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1. 发明申请

US20200239922A1 MEANS AND METHODS FOR VITAMIN B12 PRODUCTION IN DUCKWEED 审中-公开
公开(公告)号：US20200239922A1
公开(公告)日：2020-07-30
申请号：US16841770
申请日：2020-04-07
申请人： Hinoman Ltd.
发明人： Vladimir GLUKHMAN , Ehud ELITUV
IPC分类号： C12P19/42 , A01H5/00 , A01H4/00 , A01H3/00 , C12N1/20
摘要： The present invention is directed to a system and method for producing a vitamin B12 enriched Duckweed Bacterial Culture (DBC) composition. The present invention further discloses a composition comprising a vitamin B12 enriched DBC, wherein said composition comprises at least one Lemnoideae species and at least one vitamin B12 producing bacteria species, further wherein said vitamin B12 content in said composition is in the range of between about 0.01 and about 100 μg per 100 g of said DBC.

2. 发明申请

US20200149084A1 SEQUENTIAL CO-CULTURING METHOD FOR PRODUCING A VITAMIN- AND PROTEIN-RICH FOOD PRODUCT 审中-公开
公开(公告)号：US20200149084A1
公开(公告)日：2020-05-14
申请号：US16632039
申请日：2018-07-23
申请人： Martin Frettlöh
发明人： Martin Frettlöh , Tanja Haag , Holger Zorn , Martina Zajul , Jenny Ahlborn
IPC分类号： C12P39/00 , C12P21/00 , C12P19/42 , C12N1/14 , C12N1/20 , A23L31/00 , A23L33/15 , A23L33/16
摘要： The present invention relates to a method for producing a vitamin- and protein-rich product, to a food product containing the vitamin- and protein-rich product, and to a nutrient medium appropriate for said method on the basis of agricultural tributaries or food tributaries.

3. 发明申请

US20120264174A1 ASSAY FOR VITAMIN B12 ABSORPTION AND METHOD OF MAKING LABELED VITAMIN B12 审中-公开
标题翻译：维生素B12吸收测定及标记维生素B12的制备方法
公开(公告)号：US20120264174A1
公开(公告)日：2012-10-18
申请号：US13523662
申请日：2012-06-14
申请人： Peter J. Anderson , Stephen Dueker , Joshua Miller , Ralph Green , John Roth , Colleen Carkeet , Bruce A. Buchholz
发明人： Peter J. Anderson , Stephen Dueker , Joshua Miller , Ralph Green , John Roth , Colleen Carkeet , Bruce A. Buchholz
IPC分类号： C12P19/42
CPC分类号： A61K51/041 , C12P19/42
摘要： The invention provides methods for labeling vitamin B12 with 14C, 13C, tritium, and deuterium. When radioisotopes are used, the invention provides for methods of labeling B12 with high specific activity. The invention also provides labeled vitamin B12 compositions made in accordance with the invention.
摘要翻译：本发明提供用14C，13C，氚和氘标记维生素B12的方法。当使用放射性同位素时，本发明提供了具有高比活性的标记B12的方法。本发明还提供了根据本发明制备的标记的维生素B12组合物。

4. 发明申请

US20120214197A1 Polypeptides Having Glucoamylase Activity and Polynucleotides Encoding Same 有权
标题翻译：具有葡糖淀粉酶活性的多肽和编码相同的多核苷酸
公开(公告)号：US20120214197A1
公开(公告)日：2012-08-23
申请号：US13504995
申请日：2010-11-30
申请人： Sara Landvik , Marc Dominique Morant , Keiichi Ayabe , Guillermo Coward-Kelly
发明人： Sara Landvik , Marc Dominique Morant , Keiichi Ayabe , Guillermo Coward-Kelly
IPC分类号： C12N9/34 , C07K14/375 , C12N9/00 , C12N9/26 , C12N9/10 , C12N9/24 , C12N15/63 , C12P7/06 , C12P7/16 , C12P7/04 , C12P7/48 , C12P7/54 , C12P7/56 , C12P7/44 , C12P7/42 , C12P7/02 , C12P7/40 , C12P7/26 , C12P7/28 , C12P13/14 , C12P13/04 , C12P3/00 , C12P1/00 , C12P37/00 , C12P29/00 , C12P23/00 , C12P25/00 , C12P19/42 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , C12N15/56
CPC分类号： C12P7/14 , C12N9/242 , C12N9/2428 , C12P7/06 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01001 , C12Y302/01003 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有葡糖淀粉酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

