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    • 5. 发明申请
    • PHOTODYNAMIC THERAPY PROCESS AND PHOTOSENSITIZER COMPOSITIONS
    • 光化疗法和光敏剂组合物
    • WO2009048868A1
    • 2009-04-16
    • PCT/US2008/079050
    • 2008-10-07
    • ONDINE INTERNATIONAL LTD.LOEBEL, NicholasSTREET, Cale
    • LOEBEL, NicholasSTREET, Cale
    • A61K31/5415A61K41/00A61P31/04A61K35/00
    • A61K31/5415A61K41/0057Y02A50/473
    • Use of a photosensitizer composition in the manufacture of a medicament for photodynamic therapy and a process for photodynamic therapy are provided along with a photosensitizer composition suitable for the use and the process. The photosensitizer composition comprises at least one photoactive ingredient in a chemically reduced state. According to the use, the photosensitizer composition having at least one photoactive ingredient in a chemically reduced state is provided. The photosensitizer composition is applied to tissue or other substrate such that the at least one photoactive ingredient is at or travels to a location adjacent a target medium and the at least one photoactive ingredient is then altered to a photoactive state. The at least one photoactive ingredient is then exposed to light energy for assisting in inhibiting at least one pathogen at the target medium. The prefered photosensitizer is methylene blue. It is preferably reduced by ascorbic acid.
    • 提供光敏剂组合物在制造用于光动力疗法的药物中的用途以及光动力疗法的方法以及适合于使用和过程的光敏剂组合物。 光敏剂组合物包含至少一种化学还原状态的光活性成分。 根据该用途,提供具有化学还原状态的至少一种光活性成分的光敏剂组合物。 将光敏剂组合物施用于组织或其他底物,使得至少一种光活性成分处于或移动到与靶介质相邻的位置,然后将至少一种光活性成分改变为光活性状态。 然后将至少一种光活性成分暴露于光能以帮助抑制目标培养基上的至少一种病原体。 优选的光敏剂是亚甲基蓝。 优选由抗坏血酸还原。
    • 10. 发明申请
    • PORTABLE PHOTODYNAMIC DISINFECTION LIGHT DELIVERY DEVICE FOR CATHETER DISINFECTION
    • 便携式消毒灯光消毒装置
    • WO2010036617A1
    • 2010-04-01
    • PCT/US2009/057699
    • 2009-09-21
    • ONDINE INTERNATIONAL HOLDINGS LTD.STREET, CaleLEDUC, PierreLEACY, CarolLATHAM, Marcus, Alan
    • STREET, CaleLEDUC, PierreLEACY, CarolLATHAM, Marcus, Alan
    • A61L2/08A61L2/10A61L2/26
    • A61L2/10A61L2202/16A61L2202/24A61M2039/167A61N5/062A61N2005/0652
    • The present invention provides a portable photodynamic disinfection light delivery device (100) comprising: two opposing light sources (26, 28), an energy source (34) to supply energy to the light sources (26, 28), and a housing (8) for receiving the two light sources (26, 28) and the energy source (34); wherein (i) the housing 8 includes two members (10, 12) each having a clamp portion (14, 16) for receiving one of the two light sources (26, 28) and an attachment mean (18) connecting the clamp portions (14, 16); (ii) the clamp portions (14, 16) during photodynamic disinfection surround a catheter disinfection site (20); and (iii) the two light sources (26, 28) together provide circumferential illumination at least one wavelength that can activate at least one photosensitizer so as to reduce microbes located at the catheter disinfection site (20). The present invention provides a catheter disinfection method comprising: applying circumferential illumination at a wavelength that activates a photosensitizer located at a catheter disinfection site (20) so as to reduce microbes located at the catheter disinfection site (20) using the portable photodynamic disinfection light device (100) described above.
    • 本发明提供了一种便携式光动力消毒灯输送装置(100),包括:两个相对的光源(26,28),用于向光源(26,28)供应能量的能量源(34) ),用于接收两个光源(26,28)和能量源(34); 其中(i)壳体8包括两个构件(10,12),每个构件具有用于容纳两个光源(26,28)中的一个的夹持部分(14,16)和连接夹持部分 14,16); (ii)光动力消毒期间的夹持部分(14,16)围绕导管消毒部位(20); 和(iii)两个光源(26,28)一起提供至少一个波长的圆周照明,其可以激活至少一个光敏剂,以便减少位于导管消毒部位(20)处的微生物。 本发明提供一种导管消毒方法,包括:以激活位于导管消毒部位(20)处的光敏剂的波长施加圆周照明,以便使用便携式光动力消毒灯装置来减少位于导管消毒部位(20)处的微生物 (100)。