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1. 发明申请

WO2015175611A1 SYSTEM AND METHOD FOR LIQUID CULTURE OF ANAEROBIC OR MICROAEROPHILIC MICROORGANISMS 审中-公开
标题翻译：无机或微生物微生物液体培养系统与方法
公开(公告)号：WO2015175611A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030491
申请日：2015-05-13
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BJORK, Jason W. , STANENAS, Adam J. , XIA, Wensheng
IPC分类号： C12N1/20 , C12Q1/04 , C12Q1/26
CPC分类号： C12Q1/04 , C12N1/20 , C12Q1/26
摘要： A culture system for culturing a microaerophilic or an anaerobic microorganism is provided. The culture system can include effective amounts of i) an enzyme of an oxidoreductase family and ii) a substrate for said enzyme, a container, and a predetermined volume of aqueous medium that supports growth of said anaerobic or microaerophilic microorganism. The enzyme can be selected from a group consisting of ascorbic acid oxidase and laccase. The effective amounts are effective to deplete dissolved oxygen in the predetermined volume to a concentration that facilitates growth of a microaerophilic microorganism or an obligately-anaerobic microorganism. A method of using the system is also provided.
摘要翻译：提供了用于培养微嗜酸或厌氧微生物的培养系统。培养系统可以包括有效量的i）氧化还原酶家族的酶，和ii）所述酶，容器和支持所述厌氧微生物微生物生长的预定体积的水性介质的底物。酶可以选自抗坏血酸氧化酶和漆酶组。有效量有效地将预定体积中的溶解氧消耗至促进微生物微生物或专一性厌氧微生物生长的浓度。还提供了一种使用该系统的方法。

2. 发明申请

WO2023084337A1 STERILIZATION INDICATOR SENSOR 审中-公开
公开(公告)号：WO2023084337A1
公开(公告)日：2023-05-19
申请号：PCT/IB2022/059787
申请日：2022-10-12
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： XIA, Wensheng , JING, Naiyong
IPC分类号： A61L2/28 , A61L2/07
摘要： In some embodiments, a sensor device includes a first electrode and a second electrode, each of the first and second electrodes being electrically coupled to an electrical bridge. The electrical bridge includes a conductive polymer having a first impedance state and a second impedance, the second impedance state being different than the first impedance sate. The sensor device also includes a latent base.

3. 发明申请

WO2016183012A1 COMPOSITION FOR REDUCING INHIBITION OF NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：用于减少抑制核酸扩增的组合物
公开(公告)号：WO2016183012A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/031478
申请日：2016-05-09
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： SITTON, Gregory W. , XIA, Wensheng , BONILLA, Tonya D.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2527/125
摘要： A composition for reducing the inhibitory effects of contaminants on nucleic acid amplification is provided. The composition includes a plurality of zirconium oxide particles, a non-ionic surfactant, and an organic iron-chelating reagent. The organic iron-chelating reagent has a first affinity constant greater than or equal to 10 4.2 with respect to ferric iron and a second affinity constant less than 10 3.8 with respect to magnesium, wherein the first affinity constant and the second affinity constant are determined in deionized water at pH 8.45 and 20° C. Optionally, the composition includes polyvinylpyrrolidone. Optionally, the composition comprises water. The composition has a pH of about 8.45 to 8.85. Methods of using the composition to prepare a sample for nucleic acid amplification are also provided.
摘要翻译：提供了用于降低污染物对核酸扩增的抑制作用的组合物。该组合物包括多个氧化锆颗粒，非离子表面活性剂和有机铁螯合剂。有机铁螯合剂相对于三价铁具有大于或等于104.2的第一亲和常数，相对于镁的第二亲和常数小于103.8，其中第一亲和常数和第二亲和常数在去离子水中测定在pH 8.45和20℃。任选地，组合物包括聚乙烯吡咯烷酮。任选地，组合物包含水。该组合物具有约8.45至8.85的pH。还提供了使用该组合物制备用于核酸扩增的样品的方法。

