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1. 发明申请

WO2008083279A1 METHOD OF DETECTION OF BIOANALYTES BY ACOUSTO-MECHANICAL DETECTION SYSTEMS COMPRISING THE ADDITION OF LIPOSOMES 审中-公开
标题翻译：通过包含脂质体添加剂的机械检测系统检测生物质的方法
公开(公告)号：WO2008083279A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/089053
申请日：2007-12-28
申请人： 3M INNOVATIVE PROPERTIES COMPANY , BJORK, Jason W. , GASON, Samuel J. , PALAZZOTTO, Michael C. , ROSCOE, Stephen B.
发明人： BJORK, Jason W. , GASON, Samuel J. , PALAZZOTTO, Michael C. , ROSCOE, Stephen B.
IPC分类号： G01N27/00 , G01N33/543
CPC分类号： G01N33/54373 , G01N29/022 , G01N29/30 , G01N2291/0255 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423
摘要： Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection of the target biological analytes in sample material are enhanced by contacting the target biological analyte and/or the sensor surface with liposomes that amplify the sensor sensitivity by (1) modifying the rheological properties of the fluid near the sensor surface; (2) changing the mass attached to the surface; and/or (3) modifying the dielectric properties of the fluid near the sensor surface, the sensor surface itself and/or any intervening layers on the sensor surface.
摘要翻译：公开了使用由传感器产生的声 - 机械能来检测样品材料内的目标生物分析物的方法。声机械能可以使用诸如例如剪切水平声表面波传感器（例如LSH-SAW传感器）的表面声波传感器的声 - 机械传感器来提供。通过使目标生物分析物和/或传感器表面与通过（1）修改传感器表面附近的流体的流变特性来扩大传感器灵敏度的脂质体接触来增强样品材料中目标生物分析物的检测; （2）改变附着在表面上的质量; 和/或（3）修改传感器表面附近的流体的介电特性，传感器表面本身和/或传感器表面上的任何中间层。

2. 发明申请

WO2013019912A1 CAP HANDLING TOOLS AND METHODS OF USE 审中-公开
标题翻译： CAP处理工具和使用方法
公开(公告)号：WO2013019912A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/049242
申请日：2012-08-02
申请人： 3M INNOVATIVE PROPERTIES COMPANY , BARTHOLOMEW, Cheryl A. , BJORK, Jason W. , PERCY, Neil , SITTON, Gregory W.
发明人： BARTHOLOMEW, Cheryl A. , BJORK, Jason W. , PERCY, Neil , SITTON, Gregory W.
IPC分类号： B25B9/00 , B01L9/00 , B01L99/00
CPC分类号： B67B7/02 , B01L3/50853 , B01L3/50855 , B01L9/00 , B01L99/00 , B25B33/00 , B67B1/045
摘要： Tools (100) are provided for use in uncapping one or more of a plurality of linearly-oriented, spaced-apart tubes; each cap having a cap upper surface with a depression. The tools comprise a body (30) having first portion (40) for engagement by a user and a second portion (50) for engaging a plurality of caps. The second portion comprises a plurality of spaced-apart projections (60). Each projection is configured for releasably engaging a cap. The projection may comprise two or more spaced-apart projection elements (62,64). Optionally, the first portion is configured in a non- coplanar relationship with respect to the second portion. Methods of use are also provided.
摘要翻译：工具（100）被提供用于打开多个线性取向的间隔开的管中的一个或多个管; 每个盖具有带有凹陷的盖上表面。工具包括具有用于与使用者接合的第一部分（40）和用于接合多个盖的第二部分（50）的主体（30）。第二部分包括多个间隔开的突起（60）。每个突起构造成可释放地接合盖。突起可以包括两个或更多个间隔开的投影元件（62,64）。可选地，第一部分被配置成相对于第二部分的非共面关系。还提供了使用方法。

3. 发明申请

WO2012092123A1 EFFERVESCENT COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：有效的组合物及其用途
公开(公告)号：WO2012092123A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/066820
申请日：2011-12-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , XIA, Wensheng , MACH, Patrick A. , BEAURLINE, Joseph M. , BJORK, Jason W. , LIU, Jie J.
发明人： XIA, Wensheng , MACH, Patrick A. , BEAURLINE, Joseph M. , BJORK, Jason W. , LIU, Jie J.
IPC分类号： C12Q1/04 , C12N1/00 , C12N1/20
CPC分类号： C12Q1/045 , C12N1/14 , C12N1/20 , C12N1/38 , C12Q1/04 , C12Q1/689
摘要： A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
摘要翻译：公开了包含选择剂的潜伏泡腾体。还公开了在选择性富集目标微生物的方法中使用潜在泡腾体的方法。该方法包括提供样品，培养基和潜在泡腾体。该方法还包括在促进靶微生物生长的条件下使样品，培养基和潜在泡腾体接触。该方法还包括从潜在泡腾体释放选择剂。任选地，该方法包括检测微生物。

