequencies. The method further includes generating a report pertaining to inhomogeneous magnetization transfer occurring in the subject in response to the pulse sequence.
摘要翻译：一种系统和方法，用于使用磁共振成像（MRI）系统从从受试者收集的数据产生关于受试者的报告，该方法包括指导MRI系统执行脉冲序列以操纵受试者中的可交换磁化，该方法还包括分析所施加的RF能量的频率对成像数据的影响，以识别由以多个不同频率为中心的多个子线的总和所形成的不均匀线该方法还包括响应于脉冲序列生成关于在对象中发生的不均匀磁化转移的报告。

7. 发明申请

WO2014161766A1 DETECTION OF BONE TISSUE USING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用磁共振成像检测骨组织
公开(公告)号：WO2014161766A1
公开(公告)日：2014-10-09
申请号：PCT/EP2014/056145
申请日：2014-03-27
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： STEHNING, Christian , SCHADEWALDT, Nicole , HELLE, Michael, Günter , RENISCH, Steffen , SCHULZ, Heinrich
IPC分类号： A61B5/055 , G01R33/48 , G06T5/00 , G06T7/00
CPC分类号： G01R33/5602 , A61B5/0035 , A61B5/055 , A61B5/4504 , A61B6/037 , A61N5/1039 , G01R33/36 , G01R33/385 , G01R33/4808 , G01R33/481 , G01R33/4816 , G01R33/4828 , G01R33/5608 , G06K9/52 , G06K9/6267 , G06T7/0012 , G06T7/11 , G06T7/35 , G06T11/003 , G06T2200/04 , G06T2207/10081 , G06T2207/10088 , G06T2207/10124 , G06T2207/20128 , G06T2207/30008
摘要： The invention provides for a medical apparatus (300, 400, 500) comprising: a magnetic resonance imaging system (302) for acquiring magnetic resonance data (342) from an imaging zone (308); a processor (330) for controlling the medical apparatus; a memory (336) storing machine executable instructions (350, 352, 354, 356). Execution of the instructions causes the processor to: acquire (100, 200) the magnetic resonance data using a pulse sequence (340) which specifies an echo time greater than 400 μβ; reconstruct (102, 202) a magnetic resonance image using the magnetic resonance data; generate (104, 204) a thresholded image (346) by thresholding the magnetic resonance image to emphasize bone structures and suppressing tissue structures in the magnetic resonance image; and generate (106, 206) a bone-enhanced image by applying a background removal algorithm to the thresholded image.
摘要翻译：本发明提供一种医疗设备（300,400,500），包括：用于从成像区域（308）获取磁共振数据（342）的磁共振成像系统（302）。用于控制医疗装置的处理器（330）存储器（336），用于存储机器可执行指令（350,352,354,356）。执行指令使处理器：使用指定大于400μs的回波时间的脉冲序列（340）获取（100,200）磁共振数据; 使用磁共振数据重建（102,202）磁共振图像; 通过阈值化磁共振图像来产生（104,204）阈值图像（346），以强调骨结构并抑制磁共振图像中的组织结构; 并通过将背景去除算法应用于阈值图像来生成（106,206）骨骼增强图像。

8. 发明申请

WO2014151596A2 SYSTEM AND METHOD FOR INHOMOGENEOUS MAGNETIZATION TRANSFER MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：非均匀磁化传输磁共振成像系统与方法
公开(公告)号：WO2014151596A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/026077
申请日：2014-03-13
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER , ALSOP, David , VARMA, Gopal
发明人： ALSOP, David , VARMA, Gopal
IPC分类号： A61B5/055
CPC分类号： G01R33/5605 , A61B5/055 , A61B5/4041 , A61B5/7278 , G01R33/4828 , G01R33/50 , G01R33/5659
摘要： A system and method for producing a report about a subject from data collected from the subject using a magnetic resonance imaging (MRI] system. The method includes directing the MRI system to perform a pulse sequence to manipulate exchangeable magnetization in the subject and acquiring, with the MRI system, imaging data from the subject in response to the pulse sequence. The method also includes analyzing the effects of the frequencies of applied RF energy on the imaging data to identify inhomogeneous lines formed by a summation of multiple sublines centered at multiple different frequencies. The method further includes generating a report pertaining to inhomogeneous magnetization transfer occurring in the subject in response to the pulse sequence.
摘要翻译：一种用于使用磁共振成像（MRI）系统从从受试者收集的数据产生关于受试者的报告的系统和方法，所述方法包括指导MRI系统执行脉冲序列以操纵受试者的可交换磁化，并以 MRI系统，响应于脉冲序列成像来自受试者的数据，该方法还包括分析所施加的RF能量的频率对成像数据的影响，以识别由以多个不同频率为中心的多个子集的求和形成的不均匀线该方法还包括响应于脉冲序列产生关于受试者中发生的非均匀磁化转移的报告。

