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1. 发明申请

WO2008083279A1 METHOD OF DETECTION OF BIOANALYTES BY ACOUSTO-MECHANICAL DETECTION SYSTEMS COMPRISING THE ADDITION OF LIPOSOMES 审中-公开
标题翻译：通过包含脂质体添加剂的机械检测系统检测生物质的方法
公开(公告)号：WO2008083279A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/089053
申请日：2007-12-28
申请人： 3M INNOVATIVE PROPERTIES COMPANY , BJORK, Jason W. , GASON, Samuel J. , PALAZZOTTO, Michael C. , ROSCOE, Stephen B.
发明人： BJORK, Jason W. , GASON, Samuel J. , PALAZZOTTO, Michael C. , ROSCOE, Stephen B.
IPC分类号： G01N27/00 , G01N33/543
CPC分类号： G01N33/54373 , G01N29/022 , G01N29/30 , G01N2291/0255 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423
摘要： Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection of the target biological analytes in sample material are enhanced by contacting the target biological analyte and/or the sensor surface with liposomes that amplify the sensor sensitivity by (1) modifying the rheological properties of the fluid near the sensor surface; (2) changing the mass attached to the surface; and/or (3) modifying the dielectric properties of the fluid near the sensor surface, the sensor surface itself and/or any intervening layers on the sensor surface.
摘要翻译：公开了使用由传感器产生的声 - 机械能来检测样品材料内的目标生物分析物的方法。声机械能可以使用诸如例如剪切水平声表面波传感器（例如LSH-SAW传感器）的表面声波传感器的声 - 机械传感器来提供。通过使目标生物分析物和/或传感器表面与通过（1）修改传感器表面附近的流体的流变特性来扩大传感器灵敏度的脂质体接触来增强样品材料中目标生物分析物的检测; （2）改变附着在表面上的质量; 和/或（3）修改传感器表面附近的流体的介电特性，传感器表面本身和/或传感器表面上的任何中间层。

2. 发明申请

WO2011087711A1 METHODS OF DETECTING MICROORGANISMS AND KITS THEREFORE 审中-公开
标题翻译：检测微生物和试剂盒的方法
公开(公告)号：WO2011087711A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/060936
申请日：2010-12-17
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ROSCOE, Stephen B. , BOLEA, Philip A. , MOELLER, Stephanie J.
发明人： ROSCOE, Stephen B. , BOLEA, Philip A. , MOELLER, Stephanie J.
IPC分类号： C12Q1/04 , C12Q1/06
CPC分类号： G01N21/643 , C12Q1/04 , C12Q1/06
摘要： A method of detecting microorganisms in a test sample is provided. The method includes the steps of: a) incubating the test sample with a growth media to form an incubated sample, wherein the growth media includes an enzyme substrate and the enzyme substrate includes an enzymatically hydrolysable group and a fluorescent group, wherein microorganisms present in the test sample include an enzyme that hydrolyzes the hydrolysable group from the fluorescent group to form a fluorescently detectable product, wherein the fluorescently detectable product has both an acidic and basic species; b) exciting the fluorescently detectable product with light having a wavelength of Exλiso for a time sufficient for the fluorescently detectable product to emit light, wherein Exλiso is the absorbance isosbestic point of the fluorescently detectable product; and c) detecting light emitted at a wavelength of Emλ1.
摘要翻译：提供了一种检测试样中微生物的方法。该方法包括以下步骤：a）用生长培养基孵育测试样品以形成孵育的样品，其中生长培养基包括酶底物，酶底物包括酶促水解基团和荧光基团，其中存在于测试样品包括从荧光基团水解可水解基团以形成荧光可检测产物的酶，其中荧光检测产物具有酸性和碱性物质; b）用荧光检测产物发光的时间激发具有波长为Ex 2 iso的光的荧光检测产物，其中Ex 2 iso是荧光检测产物的吸光度等值点; 以及c）检测在Em≥1波长处发射的光。

3. 发明申请

WO2009102824A1 METHODS AND COMPOSITIONS FOR DETECTING MICROORGANISMS 审中-公开
标题翻译：检测微生物的方法和组合物
公开(公告)号：WO2009102824A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/033847
申请日：2009-02-12
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ROSCOE, Stephen B. , MOELLER, Stephanie J. , KSHIRSAGAR, Manjiri T.
发明人： ROSCOE, Stephen B. , MOELLER, Stephanie J. , KSHIRSAGAR, Manjiri T.
IPC分类号： G01N33/53
CPC分类号： G01N33/569 , G01N33/5308 , G01N2333/39 , G01N2400/24 , G01N2469/10
摘要： Methods of analyzing a sample for target microorganisms of interest are described. In particular, the methods are useful for detecting a variety of yeast and mold microorganisms based on the presence of a ubiquitous cell wall component, such as zymosan. Methods of analyzing a sample for fungal microorganisms using liposomes and/or culture media are also described.
摘要翻译：描述了目标微生物样品分析方法。特别地，该方法可用于基于普遍存在的细胞壁组分（例如酵母聚糖）的存在来检测各种酵母和霉菌微生物。还描述了使用脂质体和/或培养基分析真菌微生物样品的方法。

