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1. 发明申请

WO2014025514A1 METHOD OF MAKING AGGLOMERATED MICROBIOLOGICAL MEDIA AND COMPOSITIONS THEREOF 审中-公开
标题翻译：制备聚集微生物培养基的方法及其组合物
公开(公告)号：WO2014025514A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/051446
申请日：2013-07-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , LIU, Jie J. , XIA, Wensheng
发明人： LIU, Jie J. , XIA, Wensheng
IPC分类号： C12N1/20
CPC分类号： C12N1/20
摘要： A method of making a flowable, agglomerated nutrient medium is provided. The method comprises forming a nutrient medium composition by placing a powdered nutrient into a fluidized bed-type agglomeration chamber, flowing a fluidizing gas through the chamber, and contacting in the agglomeration chamber the powdered nutrient with an aerosol spray of an agglomeration liquid; and collecting the composition from the chamber. The nutrient component facilitates the growth of a microorganism. The composition formed by the method comprises a population of agglomerated nutrient medium particles and, optionally, nonagglomerated powdered nutrient. The population comprises at least about 30 weight percent agglomerated nutrient particles having an effective particle diameter of about 250-400 microns. Compositions, thin film culture devices, and kits comprising the flowable, dried agglomerated nutrient medium are also provided.
摘要翻译：提供了制备可流动的附聚营养培养基的方法。所述方法包括通过将粉状营养物放入流化床型附聚室中形成营养培养基组合物，使流化气体流过所述室，并使所述粉末状营养物与附聚液体的气溶胶喷雾接触; 并从室收集组合物。营养成分促进微生物的生长。通过该方法形成的组合物包含聚集的营养培养基颗粒群和任选的非团聚的粉状营养物。群体包含至少约30重量％的有效粒径为约250-400微米的附聚营养颗粒。还提供了组合物，薄膜培养装置和包含可流动，干燥的附聚营养培养基的试剂盒。

2. 发明申请

WO2006091720A3 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开
公开(公告)号：WO2006091720A3
公开(公告)日：2006-08-31
申请号：PCT/US2006/006387
申请日：2006-02-23
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ALKAN, Sefik , KIEPER, William C. , VASILAKOS, John P. , BONK, Jason D. , GRIESGRABER, George W. , LIPSON, Kenneth E. , LIU, Jie J. , MENDOZA, James D. , STOERMER, Doris , WIGHTMAN, Paul D. , JING, Naiyong , SCHULTZ, William J.
发明人： ALKAN, Sefik , KIEPER, William C. , VASILAKOS, John P. , BONK, Jason D. , GRIESGRABER, George W. , LIPSON, Kenneth E. , LIU, Jie J. , MENDOZA, James D. , STOERMER, Doris , WIGHTMAN, Paul D. , JING, Naiyong , SCHULTZ, William J.
IPC分类号： A61K31/4745 , A61K31/4748 , A61K31/437 , A61K31/4738
摘要： The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

3. 发明申请

WO2004108072A2 DELIVERY OF IMMUNE RESPONSE MODIFIER COMPOUNDS USING METAL-CONTAINING PARTICULATE SUPPORT MATERIALS 审中-公开
标题翻译：使用含金属颗粒支持材料递送免疫应答改性剂化合物
公开(公告)号：WO2004108072A2
公开(公告)日：2004-12-16
申请号：PCT/US2004/011081
申请日：2004-04-09
申请人： 3M INNOVATIVE PROPERTIES COMPANY , WIGHTMAN, Paul, D. , LIU, Jie, J. , JING, Naiyong
发明人： WIGHTMAN, Paul, D. , LIU, Jie, J. , JING, Naiyong
IPC分类号： A61K
CPC分类号： A61K47/6957 , A61K47/50 , A61K47/6903
摘要： The present invention provides immune response modifiers (IRMs) on particulate support materials that includes one or more metals, including alloys or complexes thereof.
摘要翻译：本发明提供了颗粒载体材料上的免疫应答调节剂（IRM），其包括一种或多种金属，包括其合金或复合物。