5. 发明授权

US07273729B2 Chondroitin synthase and DNA encoding the enzyme 有权
标题翻译：软骨素合成酶和编码酶的DNA
公开(公告)号：US07273729B2
公开(公告)日：2007-09-25
申请号：US10516099
申请日：2003-05-30
申请人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
发明人： Hisashi Narimatsu , Koji Kimata , Toshikazu Yada , Takashi Sato , Masanori Goto
IPC分类号： C12N9/10 , C12N15/00 , C12N5/02 , C12P21/06 , C12P19/42 , C12P19/04 , C07H21/04
CPC分类号： C12N9/1048 , C12P19/26
摘要： A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferase activity and N-acetylgalactosamine transferase activity.
摘要翻译：人源性新型软骨素合成酶，其是合成软骨素基础骨架的酶，具有葡糖醛酸转移酶活性和N-乙酰半乳糖胺转移酶活性。

6. 发明申请

US20070110670A1 Method for evaluating hair damage using an oxidized protein in hair as an indicator 审中-公开
标题翻译：使用毛发中的氧化蛋白作为指标来评价毛发损伤的方法
公开(公告)号：US20070110670A1
公开(公告)日：2007-05-17
申请号：US10581361
申请日：2004-12-08
申请人： Hiroshi Fujita , Sanae Kubo , Masaaki Yasuda , Tetsuji Hirao , Tomoyuki Kawasoe
发明人： Hiroshi Fujita , Sanae Kubo , Masaaki Yasuda , Tetsuji Hirao , Tomoyuki Kawasoe
IPC分类号： A61K49/00 , C12P19/42 , G01N33/48
CPC分类号： G01N33/6842 , G01N21/6428 , G01N33/4833 , G01N33/68
摘要： The present invention provides a method for evaluating hair damage. The method comprises specifically labeling the carbonyl group of an oxidized protein in hair with fluorescence and detecting the fluorescence. The damage can be caused by any of perm treatment, bleach treatment, treatment with an oxidation hairdye, combing, heat treatment, exposure to ultraviolet rays, and exposure to hypochlorous acid in swimming pools, or a combination thereof.
摘要翻译：本发明提供一种评估头发损伤的方法。该方法包括用荧光特异性标记头发中的氧化蛋白质的羰基并检测荧光。损伤可以由烫发处理，漂白处理，氧化发丝处理，梳理，热处理，暴露于紫外线以及暴露于游泳池中的次氯酸或其组合中的任何一种引起。