4. 发明申请

WO2009082667A1 MICROBIOLOGICAL SYSTEMS AND METHODS OF FLUID SAMPLE ANALYSIS 审中-公开
标题翻译：微生物系统和流体样品分析方法
公开(公告)号：WO2009082667A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/087399
申请日：2008-12-18
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ROSCOE, Stephen B. , KSHIRSAGAR, Manjiri , ZOOK, Cynthia D.
发明人： ROSCOE, Stephen B. , KSHIRSAGAR, Manjiri , ZOOK, Cynthia D.
IPC分类号： C12Q1/04
CPC分类号： C12Q1/10 , C12M25/06 , C12M41/36 , C12Q1/04 , C12Q1/06 , C12Q1/24 , G01N2333/245 , Y02A50/54
摘要： Methods and systems for detecting the presence of a target microorganism in a liquid sample are provided. Methods comprise the steps of passing the liquid sample through a surface filter, placing the surface filter into contact with a culture device, incubating the culture device for a period of time and detecting the presence of a target microorganism. Methods may be used with an automated detection system.
摘要翻译：提供了用于检测液体样品中目标微生物的存在的方法和系统。方法包括使液体样品通过表面过滤器，使表面过滤器与培养装置接触，培养培养装置一段时间并检测目标微生物的存在的步骤。方法可以与自动检测系统一起使用。

5. 发明申请

WO2021059195A1 COMPOSITIONS AND METHODS OF DETECTING ANALYTES 审中-公开
公开(公告)号：WO2021059195A1
公开(公告)日：2021-04-01
申请号：PCT/IB2020/058951
申请日：2020-09-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： SGOLASTRA, Federica , ROSCOE, Stephen B. , DOHMEIER, Daniel M. , NAKAMURA, Masayuki , BOTHOF, Catherine A. , YUKSEL YURT, Deniz , JOHNSON, David D. , KALSTABAKKEN, Kyle A. , DAI, Minghua , KANG, Myungchan , PERCY, Neil , HORTON, Leslie M. , KENNEDY, Stephen M.
IPC分类号： G01N33/543 , G01N33/552 , G01N33/532 , C03C12/00 , C03C11/002 , C03C17/30 , C03C2218/111 , G01N33/54313 , G01N33/54353
摘要： A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.

6. 发明申请

WO2019123124A1 POLYMERIC MATERIALS FORMED USING INITIATORS WITH TWO THIOCARBONYLTHIO-CONTAINING GROUPS 审中-公开
公开(公告)号：WO2019123124A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/059954
申请日：2018-12-12
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： LEWANDOWSKI, Kevin M. , ROSCOE, Stephen B. , GADDAM, Babu N. , WHITING, Bryan T. , BATTISTE, John L. , GRIESGRABER, George W.
IPC分类号： C08F2/38 , C08F2/48 , C08F222/10 , C09J4/06 , C08F220/28
摘要： Controlled radical initiators, reaction mixtures containing the controlled radical initiators and various ethylenically unsaturated monomers, polymeric materials formed from the reaction mixtures, crosslinkable compositions containing the polymeric materials, crosslinked compositions formed from the crosslinkable compositions, and articles containing the polymeric materials, the crosslinkable compositions, or the crosslinked compositions are provided. The controlled radical initiators are bis-dithiocarbamate or bis-dithiocarbonate compounds having a single carbon between the two dithiocarbamate or dithiocarbonate groups. Also attached to that single carbon is a ketone group.

7. 发明申请

WO2021124116A1 COMPOSITION AND METHOD FOR THE DETECTION OF ANALYTES 审中-公开
公开(公告)号：WO2021124116A1
公开(公告)日：2021-06-24
申请号：PCT/IB2020/061982
申请日：2020-12-15
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： YUKSEL YURT, Deniz , ROSCOE, Stephen B. , KANG, Myungchan , DAI, Minghua , SGOLASTRA, Federica
IPC分类号： G01N33/53 , G01N33/569 , G01N33/58 , G01N33/5308 , G01N33/56961 , G01N33/587
摘要： A method of detecting an analyte. The method includes providing a composition, the composition comprising nanoparticles coupled to a first aptamer and nanorods coupled to a second aptamer, wherein the composition is substantially free of aggregates of the nanoparticles and nanorods; contacting a sample with the composition; adding a reagent to change the morphologies of the nanoparticles or nanorods; detecting a first color change of nanoparticles responsive to a first analyte in the sample; and detecting a second color change of nanorods responsive to a second analyte in the sample.