9. 发明申请

WO2014147518A2 MR IMAGE RECONSTRUCTION USING COMPRESSED SENSING 审中-公开
标题翻译：使用压缩感测的图像重建
公开(公告)号：WO2014147518A2
公开(公告)日：2014-09-25
申请号：PCT/IB2014059660
申请日：2014-03-12
申请人： KONINKL PHILIPS NV , PHILIPS DEUTSCHLAND GMBH
发明人： FUDERER MIHA , DONEVA MARIYA IVANOVA
IPC分类号： G01R33/48
CPC分类号： G01R33/4824 , G01R33/4828 , G01R33/561 , G01R33/5611 , G01R33/56545
摘要： The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). The method comprises the steps of: subjecting the object (10) to an imaging sequence for acquiring MR signal data, wherein the MR signal data are acquired as a function of k-space position and time by using an irregular k-space sampling pattern with sub-sampling of k-space; reconstructing MR image data from the MR signal data, which MR image data comprise spatial dimensions and a frequency dimension, sparsity of the MR image data in a transform domain being exploited for suppressing sub-sampling artefacts in the MR image data. Moreover, the invention relates to a MR device (1) and to a computer program.
摘要翻译：本发明涉及放置在MR装置（1）的检查体积中的物体（10）的MR成像方法。该方法包括以下步骤：对物体（10）进行成像序列获取MR信号数据，其中通过使用不规则的k空间采样模式来获取MR信号数据作为k空间位置和时间的函数， k空间的次采样; 从MR信号数据重建MR图像数据，MR图像数据包括空间维度和频率维度，被用于抑制MR图像数据中的子采样伪像的变换域中的MR图像数据的稀疏度。此外，本发明涉及MR设备（1）和计算机程序。

10. 发明申请

WO2014085288A1 NONINVASIVE 4-D TIME-RESOLVED DYNAMIC MAGNETIC RESONANCE ANGIOGRAPHY 审中-公开
标题翻译：无损4维时间分辨动态磁共振成像
公开(公告)号：WO2014085288A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/071590
申请日：2013-11-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： WANG, Danny JJ , YAN, Lirong , SONG, Hee Kwon
IPC分类号： A61B5/055
CPC分类号： A61B5/0263 , A61B5/055 , G01R33/4806 , G01R33/4818 , G01R33/4824 , G01R33/4828 , G01R33/5601 , G01R33/5611 , G01R33/5614 , G01R33/56333 , G01R33/5635
摘要： A method for non-contrast enhanced 4D time resolved dynamic magnetic resonance angiography using arterial spin labeling of blood water as an endogenous tracer and a multiphase balanced steady state free precession readout is presented. Imaging can be accelerated with dynamic golden angle radial acquisitions and k-space weighted imaging contrast (KWIC) image reconstruction and it can be used with parallel imaging techniques. Quantitative tracer kinetic models can be formed allowing cerebral blood volume, cerebral blood flow and mean transit time to be estimated. Vascular compliance can also be assessed using 4D dMRA by synchronizing dMRA acquisitions with the systolic and diastolic phases of the cardiac cycle.
摘要翻译：提出了一种使用动脉自旋标记血液作为内源性示踪剂的非对比度增强4D时间分辨动态磁共振血管造影和多阶段平衡稳态自由进动读数的方法。可以通过动态金角径向采集和k空间加权成像对比（KWIC）图像重建来加速成像，并且可以与并行成像技术一起使用。可以形成定量示踪动力学模型，从而估计脑血容量，脑血流量和平均通过时间。也可以通过使dMRA采集与心动周期的收缩期和舒张期相同步，使用4D dMRA来评估血管依从性。

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