7. 发明申请

US20060183188A1 Genes from propionibacterium freudenreichii encoding enzymes involved in vitamin b12 biosynthesis 失效
标题翻译：编码参与维生素B12生物合成的酶的丙酸杆菌属的基因
公开(公告)号：US20060183188A1
公开(公告)日：2006-08-17
申请号：US10522389
申请日：2003-07-25
申请人： Herman Pel , Sylvia Hopper
发明人： Herman Pel , Sylvia Hopper
IPC分类号： C12P19/42 , C12P17/00 , C12P13/00 , C12P9/00 , C07H21/04 , C12P21/06 , C12N9/10
CPC分类号： C12N9/93 , C12N9/1085 , C12N9/1241 , C12N9/1288
摘要： Four new genes, and the enzymes that they encode, are disclosed, which are present in Propionibacterium freudenreichii, and which are involved in at least five steps in the biosynthetic pathway of vitamin B12. The four enzymes are: A: cobyrinic acid a, c-diamide synthase; B: a bifunctional enzyme, which is a cobinamide kinase and a cobinamide phosphate guanyl transferase; C: a cobalamin 5-phosphate synthase; and D: an adenosyl transferase. Genes encoding the four enzymes can be placed in Propionibacteria shuttle vectors and used to transform Propionibacteria hosts, in order to improve the production of vitamin B12 or a precursor thereof on an industrial scale during fermentation.
摘要翻译：公开了四种新基因及其编码的酶，它们存在于丙酸杆菌中，并且在维生素B 12的生物合成途径中参与至少五个步骤。四种酶是：A：豆油酸a，c-二酰胺合酶; B：双功能酶，它是一种辅酶酰胺激酶和一种胞嘧啶酰胺磷酸鸟嘌呤转移酶; C：钴胺素5-磷酸合成酶; 和D：腺苷酰基转移酶。编码四种酶的基因可以放置在丙酸杆菌穿梭载体中，并用于转化丙酸杆菌宿主，以便在发酵期间以工业规模提高维生素B 12 /或其前体的产生。

8. 发明授权

US5026640A Process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids 失效
标题翻译：将由微生物产生的类胡萝卜素转化为氰orr烯的方法
公开(公告)号：US5026640A
公开(公告)日：1991-06-25
申请号：US657748
申请日：1984-10-04
申请人： Agnes Kelemen , Eva Cserey Pechany , Istvan Jaksa
发明人： Agnes Kelemen , Eva Cserey Pechany , Istvan Jaksa
IPC分类号： C07D487/22 , C07H23/00 , C12P17/18 , C12P19/42 , C12R1/01 , C12R1/15 , C12R1/225
CPC分类号： C07H23/00 , C12P17/182 , C12P19/42
摘要： The invention relates to a process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids by reaction with cyanides. According to the invention a fermentation broth obtained by disruption of microorganism cells in a known manner, preferably by heat treatment in the presence or absence of sulfite ions, optionally after purification steps known per se, is contacted with a suitable adsorbent or ion exchange resin, the corrinoids adsorbed on the surface of the adsorbent or ion exchange resin are treated with an aqueous solution containing cyanide ions or a compound capable of supplying cyanide ions, in an amount providing cyanide ions in a 1.1 to 2.0-fold molar excess related to the corrinoids, the adsorbent or ion exchange resin is washed with water, and the cyanocorrinoids obtained is eluted in a known manner, preferably with aqueous ethanol.
摘要翻译：本发明涉及通过与氰化物反应将由微生物产生的类胡萝卜素转化成氰orr烯的方法。根据本发明，通过以已知方式破坏微生物细胞获得的发酵液，优选通过在存在或不存在亚硫酸根离子的情况下，任选地在本身已知的纯化步骤之后进行热处理，与合适的吸附剂或离子交换树脂接触，吸附在吸附剂或离子交换树脂表面上的类胡萝卜素用含氰化物离子或能够提供氰化物离子的化合物的水溶液进行处理，其量为氰化物离子的量为1.1-2.0倍摩尔过量，与脯氨酸相关吸附剂或离子交换树脂用水洗涤，所得的氰肟酮以已知的方式，优选用含水乙醇洗脱。