8. 发明申请

WO2019123176A1 POLYMERIC SUBSTRATES WITH ATTACHED THIOCARBONYLTHIO-CONTAINING GROUPS 审中-公开
公开(公告)号：WO2019123176A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/060118
申请日：2018-12-14
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： RASMUSSEN, Jerald K. , ROSCOE, Stephen B. , GADDAM, Babu N. , GRIESGRABER, George W. , O'NEAL, Daniel J. , NARVESON, Eli
IPC分类号： C08J7/12 , C08J7/18
CPC分类号： C08J7/123 , C08G75/26 , C08J7/18 , C08J2381/00 , C08L81/00 , G02B1/043
摘要： First articles with covalently attached thiocarbonylthio-containing groups are provided. More specifically, the first articles are a functionalized substrate that contains a solid polymeric substrate with a plurality of thiocarbonylthio-containing groups covalently attached directly to carbon atoms in a polymeric backbone of the solid polymeric substrate. Methods of making the first articles with covalently attached thiocarbonylthio-containing groups are provided. Additionally, second articles and methods of using the first articles to generate second articles with covalently attached polymeric chains are provided.

9. 发明申请

WO2018178829A1 POLYMERIC MATERIALS FORMED USING CONTROLLED RADICAL INITIATORS 审中-公开
公开(公告)号：WO2018178829A1
公开(公告)日：2018-10-04
申请号：PCT/IB2018/051990
申请日：2018-03-23
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： LEWANDOWSKI, Kevin M. , GADDAM, Babu N. , ROSCOE, Stephen B. , BATTISTE, John L.
IPC分类号： C08F265/04 , C08F287/00 , C08F293/00 , C09J7/38
摘要： Controlled radical initiators, reaction mixtures containing the controlled radical initiators and various ethylenically unsaturated monomers, polymeric materials formed from the reaction mixtures, crosslinkable compositions containing the polymeric materials, and crosslinked compositions formed from the crosslinkable compositions are provided. The controlled radical initiators are bis-dithiocarbamate or bis-dithiocarbonate compounds having a single carbon between the two dithiocarbamate or dithiocarbonate groups.

10. 发明申请

WO2015191419A2 ASSAY DEVICES AND METHOD OF DETECTING A TARGET ANALYTE 审中-公开
标题翻译：测定装置和检测目标分析仪的方法
公开(公告)号：WO2015191419A2
公开(公告)日：2015-12-17
申请号：PCT/US2015/034624
申请日：2015-06-08
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： ROSCOE, Stephen B. , KANG, Myungchan , BRUTINEL, Evan D. , MILLER, Jesse D. , CLINE, Renee K. , DAI, Minghua , LIU, Hsi-Chou
CPC分类号： B01L3/5029 , B01L3/502 , B01L2200/16 , B01L2300/0825 , B01L2400/0406 , B01L2400/0478 , G01N33/5304
摘要： Assay devices are provided including a receptacle having a sample entry port; a plunger disposed within the receptacle; at least one reagent; a membrane attached to a first surface of the plunger; a wick providing capillary force; and a detection zone. The membrane includes a target conjugate zone in which affinity components are disposed. Capture compounds are immobilized in a detection zone, which is located between the target conjugate zone and the wick. A method of detecting a target analyte is also provided, including providing the assay device; providing a sample suspected to contain a target analyte; adding the sample onto the device; allowing the sample to travel along the membrane until the sample reaches the detection zone; immobilizing the target analyte through reaction of the target analyte with the capture compounds; reacting the immobilized target analyte with a reagent to generate a detectable signal; and detecting the generated signal.
摘要翻译：提供测定装置，包括具有样品入口的容器; 设置在所述容器内的柱塞; 至少一种试剂; 膜附接到柱塞的第一表面; 提供毛细管力的灯芯; 和检测区。膜包括其中配置亲和成分的靶共轭区。捕获化合物被固定在位于靶共轭区和芯之间的检测区中。还提供了检测目标分析物的方法，包括提供测定装置; 提供怀疑含有目标分析物的样品; 将样品添加到设备上; 允许样品沿着膜移动直到样品到达检测区域; 通过靶分析物与捕获化合物的反应固定目标分析物; 使固定化的目标分析物与试剂反应以产生可检测的信号; 并检测所生成的信号。

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