4. 发明申请

WO2004091500A2 DELIVERY OF IMMUNE RESPONSE MODIFIER COMPOUNDS 审中-公开
标题翻译：交付免疫反应调节剂化合物
公开(公告)号：WO2004091500A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011062
申请日：2004-04-09
申请人： 3M INNOVATIVE PROPERTIES COMPANY , WIGHTMAN, Paul, D. , ZARRAGA, Isidro, Angelo, E. , LIU, Jie, J. , JING, Naiyong
发明人： WIGHTMAN, Paul, D. , ZARRAGA, Isidro, Angelo, E. , LIU, Jie, J. , JING, Naiyong
IPC分类号： A61K
CPC分类号： A61K47/6957 , A61K47/50 , A61K47/6903
摘要： The present invention provides immune response modifiers (IRMs) associated with (typically, attached to, and preferably, covalently attached to) macromolecular support materials. The IRM compounds in such IRM-support complexes retain biological activity. Such attachment of an IRM to a macromolecular support material provides for the localized biological activity of the IRM.
摘要翻译：本发明提供与（通常附着于，优选共价连接）大分子支持材料相关的免疫应答调节剂（IRM）。这种IRM支持复合物中的IRM化合物保留生物活性。将IRM附着到大分子载体材料上提供IRM的局部生物活性。

5. 发明申请

WO2014018433A1 AGGLOMERATED MICROBIOLOGICAL MEDIA 审中-公开
标题翻译：组织微生物培养基
公开(公告)号：WO2014018433A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051449
申请日：2013-07-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , LIU, Jie J. , XIA, Wensheng
发明人： LIU, Jie J. , XIA, Wensheng
IPC分类号： C12N1/20
CPC分类号： C12N1/20 , C12N1/14 , C12N1/16 , C12N2500/46 , C12N2500/60
摘要： A method of making a flowable, dried agglomerated nutrient medium is provided. The method comprises introducing a nutrient component comprising a powdered nutrient, and an agglomeration liquid, into an agglomerator comprising a flow-through-type agglomeration chamber, wet-massing the nutrient component with the agglomeration liquid in the agglomeration chamber for a predetermined period of time to form agglomerated nutrient medium particles, and exposing the agglomerated nutrient medium particles to drying conditions for a period of time to form the dried, agglomerated nutrient medium. The nutrient component facilitates the growth of a microorganism. Compositions, articles, and kits comprising the flowable, dried agglomerated nutrient medium are also provided.
摘要翻译：提供了制备可流动的，干燥的附聚营养培养基的方法。该方法包括将包含粉末状营养物和附聚液的营养成分引入包含流通型附聚室的附聚器中，将附聚液中的营养成分与附聚室湿式预定一段时间以形成附聚的营养培养基颗粒，并将附聚的营养培养基颗粒暴露于干燥条件下一段时间以形成干燥的聚集的营养培养基。营养成分促进微生物的生长。还提供了包含可流动，干燥的附聚营养培养基的组合物，制品和试剂盒。

6. 发明申请

WO2006091720A2 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开
标题翻译：用于定向递送免疫应答改性剂的组合物和方法
公开(公告)号：WO2006091720A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006387
申请日：2006-02-23
申请人： 3M INNOVATIVE PROPERTIES CO , ALKAN SEFIK , KIEPER WILLIAM C , VASILAKOS JOHN P , BONK JASON D , GRIESGRABER GEORGE W , LIPSON KENNETH E , LIU JIE J , MENDOZA JAMES D , STOERMER DORIS , WIGHTMAN PAUL D , JING NAIYONG , SCHULTZ WILLIAM J
发明人： ALKAN SEFIK , KIEPER WILLIAM C , VASILAKOS JOHN P , BONK JASON D , GRIESGRABER GEORGE W , LIPSON KENNETH E , LIU JIE J , MENDOZA JAMES D , STOERMER DORIS , WIGHTMAN PAUL D , JING NAIYONG , SCHULTZ WILLIAM J
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745 , A61K47/6803 , A61K47/6849 , A61K47/6851
摘要： The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.
摘要翻译：本发明提供免疫调节组合物包括与靶向部分偶联的免疫应答调节剂部分。在另一方面，本发明提供了提供IRM的靶向递送，产生局部免疫应答和治疗受试者的病症的方法。通常，所述方法包括向受试者施用免疫调节组合物，其包含与识别递送目标的靶向部分偶联的免疫应答调节剂部分。

7. 发明申请

WO2004108072A3 DELIVERY OF IMMUNE RESPONSE MODIFIER COMPOUNDS USING METAL-CONTAINING PARTICULATE SUPPORT MATERIALS 审中-公开
标题翻译：使用含金属颗粒支持材料递送免疫应答改性剂化合物
公开(公告)号：WO2004108072A3
公开(公告)日：2005-08-04
申请号：PCT/US2004011081
申请日：2004-04-09
申请人： 3M INNOVATIVE PROPERTIES CO , WIGHTMAN PAUL D , LIU JIE J , JING NAIYONG
发明人： WIGHTMAN PAUL D , LIU JIE J , JING NAIYONG
IPC分类号： A01N33/24 , A01N59/16 , A61F2/06 , A61F2/24 , A61F2/76 , A61K20060101 , A61K9/14 , A61K39/395 , A61K45/00 , A61K47/00 , A61K48/00
CPC分类号： A61K47/6957 , A61K47/50 , A61K47/6903
摘要： The present invention provides immune response modifiers (IRMs) on particulate support materials that includes one or more metals, including alloys or complexes thereof.
摘要翻译：本发明提供了颗粒载体材料上的免疫应答调节剂（IRM），其包括一种或多种金属，包括其合金或复合物。