4. 发明申请

WO2014025514A1 METHOD OF MAKING AGGLOMERATED MICROBIOLOGICAL MEDIA AND COMPOSITIONS THEREOF 审中-公开
标题翻译：制备聚集微生物培养基的方法及其组合物
公开(公告)号：WO2014025514A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/051446
申请日：2013-07-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , LIU, Jie J. , XIA, Wensheng
发明人： LIU, Jie J. , XIA, Wensheng
IPC分类号： C12N1/20
CPC分类号： C12N1/20
摘要： A method of making a flowable, agglomerated nutrient medium is provided. The method comprises forming a nutrient medium composition by placing a powdered nutrient into a fluidized bed-type agglomeration chamber, flowing a fluidizing gas through the chamber, and contacting in the agglomeration chamber the powdered nutrient with an aerosol spray of an agglomeration liquid; and collecting the composition from the chamber. The nutrient component facilitates the growth of a microorganism. The composition formed by the method comprises a population of agglomerated nutrient medium particles and, optionally, nonagglomerated powdered nutrient. The population comprises at least about 30 weight percent agglomerated nutrient particles having an effective particle diameter of about 250-400 microns. Compositions, thin film culture devices, and kits comprising the flowable, dried agglomerated nutrient medium are also provided.
摘要翻译：提供了制备可流动的附聚营养培养基的方法。所述方法包括通过将粉状营养物放入流化床型附聚室中形成营养培养基组合物，使流化气体流过所述室，并使所述粉末状营养物与附聚液体的气溶胶喷雾接触; 并从室收集组合物。营养成分促进微生物的生长。通过该方法形成的组合物包含聚集的营养培养基颗粒群和任选的非团聚的粉状营养物。群体包含至少约30重量％的有效粒径为约250-400微米的附聚营养颗粒。还提供了组合物，薄膜培养装置和包含可流动，干燥的附聚营养培养基的试剂盒。

5. 发明申请

WO2023002349A1 CHLORINATED 4'-ALKYLUMBELLIFERYL α-D-GLUCOPYRANOSIDE AND METHOD OF ASSESSING EFFICACY OF A STERILIZATION PROCESS INCLUDING THE SAME 审中-公开
公开(公告)号：WO2023002349A1
公开(公告)日：2023-01-26
申请号：PCT/IB2022/056605
申请日：2022-07-18
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： ROSCOE, Stephen B. , GRIESGRABER, George W. , BONILLA, Tonya D. , BOMMARITO, Giuseppe M. , XIA, Wensheng , FLYNN, Jeffrey M.
IPC分类号： C07H17/075 , A61L2/28 , C12M1/34 , C12Q1/22
摘要： A chlorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) One of R1 and R2 is Cl and the other is H. R3 represents an alkyl group having 1 to 12 carbon atoms. A method of assessing efficacy of a sterilization process including the same is also disclosed.

6. 发明申请

WO2017192305A1 METHOD OF DISINFECTING A MEDICAL DEVICE 审中-公开
标题翻译：消毒医疗设备的方法
公开(公告)号：WO2017192305A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/029370
申请日：2017-04-25
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： JING, Naiyong , WOLDT, Ryan T. , XIA, Wensheng , LANDGREBE, Kevin D. , NIES, Timothy J. , BAKER, Bryan A. , COLAK ATAN, Semra , JORGENSEN, Gary W. , BOMMARITO, Giuseppe M. , SWANSON, David P. , GRIESGRABER, George W. , PARTHASARATHY, Ranjani V.
IPC分类号： A61L2/18 , A61L2/28 , A01N47/00 , C12Q1/00
CPC分类号： A61L2/18 , A01N33/02 , A01N35/02 , A61L2/28 , A61L2202/24 , C12Q1/22 , A01N25/02 , A01N25/10
摘要： A method of disinfecting a medical device comprises three steps. First, a disinfectant is contacted with a process indicator and the medical device. The disinfectant comprises at least one aldehyde. The process indicator contains a synthetic amine-containing compound disposed on a substrate. The synthetic amine-containing compound comprises at least one of primary amino groups or secondary amino groups, and is reactive with the disinfectant to form at least one adduct. The synthetic amine-containing compound and the medical device are in fluid communication through the disinfectant. A predetermined disinfectant exposure criterion exists for contacting the disinfectant with the medical device. Second, the process indicator is spectrally observed and at least one parameter is obtained therefrom that is predictive of the predetermined disinfectant exposure criterion. The third step is determining that the predetermined disinfectant exposure criterion has been achieved.
摘要翻译：消毒医疗装置的方法包括三个步骤。首先，将消毒剂与过程指示器和医疗设备接触。消毒剂包含至少一种醛。该过程指示器包含置于基底上的合成的含胺化合物。合成的含胺化合物包含伯氨基或仲氨基中的至少一种，并且与消毒剂反应形成至少一种加合物。合成的含胺化合物和医疗装置通过消毒剂流体连通。存在用于使消毒剂与医疗装置接触的预定消毒剂暴露标准。其次，对过程指示符进行光谱观察，并从中获得预测预定消毒剂暴露标准的至少一个参数。第三步是确定已达到预定的消毒剂暴露标准。