4. 发明申请

WO2019234661A1 HARDENABLE DENTAL COMPOSITIONS COMPRISING BASIC CORE MATERIAL ENCAPSULATED IN AN INORGANIC SHELL AND DISPENSING DEVICES THEREWITH 审中-公开
公开(公告)号：WO2019234661A1
公开(公告)日：2019-12-12
申请号：PCT/IB2019/054690
申请日：2019-06-05
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： CHRISTENSEN, Randilynn B. , BUDD, Kenton D. , FALSAFI, Afshin , AKSIT, Mahmut , NINKOVIC, Jana , LIU, Jie J. , AGRE, Mark B. , NAKAMURA, Masayuki , BJORK, Jason W. , CRAIG, Bradley D. , RUSIN, Richard P. , HOMNICK, Paul J. , OXMAN, Joel D. , WANG, Yizhong , KLAIBER, Paul R.
IPC分类号： A61C5/64 , A61C5/68 , A61K6/00 , A61K6/02 , A61K6/027 , A61K6/06 , A61K6/083 , B01F13/00 , B05C17/005
摘要： A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardneable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition for application to a tooth structure.

5. 发明申请

WO2019234633A1 TWO-PART DENTAL SEALANT, METHOD OF APPLYING WITH A SYRINGE DEVICE, AND KIT 审中-公开
公开(公告)号：WO2019234633A1
公开(公告)日：2019-12-12
申请号：PCT/IB2019/054644
申请日：2019-06-04
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： CHRISTENSEN, Randilynn B. , BUDD, Kenton D. , FALSAFI, Afshin , AKSIT, Mahmut , NINKOVIC, Jana , LIU, Jie J. , AGRE, Mark B. , NAKAMURA, Masayuki , BJORK, Jason W. , CRAIG, Bradley D. , RUSIN, Richard P. , HOMNICK, Paul J. , OXMAN, Joel D. , WANG, Yizhong , KLAIBER, Paul R. , DODGE, Bill H.
IPC分类号： A61C5/64 , A61C5/68 , A61K6/00 , B01F5/06 , B01F13/00 , B05C17/005
摘要： A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

6. 发明申请

WO2018067532A1 METHODS OF MAKING FIBRIN COMPOSITIONS AND ARTICLES 审中-公开
标题翻译：制备纤维蛋白组合物和制品的方法
公开(公告)号：WO2018067532A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/054892
申请日：2017-10-03
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： O'HARE, Jonathan J. , PEKUROVSKY, Mikhail L. , DETERMAN, Amy S. , PITERA, Gino L. , BJORK, Jason W. , NORTON, Daniel V. , ASMUS, Robert A.
IPC分类号： A61F13/00 , B32B37/24 , A61L15/32
摘要： A method of forming a fibrin hydrogel composition including providing one or more unitary masses of a fibrin hydrogel, dividing at least one of the unitary masses of the fibrin hydrogel into a multiplicity of smaller pieces of the fibrin hydrogel, and recombining at least a portion of the smaller pieces into a cohesive mass. Dividing at least one of the unitary masses of fibrin hydrogel into a multiplicity of smaller pieces may include shearing or cutting the unitary masses to form an aqueous dispersion of the fibrin hydrogel in an aqueous medium. The aqueous dispersion of fibrin hydrogel may be applied to a substrate on a roller or an endless belt, and is optionally overlaid by a scrim. The cohesive mass of fibrin hydrogel, which may be formed by removing at least a portion of the aqueous medium from the aqueous dispersion of the smaller pieces of the fibrin hydrogel, finds uses in wound dressing articles.
摘要翻译：一种形成纤维蛋白水凝胶组合物的方法，包括提供一个或多个纤维蛋白水凝胶的单一团块，将纤维蛋白水凝胶的单一团块中的至少一个分成多个纤维蛋白水凝胶的较小片段并且将至少一部分小块重新组合成粘性物质。将至少一个单一纤维蛋白水凝胶块分成多个小块可包括剪切或切割整体块以形成纤维蛋白水凝胶在水性介质中的水分散体。纤维蛋白水凝胶的水分散体可以施加到辊或环形带上的基底上，并且任选地被稀松布覆盖。可以通过从纤维蛋白水凝胶的较小部分的水分散体中除去至少一部分水性介质而形成的纤维蛋白水凝胶的粘着块可用于伤口敷料制品。

7. 发明申请

WO2021250494A1 IMPEDANCE BASED WOUND HEALING MONITOR 审中-公开
公开(公告)号：WO2021250494A1
公开(公告)日：2021-12-16
申请号：PCT/IB2021/054553
申请日：2021-05-25
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： KENNEDY, Stephen M. , ODOM, Jacob E. , KALISH, Jeffrey P. , SWEETNAM, Sean M. , BENSON, Michael D. , NINKOVIC, Jana , HUNERDOSSE, Devon M. , BJORK, Jason W.
IPC分类号： A61B5/0531 , A61B5/00 , A61B2560/0468 , A61B5/445 , A61B5/683 , A61B5/7275
摘要： A method and system for tissue impedance measurement are disclosed. In examples, the system comprises electrical contacts configured to be coupled to a first tissue and a first device configured to apply a first electrical signal to the first tissue via the electrical contacts. The system further comprises a second device configured to determine a first impedance phase angle of epithelial tissue of the first tissue site based on the first applied electrical signal, determine a baseline impedance phase angle of epithelial tissue corresponding to a second tissue, determine information indicative of epithelial tissue characteristics based on a ratio of the first impedance phase angle and the baseline impedance phase angle, and output information indicative of the epithelial tissue characteristics.