8. 发明申请

WO2004091500A3 DELIVERY OF IMMUNE RESPONSE MODIFIER COMPOUNDS 审中-公开
标题翻译：交付免疫反应调节剂化合物
公开(公告)号：WO2004091500A3
公开(公告)日：2005-07-07
申请号：PCT/US2004011062
申请日：2004-04-09
申请人： 3M INNOVATIVE PROPERTIES CO , WIGHTMAN PAUL D , ZARRAGA ISIDRO ANGELO E , LIU JIE J , JING NAIYONG
发明人： WIGHTMAN PAUL D , ZARRAGA ISIDRO ANGELO E , LIU JIE J , JING NAIYONG
IPC分类号： A01N33/24 , A01N59/16 , A61F2/06 , A61F2/24 , A61F2/76 , A61K20060101 , A61K9/14 , A61K39/395 , A61K45/00 , A61K47/00 , A61K48/00
CPC分类号： A61K47/6957 , A61K47/50 , A61K47/6903
摘要： The present invention provides immune response modifiers (IRMs) associated with (typically, attached to, and preferably, covalently attached to) macromolecular support materials. The IRM compounds in such IRM-support complexes retain biological activity. Such attachment of an IRM to a macromolecular support material provides for the localized biological activity of the IRM.
摘要翻译：本发明提供与（通常附着于，优选共价连接）大分子支持材料相关的免疫应答调节剂（IRM）。这种IRM支持复合物中的IRM化合物保留生物活性。将IRM附着到大分子载体材料上提供IRM的局部生物活性。

9. 发明申请

WO2012092123A1 EFFERVESCENT COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：有效的组合物及其用途
公开(公告)号：WO2012092123A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/066820
申请日：2011-12-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , XIA, Wensheng , MACH, Patrick A. , BEAURLINE, Joseph M. , BJORK, Jason W. , LIU, Jie J.
发明人： XIA, Wensheng , MACH, Patrick A. , BEAURLINE, Joseph M. , BJORK, Jason W. , LIU, Jie J.
IPC分类号： C12Q1/04 , C12N1/00 , C12N1/20
CPC分类号： C12Q1/045 , C12N1/14 , C12N1/20 , C12N1/38 , C12Q1/04 , C12Q1/689
摘要： A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
摘要翻译：公开了包含选择剂的潜伏泡腾体。还公开了在选择性富集目标微生物的方法中使用潜在泡腾体的方法。该方法包括提供样品，培养基和潜在泡腾体。该方法还包括在促进靶微生物生长的条件下使样品，培养基和潜在泡腾体接触。该方法还包括从潜在泡腾体释放选择剂。任选地，该方法包括检测微生物。

10. 发明申请

WO2009006131A1 AN INDICATING FIBER 审中-公开
标题翻译：指示纤维
公开(公告)号：WO2009006131A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068094
申请日：2008-06-25
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZHANG, Yifan , LIU, Jie J. , MOORE, Eric M. , PORBENI, Francis E. , TUMAN, Scott J. , WOLK, Diane R.
发明人： ZHANG, Yifan , LIU, Jie J. , MOORE, Eric M. , PORBENI, Francis E. , TUMAN, Scott J. , WOLK, Diane R.
IPC分类号： D01F1/10 , G01N33/52
CPC分类号： D01F1/10 , G01N33/528 , Y10T436/143333
摘要： A fiber, an articles formed from a fiber and methods of making the fiber and associate article are disclosed. In one embodiment, the fiber comprises a synthetic polymer and a color-changing indicator. The color-changing indicator is dispersed throughout the synthetic polymer. The color-changing indicator reacts in the presence of a stimulus to produce a color change.
摘要翻译：公开了一种纤维，由纤维形成的制品和制造纤维和副制品的方法。在一个实施方案中，纤维包括合成聚合物和颜色变化指示剂。颜色变化指示剂分散在整个合成聚合物中。颜色变化指示器在存在刺激的情况下反应以产生颜色变化。

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