7. 发明申请

WO2013184398A1 MULTIWELL PLATE 审中-公开
标题翻译：多层板
公开(公告)号：WO2013184398A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/042563
申请日：2013-05-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY , KIRSCHHOFFER, Jon A. , TILSTRA, Andrew H. , XIA, Wensheng
发明人： KIRSCHHOFFER, Jon A. , TILSTRA, Andrew H. , XIA, Wensheng
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L2200/025 , B01L2200/028 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851
摘要： An assembly for processing a sample is provided. The assembly comprises a first body having a plurality of spaced-apart conduits and a second body having a plurality of chambers wherein each conduit is fluidically connected to a separate chamber. The assembly forms a plurality of liquid flow paths, each flow path comprising a conduit and a chamber. An analyte capture element is detachably attached to a conduit and is in fluidic communication with the liquid flow path of the conduit. Optionally, the assembly further may comprise a third body comprising a plurality of reservoirs. The assembly can be used to process a liquid sample for detecting an analyte.
摘要翻译：提供了一种用于处理样品的组件。组件包括具有多个间隔开的管道的第一主体和具有多个室的第二主体，其中每个管道流体连接到单独的室。组件形成多个液体流动路径，每个流动路径包括导管和腔室。分析物捕获元件可拆卸地附接到导管并且与导管的液体流动路径流体连通。可选地，组件还可包括包括多个储存器的第三主体。该组件可用于处理用于检测分析物的液体样品。

8. 发明申请

WO2013184397A1 APPARATUS AND METHOD FOR PROCESSING A SAMPLE 审中-公开
标题翻译：用于处理样品的装置和方法
公开(公告)号：WO2013184397A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/042560
申请日：2013-05-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY , KIRSCHHOFFER, Jon A. , TILSTRA, Andrew H. , XIA, Wensheng
发明人： KIRSCHHOFFER, Jon A. , TILSTRA, Andrew H. , XIA, Wensheng
IPC分类号： B01L3/00
CPC分类号： C12Q1/04 , B01L3/5023 , B01L2200/026 , B01L2200/04 , B01L2300/0609 , B01L2300/0825 , B01L2300/0877 , C12Q1/24
摘要： An apparatus and an assembly for processing a sample are provided. The apparatus comprises a plurality of spaced-apart reservoirs, a plurality of channels, and a plurality of outlets, each outlet comprising an effluent discharge opening. The apparatus forms a plurality of flow paths, each flow path comprising a reservoir, a channel, and an outlet. An analyte capture element can be slideably engaged in a channel in a position where it is in fluid communication with the flow path. The apparatus with the analyte capture element disposed in the flow path can be used to process a liquid sample. A method of detecting an analyte in the liquid sample is also provided.
摘要翻译：提供了一种用于处理样品的装置和组件。该装置包括多个间隔开的储存器，多个通道和多个出口，每个出口包括流出物排出口。该装置形成多个流动路径，每个流动路径包括储存器，通道和出口。分析物捕获元件可以在其与流动路径流体连通的位置中可滑动地接合在通道中。具有设置在流路中的分析物捕捉元件的装置可用于处理液体样品。还提供了检测液体样品中的分析物的方法。

9. 发明申请

WO2008134464A2 SAMPLE-PROCESSING REAGENT COMPOSITIONS, METHODS, AND DEVICES 审中-公开
标题翻译：样品处理试剂组合物，方法和装置
公开(公告)号：WO2008134464A2
公开(公告)日：2008-11-06
申请号：PCT/US2008/061488
申请日：2008-04-25
申请人： 3M INNOVATIVE PROPERTIES COMPANY , XIA, Wensheng , PARTHASARATHY, Ranjani, V.
发明人： XIA, Wensheng , PARTHASARATHY, Ranjani, V.
IPC分类号： C12N15/10 , C12Q1/68 , A61K38/46
CPC分类号： C12N15/1006
摘要： Stable compositions comprising a nucleic acid binding support material comprising a substrate with functional groups attached to the substrate; a lysing enzyme; a water dispersible matrix material; and a saccharide, methods of using the compositions, and products and devices which include the compositions are disclosed.
摘要翻译：包含核酸结合载体材料的稳定组合物，所述核酸结合载体材料包含具有连接至所述底物的官能团的底物; 裂解酶; 水分散性基质材料; 和糖，公开了使用该组合物的方法，以及包含该组合物的产品和装置。

10. 发明申请

WO2022229741A1 SENSOR DEVICE 审中-公开
公开(公告)号：WO2022229741A1
公开(公告)日：2022-11-03
申请号：PCT/IB2022/052970
申请日：2022-03-30
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： XIA, Wensheng , JING, Naiyong , PHIPPS, James A.
IPC分类号： A61L2/28 , C12Q1/22 , G01N27/02
摘要： A sensor device includes a first electrode and a second electrode. Each of the first and second electrodes are electrically coupled to an electrical bridge. The electrical bridge includes a conductive polymer having a first impedance state and a second impedance state that is different than the first impedance sate. The electrical bridge includes metal or metal containing particles.

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