8. 发明申请

WO2016160541A1 FIBRIN COMPOSITION, METHOD AND WOUND ARTICLES 审中-公开
标题翻译： FIBRIN组合物，方法和创新文章
公开(公告)号：WO2016160541A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/024141
申请日：2016-03-25
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BJORK, Jason W. , YOUNG, Alexi J. , BEEN, Raha A. , NINKOVIC, Jana , BAKER, Bryan A.
IPC分类号： A61L24/10
CPC分类号： A61L26/008 , A61F13/0259 , A61F2013/00089 , A61F2013/00655 , A61F2013/00676 , A61F2013/00706 , A61L24/106 , A61L26/0042 , A61L26/0071
摘要： A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.
摘要翻译：描述了形成纤维蛋白水凝胶组合物的方法。该方法包括形成包含纤维蛋白原，纤维蛋白形成酶和纤维蛋白水凝胶形成盐的水溶液。纤维蛋白水凝胶形成盐浓度大于或等于阈值浓度以形成纤维蛋白水凝胶。该方法还包括将盐浓度降低到阈值浓度以下以形成纤维蛋白水凝胶。在一些实施方案中，水溶液还包含增塑剂。还描述了纤维蛋白组合物，其包含纤维蛋白浓度范围为0.1至10重量％的纤维蛋白水凝胶; 和纤维蛋白水凝胶形成盐。纤维蛋白水凝胶形成盐的浓度小于阈值浓度以形成纤维蛋白水凝胶。纤维蛋白水凝胶或脱水纤维蛋白水凝胶可以是各种物理形式，例如片，泡沫或多个片。还描述了形成纤维蛋白制品，伤口敷料和伤口治疗方法的方法。

9. 发明申请

WO2015175611A1 SYSTEM AND METHOD FOR LIQUID CULTURE OF ANAEROBIC OR MICROAEROPHILIC MICROORGANISMS 审中-公开
标题翻译：无机或微生物微生物液体培养系统与方法
公开(公告)号：WO2015175611A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030491
申请日：2015-05-13
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BJORK, Jason W. , STANENAS, Adam J. , XIA, Wensheng
IPC分类号： C12N1/20 , C12Q1/04 , C12Q1/26
CPC分类号： C12Q1/04 , C12N1/20 , C12Q1/26
摘要： A culture system for culturing a microaerophilic or an anaerobic microorganism is provided. The culture system can include effective amounts of i) an enzyme of an oxidoreductase family and ii) a substrate for said enzyme, a container, and a predetermined volume of aqueous medium that supports growth of said anaerobic or microaerophilic microorganism. The enzyme can be selected from a group consisting of ascorbic acid oxidase and laccase. The effective amounts are effective to deplete dissolved oxygen in the predetermined volume to a concentration that facilitates growth of a microaerophilic microorganism or an obligately-anaerobic microorganism. A method of using the system is also provided.
摘要翻译：提供了用于培养微嗜酸或厌氧微生物的培养系统。培养系统可以包括有效量的i）氧化还原酶家族的酶，和ii）所述酶，容器和支持所述厌氧微生物微生物生长的预定体积的水性介质的底物。酶可以选自抗坏血酸氧化酶和漆酶组。有效量有效地将预定体积中的溶解氧消耗至促进微生物微生物或专一性厌氧微生物生长的浓度。还提供了一种使用该系统的方法。

10. 发明申请

WO2018102484A1 BASIC CORE MATERIAL ENCAPSULATED IN AN INORGANIC SHELL SUITABLE FOR USE IN BIOLOGICAL CARRIER MATERIALS 审中-公开
公开(公告)号：WO2018102484A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/063829
申请日：2017-11-30
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： CHRISTENSEN, Randilynn B. , BUDD, Kenton D. , FALSAFI, Afshin , AKSIT, Mahmut , NINKOVIC, Jana , LIU, Jie J. , AGRE, Mark B. , NAKAMURA, Masayuki , BJORK, Jason W.
IPC分类号： A61K6/00 , A61K6/06 , A61K6/02 , A61K9/50
摘要： A (e.g. hardenable dental) composition is described comprising (e.g. a first part comprising) an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core; and (e.g. a second part comprising) water or an acidic component. Also described is an encapsulated material (e.g. suitable for use in a biological carrier material) comprising a basic core material and an inorganic shell material comprising a metal oxide surrounding the core.

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