9. 发明授权

US4119492A Process for fermentatively producing vitamin B.sub.12 失效
标题翻译：发酵生产维生素B的方法（HD 12
公开(公告)号：US4119492A
公开(公告)日：1978-10-10
申请号：US763539
申请日：1977-01-28
申请人： Ichiro Kojima , Hiroshi Sato , Yasuo Fujiwara
发明人： Ichiro Kojima , Hiroshi Sato , Yasuo Fujiwara
IPC分类号： C12N1/32 , C12P19/42 , C12R1/06 , C12D5/06
CPC分类号： C12P19/42 , C12N1/32 , Y10S435/83
摘要： A process for producing vitamin B.sub.12, which comprises cultivating a vitamin B.sub.12 -producing micro-organism of the genus Arthrobacter under aerobic conditions in a culture medium containing at least one compound selected from the group consisting of alcohols with 2 or 3 carbon atoms and ketones, and separating vitamin B.sub.12 from the culture broth.
摘要翻译：一种生产维生素B12的方法，其包括在需氧条件下，在含有至少一种选自具有2或3个碳原子的醇和酮的化合物的培养基中培养节杆菌属的维生素B12生产微生物，并从培养液中分离维生素B12。

10. 发明授权

US3979259A Process for the production of fermentation broth with increased vitamin B.sub.12 content by synchronizing the bacterium population 失效
标题翻译：生产具有增加维生素B的发酵肉汤的方法{HD 12 {通过同步细菌群体的B含量
公开(公告)号：US3979259A
公开(公告)日：1976-09-07
申请号：US517788
申请日：1974-10-24
申请人： Bela Johan , Laszlo Szemler , Tamas Szontagh , Laszlo Kuti , Emilia Simonovits , Judit Bekes nee Erdos , Denes Szekely , Janos Kiss , Erzsebet Kovacs nee Komoroczy , Aniko Hargitai nee Franyo
发明人： Bela Johan , Laszlo Szemler , Tamas Szontagh , Laszlo Kuti , Emilia Simonovits , Judit Bekes nee Erdos , Denes Szekely , Janos Kiss , Erzsebet Kovacs nee Komoroczy , Aniko Hargitai nee Franyo
IPC分类号： C12N1/32 , C12P5/02 , C12P19/42 , C12R1/01 , C12D5/06
CPC分类号： C12P5/023 , C12P19/42 , Y02E50/343 , Y10S435/801 , Y10S435/802 , Y10S435/813
摘要： The invention relates to a process for the production of a fermentation broth with increased vitamin B.sub.12 content by a fermentation process carried out with a methane-producing mixed bacterium population under anaerobic septic conditions in the presence of known nutrient components and precursors. According to the invention, methanol, preferably in an amount of 0.5 v/v %, is added for some days, preferably for 3 days to the fermentation broth containing vitamin B.sub.12 used as the starting substance. Thereafter a minor part, preferably 10% of the fermentation broth, is removed and an equal volume of a nutrient broth containing the usual components in tenfold concentrations is added periodically in every 5th to 12th day, then the removal of fermentation broth is interrupted for 0 to 2 days, preferably for 1 day, and only 0.4 to 1.5 v/v% of methanol are added to the fermentation broth, and subsequently a minor part, preferably 10% of the fermentation broth, is removed daily and an equal volume of a nutrient broth containing the usual components in the usual concentrations is added together with 0.4 to 1.5 v/v % of methanol, depending on the biogas production of the fermentation broth. This series of operations is repeated periodically during the complete fermentation procedure taking into consideration the pH of the fermentation broth.
摘要翻译：本发明涉及通过在已知营养成分和前体的存在下在厌氧脓毒症条件下用产甲烷混合菌群进行的发酵方法来生产具有增加的维生素B12含量的发酵液的方法。根据本发明，优选以0.5v / v％的量将甲醇加入含有用作起始物质的维生素B12的发酵液中几天，优选3天。此后，除去少量的发酵肉汤，并且每5至12天定期添加等体积的含有十倍浓度的通常组分的营养肉汤，然后将发酵肉汤的去除中断0 至2天，优选1天，并且仅将0.4至1.5v / v％的甲醇加入到发酵液中，随后每天除去少部分，优选10％的发酵液，并加入等体积的根据发酵液的生物气产量，含有通常浓度的通常组分的营养肉汤与0.4至1.5v / v％的甲醇一起加入。考虑到发酵液的pH值，在整个发酵过程中定期重复这一系列操作。

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